Objective: The Objective of the study was to evaluate the perioperative cerebral protective effect of sevoflurane and propofol in patients with carotid artery stenosis undergoing coronary artery bypass grafting. Materials and Methods: A randomized clinical study included 200 patients with preoperative carotid artery stenosis <50% scheduled for cardiac surgery with cardiopulmonary bypass. The patients were classified into 2 groups (each=100), Sevoflurane group: The patients received sevoflurane (concentration 1% to 4%) as an inhalational agent. Propofol group: The patients received propofol infusion (4-6 mg/kg/hr). The sevoflurane and propofol were given during the whole procedure (before, during, and after cardiopulmonary bypass). The monitors included heart rate, mean arterial blood pressure (MAP), central venous pressure and cerebral near-infrared spectroscopy (NIRS), the incidence of postoperative cognitive dysfunction and stroke. Results: There was no significant difference in the perioperative heart rate, mean arterial blood pressure, central venous pressure, and the right or left regional cerebral oxygen saturation between the two groups (P>0.05). The incidence of postoperative neurological complication was significantly lower with sevoflurane than propofol (P=0.012). The incidence of delirium was significantly lower with sevoflurane than propofol (P=0.023). The incidence of stroke was lower with sevoflurane than propofol, but the difference was insignificant (P=0.682). The ICU and hospital length of stay were shorter with sevoflurane than propofol (P=0.013, P=0.033 respectively). Conclusions: The sevoflurane was associated with a lower incidence of postoperative cognitive dysfunction than propofol in patients with carotid artery stenosis undergoing coronary artery bypass grafting.
| Published in | International Journal of Anesthesia and Clinical Medicine (Volume 12, Issue 1) |
| DOI | 10.11648/j.ijacm.20241201.18 |
| Page(s) | 38-46 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Carotid Artery Stenosis, Sevoflurane, Propofol, Coronary Artery Bypasses Grafting, Delirium, Stroke
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APA Style
Nasr, R., Soliman, A. (2024). Comparison the Cerebroprotective Effect of Sevoflurane and Propofol in Patients with Carotid Artery Stenosis Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Study. International Journal of Anesthesia and Clinical Medicine, 12(1), 38-46. https://doi.org/10.11648/j.ijacm.20241201.18
ACS Style
Nasr, R.; Soliman, A. Comparison the Cerebroprotective Effect of Sevoflurane and Propofol in Patients with Carotid Artery Stenosis Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Study. Int. J. Anesth. Clin. Med. 2024, 12(1), 38-46. doi: 10.11648/j.ijacm.20241201.18
AMA Style
Nasr R, Soliman A. Comparison the Cerebroprotective Effect of Sevoflurane and Propofol in Patients with Carotid Artery Stenosis Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Study. Int J Anesth Clin Med. 2024;12(1):38-46. doi: 10.11648/j.ijacm.20241201.18
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Download@article{10.11648/j.ijacm.20241201.18,
author = {Rabie Nasr and Ahmed Soliman},
title = {Comparison the Cerebroprotective Effect of Sevoflurane and Propofol in Patients with Carotid Artery Stenosis Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Study
},
journal = {International Journal of Anesthesia and Clinical Medicine},
volume = {12},
number = {1},
pages = {38-46},
doi = {10.11648/j.ijacm.20241201.18},
url = {https://doi.org/10.11648/j.ijacm.20241201.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijacm.20241201.18},
abstract = {Objective: The Objective of the study was to evaluate the perioperative cerebral protective effect of sevoflurane and propofol in patients with carotid artery stenosis undergoing coronary artery bypass grafting. Materials and Methods: A randomized clinical study included 200 patients with preoperative carotid artery stenosis 0.05). The incidence of postoperative neurological complication was significantly lower with sevoflurane than propofol (P=0.012). The incidence of delirium was significantly lower with sevoflurane than propofol (P=0.023). The incidence of stroke was lower with sevoflurane than propofol, but the difference was insignificant (P=0.682). The ICU and hospital length of stay were shorter with sevoflurane than propofol (P=0.013, P=0.033 respectively). Conclusions: The sevoflurane was associated with a lower incidence of postoperative cognitive dysfunction than propofol in patients with carotid artery stenosis undergoing coronary artery bypass grafting.
},
year = {2024}
}
TY - JOUR T1 - Comparison the Cerebroprotective Effect of Sevoflurane and Propofol in Patients with Carotid Artery Stenosis Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Study AU - Rabie Nasr AU - Ahmed Soliman Y1 - 2024/05/10 PY - 2024 N1 - https://doi.org/10.11648/j.ijacm.20241201.18 DO - 10.11648/j.ijacm.20241201.18 T2 - International Journal of Anesthesia and Clinical Medicine JF - International Journal of Anesthesia and Clinical Medicine JO - International Journal of Anesthesia and Clinical Medicine SP - 38 EP - 46 PB - Science Publishing Group SN - 2997-2698 UR - https://doi.org/10.11648/j.ijacm.20241201.18 AB - Objective: The Objective of the study was to evaluate the perioperative cerebral protective effect of sevoflurane and propofol in patients with carotid artery stenosis undergoing coronary artery bypass grafting. Materials and Methods: A randomized clinical study included 200 patients with preoperative carotid artery stenosis 0.05). The incidence of postoperative neurological complication was significantly lower with sevoflurane than propofol (P=0.012). The incidence of delirium was significantly lower with sevoflurane than propofol (P=0.023). The incidence of stroke was lower with sevoflurane than propofol, but the difference was insignificant (P=0.682). The ICU and hospital length of stay were shorter with sevoflurane than propofol (P=0.013, P=0.033 respectively). Conclusions: The sevoflurane was associated with a lower incidence of postoperative cognitive dysfunction than propofol in patients with carotid artery stenosis undergoing coronary artery bypass grafting. VL - 12 IS - 1 ER -
Department of Anesthesia, Cairo University, Giza, Egypt; Department of Anesthesia, AlSeef Hospital, Salmiya, Kuwait
Health Sciences, Ottawa University, Ottawa, Canada
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