Analgesic and Anti-inflammatory Effects of <i>Tanacetum balsamita</i> Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats

Mohammad Kazemzadeh; Parichehr Yaghmaei; Saeed Mohammadi

doi:doi:10.11648/j.cnn.20170103.13

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Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats

Mohammad Kazemzadeh, Parichehr Yaghmaei, Saeed Mohammadi

Published in Clinical Neurology and Neuroscience (Volume 1, Issue 3)

Received: 29 March 2017 Accepted: 13 April 2017 Published: 26 May 2017

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Abstract

Tanacetum balsamita is one of the important medicinal plants that is used by iranianan folk medicines. This study aimed to assess the phytochemical Screening, analgesic and anti-inflammatory effects of Tanacetum balsamita essential oil in rats. The essential oil of Tanacetum balsamita (EOTB) was treatment in doses of 10, 50, and 100 mg/kg. In addition, anti-nociceptive activity of EOTB was evaluated by formalin, writhing, and tail-flick tests. The EOTB was also combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene-induced ear edema. In addition, the EOTB origin has been analyzed by a combination of GC and GC/MS. The EOTB at doses of 10-100 mg/kg have been shown significant analgesic effects (P<0.05). In compare of standard opioid agonist drug (morphine) and non-steroidal anti-inflammatory drug (indomethacine), Use of naloxone plus EOTB has been inhibited pain in all three models. The present results have been shown significant (P<0.05) anti-inflammatory effect of EOTB in the xylene-induced ear edema test in compare to dexamethasone. The major components in the tested oils were mainly contained quercetin, Isoquercitrin and luteolin. In conclusion, findings propose that EOTB probably have analgesic and anti-inflammatory effects. Existent of quercetin may be an important reason for mentioned effects.

Published in	Clinical Neurology and Neuroscience (Volume 1, Issue 3)
DOI	10.11648/j.cnn.20170103.13
Page(s)	60-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Pain, Inflammation, Medicinal Plant, Tanacetum balsamita, Quercetin

References

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APA Style

Mohammad Kazemzadeh, Parichehr Yaghmaei, Saeed Mohammadi. (2017). Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats. Clinical Neurology and Neuroscience, 1(3), 60-66. https://doi.org/10.11648/j.cnn.20170103.13

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ACS Style

Mohammad Kazemzadeh; Parichehr Yaghmaei; Saeed Mohammadi. Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats. Clin. Neurol. Neurosci. 2017, 1(3), 60-66. doi: 10.11648/j.cnn.20170103.13

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AMA Style

Mohammad Kazemzadeh, Parichehr Yaghmaei, Saeed Mohammadi. Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats. Clin Neurol Neurosci. 2017;1(3):60-66. doi: 10.11648/j.cnn.20170103.13

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@article{10.11648/j.cnn.20170103.13,
  author = {Mohammad Kazemzadeh and Parichehr Yaghmaei and Saeed Mohammadi},
  title = {Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats},
  journal = {Clinical Neurology and Neuroscience},
  volume = {1},
  number = {3},
  pages = {60-66},
  doi = {10.11648/j.cnn.20170103.13},
  url = {https://doi.org/10.11648/j.cnn.20170103.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20170103.13},
  abstract = {Tanacetum balsamita is one of the important medicinal plants that is used by iranianan folk medicines. This study aimed to assess the phytochemical Screening, analgesic and anti-inflammatory effects of Tanacetum balsamita essential oil in rats. The essential oil of Tanacetum balsamita (EOTB) was treatment in doses of 10, 50, and 100 mg/kg. In addition, anti-nociceptive activity of EOTB was evaluated by formalin, writhing, and tail-flick tests. The EOTB was also combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene-induced ear edema. In addition, the EOTB origin has been analyzed by a combination of GC and GC/MS. The EOTB at doses of 10-100 mg/kg have been shown significant analgesic effects (P<0.05). In compare of standard opioid agonist drug (morphine) and non-steroidal anti-inflammatory drug (indomethacine), Use of naloxone plus EOTB has been inhibited pain in all three models. The present results have been shown significant (P<0.05) anti-inflammatory effect of EOTB in the xylene-induced ear edema test in compare to dexamethasone. The major components in the tested oils were mainly contained quercetin, Isoquercitrin and luteolin. In conclusion, findings propose that EOTB probably have analgesic and anti-inflammatory effects. Existent of quercetin may be an important reason for mentioned effects.},
 year = {2017}
}

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TY - JOUR
T1 - Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats
AU - Mohammad Kazemzadeh
AU - Parichehr Yaghmaei
AU - Saeed Mohammadi
Y1 - 2017/05/26
PY - 2017
N1 - https://doi.org/10.11648/j.cnn.20170103.13
DO - 10.11648/j.cnn.20170103.13
T2 - Clinical Neurology and Neuroscience
JF - Clinical Neurology and Neuroscience
JO - Clinical Neurology and Neuroscience
SP - 60
EP - 66
PB - Science Publishing Group
SN - 2578-8930
UR - https://doi.org/10.11648/j.cnn.20170103.13
AB - Tanacetum balsamita is one of the important medicinal plants that is used by iranianan folk medicines. This study aimed to assess the phytochemical Screening, analgesic and anti-inflammatory effects of Tanacetum balsamita essential oil in rats. The essential oil of Tanacetum balsamita (EOTB) was treatment in doses of 10, 50, and 100 mg/kg. In addition, anti-nociceptive activity of EOTB was evaluated by formalin, writhing, and tail-flick tests. The EOTB was also combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene-induced ear edema. In addition, the EOTB origin has been analyzed by a combination of GC and GC/MS. The EOTB at doses of 10-100 mg/kg have been shown significant analgesic effects (P<0.05). In compare of standard opioid agonist drug (morphine) and non-steroidal anti-inflammatory drug (indomethacine), Use of naloxone plus EOTB has been inhibited pain in all three models. The present results have been shown significant (P<0.05) anti-inflammatory effect of EOTB in the xylene-induced ear edema test in compare to dexamethasone. The major components in the tested oils were mainly contained quercetin, Isoquercitrin and luteolin. In conclusion, findings propose that EOTB probably have analgesic and anti-inflammatory effects. Existent of quercetin may be an important reason for mentioned effects.
VL - 1
IS - 3
ER -

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Author Information

Mohammad Kazemzadeh

International Campus, Hamadan University of Medical Sciences, Hamadan, Iran
Parichehr Yaghmaei

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Saeed Mohammadi

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

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Mohammad Kazemzadeh, Parichehr Yaghmaei, Saeed Mohammadi. (2017). Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats. Clinical Neurology and Neuroscience, 1(3), 60-66. https://doi.org/10.11648/j.cnn.20170103.13

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ACS Style

Mohammad Kazemzadeh; Parichehr Yaghmaei; Saeed Mohammadi. Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats. Clin. Neurol. Neurosci. 2017, 1(3), 60-66. doi: 10.11648/j.cnn.20170103.13

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AMA Style

Mohammad Kazemzadeh, Parichehr Yaghmaei, Saeed Mohammadi. Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats. Clin Neurol Neurosci. 2017;1(3):60-66. doi: 10.11648/j.cnn.20170103.13

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@article{10.11648/j.cnn.20170103.13,
  author = {Mohammad Kazemzadeh and Parichehr Yaghmaei and Saeed Mohammadi},
  title = {Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats},
  journal = {Clinical Neurology and Neuroscience},
  volume = {1},
  number = {3},
  pages = {60-66},
  doi = {10.11648/j.cnn.20170103.13},
  url = {https://doi.org/10.11648/j.cnn.20170103.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20170103.13},
  abstract = {Tanacetum balsamita is one of the important medicinal plants that is used by iranianan folk medicines. This study aimed to assess the phytochemical Screening, analgesic and anti-inflammatory effects of Tanacetum balsamita essential oil in rats. The essential oil of Tanacetum balsamita (EOTB) was treatment in doses of 10, 50, and 100 mg/kg. In addition, anti-nociceptive activity of EOTB was evaluated by formalin, writhing, and tail-flick tests. The EOTB was also combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene-induced ear edema. In addition, the EOTB origin has been analyzed by a combination of GC and GC/MS. The EOTB at doses of 10-100 mg/kg have been shown significant analgesic effects (P<0.05). In compare of standard opioid agonist drug (morphine) and non-steroidal anti-inflammatory drug (indomethacine), Use of naloxone plus EOTB has been inhibited pain in all three models. The present results have been shown significant (P<0.05) anti-inflammatory effect of EOTB in the xylene-induced ear edema test in compare to dexamethasone. The major components in the tested oils were mainly contained quercetin, Isoquercitrin and luteolin. In conclusion, findings propose that EOTB probably have analgesic and anti-inflammatory effects. Existent of quercetin may be an important reason for mentioned effects.},
 year = {2017}
}

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