Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria

Sihem Bensalem; Assia Bensalem; Abdellaziz Ammari; Zaim Younsi; Aicha Djemaa

doi:doi:10.11648/j.ijcocr.20220702.16

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Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria

Sihem Bensalem, Assia Bensalem, Abdellaziz Ammari, Zaim Younsi, Aicha Djemaa

Published in International Journal of Clinical Oncology and Cancer Research (Volume 7, Issue 2)

Received: 13 May 2022 Accepted: 13 June 2022 Published: 27 June 2022

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Abstract

Background: Breast cancer and type 2 diabetes mellitus (T2DM); two worrying public health problems of our century and frequently in our country, have many risk factors in common as well as pathophysiological links. The main objective of the present study is to estimate the frequency of the T2DM-breast cancer association in women in the city of Constantine, while looking for risk factors for breast cancer in this population. Patients and methods: A prospective multicenter descriptive study was conducted from January 1, 2019 until December 31, 2020, in women with T2DM associated with newly diagnosed breast cancer. The patients had answered a questionnaire and underwent a clinical and laboratory examination. Results: 901 women with breast cancer were seen during the study period, 152 of whom were type 2 diabetics (17%). Their average age was 64 ± 10 years. The age of discovery of T2DM and breast cancer were 53 ± 9.75 years and 62 ± 10 years, respectively. As for the mean duration of diabetes, it was 11 ± 8 years. Insulin was taken over an average of nine years with a calculated average dose of 93 u/d. For the cancer stage, the majority were in stages IIIA (41.5%) and IIIB (32.3%). The common risk factors for T2DM and breast cancer found were sedentary lifestyle (78% of patients), overweight or obesity (81.5%), abdominal obesity (86.5%), low HDLc (70%), hypertriglyceridemia (72.5%). Diabetic imbalance was found in 61.4% of patients. In addition, overweight and obesity were correlated with cancer severity (OR: 1.237; p = 0,0001) as well as abdominal obesity (OR: 1.162; p = 0,0001). Conclusion: The noted frequency of the association of type 2 diabetes and breast cancer requires a targeted cancer screening strategy as well as joint management of risk factors, the only guarantee of a better prognosis for this cancer.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 7, Issue 2)
DOI	10.11648/j.ijcocr.20220702.16
Page(s)	46-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Type 2 Diabetes Mellitus, Breast Cancer, Association, Frequency and Risk Factors

References

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[3]	Boyle P, Boniol M, Koechlin A, Robertson C, Valentini F, Coppens K, Fairley LL, Boniol M, Zheng T, Zhang Y et al.: Diabetes and breast cancer risk: a meta-analysis. British journal of cancer 2012, 107 (9): 1608-1617.
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[6]	Wolf I, Sadetzki S, Catane R, Karasik A, Kaufman B: Diabetes mellitus and breast cancer. The Lancet Oncology 2005, 6 (2): 103-111.
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[8]	Sanderson M, Peltz G, Perez A, Johnson M, Vernon SW, Fernandez ME, Fadden MK: Diabetes, physical activity and breast cancer among Hispanic women. Cancer epidemiology 2010, 34 (5): 556-561.
[9]	Cleveland RJ, North KE, Stevens J, Teitelbaum SL, Neugut AI, Gammon MD: The association of diabetes with breast cancer incidence and mortality in the Long Island Breast Cancer Study Project. Cancer causes & control: CCC 2012, 23 (7): 1193-1203.
[10]	García-Esquinas E, Guinó E, Castaño-Vinyals G, Pérez-Gómez B, Llorca J, Altzibar JM, Peiró-Pérez R, Martín V, Moreno-Iribas C, Tardón A et al.: Association of diabetes and diabetes treatment with incidence of breast cancer. Acta diabetologica 2016, 53 (1): 99-107.
[11]	Erickson K, Patterson RE, Flatt SW, Natarajan L, Parker BA, Heath DD, Laughlin GA, Saquib N, Rock CL, Pierce JP: Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 2011, 29 (1): 54-60.
[12]	Chang YL, Sheu WH, Lin SY, Liou WS: Good glycaemic control is associated with a better prognosis in breast cancer patients with type 2 diabetes mellitus. Clinical and experimental medicine 2018, 18 (3): 383-390.
[13]	Schrauder MG, Fasching PA, Häberle L, Lux MP, Rauh C, Hein A, Bayer CM, Heusinger K, Hartmann A, Strehl JD et al.: Diabetes and prognosis in a breast cancer cohort. Journal of cancer research and clinical oncology 2011, 137 (6): 975-983.

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APA Style

Sihem Bensalem, Assia Bensalem, Abdellaziz Ammari, Zaim Younsi, Aicha Djemaa. (2022). Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria. International Journal of Clinical Oncology and Cancer Research, 7(2), 46-52. https://doi.org/10.11648/j.ijcocr.20220702.16

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ACS Style

Sihem Bensalem; Assia Bensalem; Abdellaziz Ammari; Zaim Younsi; Aicha Djemaa. Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria. Int. J. Clin. Oncol. Cancer Res. 2022, 7(2), 46-52. doi: 10.11648/j.ijcocr.20220702.16

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AMA Style

Sihem Bensalem, Assia Bensalem, Abdellaziz Ammari, Zaim Younsi, Aicha Djemaa. Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria. Int J Clin Oncol Cancer Res. 2022;7(2):46-52. doi: 10.11648/j.ijcocr.20220702.16

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@article{10.11648/j.ijcocr.20220702.16,
  author = {Sihem Bensalem and Assia Bensalem and Abdellaziz Ammari and Zaim Younsi and Aicha Djemaa},
  title = {Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {7},
  number = {2},
  pages = {46-52},
  doi = {10.11648/j.ijcocr.20220702.16},
  url = {https://doi.org/10.11648/j.ijcocr.20220702.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20220702.16},
  abstract = {Background: Breast cancer and type 2 diabetes mellitus (T2DM); two worrying public health problems of our century and frequently in our country, have many risk factors in common as well as pathophysiological links. The main objective of the present study is to estimate the frequency of the T2DM-breast cancer association in women in the city of Constantine, while looking for risk factors for breast cancer in this population. Patients and methods: A prospective multicenter descriptive study was conducted from January 1, 2019 until December 31, 2020, in women with T2DM associated with newly diagnosed breast cancer. The patients had answered a questionnaire and underwent a clinical and laboratory examination. Results: 901 women with breast cancer were seen during the study period, 152 of whom were type 2 diabetics (17%). Their average age was 64 ± 10 years. The age of discovery of T2DM and breast cancer were 53 ± 9.75 years and 62 ± 10 years, respectively. As for the mean duration of diabetes, it was 11 ± 8 years. Insulin was taken over an average of nine years with a calculated average dose of 93 u/d. For the cancer stage, the majority were in stages IIIA (41.5%) and IIIB (32.3%). The common risk factors for T2DM and breast cancer found were sedentary lifestyle (78% of patients), overweight or obesity (81.5%), abdominal obesity (86.5%), low HDLc (70%), hypertriglyceridemia (72.5%). Diabetic imbalance was found in 61.4% of patients. In addition, overweight and obesity were correlated with cancer severity (OR: 1.237; p = 0,0001) as well as abdominal obesity (OR: 1.162; p = 0,0001). Conclusion: The noted frequency of the association of type 2 diabetes and breast cancer requires a targeted cancer screening strategy as well as joint management of risk factors, the only guarantee of a better prognosis for this cancer.},
 year = {2022}
}

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TY - JOUR
T1 - Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria
AU - Sihem Bensalem
AU - Assia Bensalem
AU - Abdellaziz Ammari
AU - Zaim Younsi
AU - Aicha Djemaa
Y1 - 2022/06/27
PY - 2022
N1 - https://doi.org/10.11648/j.ijcocr.20220702.16
DO - 10.11648/j.ijcocr.20220702.16
T2 - International Journal of Clinical Oncology and Cancer Research
JF - International Journal of Clinical Oncology and Cancer Research
JO - International Journal of Clinical Oncology and Cancer Research
SP - 46
EP - 52
PB - Science Publishing Group
SN - 2578-9511
UR - https://doi.org/10.11648/j.ijcocr.20220702.16
AB - Background: Breast cancer and type 2 diabetes mellitus (T2DM); two worrying public health problems of our century and frequently in our country, have many risk factors in common as well as pathophysiological links. The main objective of the present study is to estimate the frequency of the T2DM-breast cancer association in women in the city of Constantine, while looking for risk factors for breast cancer in this population. Patients and methods: A prospective multicenter descriptive study was conducted from January 1, 2019 until December 31, 2020, in women with T2DM associated with newly diagnosed breast cancer. The patients had answered a questionnaire and underwent a clinical and laboratory examination. Results: 901 women with breast cancer were seen during the study period, 152 of whom were type 2 diabetics (17%). Their average age was 64 ± 10 years. The age of discovery of T2DM and breast cancer were 53 ± 9.75 years and 62 ± 10 years, respectively. As for the mean duration of diabetes, it was 11 ± 8 years. Insulin was taken over an average of nine years with a calculated average dose of 93 u/d. For the cancer stage, the majority were in stages IIIA (41.5%) and IIIB (32.3%). The common risk factors for T2DM and breast cancer found were sedentary lifestyle (78% of patients), overweight or obesity (81.5%), abdominal obesity (86.5%), low HDLc (70%), hypertriglyceridemia (72.5%). Diabetic imbalance was found in 61.4% of patients. In addition, overweight and obesity were correlated with cancer severity (OR: 1.237; p = 0,0001) as well as abdominal obesity (OR: 1.162; p = 0,0001). Conclusion: The noted frequency of the association of type 2 diabetes and breast cancer requires a targeted cancer screening strategy as well as joint management of risk factors, the only guarantee of a better prognosis for this cancer.
VL - 7
IS - 2
ER -

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Author Information

Sihem Bensalem

Endocrinology-Diabetology and Metabolic Diseases, Regional University Military Hospital Commander Abdellali Benbaatouche (HMRUC), Faculty of Medicine, University Constantine3, Constantine, Algeria
Assia Bensalem

Medical Oncology Department, Hospital Establishment DIDOUCHE Mourad, Faculty of Medicine, University Constantine3, Constantine, Algeria
Abdellaziz Ammari

Medical Oncology Department, Hospital Establishment DIDOUCHE Mourad, Faculty of Medicine, University Constantine3, Constantine, Algeria
Zaim Younsi

Medical Oncology Department, Regional University Military Hospital Commander Abdellali Benbaatouche (HMRUC), Faculty of Medicine, University Constantine3, Constantine, Algeria
Aicha Djemaa

Radiotherapy Department, Centre Anti-Cancer, University Hospital Center Dr BENBADIS, Faculty of Medicine, University Constantine3, Constantine, Algeria

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APA Style

Sihem Bensalem, Assia Bensalem, Abdellaziz Ammari, Zaim Younsi, Aicha Djemaa. (2022). Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria. International Journal of Clinical Oncology and Cancer Research, 7(2), 46-52. https://doi.org/10.11648/j.ijcocr.20220702.16

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ACS Style

Sihem Bensalem; Assia Bensalem; Abdellaziz Ammari; Zaim Younsi; Aicha Djemaa. Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria. Int. J. Clin. Oncol. Cancer Res. 2022, 7(2), 46-52. doi: 10.11648/j.ijcocr.20220702.16

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AMA Style

Sihem Bensalem, Assia Bensalem, Abdellaziz Ammari, Zaim Younsi, Aicha Djemaa. Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria. Int J Clin Oncol Cancer Res. 2022;7(2):46-52. doi: 10.11648/j.ijcocr.20220702.16

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@article{10.11648/j.ijcocr.20220702.16,
  author = {Sihem Bensalem and Assia Bensalem and Abdellaziz Ammari and Zaim Younsi and Aicha Djemaa},
  title = {Frequency and Risk Factors of Association of Breast Cancer and Diabetes Type 2 in Constantine, the Eastern City of Algeria},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {7},
  number = {2},
  pages = {46-52},
  doi = {10.11648/j.ijcocr.20220702.16},
  url = {https://doi.org/10.11648/j.ijcocr.20220702.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20220702.16},
  abstract = {Background: Breast cancer and type 2 diabetes mellitus (T2DM); two worrying public health problems of our century and frequently in our country, have many risk factors in common as well as pathophysiological links. The main objective of the present study is to estimate the frequency of the T2DM-breast cancer association in women in the city of Constantine, while looking for risk factors for breast cancer in this population. Patients and methods: A prospective multicenter descriptive study was conducted from January 1, 2019 until December 31, 2020, in women with T2DM associated with newly diagnosed breast cancer. The patients had answered a questionnaire and underwent a clinical and laboratory examination. Results: 901 women with breast cancer were seen during the study period, 152 of whom were type 2 diabetics (17%). Their average age was 64 ± 10 years. The age of discovery of T2DM and breast cancer were 53 ± 9.75 years and 62 ± 10 years, respectively. As for the mean duration of diabetes, it was 11 ± 8 years. Insulin was taken over an average of nine years with a calculated average dose of 93 u/d. For the cancer stage, the majority were in stages IIIA (41.5%) and IIIB (32.3%). The common risk factors for T2DM and breast cancer found were sedentary lifestyle (78% of patients), overweight or obesity (81.5%), abdominal obesity (86.5%), low HDLc (70%), hypertriglyceridemia (72.5%). Diabetic imbalance was found in 61.4% of patients. In addition, overweight and obesity were correlated with cancer severity (OR: 1.237; p = 0,0001) as well as abdominal obesity (OR: 1.162; p = 0,0001). Conclusion: The noted frequency of the association of type 2 diabetes and breast cancer requires a targeted cancer screening strategy as well as joint management of risk factors, the only guarantee of a better prognosis for this cancer.},
 year = {2022}
}

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