Research Article | | Peer-Reviewed

Determination of Optimal Irrigation Scheduling for Onion Under Furrow Irrigation Method in Eastern Hararghe Zone, Ethiopia

Published in Hydrology (Volume 14, Issue 1)
Received: 1 May 2026     Accepted: 29 May 2026     Published: 10 June 2026
Views:       Downloads:
Abstract

Efficient irrigation water management is critical for optimizing crop productivity and ensuring the sustainable use of limited water resources, particularly in semi-arid regions. This study was conducted during the 2022/23 and 2023/24 cropping seasons at Kombolcha District, East Hararghe Zone, Oromia regional state, Ethiopia. The purpose of the activity was to create optimal irrigation regimes (when and how much to irrigate) for onions and evaluate the effect of different irrigation timings on the water productivity and yield of the onion crop. The results showed that irrigation water, maximum irrigation frequency, and short irrigation intervals were achieved by scheduling irrigation at 60% of the ASMDL treatment. The next maximum irrigation frequency was obtained by scheduling irrigation at 80% of ASMDL treatment. Minimum irrigation frequency and minimum water consumed by scheduling irrigation at 140% ASMDL treatment. The results show that the maximum onion yield was obtained by scheduling irrigation at 60% of ASMDL treatment, followed by 80% ASMDL treatment. Statistically, there is no significant difference between 60% ASMDL and 80% ASMDL treatments in terms of onion yield. Maximum water productivity was obtained by scheduling irrigation at 80% ASMD treatment followed by 60% ASMDL treatment. Statistically, there is no significant difference between 60%, 100%, and 120% ASMDL treatments in terms of onion water productivity. The minimum water productivity was reached by scheduling irrigation at 140% ASMDL treatment. So, scheduling irrigation at 80% ASMDL is recommended for onion with 5-day, 6-day, 7-day, and 10-day irrigation intervals at initial, development, mid, and maturity stages of onion, respectively.

Published in Hydrology (Volume 14, Issue 1)
DOI 10.11648/j.hyd.20261401.12
Page(s) 15-21
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Irrigation Scheduling, Onion, Water Demand

1. Introduction
The rapid exponential increment of population growth worldwide, in general and in developing countries, is forcing the environment to produce more food and cash crops to feed and enhance the economic development of the people . However, environmental resources, such as land and water, are limited and even decreasing due to overexploitation, pollution, and climate change . Irrigation schedules must be tailored to local environmental circumstances, soil type, and water availability to ensure sustainable use of water resources in agriculture. .
In Ethiopia, although irrigation has long been conducted at different farm levels, there is no efficient and well-managed irrigation water practice . According to the USA Bureau of Reclamation (2005), Irrigation water management is the act of timing and regulating irrigation water applications without the waste of water, soil, and plant nutrients . Consequently, conserving water in irrigation is the most critical issue to be considered . Irrigation water is considered a crucial element for crop production . In Ethiopia, onions are produced in many parts of the country by small farmers, private growers, and state enterprises . In many parts of the country, the off-season crop (irrigated) accounts for a significant portion of onion production .
Among vegetable crops, onion is one of the most extensively utilized foods globally . The average world yield grew from 18.4 t/ha in 2004 to 19.2 t/ha in 2018. The top onion-producing countries are China, India, and the United States of America, accounting for 20% of global production . Water requirements for onions vary depending on location and irrigation system . Onions have a maximum root penetration of 76 cm, although the majority of it occurs in the first 18 cm of soil, limiting the amount of soil water available to roots . Rainfall is therefore insufficient to maintain its output, making irrigation essential. To avoid over- or under-irrigation, it is important to know how much water is available to the plant and how efficiently the crop can use it, which means irrigation scheduling . Developing the best irrigation schedules (when and how much to irrigate) for onions and assessing the impact of various irrigation schedules on water productivity and onion crop output were the goals of the work.
2. Methods and Materials
Figure 1. The Research Area Map.
2.1. Description of the Experimental Site
The experiment was carried out at KPT College in the Kombolcha district of the Eastern Hararghe zone of Oromia, which is situated at an elevation of 2160 m above sea level and has an irregular and uneven rainfall distribution. The mean minimum and maximum temperatures there are 10°C and 27.8°C, respectively. The irrigation water came from manually drilled tube wells.
2.2. Climatic Characteristics
The climatic data, maximum and minimum temperature, relative humidity, Rainfall, wind speed, and sunshine hours every month were collected from the nearby meteorological station. Potential evapotranspiration (ETo) was estimated using the CROPWAT software version 8.
Figure 2. Long-term mean monthly climatic data of the experimental area (2000 – 2023).
2.3. Design of the Experiment
Five treatments with three replications made up the Randomized Complete Block Design (RCBD) used in the investigation. Five soil moisture depletion levels (SMDL), which dictate when to water onions, were used in the treatment combination. There were fifteen experimental plots, with two meters separating each plot from the block. The Sifan onion variety was used as a test crop.
Table 1. Treatment Plan.

Treatment

Description of Treatment

T1

60% of ASMDL

T2

80% of ASMDL

T3

100% of ASMDL*

T4

120% of ASMDL

T5

140% of ASMDL

2.4. De-estimation of Crop Water Requirement of Onion
Climatic data (rainfall, temperature, wind speed, relative humidity, and sunshine hours) were used for the determination of the water requirement of onion. ETo is computed by the CROPWAT model version 8.0 using the FAO Penman-Monteith approach formula.
2.5. Scheduling Irrigation
Soil water depletion replenishments were used to schedule the irrigation. A digital smart soil moisture meter (Theta probe ML3) and the gravimetric method were used to measure the soil water content both before and after full irrigation in order to keep it between the field capacity and the permitted depletion level.
2.6. Calculating the Net Water Need for Irrigation
The equation,In = ETc - PE(1)
The following equation was used to calculate effective rainfall: Peff = 0.6 * P - 10 for precipitation less than or equal to 70 mm, Peff = 0.8 * P - 24 for precipitation greater than 70 mm, where Peff is the effective precipitation (mm) and P is the precipitation (mm). In-Net Irrigation Depth (mm), ETc is the crop water requirement (mm), and Pe is the effective rainfall (mm).
2.7. Total Depth of Irrigation
60% was considered to be the irrigation efficiency, which is typical for surface irrigation techniques in furrow irrigation. . The gross irrigation water need was computed as follows using the net irrigation depth and irrigation application efficiency:
Ig=InEa(2)
Where: Ea - Furrow Application Efficiency (%), In - Net Irrigation Depth (mm), and Ig - Gross Irrigation Depth (mm).
The ratio of the applied water volume to the discharge-head relation of 3-inch PF was used to determine how long each treatment would take to irrigate. An equation provided by was used to determine the amount of time needed to supply the correct depth of water into each furrow.
T=Ig*W*L6Q(3)
Where: W is the plot's space of furrow (m), L is its length (m), Q is its flow rate (l/s), and Ig is the gross depth of water applied (cm).
2.8. Productivity of Water
Crop yield per unit volume of water supplied to the crops is known as water productivity . The ratio of onion production to the total irrigation depth used during the season was used in this study to determine agricultural water productivity. It is stated as:
Wp=YW(4)
Where W is the seasonally applied irrigation depth (m3/ha), and Y is the onion yield (kg/ha).
2.9. Data Analysis
GenStat software was used to do an analysis of variance (ANOVA) on the data. At the 5% level of probability, treatment averages were compared using the least significant difference (LSD).
3. Results and Discussions
3.1. Analysis of Soil Properties of the Experimental Site for CWR Input
The soil physical property used for CropWat input was used for the determination of the crop water requirement of onion.
Table 2. Soil physical properties of experimental site.

D (cm)

Sand

Clay

silt

Textural class

BD (g/cm3)

FC (%)

PWP (%)

TAW (mm/m)

0-15

47

27

26

Sandy clay loam

1.31

30.60

19.20

149.34

15-30

43

30

27

Clay loam

1.20

30.20

18.00

146.40

30-45

43

33

24

Clay loam

1.13

32.40

20.20

137.86

45-60

41

35

24

Clay loam

1.14

35.30

22.80

142.50

Total available water in the effective root zone of mm/m

144.02

The average percentages of clay, silt, and sand were 32, 25, and 43, respectively, according to the results of the soil physical property analysis. Therefore, the particle size distribution of the experimental location indicated that the soil textural class is clay loam based on the USDA soil textural classification. The experimental site's bulk density was determined to be between 1.13 and 1.31 g/cm3. The research area's bulk density was suitable for crop development and the flow of water and air through the soil, according to .
3.2. Onion Irrigation Scheduling Was Applied Based on the SMDL Treatment
Based on the treatment, different irrigation schedules at different onion growth stages were obtained, and water consumption was also determined.
Table 3. Onion irrigation scheduling applied based on SMDL treatment.

Treatments

Depletion fraction (P)

Irrigation frequency

Irrigation interval

Water used (m3/ha)

Initial

Mid

Dev

End

60% ASMDL

0.21

22

4

5

6

9

5198.3

80% ASMDL

0.28

19

5

6

7

10

4861.6

100% ASMDL*

0.35

15

5

7

8

11

4713.3

120% ASMDL

0.42

13

6

11

12

15

4603.3

140% ASMDL

0.49

9

10

14

15

16

4271.6

Table 3 shows that irrigation water, maximum irrigation frequency, and short irrigation interval were obtained by scheduling irrigation at 60% of ASMDL treatment. This implies that as irrigation intervals are close to each other, more irrigation water is consumed by this treatment. The next maximum irrigation frequency was obtained by scheduling irrigation at 80% of ASMDL treatment. Minimum irrigation frequency and minimum water consumed by scheduling irrigation at 140% ASMDL treatment.
3.3. How Soil Moisture Depletion Affects Onion Production and Yield Components
The treatment significantly affected the yield and yield components of onion when irrigation was scheduled at different soil moisture depletion levels.
Table 4. Effect of Soil moisture depletion level on onion yield and yield components.

Treatments

PH (cm)

Bulb diameter (cm)

Bulb yield (qt ha-1)

60% ASMDL

49.83 a

5.083 a

317.2 a

80% ASMDL

44.83 b

4.350 b

310.0 a

100% ASMDL*

42.50 c

3.500 c

277.8 b

120% ASMDL

36.17 d

3.000 cd

261.7 c

140% ASMDL

31.83 e

2.833 d

208.9 d

CV

3.1

13.7

4.7

LSD

1.52

0.62

15.49

The above ANOVA Table 4 showed that different irrigation schedule treatments had a significant effect on onion yield and yield components. The results show that the maximum onion yield was obtained by scheduling irrigation at 60% of ASMDL treatment, followed by 80% ASMDL treatment. Statistically, there is no significant difference between 60% ASMDL and 80% ASMDL treatments in terms of bulb yield. The result is in line with , who report that the highest onion bulb yield (363.9 qt/ha) was obtained from 60% ASMDL. By scheduling irrigation at 140% of ASMDL treatment, the minimum onion production was achieved. This implies that as the onion is more stressed and the irrigation interval increases, onion yield decreases. The result also indicates that both plant height and bulb diameter were decreased as the irrigation interval elongated or became farther apart. The result is in line with the findings of , who report that bulb diameter decreased as the crop is more stressed.
3.4. Effect of Soil Moisture Depletion Level on Onion Water Productivity
The water productivity of onion is affected by different irrigation scheduling treatments. There is a significant difference between treatments at different soil moisture depletion treatments.
Table 5. Effect of Soil moisture depletion level on onion water productivity.

Treatments

Bulb yield (qt ha-1)

Water productivity (kg/m3)

60% ASMDL

317.2a

10.171ab

80% ASMDL

310.0a

10.627a

100% ASMDL

277.8b

9.812b

120% ASMDL

261.7c

10.064b

140% ASMDL

208.9d

8.150c

CV

4.7

4.5

LSD

15.489

0.523

Maximum water productivity was obtained by scheduling irrigation at 80% ASMDL treatment followed by 60% ASMDL treatment. Statistically, there is no significant difference between 60%, 100%, and 120% ASMDL treatments in terms of onion water productivity. Water productivity was at its lowest when irrigation was scheduled at 140% ASMDL treatment.
3.5. Effect of Irrigation Scheduling on Ky and the Yield Reduction of Onion
From the result, it’s observed that the percent of yield reduction increases when the crop is more stressed, and the irrigation interval is elongated.
Table 6. The impact of irrigation timing on Ky and the decrease of onion output.

Treatments

Yield (qt/ha)

Yield reduction (%)

Yield response factor Ky.

60% ASMDL

317.2a

-

-

80% ASMDL

310.0a

-

-

100% ASMDL

277.8b

*

*

120% ASMDL

261.7c

5.79

2.46

140% ASMDL

208.9d

24.80

1.53

The result showed that both the 120% and 140% ASMDL treatments had yield response factors (Ky) greater than one. Onion yield is significantly reduced as a result of treatments when ky is more than one. At those treatments, the yield drop as a percentage was likewise large, suggesting that irrigation scheduling results in a notable yield reduction.
4. Conclusions and Recommendations
The study was carried out at Kombolcha District, in East Hararghe Zone, Oromia Regional State, Ethiopia, during the 2022/23 and 2023/24 irrigation seasons to assess the impact of various irrigation regimes on Onion productivity and water use. Using five irrigation treatments based on allowed soil moisture depletion levels (ASMDL) 60%, 80%, 100%, 120%, and 140%, the experiment was set up in three replications using a Randomized Complete Block Design (RCBD).
The Eastern Hararghe Zone's onion production under furrow irrigation is biologically and economically optimal at 80% ASMDL, according to the study's findings. The 80% ASMDL treatment preserved a steady soil moisture tension that supported continuous physiological development, in contrast to the traditional 100% depletion level.
The result of the effect of different irrigation schedules on onion indicates that maximum water productivity (10.627 kg/ha) and optimum yield (310.0 qt/ha) were obtained by scheduling irrigation at 80% ASMDL treatment over other treatments. Hence, for onions with 5- day, 6-day, 7-day, and 10-day irrigation intervals at the initial, development, mid, and maturity stages of onions, respectively, in the study area and the same agro-ecology, scheduling irrigation at 80% ASMDL (at p < 0.5) has been advised.
Abbreviations

ANOVA

Analysis of Variance

ASMDL

Allowed Soil Moisture Depletion Levels

BD

Bulk Density

CWR

Crop Water Requirement

ETo

Reference Evapotranspiration

FC

Field Capacity

KPT

Kombolcha Polytechnique

LSD

Least Significant Difference

PE

Effective Rainfall

PWP

Permanent Welting Point

RCBD

Randomized Complete Block Design

SMDL

Soil Moisture Depletion Levels

TAW

Total Available Water

USDA

United States Department of Agriculture

Acknowledgments
We would like to thank Oromia Agricultural Research Institute (OARI) and Fedis Agricultural Research Center for granting us the research fund. We would like to extend our sincere gratitude to the field assistance (FA) and drivers for their support during data collection, logistics, and transportation, which made this activity possible.
Author Contributions
Ayela Tade: Conceptualization, Formal Analysis, Funding acquisition, Software, Writing – original draft, Writing – review & editing
Lalisa Ofga: Data curation, Funding acquisition, Investigation, Methodology, Visualization
Jemal Nur: Conceptualization, Data curation, Investigation, Methodology, Visualization
Conflicts of Interest
The authors declare no conflicts of interest.
References
[1] G. G. Haile, T. G. Gebremicael, M. Kifle, and T. Gebremedhin, “Effects of irrigation scheduling and different irrigation methods on onion and water productivity in Tigray, northern Ethiopia,” 2019.
[2] M. Habtewold, D. Mengist, N. Resource, and M. Directorate, “Evaluating the impact of different furrow irrigation methods on onion bulb yield and water productivity: The case of Hadero Tunto district, Southern Ethiopia,” vol. 17, no. October 2024, pp. 175–185, 2025.
[3] G. Ashemi, “Response of Onion (Allium cepa L.) to Different Irrigation Levels Under Conventional Furrow Irrigation With and Without Mulch at Melkassa, Central Rift Valley of Ethiopia,” vol. 89, pp. 21–31, 2021,
[4] B. M. Mekonen and M. F. Moges, “Determination of Optimal Irrigation Scheduling for Onion (Allium cepa L) in Gumara Scheme, North Western Ethiopia,” no. February, 2022,
[5] T. Bekele and M. Abebo, “Evaluation of Furrow Irrigation Systems on Onion Yield and Water Use Efficiency in Misrak Azernet Berbere woreda, Ethiopia,” 2019.
[6] S. Kim et al., “Green Onion (Allium fistulosum): An Aromatic Vegetable Crop Esteemed for Food, Nutritional and Therapeutic Significance,” pp. 1–20, 2023.
[7] M. Abera, A. Wale, Y. Abie, and T. Esubalew, “Verification of the Efficiency of Alternate Furrow Irrigation on the Amount of Water Productivity and Yield of Onion at Sekota Woreda,” vol. 9, no. September, pp. 1–5, 2020,
[8] M. Derbie, A. A. Beyene, S. Asres, and M. Yenesew, “Modelling soil water and nutrient dynamics under different irrigation techniques of onion production,” Water Sci., vol. 38, no. 1, pp. 485–500, 2024,
[9] A. H. Tefera, S. G. Kebede, and G. T. Mola, “Optimal Irrigation Scheduling for Garlic (Allium sativum L) in the Central Highland Vertisols Areas of Ethiopia,” vol. 5, no. 2, pp. 308–316, 2021,
[10] A. Martínez-López, J. A.; López-Urrea, R.; Martínez-Romero, Á.; Pardo, J. J.; Montoya, F.; Domínguez, “Improving the Sustainability and Profitability of Oat and Garlic Crops in a Mediterranean Agro-Ecosystem under,” 2022.
[11] U. K. Chaudhry, E. Coordination, and A. F. Gokce, “Effects of Salinity and Drought Stresses on the Physio-Morphological Attributes of Onion Cultivars at Bulbification Stage Effects of Salinity and Drought Stresses on the Physio-Morphological Attributes of Onion Cultivars at Bulbification Stage,” no. October 2020, 2021,
[12] S. Lindi, B. Iticha, and M. Hone, “Response of Onion to Furrow Irrigation Methods under Different Deficit Irrigation Levels at Ziway Dugda District, Arsi Zone, Ethiopia,” no. December 2023,
[13] K. Albala, Food and Agriculture Organization of the United Nations (FAO). 2015.
[14] D. M. and S. C. Bharat Sharma1, “This document is discoverable and free to researchers across the globe due to the work of AgEcon Search. Help ensure our sustainability. Water use efficiency in agriculture : Measurement, current situation and trends,” 2018.
[15] D. Kolleh, M. K. Lah, and D. M. Kokulo, “Investigating the Physical and Chemical Characteristics of Latosols Soil and its Influence on Plant Growth in Suakoko, Bong County,” vol. 3, no. 3, pp. 944–948, 2023.
[16] T. Gragn, O. Wolde, and A. Mamo, “Determination of Optimal Irrigation using Soil Moisture Depletion on Yield, Yield Component and Water Productivity of Onion at Odo Shakiso District, Guji zone, Southern Ethiopia,” no. May, 2023,
Cite This Article
  • APA Style

    Tade, A., Ofga, L., Nur, J. (2026). Determination of Optimal Irrigation Scheduling for Onion Under Furrow Irrigation Method in Eastern Hararghe Zone, Ethiopia. Hydrology, 14(1), 15-21. https://doi.org/10.11648/j.hyd.20261401.12

    Copy | Download

    ACS Style

    Tade, A.; Ofga, L.; Nur, J. Determination of Optimal Irrigation Scheduling for Onion Under Furrow Irrigation Method in Eastern Hararghe Zone, Ethiopia. Hydrology. 2026, 14(1), 15-21. doi: 10.11648/j.hyd.20261401.12

    Copy | Download

    AMA Style

    Tade A, Ofga L, Nur J. Determination of Optimal Irrigation Scheduling for Onion Under Furrow Irrigation Method in Eastern Hararghe Zone, Ethiopia. Hydrology. 2026;14(1):15-21. doi: 10.11648/j.hyd.20261401.12

    Copy | Download

  • @article{10.11648/j.hyd.20261401.12,
      author = {Ayela Tade and Lalisa Ofga and Jemal Nur},
      title = {Determination of Optimal Irrigation Scheduling for Onion Under Furrow Irrigation Method in Eastern Hararghe Zone, Ethiopia},
      journal = {Hydrology},
      volume = {14},
      number = {1},
      pages = {15-21},
      doi = {10.11648/j.hyd.20261401.12},
      url = {https://doi.org/10.11648/j.hyd.20261401.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.hyd.20261401.12},
      abstract = {Efficient irrigation water management is critical for optimizing crop productivity and ensuring the sustainable use of limited water resources, particularly in semi-arid regions. This study was conducted during the 2022/23 and 2023/24 cropping seasons at Kombolcha District, East Hararghe Zone, Oromia regional state, Ethiopia. The purpose of the activity was to create optimal irrigation regimes (when and how much to irrigate) for onions and evaluate the effect of different irrigation timings on the water productivity and yield of the onion crop. The results showed that irrigation water, maximum irrigation frequency, and short irrigation intervals were achieved by scheduling irrigation at 60% of the ASMDL treatment. The next maximum irrigation frequency was obtained by scheduling irrigation at 80% of ASMDL treatment. Minimum irrigation frequency and minimum water consumed by scheduling irrigation at 140% ASMDL treatment. The results show that the maximum onion yield was obtained by scheduling irrigation at 60% of ASMDL treatment, followed by 80% ASMDL treatment. Statistically, there is no significant difference between 60% ASMDL and 80% ASMDL treatments in terms of onion yield. Maximum water productivity was obtained by scheduling irrigation at 80% ASMD treatment followed by 60% ASMDL treatment. Statistically, there is no significant difference between 60%, 100%, and 120% ASMDL treatments in terms of onion water productivity. The minimum water productivity was reached by scheduling irrigation at 140% ASMDL treatment. So, scheduling irrigation at 80% ASMDL is recommended for onion with 5-day, 6-day, 7-day, and 10-day irrigation intervals at initial, development, mid, and maturity stages of onion, respectively.},
     year = {2026}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Determination of Optimal Irrigation Scheduling for Onion Under Furrow Irrigation Method in Eastern Hararghe Zone, Ethiopia
    AU  - Ayela Tade
    AU  - Lalisa Ofga
    AU  - Jemal Nur
    Y1  - 2026/06/10
    PY  - 2026
    N1  - https://doi.org/10.11648/j.hyd.20261401.12
    DO  - 10.11648/j.hyd.20261401.12
    T2  - Hydrology
    JF  - Hydrology
    JO  - Hydrology
    SP  - 15
    EP  - 21
    PB  - Science Publishing Group
    SN  - 2330-7617
    UR  - https://doi.org/10.11648/j.hyd.20261401.12
    AB  - Efficient irrigation water management is critical for optimizing crop productivity and ensuring the sustainable use of limited water resources, particularly in semi-arid regions. This study was conducted during the 2022/23 and 2023/24 cropping seasons at Kombolcha District, East Hararghe Zone, Oromia regional state, Ethiopia. The purpose of the activity was to create optimal irrigation regimes (when and how much to irrigate) for onions and evaluate the effect of different irrigation timings on the water productivity and yield of the onion crop. The results showed that irrigation water, maximum irrigation frequency, and short irrigation intervals were achieved by scheduling irrigation at 60% of the ASMDL treatment. The next maximum irrigation frequency was obtained by scheduling irrigation at 80% of ASMDL treatment. Minimum irrigation frequency and minimum water consumed by scheduling irrigation at 140% ASMDL treatment. The results show that the maximum onion yield was obtained by scheduling irrigation at 60% of ASMDL treatment, followed by 80% ASMDL treatment. Statistically, there is no significant difference between 60% ASMDL and 80% ASMDL treatments in terms of onion yield. Maximum water productivity was obtained by scheduling irrigation at 80% ASMD treatment followed by 60% ASMDL treatment. Statistically, there is no significant difference between 60%, 100%, and 120% ASMDL treatments in terms of onion water productivity. The minimum water productivity was reached by scheduling irrigation at 140% ASMDL treatment. So, scheduling irrigation at 80% ASMDL is recommended for onion with 5-day, 6-day, 7-day, and 10-day irrigation intervals at initial, development, mid, and maturity stages of onion, respectively.
    VL  - 14
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Abstract
  • Keywords
  • Document Sections

    1. 1. Introduction
    2. 2. Methods and Materials
    3. 3. Results and Discussions
    4. 4. Conclusions and Recommendations
    Show Full Outline
  • Abbreviations
  • Acknowledgments
  • Author Contributions
  • Conflicts of Interest
  • References
  • Cite This Article
  • Author Information