Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products.
| Published in | International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 2) |
| DOI | 10.11648/j.ijcocr.20170202.12 |
| Page(s) | 31-44 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Doxorubicin, Cardiotoxicity, Natural Products
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APA Style
Hayder M. Alkuraishy, Ali I. Al-Gareeb, Hany Akeel Al-hussaniy. (2017). Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products. International Journal of Clinical Oncology and Cancer Research, 2(2), 31-44. https://doi.org/10.11648/j.ijcocr.20170202.12
ACS Style
Hayder M. Alkuraishy; Ali I. Al-Gareeb; Hany Akeel Al-hussaniy. Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products. Int. J. Clin. Oncol. Cancer Res. 2017, 2(2), 31-44. doi: 10.11648/j.ijcocr.20170202.12
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Download@article{10.11648/j.ijcocr.20170202.12,
author = {Hayder M. Alkuraishy and Ali I. Al-Gareeb and Hany Akeel Al-hussaniy},
title = {Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products},
journal = {International Journal of Clinical Oncology and Cancer Research},
volume = {2},
number = {2},
pages = {31-44},
doi = {10.11648/j.ijcocr.20170202.12},
url = {https://doi.org/10.11648/j.ijcocr.20170202.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170202.12},
abstract = {Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products.},
year = {2017}
}
TY - JOUR T1 - Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products AU - Hayder M. Alkuraishy AU - Ali I. Al-Gareeb AU - Hany Akeel Al-hussaniy Y1 - 2017/03/20 PY - 2017 N1 - https://doi.org/10.11648/j.ijcocr.20170202.12 DO - 10.11648/j.ijcocr.20170202.12 T2 - International Journal of Clinical Oncology and Cancer Research JF - International Journal of Clinical Oncology and Cancer Research JO - International Journal of Clinical Oncology and Cancer Research SP - 31 EP - 44 PB - Science Publishing Group SN - 2578-9511 UR - https://doi.org/10.11648/j.ijcocr.20170202.12 AB - Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products. VL - 2 IS - 2 ER -
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