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Application and Research Status of 125I Seeds Brachytherapy in Unresectable Pancreatic Cancer

Received: 2 June 2022     Accepted: 16 June 2022     Published: 27 June 2022
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Abstract

Pancreatic cancer is a digestive system tumor with high degree of malignancy. At present, systemic chemotherapy is the main treatment method. However, due to the difficulty in early diagnosis and easy spread of pancreatic cancer, the survival cycle of patients is short and the treatment effect is poor. 125I seed brachytherapy has obvious advantages in the treatment of malignant tumors, and has been widely used in the treatment of unresectable pancreatic cancer. Either used alone or combined with chemotherapy, the treatment of 125I seed brachytherapy can effectively relieve pain, improve life quality and prolong survival. However, there are few reports about the application status. This article reviews the current updates of 125I seed brachytherapy for resectable pancreatic cancer, and expounds the application status of 125I seeds brachytherapy in combination with monotherapy chemotherapy, dual drug chemotherapy, targeted therapy, immunity therapy, palliative surgery, external radiotherapy and traditional Chinese medicine. Based on the retrospective review, future directions of research and development of brachytherapy for unresectable pancreatic cancer is also proposed, to provide better treatment care for pancreatic cancer patients. At present, there are still many problems to be solved, such as formulating the principles and standards for the application of radioactive particle implantation in the comprehensive treatment of pancreatic cancer; We will continue to standardize and optimize the operation process and distribution means of radioactive seed implantation technology, and better promote 125I radioactive seed implantation technology.

Published in Cancer Research Journal (Volume 10, Issue 2)
DOI 10.11648/j.crj.20221002.14
Page(s) 38-45
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

125I Seeds, Brachytherapy, Advanced Pancreatic Cancer, Combination Therapy, Chemotherapy

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Cite This Article
  • APA Style

    Xinxin Duan, Liuyi Yang, Jie Zhou, Ting Xiong, Aixia Sui. (2022). Application and Research Status of 125I Seeds Brachytherapy in Unresectable Pancreatic Cancer. Cancer Research Journal, 10(2), 38-45. https://doi.org/10.11648/j.crj.20221002.14

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    ACS Style

    Xinxin Duan; Liuyi Yang; Jie Zhou; Ting Xiong; Aixia Sui. Application and Research Status of 125I Seeds Brachytherapy in Unresectable Pancreatic Cancer. Cancer Res. J. 2022, 10(2), 38-45. doi: 10.11648/j.crj.20221002.14

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    AMA Style

    Xinxin Duan, Liuyi Yang, Jie Zhou, Ting Xiong, Aixia Sui. Application and Research Status of 125I Seeds Brachytherapy in Unresectable Pancreatic Cancer. Cancer Res J. 2022;10(2):38-45. doi: 10.11648/j.crj.20221002.14

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  • @article{10.11648/j.crj.20221002.14,
      author = {Xinxin Duan and Liuyi Yang and Jie Zhou and Ting Xiong and Aixia Sui},
      title = {Application and Research Status of 125I Seeds Brachytherapy in Unresectable Pancreatic Cancer},
      journal = {Cancer Research Journal},
      volume = {10},
      number = {2},
      pages = {38-45},
      doi = {10.11648/j.crj.20221002.14},
      url = {https://doi.org/10.11648/j.crj.20221002.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221002.14},
      abstract = {Pancreatic cancer is a digestive system tumor with high degree of malignancy. At present, systemic chemotherapy is the main treatment method. However, due to the difficulty in early diagnosis and easy spread of pancreatic cancer, the survival cycle of patients is short and the treatment effect is poor. 125I seed brachytherapy has obvious advantages in the treatment of malignant tumors, and has been widely used in the treatment of unresectable pancreatic cancer. Either used alone or combined with chemotherapy, the treatment of 125I seed brachytherapy can effectively relieve pain, improve life quality and prolong survival. However, there are few reports about the application status. This article reviews the current updates of 125I seed brachytherapy for resectable pancreatic cancer, and expounds the application status of 125I seeds brachytherapy in combination with monotherapy chemotherapy, dual drug chemotherapy, targeted therapy, immunity therapy, palliative surgery, external radiotherapy and traditional Chinese medicine. Based on the retrospective review, future directions of research and development of brachytherapy for unresectable pancreatic cancer is also proposed, to provide better treatment care for pancreatic cancer patients. At present, there are still many problems to be solved, such as formulating the principles and standards for the application of radioactive particle implantation in the comprehensive treatment of pancreatic cancer; We will continue to standardize and optimize the operation process and distribution means of radioactive seed implantation technology, and better promote 125I radioactive seed implantation technology.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Application and Research Status of 125I Seeds Brachytherapy in Unresectable Pancreatic Cancer
    AU  - Xinxin Duan
    AU  - Liuyi Yang
    AU  - Jie Zhou
    AU  - Ting Xiong
    AU  - Aixia Sui
    Y1  - 2022/06/27
    PY  - 2022
    N1  - https://doi.org/10.11648/j.crj.20221002.14
    DO  - 10.11648/j.crj.20221002.14
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 38
    EP  - 45
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20221002.14
    AB  - Pancreatic cancer is a digestive system tumor with high degree of malignancy. At present, systemic chemotherapy is the main treatment method. However, due to the difficulty in early diagnosis and easy spread of pancreatic cancer, the survival cycle of patients is short and the treatment effect is poor. 125I seed brachytherapy has obvious advantages in the treatment of malignant tumors, and has been widely used in the treatment of unresectable pancreatic cancer. Either used alone or combined with chemotherapy, the treatment of 125I seed brachytherapy can effectively relieve pain, improve life quality and prolong survival. However, there are few reports about the application status. This article reviews the current updates of 125I seed brachytherapy for resectable pancreatic cancer, and expounds the application status of 125I seeds brachytherapy in combination with monotherapy chemotherapy, dual drug chemotherapy, targeted therapy, immunity therapy, palliative surgery, external radiotherapy and traditional Chinese medicine. Based on the retrospective review, future directions of research and development of brachytherapy for unresectable pancreatic cancer is also proposed, to provide better treatment care for pancreatic cancer patients. At present, there are still many problems to be solved, such as formulating the principles and standards for the application of radioactive particle implantation in the comprehensive treatment of pancreatic cancer; We will continue to standardize and optimize the operation process and distribution means of radioactive seed implantation technology, and better promote 125I radioactive seed implantation technology.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Graduate School, North China University of Science and Technology, Tangshan, China

  • Graduate School, North China University of Science and Technology, Tangshan, China

  • Graduate School, North China University of Science and Technology, Tangshan, China

  • Graduate School, North China University of Science and Technology, Tangshan, China

  • Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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