Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature

Azka Ali; Raphael Charles Bosse; Bently Patrick Doonan; Preeti Narayan; Grant Alan Jester; Jess David Delaune; Jacob Leo Barish; Samantha Leigh Welniak; Hannah Friggle Norton; Coy Don Heldermon

doi:doi:10.11648/j.ijcocr.20190402.12

Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature

Azka Ali, Raphael Charles Bosse, Bently Patrick Doonan, Preeti Narayan, Grant Alan Jester, Jess David Delaune, Jacob Leo Barish, Samantha Leigh Welniak, Hannah Friggle Norton, Coy Don Heldermon

Published in International Journal of Clinical Oncology and Cancer Research (Volume 4, Issue 2)

Received: 21 February 2019 Accepted: 8 April 2019 Published: 11 June 2019

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Abstract

First introduced in 1963, ommaya reservoirs (OmRs) are indwelling intraventricular catheters used for decompression of hydrocephalus, antibiotics, and chemotherapy delivery. They are important alternatives when lumbar punctures are not practical or when long-term administration of medications is needed. Despite being used for over 50 years, placement of these devices can still contribute to significant morbidity and mortality. We performed a single-center retrospective review at the University of Florida Cancer Center evaluating OmR related complications in patients in whom OmR was placed for chemotherapy. We also conducted a systematic review of OmR related and LP complications in setting of chemotherapy delivery. 13 patients met criteria for inclusion in this retrospective study. Time points evaluated for complications were: placement, up to 6 months, 6-12 months, > 12 months, removal and post-discharge. Our institutional data showed a complicated rate of <7% at each time point. For systematic review, 38 studies were reviewed for OmR data, and 8 studies were reviewed for LP data. Infectious complications were more prevalent in OmR studies with statistical significance (p=0.0017), whereas noninfectious complications were more prevalent in LP studies with statistical significance (p=0.0004). This study compared complication rates from infectious and non-infectious sources between patients receiving intrathecal chemotherapy through Ommaya reservoirs versus lumbar puncture. OmR can be very useful in long-term administration of medication, and the relatively high complication rate (especially infectious) can be deemed an acceptable risk for patient population with high morbidity.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 4, Issue 2)
DOI	10.11648/j.ijcocr.20190402.12
Page(s)	10-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Ommaya Reservoir, Lumbar Puncture, Chemotherapy

References

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Azka Ali, Raphael Charles Bosse, Bently Patrick Doonan, Preeti Narayan, Grant Alan Jester, et al. (2019). Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature. International Journal of Clinical Oncology and Cancer Research, 4(2), 10-24. https://doi.org/10.11648/j.ijcocr.20190402.12

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ACS Style

Azka Ali; Raphael Charles Bosse; Bently Patrick Doonan; Preeti Narayan; Grant Alan Jester, et al. Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature. Int. J. Clin. Oncol. Cancer Res. 2019, 4(2), 10-24. doi: 10.11648/j.ijcocr.20190402.12

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AMA Style

Azka Ali, Raphael Charles Bosse, Bently Patrick Doonan, Preeti Narayan, Grant Alan Jester, et al. Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature. Int J Clin Oncol Cancer Res. 2019;4(2):10-24. doi: 10.11648/j.ijcocr.20190402.12

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@article{10.11648/j.ijcocr.20190402.12,
  author = {Azka Ali and Raphael Charles Bosse and Bently Patrick Doonan and Preeti Narayan and Grant Alan Jester and Jess David Delaune and Jacob Leo Barish and Samantha Leigh Welniak and Hannah Friggle Norton and Coy Don Heldermon},
  title = {Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {4},
  number = {2},
  pages = {10-24},
  doi = {10.11648/j.ijcocr.20190402.12},
  url = {https://doi.org/10.11648/j.ijcocr.20190402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20190402.12},
  abstract = {First introduced in 1963, ommaya reservoirs (OmRs) are indwelling intraventricular catheters used for decompression of hydrocephalus, antibiotics, and chemotherapy delivery. They are important alternatives when lumbar punctures are not practical or when long-term administration of medications is needed. Despite being used for over 50 years, placement of these devices can still contribute to significant morbidity and mortality. We performed a single-center retrospective review at the University of Florida Cancer Center evaluating OmR related complications in patients in whom OmR was placed for chemotherapy. We also conducted a systematic review of OmR related and LP complications in setting of chemotherapy delivery. 13 patients met criteria for inclusion in this retrospective study. Time points evaluated for complications were: placement, up to 6 months, 6-12 months, > 12 months, removal and post-discharge. Our institutional data showed a complicated rate of <7% at each time point. For systematic review, 38 studies were reviewed for OmR data, and 8 studies were reviewed for LP data. Infectious complications were more prevalent in OmR studies with statistical significance (p=0.0017), whereas noninfectious complications were more prevalent in LP studies with statistical significance (p=0.0004). This study compared complication rates from infectious and non-infectious sources between patients receiving intrathecal chemotherapy through Ommaya reservoirs versus lumbar puncture. OmR can be very useful in long-term administration of medication, and the relatively high complication rate (especially infectious) can be deemed an acceptable risk for patient population with high morbidity.},
 year = {2019}
}

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AU  - Azka Ali
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AU  - Bently Patrick Doonan
AU  - Preeti Narayan
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AU  - Jess David Delaune
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JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
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PB  - Science Publishing Group
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AB  - First introduced in 1963, ommaya reservoirs (OmRs) are indwelling intraventricular catheters used for decompression of hydrocephalus, antibiotics, and chemotherapy delivery. They are important alternatives when lumbar punctures are not practical or when long-term administration of medications is needed. Despite being used for over 50 years, placement of these devices can still contribute to significant morbidity and mortality. We performed a single-center retrospective review at the University of Florida Cancer Center evaluating OmR related complications in patients in whom OmR was placed for chemotherapy. We also conducted a systematic review of OmR related and LP complications in setting of chemotherapy delivery. 13 patients met criteria for inclusion in this retrospective study. Time points evaluated for complications were: placement, up to 6 months, 6-12 months, > 12 months, removal and post-discharge. Our institutional data showed a complicated rate of <7% at each time point. For systematic review, 38 studies were reviewed for OmR data, and 8 studies were reviewed for LP data. Infectious complications were more prevalent in OmR studies with statistical significance (p=0.0017), whereas noninfectious complications were more prevalent in LP studies with statistical significance (p=0.0004). This study compared complication rates from infectious and non-infectious sources between patients receiving intrathecal chemotherapy through Ommaya reservoirs versus lumbar puncture. OmR can be very useful in long-term administration of medication, and the relatively high complication rate (especially infectious) can be deemed an acceptable risk for patient population with high morbidity.
VL  - 4
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Author Information

Azka Ali

Department of Internal Medicine, University of Florida, Gainesville, USA
Raphael Charles Bosse

Department of Internal Medicine, University of Florida, Gainesville, USA
Bently Patrick Doonan

Department of Internal Medicine, University of Florida, Gainesville, USA
Preeti Narayan

Division of Hematology and Oncology, University of Florida, Gainesville, USA
Grant Alan Jester

Department of Internal Medicine, University of Florida, Gainesville, USA
Jess David Delaune

Department of Internal Medicine, University of Florida, Gainesville, USA
Jacob Leo Barish

Department of Internal Medicine, University of Florida, Gainesville, USA
Samantha Leigh Welniak

Department of Internal Medicine, University of Florida, Gainesville, USA
Hannah Friggle Norton

Health Science Center Libraries, University of Florida, Gainesville, USA
Coy Don Heldermon

Division of Hematology and Oncology, University of Florida, Gainesville, USA

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Azka Ali, Raphael Charles Bosse, Bently Patrick Doonan, Preeti Narayan, Grant Alan Jester, et al. (2019). Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature. International Journal of Clinical Oncology and Cancer Research, 4(2), 10-24. https://doi.org/10.11648/j.ijcocr.20190402.12

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ACS Style

Azka Ali; Raphael Charles Bosse; Bently Patrick Doonan; Preeti Narayan; Grant Alan Jester, et al. Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature. Int. J. Clin. Oncol. Cancer Res. 2019, 4(2), 10-24. doi: 10.11648/j.ijcocr.20190402.12

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AMA Style

Azka Ali, Raphael Charles Bosse, Bently Patrick Doonan, Preeti Narayan, Grant Alan Jester, et al. Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature. Int J Clin Oncol Cancer Res. 2019;4(2):10-24. doi: 10.11648/j.ijcocr.20190402.12

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@article{10.11648/j.ijcocr.20190402.12,
  author = {Azka Ali and Raphael Charles Bosse and Bently Patrick Doonan and Preeti Narayan and Grant Alan Jester and Jess David Delaune and Jacob Leo Barish and Samantha Leigh Welniak and Hannah Friggle Norton and Coy Don Heldermon},
  title = {Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {4},
  number = {2},
  pages = {10-24},
  doi = {10.11648/j.ijcocr.20190402.12},
  url = {https://doi.org/10.11648/j.ijcocr.20190402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20190402.12},
  abstract = {First introduced in 1963, ommaya reservoirs (OmRs) are indwelling intraventricular catheters used for decompression of hydrocephalus, antibiotics, and chemotherapy delivery. They are important alternatives when lumbar punctures are not practical or when long-term administration of medications is needed. Despite being used for over 50 years, placement of these devices can still contribute to significant morbidity and mortality. We performed a single-center retrospective review at the University of Florida Cancer Center evaluating OmR related complications in patients in whom OmR was placed for chemotherapy. We also conducted a systematic review of OmR related and LP complications in setting of chemotherapy delivery. 13 patients met criteria for inclusion in this retrospective study. Time points evaluated for complications were: placement, up to 6 months, 6-12 months, > 12 months, removal and post-discharge. Our institutional data showed a complicated rate of <7% at each time point. For systematic review, 38 studies were reviewed for OmR data, and 8 studies were reviewed for LP data. Infectious complications were more prevalent in OmR studies with statistical significance (p=0.0017), whereas noninfectious complications were more prevalent in LP studies with statistical significance (p=0.0004). This study compared complication rates from infectious and non-infectious sources between patients receiving intrathecal chemotherapy through Ommaya reservoirs versus lumbar puncture. OmR can be very useful in long-term administration of medication, and the relatively high complication rate (especially infectious) can be deemed an acceptable risk for patient population with high morbidity.},
 year = {2019}
}

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TY  - JOUR
T1  - Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature
AU  - Azka Ali
AU  - Raphael Charles Bosse
AU  - Bently Patrick Doonan
AU  - Preeti Narayan
AU  - Grant Alan Jester
AU  - Jess David Delaune
AU  - Jacob Leo Barish
AU  - Samantha Leigh Welniak
AU  - Hannah Friggle Norton
AU  - Coy Don Heldermon
Y1  - 2019/06/11
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcocr.20190402.12
DO  - 10.11648/j.ijcocr.20190402.12
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 10
EP  - 24
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20190402.12
AB  - First introduced in 1963, ommaya reservoirs (OmRs) are indwelling intraventricular catheters used for decompression of hydrocephalus, antibiotics, and chemotherapy delivery. They are important alternatives when lumbar punctures are not practical or when long-term administration of medications is needed. Despite being used for over 50 years, placement of these devices can still contribute to significant morbidity and mortality. We performed a single-center retrospective review at the University of Florida Cancer Center evaluating OmR related complications in patients in whom OmR was placed for chemotherapy. We also conducted a systematic review of OmR related and LP complications in setting of chemotherapy delivery. 13 patients met criteria for inclusion in this retrospective study. Time points evaluated for complications were: placement, up to 6 months, 6-12 months, > 12 months, removal and post-discharge. Our institutional data showed a complicated rate of <7% at each time point. For systematic review, 38 studies were reviewed for OmR data, and 8 studies were reviewed for LP data. Infectious complications were more prevalent in OmR studies with statistical significance (p=0.0017), whereas noninfectious complications were more prevalent in LP studies with statistical significance (p=0.0004). This study compared complication rates from infectious and non-infectious sources between patients receiving intrathecal chemotherapy through Ommaya reservoirs versus lumbar puncture. OmR can be very useful in long-term administration of medication, and the relatively high complication rate (especially infectious) can be deemed an acceptable risk for patient population with high morbidity.
VL  - 4
IS  - 2
ER  -

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