@article{10.11648/j.cnn.20170101.12,
  author = {Soumaila Boubacar and Ngor Side Diagne and Eric Gueumekane Lamou Bila and Christian Madjirabe Ngarndiguina and Ibrahima Mariam Diallo and Patrice Ntenga and Ousmane Cisse and Alassane Mamadou Diop and Ndiaga Matar Gaye and Maouly Fall and Marième Soda Diop and Anna Modji Basse and Adjaratou Dieynabou Sow and Hamid Assadeck and Youssoufa Maiga and Lala Bouna Seck and Kamadore Touré and Moustapha Ndiaye and Amadou Gallo Diop and Mouhamadou Mansour Ndiaye},
  title = {Occurrence of Biermer's Disease After 8 Years of Follow-Up of Myasthenia Gravis: About a Clinical Case},
  journal = {Clinical Neurology and Neuroscience},
  volume = {1},
  number = {1},
  pages = {5-7},
  doi = {10.11648/j.cnn.20170101.12},
  url = {https://doi.org/10.11648/j.cnn.20170101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20170101.12},
  abstract = {The auto immune myasthenia comorbidity and Biermer disease is less documented and rarely brought in the literature. We bring back the observation of a Senegalese patient hospitalized in our department of Neurology at Fann hospital (Dakar). It concerned a patient aged 58 years followed up for auto-immune myasthenia to antibodies anti-receptors of acetylcholine Ac RACH since 8 years and having a benefit of recurrent blood transfusion with a blood group A rhesus positive. He was received on neurologic consultation for a tiredness associated to an effort dyspnea and a gastro esophageal reflux accompanied by vomiting. The interrogatory found palpitations which necessitated a hospitalization two month before. Physical examination had objective a myasthenia syndrome, an anemic syndrome on the other hand, sub icteric mucosa’s were noted but no melanodermia no glossite. The rest of the physical examination was without particularity. The diagnoses of the Biermer illness was carried out in front of the anemic syndrome, the chronicity of the symptomatology without notion of fluctuation and the complementary exams having as objective a low rate of hemoglobin and a deficit in vitamin B12. The origin auto-immune of this anemia was confirmed by the immunologic test which had put in evidence a high rate of anti-bodies anti- intrinsic factor. The patient benefited from a blood transfusion then a treatment from cobalamin (for life) was also installed associated to a symptomatic management of the patient. The evolution after 6 weeks of the treatment was favorable with a complete regression of the dyspnea, vomiting and the attenuation of the effort tiredness. Myasthenia gravis and Biermer disease comorbidity has to be discussed in front of every myasthenia patient presenting clinical signs of effort dyspnea to a chronic anemia because early diagnoses of this association of Biermer illness and myasthenia gravis favors a better prognosis and not to progress to the combined degeneration of the spinal cord. The autoimmune substratum of the mechanism of this comorbidity remains to be elucidated but in all cases multidisciplinary management is necessary.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Occurrence of Biermer's Disease After 8 Years of Follow-Up of Myasthenia Gravis: About a Clinical Case
AU  - Soumaila Boubacar
AU  - Ngor Side Diagne
AU  - Eric Gueumekane Lamou Bila
AU  - Christian Madjirabe Ngarndiguina
AU  - Ibrahima Mariam Diallo
AU  - Patrice Ntenga
AU  - Ousmane Cisse
AU  - Alassane Mamadou Diop
AU  - Ndiaga Matar Gaye
AU  - Maouly Fall
AU  - Marième Soda Diop
AU  - Anna Modji Basse
AU  - Adjaratou Dieynabou Sow
AU  - Hamid Assadeck
AU  - Youssoufa Maiga
AU  - Lala Bouna Seck
AU  - Kamadore Touré
AU  - Moustapha Ndiaye
AU  - Amadou Gallo Diop
AU  - Mouhamadou Mansour Ndiaye
Y1  - 2017/03/01
PY  - 2017
N1  - https://doi.org/10.11648/j.cnn.20170101.12
DO  - 10.11648/j.cnn.20170101.12
T2  - Clinical Neurology and Neuroscience
JF  - Clinical Neurology and Neuroscience
JO  - Clinical Neurology and Neuroscience
SP  - 5
EP  - 7
PB  - Science Publishing Group
SN  - 2578-8930
UR  - https://doi.org/10.11648/j.cnn.20170101.12
AB  - The auto immune myasthenia comorbidity and Biermer disease is less documented and rarely brought in the literature. We bring back the observation of a Senegalese patient hospitalized in our department of Neurology at Fann hospital (Dakar). It concerned a patient aged 58 years followed up for auto-immune myasthenia to antibodies anti-receptors of acetylcholine Ac RACH since 8 years and having a benefit of recurrent blood transfusion with a blood group A rhesus positive. He was received on neurologic consultation for a tiredness associated to an effort dyspnea and a gastro esophageal reflux accompanied by vomiting. The interrogatory found palpitations which necessitated a hospitalization two month before. Physical examination had objective a myasthenia syndrome, an anemic syndrome on the other hand, sub icteric mucosa’s were noted but no melanodermia no glossite. The rest of the physical examination was without particularity. The diagnoses of the Biermer illness was carried out in front of the anemic syndrome, the chronicity of the symptomatology without notion of fluctuation and the complementary exams having as objective a low rate of hemoglobin and a deficit in vitamin B12. The origin auto-immune of this anemia was confirmed by the immunologic test which had put in evidence a high rate of anti-bodies anti- intrinsic factor. The patient benefited from a blood transfusion then a treatment from cobalamin (for life) was also installed associated to a symptomatic management of the patient. The evolution after 6 weeks of the treatment was favorable with a complete regression of the dyspnea, vomiting and the attenuation of the effort tiredness. Myasthenia gravis and Biermer disease comorbidity has to be discussed in front of every myasthenia patient presenting clinical signs of effort dyspnea to a chronic anemia because early diagnoses of this association of Biermer illness and myasthenia gravis favors a better prognosis and not to progress to the combined degeneration of the spinal cord. The autoimmune substratum of the mechanism of this comorbidity remains to be elucidated but in all cases multidisciplinary management is necessary.
VL  - 1
IS  - 1
ER  - 

Copy | Download