The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome

Liping Sun; Huixia Zhao; Yajiao Li; Lizhen Sun; Huiyu Li; Shenghua Jie

doi:doi:10.11648/j.ejcbs.20180405.11

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The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome

Liping Sun, Huixia Zhao, Yajiao Li, Lizhen Sun, Huiyu Li, Shenghua Jie

Published in European Journal of Clinical and Biomedical Sciences (Volume 4, Issue 5)

Received: 15 November 2018 Accepted: 13 December 2018 Published: 7 January 2019

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Abstract

Objective: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) with a high fatality rate. The objective of our study was to assess the mechanisms of immunofunction through detecting the presence of myeloid-derived suppressor cells (MDSC), granulocyte-colony stimulating factor (G-CFS) and T cells in SFTS patients. Methods: Serum samples from 30 SFTS cases and 20 healthy donors were collected for the test with flow cytometry and sandwich ELISA which contains CD3+, CD4+ T lymphocytes, subsets of MDSC and G-CSF. Results: Granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC) were significantly elevated in SFTS compared to normal control, and G-CSF was expressed at increased frequency. In contrast, CD3+ and CD4+ T lymphocytes were significantly diminished. Further analysis revealed that G-MDSC and G-CSF were higher in severe SFTS infection compared to the patients in mild SFTS infection, and the numbers of CD3+ and CD4+ T lymphocytes showed a more robust pattern of depression. Conclution: In summary, we have characterized an immunosuppressive mechanism in SFTSV infection dependent on G-CSF induction on MDSC and MDSC suppressing T cells.

Published in	European Journal of Clinical and Biomedical Sciences (Volume 4, Issue 5)
DOI	10.11648/j.ejcbs.20180405.11
Page(s)	63-68
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Severe Fever with Thrombocytopenia Syndrome (SFTS), Myeloid-derived Suppressor Cells (MDSC), Granulocyte-colony Stimulating Factor (G-CFS), T cells, Immunosuppression

References

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APA Style

Liping Sun, Huixia Zhao, Yajiao Li, Lizhen Sun, Huiyu Li, et al. (2019). The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome. European Journal of Clinical and Biomedical Sciences, 4(5), 63-68. https://doi.org/10.11648/j.ejcbs.20180405.11

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ACS Style

Liping Sun; Huixia Zhao; Yajiao Li; Lizhen Sun; Huiyu Li, et al. The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome. Eur. J. Clin. Biomed. Sci. 2019, 4(5), 63-68. doi: 10.11648/j.ejcbs.20180405.11

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AMA Style

Liping Sun, Huixia Zhao, Yajiao Li, Lizhen Sun, Huiyu Li, et al. The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome. Eur J Clin Biomed Sci. 2019;4(5):63-68. doi: 10.11648/j.ejcbs.20180405.11

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@article{10.11648/j.ejcbs.20180405.11,
  author = {Liping Sun and Huixia Zhao and Yajiao Li and Lizhen Sun and Huiyu Li and Shenghua Jie},
  title = {The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome},
  journal = {European Journal of Clinical and Biomedical Sciences},
  volume = {4},
  number = {5},
  pages = {63-68},
  doi = {10.11648/j.ejcbs.20180405.11},
  url = {https://doi.org/10.11648/j.ejcbs.20180405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20180405.11},
  abstract = {Objective: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) with a high fatality rate. The objective of our study was to assess the mechanisms of immunofunction through detecting the presence of myeloid-derived suppressor cells (MDSC), granulocyte-colony stimulating factor (G-CFS) and T cells in SFTS patients. Methods: Serum samples from 30 SFTS cases and 20 healthy donors were collected for the test with flow cytometry and sandwich ELISA which contains CD3+, CD4+ T lymphocytes, subsets of MDSC and G-CSF. Results: Granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC) were significantly elevated in SFTS compared to normal control, and G-CSF was expressed at increased frequency. In contrast, CD3+ and CD4+ T lymphocytes were significantly diminished. Further analysis revealed that G-MDSC and G-CSF were higher in severe SFTS infection compared to the patients in mild SFTS infection, and the numbers of CD3+ and CD4+ T lymphocytes showed a more robust pattern of depression. Conclution: In summary, we have characterized an immunosuppressive mechanism in SFTSV infection dependent on G-CSF induction on MDSC and MDSC suppressing T cells.},
 year = {2019}
}

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TY  - JOUR
T1  - The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome
AU  - Liping Sun
AU  - Huixia Zhao
AU  - Yajiao Li
AU  - Lizhen Sun
AU  - Huiyu Li
AU  - Shenghua Jie
Y1  - 2019/01/07
PY  - 2019
N1  - https://doi.org/10.11648/j.ejcbs.20180405.11
DO  - 10.11648/j.ejcbs.20180405.11
T2  - European Journal of Clinical and Biomedical Sciences
JF  - European Journal of Clinical and Biomedical Sciences
JO  - European Journal of Clinical and Biomedical Sciences
SP  - 63
EP  - 68
PB  - Science Publishing Group
SN  - 2575-5005
UR  - https://doi.org/10.11648/j.ejcbs.20180405.11
AB  - Objective: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) with a high fatality rate. The objective of our study was to assess the mechanisms of immunofunction through detecting the presence of myeloid-derived suppressor cells (MDSC), granulocyte-colony stimulating factor (G-CFS) and T cells in SFTS patients. Methods: Serum samples from 30 SFTS cases and 20 healthy donors were collected for the test with flow cytometry and sandwich ELISA which contains CD3+, CD4+ T lymphocytes, subsets of MDSC and G-CSF. Results: Granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC) were significantly elevated in SFTS compared to normal control, and G-CSF was expressed at increased frequency. In contrast, CD3+ and CD4+ T lymphocytes were significantly diminished. Further analysis revealed that G-MDSC and G-CSF were higher in severe SFTS infection compared to the patients in mild SFTS infection, and the numbers of CD3+ and CD4+ T lymphocytes showed a more robust pattern of depression. Conclution: In summary, we have characterized an immunosuppressive mechanism in SFTSV infection dependent on G-CSF induction on MDSC and MDSC suppressing T cells.
VL  - 4
IS  - 5
ER  -

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Author Information

Liping Sun

Department of Infectious Diseases, Miyun Teaching Hospital, Capital Medical University, Beijing, PR China
Huixia Zhao

Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
Yajiao Li

Center for Stem Cell Research and Application, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
Lizhen Sun

Department of Infectious Diseases, Miyun Teaching Hospital, Capital Medical University, Beijing, PR China
Huiyu Li

Center for Stem Cell Research and Application, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
Shenghua Jie

Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China

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APA Style

Liping Sun, Huixia Zhao, Yajiao Li, Lizhen Sun, Huiyu Li, et al. (2019). The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome. European Journal of Clinical and Biomedical Sciences, 4(5), 63-68. https://doi.org/10.11648/j.ejcbs.20180405.11

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ACS Style

Liping Sun; Huixia Zhao; Yajiao Li; Lizhen Sun; Huiyu Li, et al. The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome. Eur. J. Clin. Biomed. Sci. 2019, 4(5), 63-68. doi: 10.11648/j.ejcbs.20180405.11

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AMA Style

Liping Sun, Huixia Zhao, Yajiao Li, Lizhen Sun, Huiyu Li, et al. The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome. Eur J Clin Biomed Sci. 2019;4(5):63-68. doi: 10.11648/j.ejcbs.20180405.11

Copy | Download

@article{10.11648/j.ejcbs.20180405.11,
  author = {Liping Sun and Huixia Zhao and Yajiao Li and Lizhen Sun and Huiyu Li and Shenghua Jie},
  title = {The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome},
  journal = {European Journal of Clinical and Biomedical Sciences},
  volume = {4},
  number = {5},
  pages = {63-68},
  doi = {10.11648/j.ejcbs.20180405.11},
  url = {https://doi.org/10.11648/j.ejcbs.20180405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20180405.11},
  abstract = {Objective: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) with a high fatality rate. The objective of our study was to assess the mechanisms of immunofunction through detecting the presence of myeloid-derived suppressor cells (MDSC), granulocyte-colony stimulating factor (G-CFS) and T cells in SFTS patients. Methods: Serum samples from 30 SFTS cases and 20 healthy donors were collected for the test with flow cytometry and sandwich ELISA which contains CD3+, CD4+ T lymphocytes, subsets of MDSC and G-CSF. Results: Granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC) were significantly elevated in SFTS compared to normal control, and G-CSF was expressed at increased frequency. In contrast, CD3+ and CD4+ T lymphocytes were significantly diminished. Further analysis revealed that G-MDSC and G-CSF were higher in severe SFTS infection compared to the patients in mild SFTS infection, and the numbers of CD3+ and CD4+ T lymphocytes showed a more robust pattern of depression. Conclution: In summary, we have characterized an immunosuppressive mechanism in SFTSV infection dependent on G-CSF induction on MDSC and MDSC suppressing T cells.},
 year = {2019}
}

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TY  - JOUR
T1  - The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Immunosuppressive Mechanisms by Severe Fever with Thrombocytopenia Syndrome
AU  - Liping Sun
AU  - Huixia Zhao
AU  - Yajiao Li
AU  - Lizhen Sun
AU  - Huiyu Li
AU  - Shenghua Jie
Y1  - 2019/01/07
PY  - 2019
N1  - https://doi.org/10.11648/j.ejcbs.20180405.11
DO  - 10.11648/j.ejcbs.20180405.11
T2  - European Journal of Clinical and Biomedical Sciences
JF  - European Journal of Clinical and Biomedical Sciences
JO  - European Journal of Clinical and Biomedical Sciences
SP  - 63
EP  - 68
PB  - Science Publishing Group
SN  - 2575-5005
UR  - https://doi.org/10.11648/j.ejcbs.20180405.11
AB  - Objective: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) with a high fatality rate. The objective of our study was to assess the mechanisms of immunofunction through detecting the presence of myeloid-derived suppressor cells (MDSC), granulocyte-colony stimulating factor (G-CFS) and T cells in SFTS patients. Methods: Serum samples from 30 SFTS cases and 20 healthy donors were collected for the test with flow cytometry and sandwich ELISA which contains CD3+, CD4+ T lymphocytes, subsets of MDSC and G-CSF. Results: Granulocytic MDSC (G-MDSC) and monocytic MDSC (M-MDSC) were significantly elevated in SFTS compared to normal control, and G-CSF was expressed at increased frequency. In contrast, CD3+ and CD4+ T lymphocytes were significantly diminished. Further analysis revealed that G-MDSC and G-CSF were higher in severe SFTS infection compared to the patients in mild SFTS infection, and the numbers of CD3+ and CD4+ T lymphocytes showed a more robust pattern of depression. Conclution: In summary, we have characterized an immunosuppressive mechanism in SFTSV infection dependent on G-CSF induction on MDSC and MDSC suppressing T cells.
VL  - 4
IS  - 5
ER  -

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