With the arrival of an aging society, the incidence of Kümmell’s disease (KD), one of the complications of osteoporotic vertebral compression fracture (OVCF), has gradually increased, because it easily leads to vertebral instability and causes intractable pain or neurological dysfunction, and the disability rate of the disease is high, placing a serious burden on society and families. Since Dr. Kümmell Hermann first reported Kümmell’s disease in 1895, more than 100 years later, the pathogenesis of this disease has not been elucidated, but many scholars generally believe that the presence of intravertebral vacuum cleft (IVC) sign on imaging is a specific sign of vertebral ischemic osteonecrosis and Kümmell’s disease should be highly suspected. About two-thirds of patients with Kümmell’s disease have no significant back pain symptoms in the early stages, resulting in patients rarely going to the hospital for relevant examinations. At the same time, trivial injuries are easily overlooked by patients, so it is difficult to make an early diagnosis of this disease. Progressive kyphosis due to vertebral collapse has already developed in this disease at the time of diagnosis, so treatment becomes difficult, and there is currently no uniform guideline for the treatment of this disease. The purpose of this review is to discuss the latest research progress of Kümmell’s disease and provide some reference for spinal surgeons.
Published in | European Journal of Clinical and Biomedical Sciences (Volume 8, Issue 5) |
DOI | 10.11648/j.ejcbs.20220805.11 |
Page(s) | 71-74 |
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2022. Published by Science Publishing Group |
Osteoporosis, Kümmell’s Disease, Vertebral Fracture, Osteonecrosis, Intravertebral Vacuum Cleft
[1] | Cheng H, Wang G, Li T, et al. Radiographic and clinical outcomes of surgical treatment of Kümmell’s disease with thoracolumbar kyphosis: a minimal two-year follow-up. BMC musculoskeletal disorders, 2021, 22 (1): 1-761. |
[2] | Brower A C, Downey J E F. Kümmell disease: report of a case with serial radiographs. Radiology, 1981, 141 (2): 363-364. |
[3] | Swartz K, Fee D. Kümmell's disease: a case report and literature review. Spine (Philadelphia, Pa. 1976), 2008, 33 (5): E152-E155. |
[4] | Li H, Liang C, Chen Q. Kümmell's Disease, an Uncommon and Complicated Spinal Disorder: A Review. Journal of international medical research, 2012, 40 (2): 406-414. |
[5] | Lim J, Choi S, Youm J, et al. Posttraumatic Delayed Vertebral Collapse: Kummell's Disease. Journal of Korean Neurosurgical Society, 2018, 61 (1): 1-9. |
[6] | Steel H H. Kümmell's disease. The American Journal of Surgery, 1951, 81 (2): 161-167. |
[7] | Adamska O, Modzelewski K, Stolarczyk A, et al. Is Kummell's Disease a Misdiagnosed and/or an Underreported Complication of Osteoporotic Vertebral Compression Fractures? A Pattern of the Condition and Available Treatment Modalities. J Clin Med, 2021, 10 (12). |
[8] | Laredo J. Expert’s comment concerning Grand Rounds case entitled “Kümmell’s disease: delayed post-traumatic osteonecrosis of the vertebral body” (by R. Ma, R. Chow, F. H. Shen). European Spine Journal, 2010, 19 (7): 1071-1072. |
[9] | Benedek T G, Nicholas J J. Delayed traumatic vertebral body compression fracture; part II: pathologic features. Semin Arthritis Rheum, 1981, 10 (4): 271-277. |
[10] | Kümmell H. Ueber die traumatischen Erkrankungen der Wirbelsäule 1). DMW - Deutsche Medizinische Wochenschrift, 1895, 21 (11): 180-181. |
[11] | Maldague B E, Noel H M, Malghem J J. The Intravertebral Vacuum Cleft: A Sign of Ischemic Vertebral Collapse. Radiology, 1978, 129 (1): 23-29. |
[12] | Ford L T, Gilula L A, Murphy W A, et al. Analysis of gas in vacuum lumbar disc. AJR Am J Roentgenol, 1977, 128 (6): 1056-1057. |
[13] | Kong L D, Wang P, Wang L F, et al. Comparison of vertebroplasty and kyphoplasty in the treatment of osteoporotic vertebral compression fractures with intravertebral clefts. Eur J Orthop Surg Traumatol, 2014, 24 Suppl 1: S201-S208. |
[14] | Li H, Liang C, Shen C, et al. Decreases in fluid shear stress due to microcracks: A possible primary pathogenesis of Kümmell’s disease. Medical hypotheses, 2011, 77 (5): 897-899. |
[15] | Matzaroglou C, Georgiou C S, Assimakopoulos K, et al. Kümmell' s disease: A rare spine entity in a young adult. Hellenic journal of nuclear medicine, 2010, 13 (1): 52. |
[16] | Ranjan M, Mahadevan A, Prasad C, et al. Kummell's disease - uncommon or underreported disease: A clinicopathological account of a case and review of literature. J Neurosci Rural Pract, 2013, 4 (4): 439-442. |
[17] | Matzaroglou C, Georgiou C S, Assimakopoulos K, et al. Kümmell's disease: pathophysiology, diagnosis, treatment and the role of nuclear medicine. Rationale according to our experience. Hellenic journal of nuclear medicine, 2011, 14 (3): 291. |
[18] | VAN EENENAAM D P, EL-KHOURY G Y. Delayed post-traumatic vertebral collapse (Kummell's disease): case report with serial radiographs, computed tomographic scans, and bone scans. Spine (Philadelphia, Pa. 1976), 1993, 18 (9): 1236-1241. |
[19] | Theodorou D J. The intravertebral vacuum cleft sign. Radiology, 2001, 221 (3): 787-788. |
[20] | Libicher M, Appelt A, Berger I, et al. The intravertebral vacuum phenomen as specific sign of osteonecrosis in vertebral compression fractures: results from a radiological and histological study. Eur Radiol, 2007, 17 (9): 2248-2252. |
[21] | CHOU L H, KNIGHT R Q. Idiopathic avascular necrosis of a vertebral body: Case report and literature review. Spine (Philadelphia, Pa. 1976), 1997, 22 (16): 1928-1932. |
[22] | Yu C W, Hsu C Y, Shih T T, et al. Vertebral osteonecrosis: MR imaging findings and related changes on adjacent levels. AJNR Am J Neuroradiol, 2007, 28 (1): 42-47. |
[23] | Chen Z, Lou C, Yu W, et al. Comparison of Intravertebral Clefts between Kummell Disease and Acute Osteoporotic Vertebral Compression Fracture: A Radiological Study. Orthop Surg, 2021, 13 (7): 1979-1986. |
[24] | Li K, Wong T, Kung F, et al. STAGING OF KÜMMELL'S DISEASE. Journal of Musculoskeletal Research, 2011, 08 (01): 43-55. |
[25] | Nickell L T, Schucany W G, Opatowsky M J. Kummell Disease. Baylor University Medical Center Proceedings, 2017, 26 (3): 300-301. |
[26] | Yoon S T, Qureshi A A, Heller J G, et al. Kyphoplasty for salvage of a failed vertebroplasty in osteoporotic vertebral compression fractures: case report and surgical technique. J Spinal Disord Tech, 2005, 18 Suppl: S129-S134. |
[27] | Zhang B, Chen G, Yang X, et al. Percutaneous Kyphoplasty Versus Percutaneous Vertebroplasty for Neurologically Intact Osteoporotic Kümmell’s Disease: A Systematic Review and Meta-Analysis. Global Spine Journal, 2022, 12 (2): 308-322. |
[28] | Wang Y, Liu B, Sun Z, et al. Comparative Efficacy of Three Minimally Invasive Procedures for Kümmell’s Disease: A Systematic Review and Network Meta-Analysis. Frontiers in surgery, 2022, 9: 893404. |
[29] | Pappou I P, Papadopoulos E C, Swanson A N, et al. Osteoporotic vertebral fractures and collapse with intravertebral vacuum sign (Kummel's disease). Orthopedics, 2008, 31 (1): 61-66. |
APA Style
Yude Xu. (2022). Current Research Status and Progress in Kümmell’s Disease. European Journal of Clinical and Biomedical Sciences, 8(5), 71-74. https://doi.org/10.11648/j.ejcbs.20220805.11
ACS Style
Yude Xu. Current Research Status and Progress in Kümmell’s Disease. Eur. J. Clin. Biomed. Sci. 2022, 8(5), 71-74. doi: 10.11648/j.ejcbs.20220805.11
@article{10.11648/j.ejcbs.20220805.11, author = {Yude Xu}, title = {Current Research Status and Progress in Kümmell’s Disease}, journal = {European Journal of Clinical and Biomedical Sciences}, volume = {8}, number = {5}, pages = {71-74}, doi = {10.11648/j.ejcbs.20220805.11}, url = {https://doi.org/10.11648/j.ejcbs.20220805.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20220805.11}, abstract = {With the arrival of an aging society, the incidence of Kümmell’s disease (KD), one of the complications of osteoporotic vertebral compression fracture (OVCF), has gradually increased, because it easily leads to vertebral instability and causes intractable pain or neurological dysfunction, and the disability rate of the disease is high, placing a serious burden on society and families. Since Dr. Kümmell Hermann first reported Kümmell’s disease in 1895, more than 100 years later, the pathogenesis of this disease has not been elucidated, but many scholars generally believe that the presence of intravertebral vacuum cleft (IVC) sign on imaging is a specific sign of vertebral ischemic osteonecrosis and Kümmell’s disease should be highly suspected. About two-thirds of patients with Kümmell’s disease have no significant back pain symptoms in the early stages, resulting in patients rarely going to the hospital for relevant examinations. At the same time, trivial injuries are easily overlooked by patients, so it is difficult to make an early diagnosis of this disease. Progressive kyphosis due to vertebral collapse has already developed in this disease at the time of diagnosis, so treatment becomes difficult, and there is currently no uniform guideline for the treatment of this disease. The purpose of this review is to discuss the latest research progress of Kümmell’s disease and provide some reference for spinal surgeons.}, year = {2022} }
TY - JOUR T1 - Current Research Status and Progress in Kümmell’s Disease AU - Yude Xu Y1 - 2022/09/27 PY - 2022 N1 - https://doi.org/10.11648/j.ejcbs.20220805.11 DO - 10.11648/j.ejcbs.20220805.11 T2 - European Journal of Clinical and Biomedical Sciences JF - European Journal of Clinical and Biomedical Sciences JO - European Journal of Clinical and Biomedical Sciences SP - 71 EP - 74 PB - Science Publishing Group SN - 2575-5005 UR - https://doi.org/10.11648/j.ejcbs.20220805.11 AB - With the arrival of an aging society, the incidence of Kümmell’s disease (KD), one of the complications of osteoporotic vertebral compression fracture (OVCF), has gradually increased, because it easily leads to vertebral instability and causes intractable pain or neurological dysfunction, and the disability rate of the disease is high, placing a serious burden on society and families. Since Dr. Kümmell Hermann first reported Kümmell’s disease in 1895, more than 100 years later, the pathogenesis of this disease has not been elucidated, but many scholars generally believe that the presence of intravertebral vacuum cleft (IVC) sign on imaging is a specific sign of vertebral ischemic osteonecrosis and Kümmell’s disease should be highly suspected. About two-thirds of patients with Kümmell’s disease have no significant back pain symptoms in the early stages, resulting in patients rarely going to the hospital for relevant examinations. At the same time, trivial injuries are easily overlooked by patients, so it is difficult to make an early diagnosis of this disease. Progressive kyphosis due to vertebral collapse has already developed in this disease at the time of diagnosis, so treatment becomes difficult, and there is currently no uniform guideline for the treatment of this disease. The purpose of this review is to discuss the latest research progress of Kümmell’s disease and provide some reference for spinal surgeons. VL - 8 IS - 5 ER -