@article{10.11648/j.ejpm.20251306.11,
  author = {Fatma Said Mohammed and Eva Felician Mujuni and Edgar Ndaboine and Richard Kiritta},
  title = {Cardiac Characteristic in Preeclampsia and Normotensive Pregnant Women Attending Bugando Medical Centre Tanzania
},
  journal = {European Journal of Preventive Medicine},
  volume = {13},
  number = {6},
  pages = {121-129},
  doi = {10.11648/j.ejpm.20251306.11},
  url = {https://doi.org/10.11648/j.ejpm.20251306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20251306.11},
  abstract = {Background: Hemodynamic changes brought on by pregnancy, may affect the heart either by physiological or pathological changes. Preeclampsia-eclampsia (PE-E) primarily affects the cardiovascular system which leads to low cardiac output and a high systemic vascular resistance, this lead to abnormal adaptive mechanisms that may be a result of changes in vascular tone and may have effects on a woman's life. Methodology: 273 women from an obstetric ward or prenatal clinic who were at least 28 weeks pregnant and those who are 10 days postpartum at BMC participated in the comparative cross-sectional study. Transthoracic echocardiograms (TTE) were performed along with interviews of the recruited subjects. A questionnaire was implemented to gather data, and STATA version 13 was used for analysis. A level of statistical significance was defined as less than 0.05 p-value in multivariate logistic regression. Results: 49.45% out of 273 women, had PE-E. 78.7% out of 273 participants were ≤ 35 years of age. The prevalence of abnormal structural cardiac characteristics was 60% and 28.57% in PE-E and normotensive pregnant women respectively, while the prevalence of abnormal functional cardiac characteristics between them was nearly the same. No difference in LA enlargement between PE-E and normotensive pregnant women. Interventricular septum and posterior wall thickness of the LV were more than 5 to 8-fold in PE-E compared to normotensive pregnant women. EF and diastolic dysfunction were 3 and 2 fold respectively, in PE-E compared to normotensive pregnant women. Abnormal structural cardiac characteristics were more common among women with severe forms of PE-E by 2 to 9 fold, but there is no statistically significant in functional cardiac characteristics with the severity of PE-E. Conclusion and recommendations: Structural and functional cardiac abnormalities were more common in PE-E than in normotensive pregnant women, hence TTE should include as a part of an investigation into PE-E and symptomatic normotensive. Cardiac structural and functional should be followed up in patients with PE-E even after termination of pregnancy. There is a need for a larger longitudinal study to determine the proper timing of cardiac evaluation in PE-E both during ANC and post-delivery.
},
 year = {2025}
}

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TY  - JOUR
T1  - Cardiac Characteristic in Preeclampsia and Normotensive Pregnant Women Attending Bugando Medical Centre Tanzania

AU  - Fatma Said Mohammed
AU  - Eva Felician Mujuni
AU  - Edgar Ndaboine
AU  - Richard Kiritta
Y1  - 2025/12/03
PY  - 2025
N1  - https://doi.org/10.11648/j.ejpm.20251306.11
DO  - 10.11648/j.ejpm.20251306.11
T2  - European Journal of Preventive Medicine
JF  - European Journal of Preventive Medicine
JO  - European Journal of Preventive Medicine
SP  - 121
EP  - 129
PB  - Science Publishing Group
SN  - 2330-8230
UR  - https://doi.org/10.11648/j.ejpm.20251306.11
AB  - Background: Hemodynamic changes brought on by pregnancy, may affect the heart either by physiological or pathological changes. Preeclampsia-eclampsia (PE-E) primarily affects the cardiovascular system which leads to low cardiac output and a high systemic vascular resistance, this lead to abnormal adaptive mechanisms that may be a result of changes in vascular tone and may have effects on a woman's life. Methodology: 273 women from an obstetric ward or prenatal clinic who were at least 28 weeks pregnant and those who are 10 days postpartum at BMC participated in the comparative cross-sectional study. Transthoracic echocardiograms (TTE) were performed along with interviews of the recruited subjects. A questionnaire was implemented to gather data, and STATA version 13 was used for analysis. A level of statistical significance was defined as less than 0.05 p-value in multivariate logistic regression. Results: 49.45% out of 273 women, had PE-E. 78.7% out of 273 participants were ≤ 35 years of age. The prevalence of abnormal structural cardiac characteristics was 60% and 28.57% in PE-E and normotensive pregnant women respectively, while the prevalence of abnormal functional cardiac characteristics between them was nearly the same. No difference in LA enlargement between PE-E and normotensive pregnant women. Interventricular septum and posterior wall thickness of the LV were more than 5 to 8-fold in PE-E compared to normotensive pregnant women. EF and diastolic dysfunction were 3 and 2 fold respectively, in PE-E compared to normotensive pregnant women. Abnormal structural cardiac characteristics were more common among women with severe forms of PE-E by 2 to 9 fold, but there is no statistically significant in functional cardiac characteristics with the severity of PE-E. Conclusion and recommendations: Structural and functional cardiac abnormalities were more common in PE-E than in normotensive pregnant women, hence TTE should include as a part of an investigation into PE-E and symptomatic normotensive. Cardiac structural and functional should be followed up in patients with PE-E even after termination of pregnancy. There is a need for a larger longitudinal study to determine the proper timing of cardiac evaluation in PE-E both during ANC and post-delivery.

VL  - 13
IS  - 6
ER  - 

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