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High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis

Received: 27 August 2019     Accepted: 10 September 2019     Published: 24 September 2019
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Abstract

There are many researches on the correlation between C-reactive protein (CRP) and prognosis of gastric cancer, but whether CRP could be used as an evaluation indicator for prognosis of gastric cancer patients, which was still controversial. Therefore, we conducted meta-analysis based on 18 studies involving 3656 objects. The results show that, CRP was significantly correlated with the risk of poor prognosis of gastric cancer patients [HR (95%CI) 1.50 (1.24, 1.81) P=0.000], and the risk of the poor prognosis can be significantly increased when CRP>10mg/L. In the different clinical stage, high expression of CRP can increases the risk of poor prognosis. The CRP can be used as an important indicator of poor prognosis of gastric cancer patients.

Published in Cancer Research Journal (Volume 7, Issue 3)
DOI 10.11648/j.crj.20190703.16
Page(s) 117-124
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

C-reactive Protein, Gastric Cancer, Prognosis, Meta-analysis

References
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Cite This Article
  • APA Style

    Fulun Li, Ke Liu, Qianlong Zhao, Junyi Chen, Lingfei Liu, et al. (2019). High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis. Cancer Research Journal, 7(3), 117-124. https://doi.org/10.11648/j.crj.20190703.16

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    ACS Style

    Fulun Li; Ke Liu; Qianlong Zhao; Junyi Chen; Lingfei Liu, et al. High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis. Cancer Res. J. 2019, 7(3), 117-124. doi: 10.11648/j.crj.20190703.16

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    AMA Style

    Fulun Li, Ke Liu, Qianlong Zhao, Junyi Chen, Lingfei Liu, et al. High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis. Cancer Res J. 2019;7(3):117-124. doi: 10.11648/j.crj.20190703.16

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  • @article{10.11648/j.crj.20190703.16,
      author = {Fulun Li and Ke Liu and Qianlong Zhao and Junyi Chen and Lingfei Liu and Qing-Mu Xie and Jing Yang},
      title = {High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A  Meta-analysis},
      journal = {Cancer Research Journal},
      volume = {7},
      number = {3},
      pages = {117-124},
      doi = {10.11648/j.crj.20190703.16},
      url = {https://doi.org/10.11648/j.crj.20190703.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190703.16},
      abstract = {There are many researches on the correlation between C-reactive protein (CRP) and prognosis of gastric cancer, but whether CRP could be used as an evaluation indicator for prognosis of gastric cancer patients, which was still controversial. Therefore, we conducted meta-analysis based on 18 studies involving 3656 objects. The results show that, CRP was significantly correlated with the risk of poor prognosis of gastric cancer patients [HR (95%CI) 1.50 (1.24, 1.81) P=0.000], and the risk of the poor prognosis can be significantly increased when CRP>10mg/L. In the different clinical stage, high expression of CRP can increases the risk of poor prognosis. The CRP can be used as an important indicator of poor prognosis of gastric cancer patients.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A  Meta-analysis
    AU  - Fulun Li
    AU  - Ke Liu
    AU  - Qianlong Zhao
    AU  - Junyi Chen
    AU  - Lingfei Liu
    AU  - Qing-Mu Xie
    AU  - Jing Yang
    Y1  - 2019/09/24
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    N1  - https://doi.org/10.11648/j.crj.20190703.16
    DO  - 10.11648/j.crj.20190703.16
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 117
    EP  - 124
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20190703.16
    AB  - There are many researches on the correlation between C-reactive protein (CRP) and prognosis of gastric cancer, but whether CRP could be used as an evaluation indicator for prognosis of gastric cancer patients, which was still controversial. Therefore, we conducted meta-analysis based on 18 studies involving 3656 objects. The results show that, CRP was significantly correlated with the risk of poor prognosis of gastric cancer patients [HR (95%CI) 1.50 (1.24, 1.81) P=0.000], and the risk of the poor prognosis can be significantly increased when CRP>10mg/L. In the different clinical stage, high expression of CRP can increases the risk of poor prognosis. The CRP can be used as an important indicator of poor prognosis of gastric cancer patients.
    VL  - 7
    IS  - 3
    ER  - 

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Author Information
  • Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China

  • School of Applied Chemical Engineering, Lanzhou Petrochemical Polytechnic, Lanzhou, China

  • Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China

  • Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China

  • School of Public Health, Lanzhou University, Laanzhou, China

  • Department of Psychology, Tohoku University, Sendai, Japan

  • Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China

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