This study is to explore the expression differences of vimentin in the normal spinal cord tissues and the injured spinal cord tissues. The 15 SD rats were randomly divided into two experimental groups and sham group. Acute spinal cord injury models in experimental groups were performed with Lisa method and the injured spinal cord was collected after getting injured 72h. The method of immunohistochemical stain was applied to observe the expressions of vimentin in the normal spinal cord tissue and the injured spinal cord tissue of rats. The results showed the expression of vimentin was found in both the grey matter and white matter of the spinal cord of rats with a relatively even distribution. In addition, the protein expressions of vimentin in the medium injury group and the severe injury group were obviously higher than the sham group. In conclusion, expressions of vimentin were found in the spinal cord, and expression differences were observed after the spinal cord injury, which indicated that vimentin might play a part in the injured process of the spinal cord. It is poised to be a phase of advancement in the treatment of acute spinal cord injury and the importance of further elucidation of underlying pathophysiological mechanisms of vimentin.
| Published in | European Journal of Clinical and Biomedical Sciences (Volume 6, Issue 1) |
| DOI | 10.11648/j.ejcbs.20200601.12 |
| Page(s) | 5-8 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Vimentin, Spinal Cord Injury, Protein Expression
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APA Style
Huang Yumin, Zhou Liang, Lin Weichang. (2020). Expression of Vimentin in Spinal Cord Injury. European Journal of Clinical and Biomedical Sciences, 6(1), 5-8. https://doi.org/10.11648/j.ejcbs.20200601.12
ACS Style
Huang Yumin; Zhou Liang; Lin Weichang. Expression of Vimentin in Spinal Cord Injury. Eur. J. Clin. Biomed. Sci. 2020, 6(1), 5-8. doi: 10.11648/j.ejcbs.20200601.12
AMA Style
Huang Yumin, Zhou Liang, Lin Weichang. Expression of Vimentin in Spinal Cord Injury. Eur J Clin Biomed Sci. 2020;6(1):5-8. doi: 10.11648/j.ejcbs.20200601.12
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Download@article{10.11648/j.ejcbs.20200601.12,
author = {Huang Yumin and Zhou Liang and Lin Weichang},
title = {Expression of Vimentin in Spinal Cord Injury},
journal = {European Journal of Clinical and Biomedical Sciences},
volume = {6},
number = {1},
pages = {5-8},
doi = {10.11648/j.ejcbs.20200601.12},
url = {https://doi.org/10.11648/j.ejcbs.20200601.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20200601.12},
abstract = {This study is to explore the expression differences of vimentin in the normal spinal cord tissues and the injured spinal cord tissues. The 15 SD rats were randomly divided into two experimental groups and sham group. Acute spinal cord injury models in experimental groups were performed with Lisa method and the injured spinal cord was collected after getting injured 72h. The method of immunohistochemical stain was applied to observe the expressions of vimentin in the normal spinal cord tissue and the injured spinal cord tissue of rats. The results showed the expression of vimentin was found in both the grey matter and white matter of the spinal cord of rats with a relatively even distribution. In addition, the protein expressions of vimentin in the medium injury group and the severe injury group were obviously higher than the sham group. In conclusion, expressions of vimentin were found in the spinal cord, and expression differences were observed after the spinal cord injury, which indicated that vimentin might play a part in the injured process of the spinal cord. It is poised to be a phase of advancement in the treatment of acute spinal cord injury and the importance of further elucidation of underlying pathophysiological mechanisms of vimentin.},
year = {2020}
}
TY - JOUR T1 - Expression of Vimentin in Spinal Cord Injury AU - Huang Yumin AU - Zhou Liang AU - Lin Weichang Y1 - 2020/01/17 PY - 2020 N1 - https://doi.org/10.11648/j.ejcbs.20200601.12 DO - 10.11648/j.ejcbs.20200601.12 T2 - European Journal of Clinical and Biomedical Sciences JF - European Journal of Clinical and Biomedical Sciences JO - European Journal of Clinical and Biomedical Sciences SP - 5 EP - 8 PB - Science Publishing Group SN - 2575-5005 UR - https://doi.org/10.11648/j.ejcbs.20200601.12 AB - This study is to explore the expression differences of vimentin in the normal spinal cord tissues and the injured spinal cord tissues. The 15 SD rats were randomly divided into two experimental groups and sham group. Acute spinal cord injury models in experimental groups were performed with Lisa method and the injured spinal cord was collected after getting injured 72h. The method of immunohistochemical stain was applied to observe the expressions of vimentin in the normal spinal cord tissue and the injured spinal cord tissue of rats. The results showed the expression of vimentin was found in both the grey matter and white matter of the spinal cord of rats with a relatively even distribution. In addition, the protein expressions of vimentin in the medium injury group and the severe injury group were obviously higher than the sham group. In conclusion, expressions of vimentin were found in the spinal cord, and expression differences were observed after the spinal cord injury, which indicated that vimentin might play a part in the injured process of the spinal cord. It is poised to be a phase of advancement in the treatment of acute spinal cord injury and the importance of further elucidation of underlying pathophysiological mechanisms of vimentin. VL - 6 IS - 1 ER -
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