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Mutation of EGFR in Non-small Cell Lung Cancer, a Regional Study in Upper Egypt

Received: 2 December 2019     Accepted: 26 December 2019     Published: 7 January 2020
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Abstract

Management of non-small cell lung cancer has been changed dramatically since detection of EGFR mutation. The rate of EGFR mutation in Upper Egypt is unknown. In this study; EGFR mutation in non-small cell lung cancer tissue was evaluated and correlated with clinicopathological features of the tumors. Tissue samples of non-small cell lung cancer that had been confirmed by histopathological and immunohistochemical examinations were evaluated for mutation of EGFR by StripAssay. Thirty four patients with non-small cell lung cancer; 21 males and 13 females with a mean age of 55.94 years were included in this study. The median tumor size was 6.0cm and more than half of the tumors were classified as T3. Fourteen patients had N2 nodal stage and 19 patients had either malignant pleural effusion or distant metastasis. The majority of the tumors were adenocarcinomas and half of them were grade II. The two year survival rate of the patients was 70.6% and the overall survival was 58.8%. EGFR mutation was recorded in 44.1% of the tumors; all of which were adenocarcinoma variant. The mutation was significantly more frequent in large sized tumors and it was relatively associated with poor survival. Mutation of EGFR was not associated with patients` age, sex, tumor grade, T stage, N stage or status of distant metastasis. The rate of EGFR gene mutation in non-small cell lung cancer in Upper Egypt is relatively high and target therapy based on these mutations could improve patients` outcome.

Published in Cancer Research Journal (Volume 8, Issue 1)
DOI 10.11648/j.crj.20200801.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

NSCLC, EGFR Mutation, Adenocarcinoma, Tumor Size

References
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Cite This Article
  • APA Style

    Samir Shehata Mohammed Eid, Ahmed Roshdi Hamed Ahmed, Marwa Ismail Khalaf Abdelgawad, Ahmed El-Sayed Mohamed, Amany Osama Mohamed, et al. (2020). Mutation of EGFR in Non-small Cell Lung Cancer, a Regional Study in Upper Egypt. Cancer Research Journal, 8(1), 1-7. https://doi.org/10.11648/j.crj.20200801.11

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    ACS Style

    Samir Shehata Mohammed Eid; Ahmed Roshdi Hamed Ahmed; Marwa Ismail Khalaf Abdelgawad; Ahmed El-Sayed Mohamed; Amany Osama Mohamed, et al. Mutation of EGFR in Non-small Cell Lung Cancer, a Regional Study in Upper Egypt. Cancer Res. J. 2020, 8(1), 1-7. doi: 10.11648/j.crj.20200801.11

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    AMA Style

    Samir Shehata Mohammed Eid, Ahmed Roshdi Hamed Ahmed, Marwa Ismail Khalaf Abdelgawad, Ahmed El-Sayed Mohamed, Amany Osama Mohamed, et al. Mutation of EGFR in Non-small Cell Lung Cancer, a Regional Study in Upper Egypt. Cancer Res J. 2020;8(1):1-7. doi: 10.11648/j.crj.20200801.11

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  • @article{10.11648/j.crj.20200801.11,
      author = {Samir Shehata Mohammed Eid and Ahmed Roshdi Hamed Ahmed and Marwa Ismail Khalaf Abdelgawad and Ahmed El-Sayed Mohamed and Amany Osama Mohamed and Dalia Osama Mohamed and Mona Mahmoud Sayed and Ebtesam Mahmoud Aly Elgezawy and Heba Mohammed Saad-Eldeen},
      title = {Mutation of EGFR in Non-small Cell Lung Cancer, a Regional Study in Upper Egypt},
      journal = {Cancer Research Journal},
      volume = {8},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.crj.20200801.11},
      url = {https://doi.org/10.11648/j.crj.20200801.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200801.11},
      abstract = {Management of non-small cell lung cancer has been changed dramatically since detection of EGFR mutation. The rate of EGFR mutation in Upper Egypt is unknown. In this study; EGFR mutation in non-small cell lung cancer tissue was evaluated and correlated with clinicopathological features of the tumors. Tissue samples of non-small cell lung cancer that had been confirmed by histopathological and immunohistochemical examinations were evaluated for mutation of EGFR by StripAssay. Thirty four patients with non-small cell lung cancer; 21 males and 13 females with a mean age of 55.94 years were included in this study. The median tumor size was 6.0cm and more than half of the tumors were classified as T3. Fourteen patients had N2 nodal stage and 19 patients had either malignant pleural effusion or distant metastasis. The majority of the tumors were adenocarcinomas and half of them were grade II. The two year survival rate of the patients was 70.6% and the overall survival was 58.8%. EGFR mutation was recorded in 44.1% of the tumors; all of which were adenocarcinoma variant. The mutation was significantly more frequent in large sized tumors and it was relatively associated with poor survival. Mutation of EGFR was not associated with patients` age, sex, tumor grade, T stage, N stage or status of distant metastasis. The rate of EGFR gene mutation in non-small cell lung cancer in Upper Egypt is relatively high and target therapy based on these mutations could improve patients` outcome.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Mutation of EGFR in Non-small Cell Lung Cancer, a Regional Study in Upper Egypt
    AU  - Samir Shehata Mohammed Eid
    AU  - Ahmed Roshdi Hamed Ahmed
    AU  - Marwa Ismail Khalaf Abdelgawad
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    AU  - Amany Osama Mohamed
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    AU  - Heba Mohammed Saad-Eldeen
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    JO  - Cancer Research Journal
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    AB  - Management of non-small cell lung cancer has been changed dramatically since detection of EGFR mutation. The rate of EGFR mutation in Upper Egypt is unknown. In this study; EGFR mutation in non-small cell lung cancer tissue was evaluated and correlated with clinicopathological features of the tumors. Tissue samples of non-small cell lung cancer that had been confirmed by histopathological and immunohistochemical examinations were evaluated for mutation of EGFR by StripAssay. Thirty four patients with non-small cell lung cancer; 21 males and 13 females with a mean age of 55.94 years were included in this study. The median tumor size was 6.0cm and more than half of the tumors were classified as T3. Fourteen patients had N2 nodal stage and 19 patients had either malignant pleural effusion or distant metastasis. The majority of the tumors were adenocarcinomas and half of them were grade II. The two year survival rate of the patients was 70.6% and the overall survival was 58.8%. EGFR mutation was recorded in 44.1% of the tumors; all of which were adenocarcinoma variant. The mutation was significantly more frequent in large sized tumors and it was relatively associated with poor survival. Mutation of EGFR was not associated with patients` age, sex, tumor grade, T stage, N stage or status of distant metastasis. The rate of EGFR gene mutation in non-small cell lung cancer in Upper Egypt is relatively high and target therapy based on these mutations could improve patients` outcome.
    VL  - 8
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Author Information
  • Department of Clinical Oncology, Assiut University, Assiut, Egypt

  • Department of Pathology, Sohag University, Sohag, Egypt

  • Department of Clinical Oncology, Assiut University, Assiut, Egypt

  • Department of Clinical and Radiation Oncology, Sohag University, Sohag, Egypt

  • Department of Medical Biochemistry, Assiut University, Assiut, Egypt

  • Department of Radiation Oncology, South Egypt Cancer Institute, Assiut, Egypt

  • Department of Radiation Oncology, South Egypt Cancer Institute, Assiut, Egypt

  • Department of Immune-Hematology, Regional Laboratory and Central Blood Bank, Aseer Region, KSA

  • Department of Anatomy, College of Medicine, Jouf University, Jouf, the Kingdom of Saudi Arabia

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