Background: Prostate cancer is one of the most common cancer threats to men. The incidence rate and mortality rate are second only to lung cancer in Europe and America. At present, the 5-year survival rate of prostate cancer is only 29% when metastasis occurs. Prostate cancer seriously endangers the health of male patients. Early prostate cancer surgery and radiotherapy and chemotherapy effect is better, advanced endocrine therapy effect is better, because of drug resistance, eventually progress to castration resistant prostate cancer (CRPC). Although new drugs such as abiraterone acetate, enzalutamide, apalutamide and darutamide have brought new hope to patients with CRPC, when CRPC progresses to metastatic castration resistant prostate cancer (mCRPC), the effect of endocrine therapy is limited. Objective: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy bring new hope to patients with CRPC. This article will review the new progress of immunotherapy and molecular targeted therapy. Methods: A number of clinical and experimental studies were reviewed to indicate the novel advancement in the progressive therapy of CRPC. Results: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy can improve median survival time and have a decrease of PSA level. Conclusion: With the advancements in CRPC therapy made by the researchers, some novel potential methods will occupy more and more important position in the treatment of CRPC.
| Published in | International Journal of Chinese Medicine (Volume 4, Issue 3) |
| DOI | 10.11648/j.ijcm.20200403.14 |
| Page(s) | 67-70 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Castration Resistant Prostate Cancer, Immunotherapy, Molecular Targeted Therapy
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APA Style
Hai Hao, Pan Wenhai. (2020). Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer. International Journal of Chinese Medicine, 4(3), 67-70. https://doi.org/10.11648/j.ijcm.20200403.14
ACS Style
Hai Hao; Pan Wenhai. Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer. Int. J. Chin. Med. 2020, 4(3), 67-70. doi: 10.11648/j.ijcm.20200403.14
AMA Style
Hai Hao, Pan Wenhai. Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer. Int J Chin Med. 2020;4(3):67-70. doi: 10.11648/j.ijcm.20200403.14
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Download@article{10.11648/j.ijcm.20200403.14,
author = {Hai Hao and Pan Wenhai},
title = {Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer},
journal = {International Journal of Chinese Medicine},
volume = {4},
number = {3},
pages = {67-70},
doi = {10.11648/j.ijcm.20200403.14},
url = {https://doi.org/10.11648/j.ijcm.20200403.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20200403.14},
abstract = {Background: Prostate cancer is one of the most common cancer threats to men. The incidence rate and mortality rate are second only to lung cancer in Europe and America. At present, the 5-year survival rate of prostate cancer is only 29% when metastasis occurs. Prostate cancer seriously endangers the health of male patients. Early prostate cancer surgery and radiotherapy and chemotherapy effect is better, advanced endocrine therapy effect is better, because of drug resistance, eventually progress to castration resistant prostate cancer (CRPC). Although new drugs such as abiraterone acetate, enzalutamide, apalutamide and darutamide have brought new hope to patients with CRPC, when CRPC progresses to metastatic castration resistant prostate cancer (mCRPC), the effect of endocrine therapy is limited. Objective: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy bring new hope to patients with CRPC. This article will review the new progress of immunotherapy and molecular targeted therapy. Methods: A number of clinical and experimental studies were reviewed to indicate the novel advancement in the progressive therapy of CRPC. Results: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy can improve median survival time and have a decrease of PSA level. Conclusion: With the advancements in CRPC therapy made by the researchers, some novel potential methods will occupy more and more important position in the treatment of CRPC.},
year = {2020}
}
TY - JOUR T1 - Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer AU - Hai Hao AU - Pan Wenhai Y1 - 2020/09/23 PY - 2020 N1 - https://doi.org/10.11648/j.ijcm.20200403.14 DO - 10.11648/j.ijcm.20200403.14 T2 - International Journal of Chinese Medicine JF - International Journal of Chinese Medicine JO - International Journal of Chinese Medicine SP - 67 EP - 70 PB - Science Publishing Group SN - 2578-9473 UR - https://doi.org/10.11648/j.ijcm.20200403.14 AB - Background: Prostate cancer is one of the most common cancer threats to men. The incidence rate and mortality rate are second only to lung cancer in Europe and America. At present, the 5-year survival rate of prostate cancer is only 29% when metastasis occurs. Prostate cancer seriously endangers the health of male patients. Early prostate cancer surgery and radiotherapy and chemotherapy effect is better, advanced endocrine therapy effect is better, because of drug resistance, eventually progress to castration resistant prostate cancer (CRPC). Although new drugs such as abiraterone acetate, enzalutamide, apalutamide and darutamide have brought new hope to patients with CRPC, when CRPC progresses to metastatic castration resistant prostate cancer (mCRPC), the effect of endocrine therapy is limited. Objective: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy bring new hope to patients with CRPC. This article will review the new progress of immunotherapy and molecular targeted therapy. Methods: A number of clinical and experimental studies were reviewed to indicate the novel advancement in the progressive therapy of CRPC. Results: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy can improve median survival time and have a decrease of PSA level. Conclusion: With the advancements in CRPC therapy made by the researchers, some novel potential methods will occupy more and more important position in the treatment of CRPC. VL - 4 IS - 3 ER -
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