Studies were undertaken to evaluate the efficacy of purified lichen extracts against cancer induced Albino wistar rats as an animal model under in vivo condition. Lichen species were collected from different mean sea level of Yercaud hills of Tamil Nadu, India. Extraction and purification of lichen compounds were done using silica gel column chromatography with TLC analysis. Different fractions were collected from the crude extract and it was subjected to study the potential of anticancerous property. Anticancer activity was confirmed that Parmotrema reticulatum exhibited the highest control over the cervical cancer in cell line model. The compound Benzoic acid, 2, 4 dihydroxy, 6 methyl-methyl ester was identified as a potent molecule from Rocella montagnei. Anticancer effect of P. reticulatum and P. hababianum and their compounds were further evaluated to have the effective cancer drug against cervical cancer disease. Cancer cell line induced rats showing a significant reduction tumor proliferation which were treated with bioactive anti-cancer lichen compounds in comparison with the standard drug. Histopathology and hematology studies have been done to examine to confirm the level of tumor growth in the animals and to analyze the blood platelet count in tumors; respectively.
| Published in | Cancer Research Journal (Volume 4, Issue 6) |
| DOI | 10.11648/j.crj.20160406.11 |
| Page(s) | 84-89 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Cancer, Lichens, Parmotrema Reticulatum, Rocella Montagnei, Animal Model
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APA Style
Shanmugam Poornima, Ponnusamy Ponmurugan, Khader Syed Zameer Ahmed, Ganesan Ayyappadasan, Fahad Khalid Aldhafiri, et al. (2016). Evaluation of Anti-Cancer Properties of Lichens Using Albino wistar Rats as an Animal Model. Cancer Research Journal, 4(6), 84-89. https://doi.org/10.11648/j.crj.20160406.11
ACS Style
Shanmugam Poornima; Ponnusamy Ponmurugan; Khader Syed Zameer Ahmed; Ganesan Ayyappadasan; Fahad Khalid Aldhafiri, et al. Evaluation of Anti-Cancer Properties of Lichens Using Albino wistar Rats as an Animal Model. Cancer Res. J. 2016, 4(6), 84-89. doi: 10.11648/j.crj.20160406.11
AMA Style
Shanmugam Poornima, Ponnusamy Ponmurugan, Khader Syed Zameer Ahmed, Ganesan Ayyappadasan, Fahad Khalid Aldhafiri, et al. Evaluation of Anti-Cancer Properties of Lichens Using Albino wistar Rats as an Animal Model. Cancer Res J. 2016;4(6):84-89. doi: 10.11648/j.crj.20160406.11
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Download@article{10.11648/j.crj.20160406.11,
author = {Shanmugam Poornima and Ponnusamy Ponmurugan and Khader Syed Zameer Ahmed and Ganesan Ayyappadasan and Fahad Khalid Aldhafiri and Balakrishnan Santhanaraj},
title = {Evaluation of Anti-Cancer Properties of Lichens Using Albino wistar Rats as an Animal Model},
journal = {Cancer Research Journal},
volume = {4},
number = {6},
pages = {84-89},
doi = {10.11648/j.crj.20160406.11},
url = {https://doi.org/10.11648/j.crj.20160406.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160406.11},
abstract = {Studies were undertaken to evaluate the efficacy of purified lichen extracts against cancer induced Albino wistar rats as an animal model under in vivo condition. Lichen species were collected from different mean sea level of Yercaud hills of Tamil Nadu, India. Extraction and purification of lichen compounds were done using silica gel column chromatography with TLC analysis. Different fractions were collected from the crude extract and it was subjected to study the potential of anticancerous property. Anticancer activity was confirmed that Parmotrema reticulatum exhibited the highest control over the cervical cancer in cell line model. The compound Benzoic acid, 2, 4 dihydroxy, 6 methyl-methyl ester was identified as a potent molecule from Rocella montagnei. Anticancer effect of P. reticulatum and P. hababianum and their compounds were further evaluated to have the effective cancer drug against cervical cancer disease. Cancer cell line induced rats showing a significant reduction tumor proliferation which were treated with bioactive anti-cancer lichen compounds in comparison with the standard drug. Histopathology and hematology studies have been done to examine to confirm the level of tumor growth in the animals and to analyze the blood platelet count in tumors; respectively.},
year = {2016}
}
TY - JOUR T1 - Evaluation of Anti-Cancer Properties of Lichens Using Albino wistar Rats as an Animal Model AU - Shanmugam Poornima AU - Ponnusamy Ponmurugan AU - Khader Syed Zameer Ahmed AU - Ganesan Ayyappadasan AU - Fahad Khalid Aldhafiri AU - Balakrishnan Santhanaraj Y1 - 2016/11/29 PY - 2016 N1 - https://doi.org/10.11648/j.crj.20160406.11 DO - 10.11648/j.crj.20160406.11 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 84 EP - 89 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20160406.11 AB - Studies were undertaken to evaluate the efficacy of purified lichen extracts against cancer induced Albino wistar rats as an animal model under in vivo condition. Lichen species were collected from different mean sea level of Yercaud hills of Tamil Nadu, India. Extraction and purification of lichen compounds were done using silica gel column chromatography with TLC analysis. Different fractions were collected from the crude extract and it was subjected to study the potential of anticancerous property. Anticancer activity was confirmed that Parmotrema reticulatum exhibited the highest control over the cervical cancer in cell line model. The compound Benzoic acid, 2, 4 dihydroxy, 6 methyl-methyl ester was identified as a potent molecule from Rocella montagnei. Anticancer effect of P. reticulatum and P. hababianum and their compounds were further evaluated to have the effective cancer drug against cervical cancer disease. Cancer cell line induced rats showing a significant reduction tumor proliferation which were treated with bioactive anti-cancer lichen compounds in comparison with the standard drug. Histopathology and hematology studies have been done to examine to confirm the level of tumor growth in the animals and to analyze the blood platelet count in tumors; respectively. VL - 4 IS - 6 ER -
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