The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (P<0.05) antidiarrheal potential against castor oil and magnesium sulphate-induced diarrhoea in rats. APSAE also produced significant (P<0.05) reduction in propulsive movement in castor oil-induced gastrointestinal transit using charcoal meal in rats when compared with reference standard Loperamide. These findings demonstrate that Adenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea.
| Published in | International Journal of Chinese Medicine (Volume 1, Issue 4) |
| DOI | 10.11648/j.ijcm.20170104.12 |
| Page(s) | 116-120 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Adenanthera pavonina, Diarrhoea, Castor Oil, MgSO4, Loperamide
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APA Style
Ramdas Pandhare, Sangameswaran Balakrishnan, Gaurav Bangar, Pramod Dighe, Vinayak Deshmukh. (2017). Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals. International Journal of Chinese Medicine, 1(4), 116-120. https://doi.org/10.11648/j.ijcm.20170104.12
ACS Style
Ramdas Pandhare; Sangameswaran Balakrishnan; Gaurav Bangar; Pramod Dighe; Vinayak Deshmukh. Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals. Int. J. Chin. Med. 2017, 1(4), 116-120. doi: 10.11648/j.ijcm.20170104.12
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Download@article{10.11648/j.ijcm.20170104.12,
author = {Ramdas Pandhare and Sangameswaran Balakrishnan and Gaurav Bangar and Pramod Dighe and Vinayak Deshmukh},
title = {Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals},
journal = {International Journal of Chinese Medicine},
volume = {1},
number = {4},
pages = {116-120},
doi = {10.11648/j.ijcm.20170104.12},
url = {https://doi.org/10.11648/j.ijcm.20170104.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20170104.12},
abstract = {The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (PAdenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea.},
year = {2017}
}
TY - JOUR T1 - Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals AU - Ramdas Pandhare AU - Sangameswaran Balakrishnan AU - Gaurav Bangar AU - Pramod Dighe AU - Vinayak Deshmukh Y1 - 2017/08/11 PY - 2017 N1 - https://doi.org/10.11648/j.ijcm.20170104.12 DO - 10.11648/j.ijcm.20170104.12 T2 - International Journal of Chinese Medicine JF - International Journal of Chinese Medicine JO - International Journal of Chinese Medicine SP - 116 EP - 120 PB - Science Publishing Group SN - 2578-9473 UR - https://doi.org/10.11648/j.ijcm.20170104.12 AB - The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (PAdenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea. VL - 1 IS - 4 ER -
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