@article{10.11648/j.cnn.20230704.11,
  author = {Anna Modji Basse and Zeina Joubaily and Halladain Mpung Mansoj and Adjaratou Dieynabou Sow and Marie Emilie Ndong and Seynabou Dieng and Lala Bouna Seck and Moustapha Ndiaye and Amamdou Gallo Diop},
  title = {Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years},
  journal = {Clinical Neurology and Neuroscience},
  volume = {7},
  number = {4},
  pages = {77-81},
  doi = {10.11648/j.cnn.20230704.11},
  url = {https://doi.org/10.11648/j.cnn.20230704.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20230704.11},
  abstract = {Introduction: Centro-Temporal Spike Epilepsy (CTEP) is one of the idiopathic partial epilepsies of children. However, it can present atypical manifestations such as an early age of onset of seizures before 3 years of age. The objective of this work was to evaluate the clinical, paraclinical and therapeutic factors of EPCT before the age of 3 years versus EPCT from 3 years of age. Patients and method: We conducted a retrospective study between January 2005 and January 2021, covering children followed for EPCT at the Albert Royer Children's Hospital and at the Ibrahima Pierre Ndiaye Neuroscience Clinic of the Fann University Hospital Center. Results: 189 children were collected, among them, 154 started their seizures at the usual age from 3 years old (EPCTh group) while 35 started their seizures early before the age of 3 (EPCTp group). The average age was 5.22 +/- 3.71 (range 3 months and 12 years). The male gender predominated in both groups. Familial epilepsy was found in 37.5% of patients with EPCTp and in 30.1% of EPCTp patients. Parental consanguinity was 20% in the EPCTp patient group and 17.5% in the EPCTp patients. School difficulties were present in 55.6% of EPCTp patients and in 29% of EPCTh patients. The number of repetitions was 33% among EPCTp and 15.9% among EPCTh. The most frequent types of seizures were hemicorporal CPM (42.4%) in the EPCTp group, and CGTC (38.8%) in the EPCTh. Physical examination was normal in most cases. The majority of EEG abnormalities were Rolandic spikes. Imaging could only be performed in a few patients and came back normal in these cases. The majority of patients were on monotherapy with 69.7% of EPCTp and 52.2% of EPCTh under VPA and 27.3% of EPCTp and 44.2% of EPCTh under PB. The PB had 25% treatment failure and the VPA 33%. Among EPCTp, 5.7% progressed to POCS and 9.7% among EPCTh. Conclusion: EPCT is known for its usually favorable evolution, however we note that the more serious the history, the earlier the appearance of the first attacks will be. The challenge lies in the knowledge and proper management of these risk factors in order to avoid the occurrence of early onset crises.
},
 year = {2023}
}

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TY  - JOUR
T1  - Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years
AU  - Anna Modji Basse
AU  - Zeina Joubaily
AU  - Halladain Mpung Mansoj
AU  - Adjaratou Dieynabou Sow
AU  - Marie Emilie Ndong
AU  - Seynabou Dieng
AU  - Lala Bouna Seck
AU  - Moustapha Ndiaye
AU  - Amamdou Gallo Diop
Y1  - 2023/11/09
PY  - 2023
N1  - https://doi.org/10.11648/j.cnn.20230704.11
DO  - 10.11648/j.cnn.20230704.11
T2  - Clinical Neurology and Neuroscience
JF  - Clinical Neurology and Neuroscience
JO  - Clinical Neurology and Neuroscience
SP  - 77
EP  - 81
PB  - Science Publishing Group
SN  - 2578-8930
UR  - https://doi.org/10.11648/j.cnn.20230704.11
AB  - Introduction: Centro-Temporal Spike Epilepsy (CTEP) is one of the idiopathic partial epilepsies of children. However, it can present atypical manifestations such as an early age of onset of seizures before 3 years of age. The objective of this work was to evaluate the clinical, paraclinical and therapeutic factors of EPCT before the age of 3 years versus EPCT from 3 years of age. Patients and method: We conducted a retrospective study between January 2005 and January 2021, covering children followed for EPCT at the Albert Royer Children's Hospital and at the Ibrahima Pierre Ndiaye Neuroscience Clinic of the Fann University Hospital Center. Results: 189 children were collected, among them, 154 started their seizures at the usual age from 3 years old (EPCTh group) while 35 started their seizures early before the age of 3 (EPCTp group). The average age was 5.22 +/- 3.71 (range 3 months and 12 years). The male gender predominated in both groups. Familial epilepsy was found in 37.5% of patients with EPCTp and in 30.1% of EPCTp patients. Parental consanguinity was 20% in the EPCTp patient group and 17.5% in the EPCTp patients. School difficulties were present in 55.6% of EPCTp patients and in 29% of EPCTh patients. The number of repetitions was 33% among EPCTp and 15.9% among EPCTh. The most frequent types of seizures were hemicorporal CPM (42.4%) in the EPCTp group, and CGTC (38.8%) in the EPCTh. Physical examination was normal in most cases. The majority of EEG abnormalities were Rolandic spikes. Imaging could only be performed in a few patients and came back normal in these cases. The majority of patients were on monotherapy with 69.7% of EPCTp and 52.2% of EPCTh under VPA and 27.3% of EPCTp and 44.2% of EPCTh under PB. The PB had 25% treatment failure and the VPA 33%. Among EPCTp, 5.7% progressed to POCS and 9.7% among EPCTh. Conclusion: EPCT is known for its usually favorable evolution, however we note that the more serious the history, the earlier the appearance of the first attacks will be. The challenge lies in the knowledge and proper management of these risk factors in order to avoid the occurrence of early onset crises.

VL  - 7
IS  - 4
ER  - 

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