Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM

Baidyanath Mishra; Srinivasa Reddy Yathapu; Simadri Bhusan Nayak; Sushanta Sahu; Garima Gupta; Apratim Sai Rajesh

doi:doi:10.11648/j.ejpm.20261404.15

Research Article |

| Peer-Reviewed

Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM

Baidyanath Mishra^*

, Srinivasa Reddy Yathapu

, Simadri Bhusan Nayak

, Sushanta Sahu

, Garima Gupta

, Apratim Sai Rajesh

Published in European Journal of Preventive Medicine (Volume 14, Issue 4)

Received: 20 July 2026 Accepted: 4 August 2026 Published: 22 August 2026

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Abstract

Global burden of Type 2 Diabetes Mellitus (T2DM) has reached alarming proportions, with prevalence surging from 200 million to over 830 million over three decades. India bears a disproportionate share of this crisis, with approximately 77 million individuals living with T2DM and an additional 25 million in the prediabetic range (HbA1c: 5.7–6.4%), collectively imposing significant threats to workforce productivity and national healthcare expenditure. While anti-hyperglycemic (AHG) agents combined with lifestyle modifications remain the cornerstone of T2DM management, long-term dependence on escalating pharmacological doses and the risk of chronic complications have intensified interest in adjunctive therapeutic strategies. In this context, the present study evaluated the adjunctive efficacy and safety of a proprietary ayurvedic formulation (sugar-free juice), DRDC/2025/010, in individuals with T2DM already on standard AHG therapy. This ethically approved, CTRI-registered clinical study enrolled 30 T2DM participants screened against predefined inclusion and exclusion criteria. Participants received 30 mL of DRDC/2025/010 diluted in 250 mL of drinking water, consumed twice daily for 90 days, alongside their existing AHG regimen, dietary guidance, and exercise routine. Efficacy endpoints included fasting blood sugar (FBS), random blood sugar (RBS), glycated hemoglobin (HbA1c), body mass index (BMI), and quality of life (QoL). Safety was monitored through biochemical parameters, vital signs, and adverse event (AE) surveillance throughout the study period. DRDC/2025/010 demonstrated statistically significant reductions in FBS at Day 60 (p < 0.05) and Day 90 (p < 0.0001), and in RBS at Day 60 (p < 0.05) and Day 90 (p < 0.0001), relative to baseline. A significant (P<0.0001) decrease in BMI levels of the diabetic participants was observed at 90^th day (20.7±8.56 kg/m²) compared to baseline (25.1±3.00 kg/m²). Mean HbA1c levels also declined significantly at Day 90 (p = 0.024), accompanied by meaningful improvements in QoL. Notably, no adverse events were recorded, and biochemical parameters and vital signs remained stable throughout the intervention, affirming a favorable safety profile. These findings suggest that DRDC/2025/010 holds promising potential as a safe and effective adjunct to standard T2DM pharmacotherapy, contributing to improved glycemic control and patient well-being.

Published in	European Journal of Preventive Medicine (Volume 14, Issue 4)
DOI	10.11648/j.ejpm.20261404.15
Page(s)	94-102
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Type 2 Diabetes, Adjunctive Therapy, HbA1C, Anti-hyperglycemic (AHGs) Agents

1. Introduction

Glucose serves as fuel for metabolism and is the primary source for energy production, due to it’s ability of rapid conversion to ATP. Blood glucose levels are tightly regulated in healthy individuals through the coordinated action of insulin, secreted by pancreas, glucose deposited in the liver as glycogen, which in turn will be released into blood to meet the required concentrations. When insulin production is insufficient &/or ineffective use of produced insulin, results in raised blood glucose termed as ‘diabetes’

[1]

. Glucose is not only a necessary biochemical fuel but also play a central part of safe and effective diabetes control

[2]

According to the Centers for Disease Control and Prevention’s National Diabetes Statistics Report

[3]

, an estimated 40 million people in the United States, or 11.6% of the population, have diabetes. About 1 in 5 adults with diabetes don’t know that they are diabetic. A survey carried out among Indian adults aged 45 years have reported diabetes prevalence of 19·8% (95% CI 19·4-20·2), with men and women are equally affected

[4]

. In addition, the same study unveiled that diabetes prevalence (30·0% [95% CI 29·1-30·8]) among adults from urban area was approximately twice as high as rural prevalence (15·0% [14·6-15·5]).

Hyperglycaemia, the raised blood glucose or raised blood sugar, is a chronic non-communicable disease, over time leads to serious damage to many of the body's systems, especially the nerves and blood vessels. Microvascular complications include neuropathy, retinopathy, and nephropathy, while macrovascular disease affects the coronary arteries, cerebral circulation, and peripheral arteries

[5, 6]

NIDDM (Non-Insulin-Dependent Diabetes Mellitus), a term historically used to describe what is now universally known as Type 2 Diabetes (T2D), is a major condition reported worldwide and a leading cause of lifestyle diseases. Diabetes affects the Quality-of-Life (QoL) by affecting both physiological and psychological functions. For instance, persistent fatigue and tiredness can occur due to elevated blood glucose levels

[7]

. In addition, polyuria, polyphagia, polydipsia, visual disturbances, etc. are associated with chronic diabetes, which ultimately lead to compromised QoL among diabetes persons. Systematic analysis of the data collated from diabetes person’s life-expectancy suggested that an estimated shorter life span of 6 years for chronic diabetes individuals compared to people without diabetes, due to the chronic diabetes complications

[8, 9]

Treatment options vary depending upon the diabetes categories viz. type 1 diabetes must rely on insulin, whereas type 2 diabetes can use either oral medications or injectable-insulin to manage their diabetes effectively. Medicaments of type 2 diabetes include, Metformin, Dipeptidyl peptidase 4 (DPP-4) inhibitors, Glucagon-like peptide 1 (GLP-1) and dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists, Sodium-glucose cotransporter 2 (SGLT2) inhibitors, Sulfonylureas, Thiazolidinediones (TZDs)

[10]

. The mode of action all these drugs varies in the maintenance of blood glucose levels and have their own side effects eg. Metformin causes diarrhoea, if not taken with food. It has been evident that apart from ‘Anti-hyper glycaemic’ (AHGs) agents constant use to maintain the target blood glucose levels, the lifestyle changes like dietary habits, physical activity/exercise etc. are advised by healthcare professionals. In addition, certain botanical/herbal ingredients, food / health supplements were known for their adjunctive action in controlling the blood sugar levels along with AHGs

[11]

. Traditional system of medicine has also reported the anti-glycaemic potential of medicinal plants.

In view of the above Dabur India Ltd., has formulated the ‘Ayurvedic Sugar Free Juice’ (Code: DRDC/2025/010) to address the maintenance of blood sugar levels and improvement in QoL among diabetes individuals.

2. Methodology

2.1. Study Site and Participants

The study was carried out in Type II Diabetics patients at Govt. Ayurveda College & Hospital (GAC&H), Balangir, Odisha in India, after obtaining the Ethical committee approvals and registration of the study with ‘Clinical Trial Registry of India’ (CTRI). A total of 30 participants, were screened as per inclusion and exclusion criteria mentioned in the Table 1. The schematic flow of the study with activities and scheduled visits was given in Figure 1.

Table 1. Inclusion & Exclusion Criteria.

Inclusion Criteria

Exclusion Criteria

1. Subjects aged > 18 years of age who agreed to participate in the study and able to answer the questionnaire and give their written informed consent.

2. Participants were recruited with following criteria:

For Diabetics:

1) Participant with initial HbA1c value 6.5% and above.

2) Patients who are under the treatment of oral antidiabetic drugs.

3) Patients who have not changed their medication in the last three months prior to signing up for the study. (However, dosage modifications were allowed and documented on CRF).

For prediabetics:

1) Participant with initial HbA1c value 5.7 to 6.4%.

2) Known cases of pre-diabetes with fasting blood sugar not exceeding 130mg/dl with obesity and having family history of diabetes.

3. Subjects with Body Mass Index (BMI) >23 kg/m² and <45 kg/m²

4. Women of childbearing potential must be willing to use double-barrier contraception for the entire study.

1) Women with regular menstruation history having missed periods.

2) Confirmed cases of pregnancy and lactation.

3) Patients who are on insulin therapy.

4) Patients with a history of chronic illness type 1 diabetes and /or history of ketoacidosis.

5) Patients with Insulin use and/or hyperosmolar hyperglycaemic state.

6) Patients with secondary diabetes (including disease of the exocrine pancreas, endocrinopathies.

7) 7. Any condition of the patient which may have an impact on the objective and outcome of the trial example: patients currently undergoing major/minor surgical procedures.

Download: Download full-size image

Figure 1. Schematic Flow of Study with Events & Visits. The information of the clinical sites, number of participants, screening through inclusion & exclusion criteria were shown. The events with timelines for follow-up visits and assessment activities was provided.

2.2. Follow-up Visits & Parameters Assessed

At baseline/screening visit, the information about demographic, anthropometric, medical history was recorded from all the participants. Vitals such a pulse, respiration rate, blood pressure and body temperature were recorded. Blood was collected analyzed for complete blood count (CBC), lipid profile, liver & renal function tests.

The test compound was disbursed and instructed the dosage and frequency as ‘30mL of DRDC/2025/010’ diluted with 250 mL of drinking water and consumed twice a day preferably at least one hour, before breakfast and before dinner for a period of 90 days. The diabetic participants who were following specific dietary, exercise activities and AHGs, were advised to continue those practices as such through-out the study period. The participants were informed about the follow-up visits on every 30^th day during the study period without overnight fasting. Efficacy of the test compound was assessed by change in diabetic parameters viz. Fasting Blood Sugar (FBS), Random Blood Sugar (RBS) and HbA1C levels on 3 follow-up visits from baseline. In addition, the change in Body Mass Index (BMI) and improvement in Quality of Life (QoL) through questionnaire pertaining to the symptoms of diabetes were assessed at baseline and 90^th day. The Adverse Events (AEs), if any related to the test compound consumption were documented. Biochemical parameters such as CBC, lipid profile, LFT and RFT were analyzed at 90^th day (last follow-up visit).

Download: Download full-size image

Figure 2. Diabetic Parameters - FBS, RBS & HbA1C levels. Bars represent mean±SD of FBS, RBS & HbA1C levels of the participants at different time points. Differ-ent superscripts indicated significantly difference from baseline to end of treatment. HbA1C levels were as-sessed at baseline, 30 days, 60 days and 90 days.

2.3. Statistical Analysis

Both quantitative and qualitative data were compiled and analyzed. Quantitative variables were expressed as mean ± standard deviation (SD), while qualitative variables were summarized as counts and percentages. For categorical data, McNemar’s test was applied to evaluate before-and-after treatment effects. The treatment effects were assessed using the paired sample t-test, and the Wilcoxon signed-rank test respectively. All analyses were performed using RStudio 2026.01.1 with p-values reported from two-sided tests. Statistical significance was interpreted at the 5% level (α = 0.05).

3. Results

3.1. Demographic and Anthropometric Profile

A total of 30 participants were recruited into the study and among them 26 nos. of participants completed the study (male - 18 and female - 8). During course of study 4 participants dropped out. The participants the study site were residing in the urban, sub-urban and rural regions of the Balangir town. Occupation of the diabetic participants of clinical sites includes home-makers (majority of female participants), Govt. employees, business, private and daily-wage employees. Mean age of participants was 49±9.60 years, with a range from 33 - 67 years. The height of participants ranged between 162.1±8.19 cm; and weight was 66.6±11.37 kg.

3.2. Diabetic Parameters

The diabetic parameters such as FBS, RBS & HbA1C of participants have been shown in Figure 2. The mean FBS levels at baseline, 1^st month, 2^nd month and 3^rd month visits were 200.2±65.11; 177.0±57.98; 154.2±36.86 and 137.6±28.92 mg/dL, respectively. Though mean FBS levels were reduced at 1^st month visit compared to baseline, but statistically insignificant. Whereas subsequent visits i.e. 2^nd (p<0.0063) and 3^rd month (p<0.0001) follow-up visits the FBS levels were significantly reduced compared to baseline (Figure 2). In between visit FBS levels viz. 1^st month vs 2^nd month and 2^nd month vs 3^rd month were statistically insignificant, however 3^rd month FBS mean levels were significantly (p<0.026) reduced compared to 1^st month (Figure 2).

Similarly, mean RBS levels at baseline, 1^st month, 2^nd month and 3^rd month visits were 276.1±89.50; 247.4±85.89; 214.7±60.82 and 189.6±52.28 mg/dL, respectively. The mean RBS levels were significantly decreased at 02^nd (p<0.016) and 03^rd (p<0.0003) month visits when compared to baseline. However, no difference was noted baseline vs 1^st month and 1^st month vs 2^nd month visit RBS levels. Nonetheless, mean RBS levels were significantly reduced at 3^rd month visit compared to 2^nd month visit (p<0.026) (Figure 2).

The mean HbA1C levels of pooled data at baseline, 2^nd & 3^rd month visits were 8.57±1.84; 7.57±1.35 and 6.90±1.04%, respectively. The mean HbA1C levels were significantly decreased at 2^nd (p<0.043) and 3^rd (p<0.0003) month visit compared with baseline. (Figure 2).

3.3. BMI and QoL

The BMI of the diabetic participants at baseline was 25.1±3.00 kg/m² and at end of the study period the BMI was 20.7±8.56 kg/m². A significant (p<0.0001) decrease in mean BMI levels of the diabetic participants was observed at 90^th day compared to baseline.

The QoL assessed by symptoms viz. Polyuria, Polyphagia, Exhaustion /Tiredness and Body ache were reduced among the diabetic participants by the end of treatment compared to baseline. Although there was change in multiple parameters at Day 0 and Day 90, but statistically insignificant (Table 2).

Table 2. QoL - Symptoms of Diabetes.

S. No.	QoL Parameter	Time Points
S. No.	QoL Parameter	0^th Day	90^th Day
1	Polyuria	46	42
2	Polyphagia	35	35
3	Polydipsia	19	12
4	Exhaustion / Tiredness	77	65
5	BW loss	27	27
6	Body ache	77	65
7	Giddiness	65	62
8	Polyneuritis	73	58
9	Visual Disturbances	12	12

Values are% of individuals with symptoms.

3.4. Biochemical Parameters

CBC parameters of the participants viz., MCV, MCH, MCHC, monocytes and platelet levels were significantly different from baseline to end of the treatment period, whereas other CBC parameters were comparable (Table 3). The LFT and RFT parameters have not shown significant difference between end of treatment period and baseline, except that BUN levels were significantly different between two time points (Table 3). The mean cholesterol levels were notably decreased at day 90 (163.0 + 37.25), compared to baseline – day 0 (189.1 + 53.61). Similarly, triglyceride and VLDL levels were noted to decrease at day 90 compared to baseline (Figure 3). Furthermore, the mean HDL levels increased significantly (p<0.001) at day 90 compared to baseline, while there was a significant decrease in LDL levels (p<0.001) at end of day 90 compared to baseline (Figure 3).

Table 3. Hematological Parameters of Participants.

S. No.	Parameter	0^th Day	90^th Day
Haematological Parameters
1	Hb (gm/dl)	14.3±2.02	14.5±1.15
2	RBC (×10⁶/µL)	5.6±0.64	5.3±0.54
3	MCV	84.9±9.05	93.2±7.29**
4	MCH	25.5±3.13	27.6±3.18*
5	MCHC	30.0±1.73	28.6±1.11**
6	WBC (×10³/µL)	8.6±1.92	8.1±1.45
7	Neutrophil (%)	61.3±6.32	61.9±6.64
8	Lymphocyte (%)	31.1±6.10	30.1±6.70
9	Monocyte (%)	3.2±3.33	3.2±0.78
10	Eosinophil (%)	4.2±3.11	4.2±1.69
11	Basophil (%)	0.59±0.298	0.47±0.201
12	Platelet (×10³/µL)	285.1±73.41	247.7±72.05*

*P<0.05 & **p<0.001 are Level of significance at two different time points.

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Figure 3. Lipid Profile of Participants – Total Cholesterol, HDL, LDL, Triglycerides, VLDL. Bars represent mean±SD of Total Cholesterol, HDL, LDL, Triglycerides, VLDL levels of the participants. Different superscripts indicated significantly difference from baseline to end of treatment. The lipid profile was assessed at baseline and at end of treatment (90 days).

3.5. Vitals

The pulse of the diabetic patients were noted at 74.4±4.96/min at day 0 and 75.9±3.82/min day 90. Similarly, respiration rate/min at day 0 was noted at 18.1±1.04 and at day 90 was noted at 18.7±0.84; body temperature (in ^oF) at day 0 was 98.4±0.24 and at day 90 was 98.2±0.27; the Blood pressure (mm of Hg) systolic was noted to be 126.9±10.87 at day 0 and 126.4±10.65 at day 90 while the diastolic readings were 80.8±8.12 at day 0 and 80.6± 8.12 at day 90. The vitals above, were comparable before and after intake of the test compound.

3.6. Safety of Test Compound

None of the participants from the clinical study site have shown any adverse event (AE) / adverse drug reaction (ADR) related to the test compound i.e. Ayurvedic Sugar Free Juice. In addition, no significant difference in the vitals recorded during the course of study period suggests that the test compound have no visible side effects. Further to this, the biochemical analysis such as CBC, LFT and RFT parameters were also comparable, though few parameters varied in the participants at initial to end of the treatment period (90 days) suggests the test compound’s safety.

4. Discussion

Adjunctive therapeutic process / agents are gaining the momentum in counter-acting the chronic effects of diabetes along with ‘Anti-hyper glycaemic’ (AHGs) agents. The QoL of diabetes patient with chronic and severe hyperglycaemia is adversely affected, and resulting in tiredness and lethargy thereby a decrease in work performance was noted in adults

[12]

. To meet the requirements and avoid further increase the dosage of AHGs healthcare professional suggests for life-style changes for diabetes individuals especially dietary modifications and regular exercise. A study carried out among diabetes personal with stress management showed small but significant decrease in glycohemoglobin after 1 year

[13]

In addition, to the life-style changes use of alternate medicines such as botanical/herbal ingredients, food / health supplements were known for their adjunctive action in controlling the blood sugar levels along with AHGs (Pandey, et al., 2011). In the current study, the test compound is comprised of botanicals such as Aloe barbadensis, Emblica officinalis, Syzgium cumini, Momordica charantia, Azadirachta indica, Tinospora cordifolia, Terminalia chebula, Terminalia billerica, Gymnema sylvestre, Trigonella foenumgraecum, Withania somnifera, Pterocarpus marsupium.

Different species of Aloe vera have reported the hypoglycemic and antidiabetic potential through in vitro and in vivo studies

[14]

. Similarly a study conducted on rats with Jamun and metformin, alone and combination have revealed that combination of metformin and Jamun have significantly reduced the HbA1C levels in diabetic condition, whereas in prediabetics alone of Jamun could show it’s potential effect

[15]

. Current study results corroborated with reduction in HbA1C levels at 90 days regular consumption along with AHGs. In addition, the RBS and FBS levels were also significantly decreased among the diabetic participants at end of treatment duration (12^th week) compared to baseline / screening stage along with AHGs, their regular dietary and exercise pattern.

Overall, in the study it was observed that upon systematic usage of the test compound DRDC/2025/010 for 90 days, there was 31.27% reduction in fasting blood sugar (FBS), 31.33% reduction in random blood sugar (RBS) and 19.49% reduction in glycated hemoglobin (HbA1c) among the study participants. Further, the QoL assessed by set of questionnaires have also revealed notable decrease in the symptoms associated with diabetes. The test compound have shown no adverse events (AEs) / ADRs during the course of efficacy evaluation. Added to this, the vitals and biochemical parameters were in the normal range suggesting the safety of the test compound.

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Figure 4. Liver Function Assessment of Participants – ALP, Total Bilirubin, SGPT, SGOT. Bars represent mean±SD of ALP, Total Bilirubin, SGPT, SGOT levels of the participants. Different superscripts indicated significantly difference from baseline to end of treatment. The lipid profile was assessed at baseline and at end of treatment (90 days).

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Figure 5. Renal Function Assessment of Participants – BUN, Creatinine, Urea, Uric Aci Bars represent mean±SD of BUN, Creatinine, Urea, Uric Acid levels of the participants. Different super-scripts indicated significantly difference from baseline to end of treatment. The lipid profile was assessed at baseline and at end of treatment (90 days).

5. Conclusion

Current study has unveiled the safety of the test compound as there were no adverse events, vitals and biochemical parameters within the normal range during the course of the experimental period. The test compound DRDC/2025/010 have shown significant (p<0.05) reduction in FBS, RBS, HbA1c and BMI levels among the participants of study at the ‘end of treatment (90 days)’, compared to baseline. The above observations indicate the test compound’s potential as an ‘adjunctive agent’ for diabetic patients, who are on AHGs, following the dietary and exercise guidelines, could improve from hyper-glycemia, upon constant usage.

Abbreviations

ALP	Alkaline Phosphatase
ATP	Adenosine Triphosphate
BUN	Blood Urea Nitrogen
DL	Decilitre
FBS	Fasting Blood Sugar
GM	Gram
HB	Hemoglobin
HbA1c	Hemoglobin A1c Also Called Glycated Hemoglobin
HDL	High-density Lipoprotein
LDL	Low-density Lipoprotein
LFT	Liver Function Test
MCHC	Mean Corpuscular Hemoglobin Concentration
MCV	Mean Corpuscular Volume
MG	Milligram
QoL	Quality of Life
RBC	Red Blood Cells
RBS	Random Blood Sugar
RFT	Renal Functional Test
SGOT	Serum Glutamate Pyruvate Transaminase
SGPT	Serum Glutamic-Oxaloacetic Transaminase
T. Bil	Total Billirubin
Trigly.	Triglyceride
Ul	Micro-liter
VLDL	Very-low-density Lipoprotein
WBC	White Blood Cells

Author Contributions

Baidyanath Mishra: Conceptualization, Resources, Funding acquisition, Project administration, Supervision, Validation

Srinivasa Reddy Yathapu: Supervision, Methodology, Formal Analysis, Validation, Writing – original draft, Writing – review & editing

Simadri Bhusan Nayak: Investigation, Data curation, Formal Analysis

Sushanta Sahu: Investigation, Data curation, Formal Analysis

Garima Gupta: Project administration, Supervision, Methodology, Investigation, Formal Analysis

Apratim Sai Rajesh: Project administration, Data Analysis, Writing – original draft, Writing – review & editing

Conflicts of Interest

The authors declare no conflict of interest.

References

[1]	WHO (World Health Organization) Fact Sheet, 2014. https://www.who.int/news-room/fact-sheets/detail/diabetes
[2]	Mishra AB. Glucose A Universal Fuel: Indispensible In Diabetes Too. Eur. J. Cardiovasc. Med. 2025; 15: 182 - 185. https://doi.org/10.61336/ejcm/25-11-25
[3]	CDC (Centre for Disease Control and prevention): https://www.cdc.gov/diabetes/about/index.html
[4]	Sekher T, Flood D, Green H et al. Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older. The Lancet Global Health, 2025; 13, e1543-e1552. https://doi.org/10.1016/S2214-109X(23)00502-8
[5]	Vithian K., Hurel S. Microvascular complications: Pathophysiology and management. Clin. Med. 2010; 10: 505-509. https://doi.org/10.7861/clinmedicine.10-5-505.
[6]	Migdalis I. N., Papanas N., Raptis A. E., Ioannidis I. M., Sotiropoulos A. E., Dimitriadis G. D. The prevalence of diabetic chronic kidney disease in adult Greek subjects with type 2 diabetes mellitus: A series from hospital-based diabetes clinics. Diabetes Res. Clin. Pract. 2020; 166: 108243. https://doi.org/10.1016/j.diabres.2020.108243.
[7]	Aarthy R, Mikocka-Walus A, Pradeepa R, Anjana RM, Mohan V, Aston-Mourney K. Quality of Life and Diabetes in India: A Scoping Review. Indian J Endocrinol Metab. 2021; 25(5): 365-380. https://doi.org/10.4103/ijem.ijem_336_21
[8]	Gregg E. W., Zhuo X., Cheng Y. J., Albright A. L., Narayan K. M. V., Thompson T. J. Trends in lifetime risk and years of life lost due to diabetes in the USA, 1985-2011: A modeling study. Lancet Diabetes Endocrinol. 2014; 2: 867-874. https://doi.org/10.1016/S2213-8587(14)70161-5
[9]	Tomic D., Morton J. I., Chen L., Salim A., Gregg E. W., Pavkov M. E., Arffman M., Balicer R., Baviera M., Dam E. B.-V., et al. Lifetime risk, life expectancy and years of life lost to type 2 diabetes in 23 high-income jurisdictions: A multinational, population-based study. Lancet Diabetes Endocrinol. 2022; 10: 795-803. https://doi.org/10.1016/S2213-8587(22)00252-2
[10]	American Diabetes Association: https://diabetes.org/health-wellness/medication/oral-other-injectable-diabetes-medication
[11]	Pandey A, Tripathi P, Pandey R, Srivatava R, Goswami S. Alternative therapies useful in the management of diabetes: A systematic review. J Pharm Bioallied Sci. 2011 Oct; 3(4): 504-12. https://doi.org/10.4103/0975-7406.90103
[12]	Chattopadhyay RR. Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract. Part IV. Gen Pharmacol 1996; 27: 431-4. https://doi.org/10.1016/s0378-8741(99)00094-x
[13]	Surwit RS, van Tilburg MA, Zucker N, McCaskill CC, Parekh P, Fienglos MN, et al. Stress management improves long-term glycemic control in type 2 diabetes. Diabetes Care 2002; 25: cd30-4. https://doi.org/10.2337/diacare.25.1.30
[14]	Kazeem, MI., Bankole, HA., Fatai, AA., Saibu, GM., Wusu, AD. Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review, South African Journal of Botany, 2022; 147: 1070-1077. https://doi.org/10.1016/j.sajb.2022.05.041
[15]	Mulkalwar, S., Vishwanath K., Teja D., Harshavardhan B., Abhi P., Tilak AV. “Antihyperglycemic Activity of Syzygium Cumini (Jamun) in Diabetic Rats”. Journal of Pharmaceutical Research International. 2021; 33 (35A): 12-19. https://doi.org/10.9734/jpri/2021/v33i35A31868

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Mishra, B., Yathapu, S. R., Nayak, S. B., Sahu, S., Gupta, G., et al. (2026). Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM. European Journal of Preventive Medicine, 14(4), 94-102. https://doi.org/10.11648/j.ejpm.20261404.15

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Mishra, B.; Yathapu, S. R.; Nayak, S. B.; Sahu, S.; Gupta, G., et al. Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM. Eur. J. Prev. Med. 2026, 14(4), 94-102. doi: 10.11648/j.ejpm.20261404.15

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AMA Style

Mishra B, Yathapu SR, Nayak SB, Sahu S, Gupta G, et al. Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM. Eur J Prev Med. 2026;14(4):94-102. doi: 10.11648/j.ejpm.20261404.15

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@article{10.11648/j.ejpm.20261404.15,
  author = {Baidyanath Mishra and Srinivasa Reddy Yathapu and Simadri Bhusan Nayak and Sushanta Sahu and Garima Gupta and Apratim Sai Rajesh},
  title = {Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM},
  journal = {European Journal of Preventive Medicine},
  volume = {14},
  number = {4},
  pages = {94-102},
  doi = {10.11648/j.ejpm.20261404.15},
  url = {https://doi.org/10.11648/j.ejpm.20261404.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20261404.15},
  abstract = {Global burden of Type 2 Diabetes Mellitus (T2DM) has reached alarming proportions, with prevalence surging from 200 million to over 830 million over three decades. India bears a disproportionate share of this crisis, with approximately 77 million individuals living with T2DM and an additional 25 million in the prediabetic range (HbA1c: 5.7–6.4%), collectively imposing significant threats to workforce productivity and national healthcare expenditure. While anti-hyperglycemic (AHG) agents combined with lifestyle modifications remain the cornerstone of T2DM management, long-term dependence on escalating pharmacological doses and the risk of chronic complications have intensified interest in adjunctive therapeutic strategies. In this context, the present study evaluated the adjunctive efficacy and safety of a proprietary ayurvedic formulation (sugar-free juice), DRDC/2025/010, in individuals with T2DM already on standard AHG therapy. This ethically approved, CTRI-registered clinical study enrolled 30 T2DM participants screened against predefined inclusion and exclusion criteria. Participants received 30 mL of DRDC/2025/010 diluted in 250 mL of drinking water, consumed twice daily for 90 days, alongside their existing AHG regimen, dietary guidance, and exercise routine. Efficacy endpoints included fasting blood sugar (FBS), random blood sugar (RBS), glycated hemoglobin (HbA1c), body mass index (BMI), and quality of life (QoL). Safety was monitored through biochemical parameters, vital signs, and adverse event (AE) surveillance throughout the study period. DRDC/2025/010 demonstrated statistically significant reductions in FBS at Day 60 (p ) and Day 90 (p ), and in RBS at Day 60 (p ) and Day 90 (p ), relative to baseline. A significant (Pth day (20.7±8.56 kg/m2) compared to baseline (25.1±3.00 kg/m2). Mean HbA1c levels also declined significantly at Day 90 (p = 0.024), accompanied by meaningful improvements in QoL. Notably, no adverse events were recorded, and biochemical parameters and vital signs remained stable throughout the intervention, affirming a favorable safety profile. These findings suggest that DRDC/2025/010 holds promising potential as a safe and effective adjunct to standard T2DM pharmacotherapy, contributing to improved glycemic control and patient well-being.},
 year = {2026}
}

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TY  - JOUR
T1  - Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM
AU  - Baidyanath Mishra
AU  - Srinivasa Reddy Yathapu
AU  - Simadri Bhusan Nayak
AU  - Sushanta Sahu
AU  - Garima Gupta
AU  - Apratim Sai Rajesh
Y1  - 2026/08/22
PY  - 2026
N1  - https://doi.org/10.11648/j.ejpm.20261404.15
DO  - 10.11648/j.ejpm.20261404.15
T2  - European Journal of Preventive Medicine
JF  - European Journal of Preventive Medicine
JO  - European Journal of Preventive Medicine
SP  - 94
EP  - 102
PB  - Science Publishing Group
SN  - 2330-8230
UR  - https://doi.org/10.11648/j.ejpm.20261404.15
AB  - Global burden of Type 2 Diabetes Mellitus (T2DM) has reached alarming proportions, with prevalence surging from 200 million to over 830 million over three decades. India bears a disproportionate share of this crisis, with approximately 77 million individuals living with T2DM and an additional 25 million in the prediabetic range (HbA1c: 5.7–6.4%), collectively imposing significant threats to workforce productivity and national healthcare expenditure. While anti-hyperglycemic (AHG) agents combined with lifestyle modifications remain the cornerstone of T2DM management, long-term dependence on escalating pharmacological doses and the risk of chronic complications have intensified interest in adjunctive therapeutic strategies. In this context, the present study evaluated the adjunctive efficacy and safety of a proprietary ayurvedic formulation (sugar-free juice), DRDC/2025/010, in individuals with T2DM already on standard AHG therapy. This ethically approved, CTRI-registered clinical study enrolled 30 T2DM participants screened against predefined inclusion and exclusion criteria. Participants received 30 mL of DRDC/2025/010 diluted in 250 mL of drinking water, consumed twice daily for 90 days, alongside their existing AHG regimen, dietary guidance, and exercise routine. Efficacy endpoints included fasting blood sugar (FBS), random blood sugar (RBS), glycated hemoglobin (HbA1c), body mass index (BMI), and quality of life (QoL). Safety was monitored through biochemical parameters, vital signs, and adverse event (AE) surveillance throughout the study period. DRDC/2025/010 demonstrated statistically significant reductions in FBS at Day 60 (p ) and Day 90 (p ), and in RBS at Day 60 (p ) and Day 90 (p ), relative to baseline. A significant (Pth day (20.7±8.56 kg/m2) compared to baseline (25.1±3.00 kg/m2). Mean HbA1c levels also declined significantly at Day 90 (p = 0.024), accompanied by meaningful improvements in QoL. Notably, no adverse events were recorded, and biochemical parameters and vital signs remained stable throughout the intervention, affirming a favorable safety profile. These findings suggest that DRDC/2025/010 holds promising potential as a safe and effective adjunct to standard T2DM pharmacotherapy, contributing to improved glycemic control and patient well-being.
VL  - 14
IS  - 4
ER  -

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Author Information

Baidyanath Mishra

Department of Healthcare Research & Development, Dabur India Limited, Ghaziabad, India

Contact Email

http://orcid.org/0009-0006-5601-8607
Srinivasa Reddy Yathapu

Department of Medical Affairs and Clinical Research, Dabur India Limited, Ghaziabad, India

http://orcid.org/0000-0003-2572-6943
Simadri Bhusan Nayak

Department of Kayachikitsa, Government Ayurvedic College, Balangir, India

http://orcid.org/0009-0006-0048-801X
Sushanta Sahu

Department of Swasthavritta, Government Ayurvedic College, Balangir, India

http://orcid.org/0000-0002-8877-3213
Garima Gupta

Department of Medical Affairs and Clinical Research, Dabur India Limited, Ghaziabad, India

http://orcid.org/0009-0000-6574-8288
Apratim Sai Rajesh

Department of Medical Affairs and Clinical Research, Dabur India Limited, Ghaziabad, India

http://orcid.org/0000-0001-9227-6327

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APA Style

Mishra, B., Yathapu, S. R., Nayak, S. B., Sahu, S., Gupta, G., et al. (2026). Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM. European Journal of Preventive Medicine, 14(4), 94-102. https://doi.org/10.11648/j.ejpm.20261404.15

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ACS Style

Mishra, B.; Yathapu, S. R.; Nayak, S. B.; Sahu, S.; Gupta, G., et al. Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM. Eur. J. Prev. Med. 2026, 14(4), 94-102. doi: 10.11648/j.ejpm.20261404.15

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AMA Style

Mishra B, Yathapu SR, Nayak SB, Sahu S, Gupta G, et al. Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM. Eur J Prev Med. 2026;14(4):94-102. doi: 10.11648/j.ejpm.20261404.15

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@article{10.11648/j.ejpm.20261404.15,
  author = {Baidyanath Mishra and Srinivasa Reddy Yathapu and Simadri Bhusan Nayak and Sushanta Sahu and Garima Gupta and Apratim Sai Rajesh},
  title = {Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM},
  journal = {European Journal of Preventive Medicine},
  volume = {14},
  number = {4},
  pages = {94-102},
  doi = {10.11648/j.ejpm.20261404.15},
  url = {https://doi.org/10.11648/j.ejpm.20261404.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20261404.15},
  abstract = {Global burden of Type 2 Diabetes Mellitus (T2DM) has reached alarming proportions, with prevalence surging from 200 million to over 830 million over three decades. India bears a disproportionate share of this crisis, with approximately 77 million individuals living with T2DM and an additional 25 million in the prediabetic range (HbA1c: 5.7–6.4%), collectively imposing significant threats to workforce productivity and national healthcare expenditure. While anti-hyperglycemic (AHG) agents combined with lifestyle modifications remain the cornerstone of T2DM management, long-term dependence on escalating pharmacological doses and the risk of chronic complications have intensified interest in adjunctive therapeutic strategies. In this context, the present study evaluated the adjunctive efficacy and safety of a proprietary ayurvedic formulation (sugar-free juice), DRDC/2025/010, in individuals with T2DM already on standard AHG therapy. This ethically approved, CTRI-registered clinical study enrolled 30 T2DM participants screened against predefined inclusion and exclusion criteria. Participants received 30 mL of DRDC/2025/010 diluted in 250 mL of drinking water, consumed twice daily for 90 days, alongside their existing AHG regimen, dietary guidance, and exercise routine. Efficacy endpoints included fasting blood sugar (FBS), random blood sugar (RBS), glycated hemoglobin (HbA1c), body mass index (BMI), and quality of life (QoL). Safety was monitored through biochemical parameters, vital signs, and adverse event (AE) surveillance throughout the study period. DRDC/2025/010 demonstrated statistically significant reductions in FBS at Day 60 (p ) and Day 90 (p ), and in RBS at Day 60 (p ) and Day 90 (p ), relative to baseline. A significant (Pth day (20.7±8.56 kg/m2) compared to baseline (25.1±3.00 kg/m2). Mean HbA1c levels also declined significantly at Day 90 (p = 0.024), accompanied by meaningful improvements in QoL. Notably, no adverse events were recorded, and biochemical parameters and vital signs remained stable throughout the intervention, affirming a favorable safety profile. These findings suggest that DRDC/2025/010 holds promising potential as a safe and effective adjunct to standard T2DM pharmacotherapy, contributing to improved glycemic control and patient well-being.},
 year = {2026}
}

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TY  - JOUR
T1  - Efficacy Evaluation of Dabur Dia Control Juice, an Ayurvedic Formulation as an Adjuvant in NIDDM
AU  - Baidyanath Mishra
AU  - Srinivasa Reddy Yathapu
AU  - Simadri Bhusan Nayak
AU  - Sushanta Sahu
AU  - Garima Gupta
AU  - Apratim Sai Rajesh
Y1  - 2026/08/22
PY  - 2026
N1  - https://doi.org/10.11648/j.ejpm.20261404.15
DO  - 10.11648/j.ejpm.20261404.15
T2  - European Journal of Preventive Medicine
JF  - European Journal of Preventive Medicine
JO  - European Journal of Preventive Medicine
SP  - 94
EP  - 102
PB  - Science Publishing Group
SN  - 2330-8230
UR  - https://doi.org/10.11648/j.ejpm.20261404.15
AB  - Global burden of Type 2 Diabetes Mellitus (T2DM) has reached alarming proportions, with prevalence surging from 200 million to over 830 million over three decades. India bears a disproportionate share of this crisis, with approximately 77 million individuals living with T2DM and an additional 25 million in the prediabetic range (HbA1c: 5.7–6.4%), collectively imposing significant threats to workforce productivity and national healthcare expenditure. While anti-hyperglycemic (AHG) agents combined with lifestyle modifications remain the cornerstone of T2DM management, long-term dependence on escalating pharmacological doses and the risk of chronic complications have intensified interest in adjunctive therapeutic strategies. In this context, the present study evaluated the adjunctive efficacy and safety of a proprietary ayurvedic formulation (sugar-free juice), DRDC/2025/010, in individuals with T2DM already on standard AHG therapy. This ethically approved, CTRI-registered clinical study enrolled 30 T2DM participants screened against predefined inclusion and exclusion criteria. Participants received 30 mL of DRDC/2025/010 diluted in 250 mL of drinking water, consumed twice daily for 90 days, alongside their existing AHG regimen, dietary guidance, and exercise routine. Efficacy endpoints included fasting blood sugar (FBS), random blood sugar (RBS), glycated hemoglobin (HbA1c), body mass index (BMI), and quality of life (QoL). Safety was monitored through biochemical parameters, vital signs, and adverse event (AE) surveillance throughout the study period. DRDC/2025/010 demonstrated statistically significant reductions in FBS at Day 60 (p ) and Day 90 (p ), and in RBS at Day 60 (p ) and Day 90 (p ), relative to baseline. A significant (Pth day (20.7±8.56 kg/m2) compared to baseline (25.1±3.00 kg/m2). Mean HbA1c levels also declined significantly at Day 90 (p = 0.024), accompanied by meaningful improvements in QoL. Notably, no adverse events were recorded, and biochemical parameters and vital signs remained stable throughout the intervention, affirming a favorable safety profile. These findings suggest that DRDC/2025/010 holds promising potential as a safe and effective adjunct to standard T2DM pharmacotherapy, contributing to improved glycemic control and patient well-being.
VL  - 14
IS  - 4
ER  -

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