The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation

Kalin Petrov Kalchev; Alexander Ivanov Hinev; Alkwin Wanders; Alexander Georgiev Otsetov

doi:doi:10.11648/j.ijcocr.20170204.14

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The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation

Kalin Petrov Kalchev, Alexander Ivanov Hinev, Alkwin Wanders, Alexander Georgiev Otsetov

Published in International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 4)

Received: 29 June 2017 Accepted: 26 July 2017 Published: 25 August 2017

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Abstract

Prostate cancer (PCa) progression is an intricate step-wise process, starting from malignant transformations in the benign prostatic epithelium. The hallmark of PCa is the long period of its development from premalignant transformations in the benign prostatic epithelium towards clinically active carcinoma. Along with the age, inflammation, race and genetics, which are well-recognized risk factors for prostatic carcinoma, epigenetics play also a significant role in the initiation and progression of prostatic carcinoma. DNA methylation in the CpG gene islands is a key player in the regulation of gene expression and silencing, and significantly contributes to the disease development. Progression of cancer is associated with the loss of several tumor suppressor genes such as Maspin through mutations or epigenetic silencing. Epigenetic silencing of Maspin seems to be one of the earliest somatic change, contributing to the development of prostatic carcinoma in the human prostate.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 4)
DOI	10.11648/j.ijcocr.20170204.14
Page(s)	93-98
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Prostate Carcinogenesis, Field Effect, Epigenetics, Ageing, Chronic Inflammation, Maspin

References

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APA Style

Kalin Petrov Kalchev, Alexander Ivanov Hinev, Alkwin Wanders, Alexander Georgiev Otsetov. (2017). The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation. International Journal of Clinical Oncology and Cancer Research, 2(4), 93-98. https://doi.org/10.11648/j.ijcocr.20170204.14

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ACS Style

Kalin Petrov Kalchev; Alexander Ivanov Hinev; Alkwin Wanders; Alexander Georgiev Otsetov. The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation. Int. J. Clin. Oncol. Cancer Res. 2017, 2(4), 93-98. doi: 10.11648/j.ijcocr.20170204.14

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AMA Style

Kalin Petrov Kalchev, Alexander Ivanov Hinev, Alkwin Wanders, Alexander Georgiev Otsetov. The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation. Int J Clin Oncol Cancer Res. 2017;2(4):93-98. doi: 10.11648/j.ijcocr.20170204.14

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@article{10.11648/j.ijcocr.20170204.14,
  author = {Kalin Petrov Kalchev and Alexander Ivanov Hinev and Alkwin Wanders and Alexander Georgiev Otsetov},
  title = {The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {2},
  number = {4},
  pages = {93-98},
  doi = {10.11648/j.ijcocr.20170204.14},
  url = {https://doi.org/10.11648/j.ijcocr.20170204.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170204.14},
  abstract = {Prostate cancer (PCa) progression is an intricate step-wise process, starting from malignant transformations in the benign prostatic epithelium. The hallmark of PCa is the long period of its development from premalignant transformations in the benign prostatic epithelium towards clinically active carcinoma. Along with the age, inflammation, race and genetics, which are well-recognized risk factors for prostatic carcinoma, epigenetics play also a significant role in the initiation and progression of prostatic carcinoma. DNA methylation in the CpG gene islands is a key player in the regulation of gene expression and silencing, and significantly contributes to the disease development. Progression of cancer is associated with the loss of several tumor suppressor genes such as Maspin through mutations or epigenetic silencing. Epigenetic silencing of Maspin seems to be one of the earliest somatic change, contributing to the development of prostatic carcinoma in the human prostate.},
 year = {2017}
}

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TY  - JOUR
T1  - The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation
AU  - Kalin Petrov Kalchev
AU  - Alexander Ivanov Hinev
AU  - Alkwin Wanders
AU  - Alexander Georgiev Otsetov
Y1  - 2017/08/25
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20170204.14
DO  - 10.11648/j.ijcocr.20170204.14
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 93
EP  - 98
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20170204.14
AB  - Prostate cancer (PCa) progression is an intricate step-wise process, starting from malignant transformations in the benign prostatic epithelium. The hallmark of PCa is the long period of its development from premalignant transformations in the benign prostatic epithelium towards clinically active carcinoma. Along with the age, inflammation, race and genetics, which are well-recognized risk factors for prostatic carcinoma, epigenetics play also a significant role in the initiation and progression of prostatic carcinoma. DNA methylation in the CpG gene islands is a key player in the regulation of gene expression and silencing, and significantly contributes to the disease development. Progression of cancer is associated with the loss of several tumor suppressor genes such as Maspin through mutations or epigenetic silencing. Epigenetic silencing of Maspin seems to be one of the earliest somatic change, contributing to the development of prostatic carcinoma in the human prostate.
VL  - 2
IS  - 4
ER  -

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Author Information

Kalin Petrov Kalchev

Department of Pathology, Varna Medical University, Varna, Bulgaria
Alexander Ivanov Hinev

Department of Urology, Varna Medical University, Varna, Bulgaria
Alkwin Wanders

Department of Medical Biosciences, Pathology, Ume? University, Ume?, Sweden
Alexander Georgiev Otsetov

Department of Medical Biosciences, Pathology, Ume? University, Ume?, Sweden

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Plain Text BibTeX RIS

APA Style

Kalin Petrov Kalchev, Alexander Ivanov Hinev, Alkwin Wanders, Alexander Georgiev Otsetov. (2017). The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation. International Journal of Clinical Oncology and Cancer Research, 2(4), 93-98. https://doi.org/10.11648/j.ijcocr.20170204.14

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ACS Style

Kalin Petrov Kalchev; Alexander Ivanov Hinev; Alkwin Wanders; Alexander Georgiev Otsetov. The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation. Int. J. Clin. Oncol. Cancer Res. 2017, 2(4), 93-98. doi: 10.11648/j.ijcocr.20170204.14

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AMA Style

Kalin Petrov Kalchev, Alexander Ivanov Hinev, Alkwin Wanders, Alexander Georgiev Otsetov. The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation. Int J Clin Oncol Cancer Res. 2017;2(4):93-98. doi: 10.11648/j.ijcocr.20170204.14

Copy | Download

@article{10.11648/j.ijcocr.20170204.14,
  author = {Kalin Petrov Kalchev and Alexander Ivanov Hinev and Alkwin Wanders and Alexander Georgiev Otsetov},
  title = {The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {2},
  number = {4},
  pages = {93-98},
  doi = {10.11648/j.ijcocr.20170204.14},
  url = {https://doi.org/10.11648/j.ijcocr.20170204.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170204.14},
  abstract = {Prostate cancer (PCa) progression is an intricate step-wise process, starting from malignant transformations in the benign prostatic epithelium. The hallmark of PCa is the long period of its development from premalignant transformations in the benign prostatic epithelium towards clinically active carcinoma. Along with the age, inflammation, race and genetics, which are well-recognized risk factors for prostatic carcinoma, epigenetics play also a significant role in the initiation and progression of prostatic carcinoma. DNA methylation in the CpG gene islands is a key player in the regulation of gene expression and silencing, and significantly contributes to the disease development. Progression of cancer is associated with the loss of several tumor suppressor genes such as Maspin through mutations or epigenetic silencing. Epigenetic silencing of Maspin seems to be one of the earliest somatic change, contributing to the development of prostatic carcinoma in the human prostate.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation
AU  - Kalin Petrov Kalchev
AU  - Alexander Ivanov Hinev
AU  - Alkwin Wanders
AU  - Alexander Georgiev Otsetov
Y1  - 2017/08/25
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20170204.14
DO  - 10.11648/j.ijcocr.20170204.14
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 93
EP  - 98
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20170204.14
AB  - Prostate cancer (PCa) progression is an intricate step-wise process, starting from malignant transformations in the benign prostatic epithelium. The hallmark of PCa is the long period of its development from premalignant transformations in the benign prostatic epithelium towards clinically active carcinoma. Along with the age, inflammation, race and genetics, which are well-recognized risk factors for prostatic carcinoma, epigenetics play also a significant role in the initiation and progression of prostatic carcinoma. DNA methylation in the CpG gene islands is a key player in the regulation of gene expression and silencing, and significantly contributes to the disease development. Progression of cancer is associated with the loss of several tumor suppressor genes such as Maspin through mutations or epigenetic silencing. Epigenetic silencing of Maspin seems to be one of the earliest somatic change, contributing to the development of prostatic carcinoma in the human prostate.
VL  - 2
IS  - 4
ER  -

Copy | Download