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Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia

Received: 2 February 2016     Accepted: 24 February 2016     Published: 1 April 2016
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Abstract

Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer.

Published in Cancer Research Journal (Volume 4, Issue 3)
DOI 10.11648/j.crj.20160403.11
Page(s) 43-47
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

GATA-3, p53 and Ki-67, Histopathology Grading, Breast Cancer

References
[1] American Cancer Society. 2009-2010. Breast Cancer Facts and Figures.
[2] Tjindarbumi, D., Mangunkusumo, R. 2002. Cancer In Indonesia, Present and Future. Jpn J Clin Onco. (Suplement 1) S17-S21.
[3] Li, F. Y., Wu, S. G., Zhou, J., et al. 2014. Prognostic Value of Ki-67 in Breast Cancer Patients with Positive Axillary Lymph Nodes: A Retrospective Cohort Study. Open One. 9: 2.
[4] Yoon, B. S. N. K., Maresh, B. S. E. L., et al. 2010. Higher Levels of GATA-3 Predict Better Survival in Women with Breast Cancer. Human Pathology. 41: 1794-1801.
[5] Mehra, R., Varambally, S., et al. 2005. Identification of GATA-3 as a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis. Cancer Res. 65: 11259-11264.
[6] Liu, D. P., Song, H., Xu, Y., et al. 2010. A Common Gain of Function of p53 Cancer Mutants in Inducing Genetic Instability. Oncogene. 29: 949-956.
[7] Cheang, M. C., Chia, S. K., Voduc, D., Gao, D., Leung, S., et al. 2009. Ki-67 Index, HER2 Status, and Prognosis With Luminal B Breast Cancer. Journal of the National Cancer Institute. 101: 736-750.
[8] Scholzen, T., Gerdes, J. 2000. The Ki-67 Protein: From the Known and The Unknown. Journal of Cellular Physiology. 182: 311-322.
[9] Goldhirsch, A., Ingle, J. N., Gelbert, R. D., Thurlimann, B., et al. 2009. Thresholds for Therapies: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009. Annals of Oncology. 20: 1319-1329.
[10] Nishimura, R., Osaka, T. 2010. Clinical Significance of Ki-67 in Neoadjuvant Chemotherapy for Primary Breast Cancer as a Predictor for Chemo sensitivity and for Prognosis. Department of Breast and Endocrine Surgery, Kumamoto City Hospital, Kumamoto, Japan: Japanese Breast Cancer. 17: 269-275.
[11] Weisner, G. F., Magener, A. 2009. Ki-67 as a Prognostic Molecular Marker in Routine Clinical use in Breast Cancer Patients. The Breast. 18: 135-141.
[12] Dydensborg, A. B., Rose, A. A. N., et. al. 2009. GATA-3 Inhibits Breast Cancer Growth and Pulmonary Breast Cancer Metastasis. Oncogene.28: 2634-2642.
[13] Albergaria, A., Joana, P., et al. 2009. Expression of Foxal and GATA-3 in Breast Cancer. The Prognostic Significance in Hormone Receptor-Negative Tumors.
[14] Sirvent, J. J., Salvado, M. T., et al. 1995. p53 in Breast Cancer. Its Relation to Histological Grade, Lymph-node Status, Hormon Receptors, Cell-Proliferation fraction (Ki-67) and c-erB-2. Immunohistochemical study of 153 Cases. Histopathol.10: 531-539.
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    Syarif Ibrahim, Rosdiana Natzir, Andi Asadul Islam, Tjakra Manuaba, A. Benyamin Fachruddin, et al. (2016). Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia. Cancer Research Journal, 4(3), 43-47. https://doi.org/10.11648/j.crj.20160403.11

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    ACS Style

    Syarif Ibrahim; Rosdiana Natzir; Andi Asadul Islam; Tjakra Manuaba; A. Benyamin Fachruddin, et al. Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia. Cancer Res. J. 2016, 4(3), 43-47. doi: 10.11648/j.crj.20160403.11

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    AMA Style

    Syarif Ibrahim, Rosdiana Natzir, Andi Asadul Islam, Tjakra Manuaba, A. Benyamin Fachruddin, et al. Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia. Cancer Res J. 2016;4(3):43-47. doi: 10.11648/j.crj.20160403.11

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  • @article{10.11648/j.crj.20160403.11,
      author = {Syarif Ibrahim and Rosdiana Natzir and Andi Asadul Islam and Tjakra Manuaba and A. Benyamin Fachruddin and Burhanuddin Bahar and William Hamdani and Husni Cangara and Mochammad Hatta},
      title = {Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia},
      journal = {Cancer Research Journal},
      volume = {4},
      number = {3},
      pages = {43-47},
      doi = {10.11648/j.crj.20160403.11},
      url = {https://doi.org/10.11648/j.crj.20160403.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160403.11},
      abstract = {Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia
    AU  - Syarif Ibrahim
    AU  - Rosdiana Natzir
    AU  - Andi Asadul Islam
    AU  - Tjakra Manuaba
    AU  - A. Benyamin Fachruddin
    AU  - Burhanuddin Bahar
    AU  - William Hamdani
    AU  - Husni Cangara
    AU  - Mochammad Hatta
    Y1  - 2016/04/01
    PY  - 2016
    N1  - https://doi.org/10.11648/j.crj.20160403.11
    DO  - 10.11648/j.crj.20160403.11
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 43
    EP  - 47
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20160403.11
    AB  - Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • Department of Surgery, Wahidin Sudirohusodo General Hospital, Makassar, Indonesia

  • Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

  • Department of Surgery, Neuro Surgery Division, Wahidin Sudirohusodo General Hospital/Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

  • Department of Surgery, Sanglah General Hospital/Faculty of Medicine, Udayana University, Denpasar, Indonesia

  • Department of Internal Division, Wahidin Sudirohusodo General Hospital/Faculty of medicine, Hasanuddin University, Makassar, Indonesia

  • Department of Epidemiology Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

  • Department of Surgery, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

  • Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

  • Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

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