A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED<sup>®</sup>, A New Vaccine Against Edema Disease in Pigs

Eva Perozo; Joaquim Mallorquí; Ainhoa Puig; David Sabaté; Laura Ferrer-Soler; Ricard March

doi:doi:10.11648/j.avs.20180606.11

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A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED^®, A New Vaccine Against Edema Disease in Pigs

Eva Perozo, Joaquim Mallorquí, Ainhoa Puig, David Sabaté, Laura Ferrer-Soler, Ricard March

Published in Animal and Veterinary Sciences (Volume 6, Issue 6)

Received: 11 December 2018 Accepted: 2 January 2019 Published: 31 January 2019

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Abstract

The aim of this study was to evaluate under field conditions the efficacy and safety of Vepured, a new recombinant vaccine against Edema Disease in pigs. The study was conducted on five commercial farrow-to-finish pig farms, which had historical records of clinical signs and presented F18-positive E.coli producing VT2e. The study was designed as a multicenter, randomized, placebo-controlled, blinded field trial comparing Vepured vaccine to a placebo (phosphate-buffered saline). Animals, at the age of 2-3 days, were administered intramuscularly with 1mL of Vepured (n=945) or with 1mL of phosphate-buffered saline (n=824). After product administration, animals were followed-up until slaughter. During this period, several efficacy and safety parameters were evaluated. On each farm, animals from both groups were held in the same unit and subjected to the same husbandry practices throughout the study. Clinical outbreaks of edema disease were only reported on four farms. On these farms, vaccination with Vepured resulted in a statistically significant reduction in both the mortality rate and the occurrence of clinical signs related to the disease. A statistically significantly higher mean growth performance was also reported in the vaccinated group compared to the placebo group. In the farm without clinical outbreak of edema disease differences were also observed in growth performance in favor of the vaccinated group. No systemic reactions were observed during or immediately after vaccination with Vepured. Only mild transient local reactions, and slight clinically non-relevant temperature increases were reported in some animals. The results obtained in this study demonstrate that vaccination with Vepured is safe and efficacious against naturally occurring edema disease infection.

Published in	Animal and Veterinary Sciences (Volume 6, Issue 6)
DOI	10.11648/j.avs.20180606.11
Page(s)	95-101
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Edema Disease, Vaccine, Verotoxin 2e (VT2e), Vepured, Pig

References

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[13]	Toshio S., Takeshi M., Eiji T., Yumiko K., Sou-Ichi M., Ko K., Kazutoshi S. and Takashi H. 2013. Evaluation of Recombinant Forms of the Shiga Toxin Variant Stx2eB Subunit and Non-Toxic Mutant Stx2e as Vaccine Candidates against Porcine Edema Disease. J Vet Med Sci. 75(10): 1309–1315.
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APA Style

Eva Perozo, Joaquim Mallorquí, Ainhoa Puig, David Sabaté, Laura Ferrer-Soler, et al. (2019). A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs. Animal and Veterinary Sciences, 6(6), 95-101. https://doi.org/10.11648/j.avs.20180606.11

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ACS Style

Eva Perozo; Joaquim Mallorquí; Ainhoa Puig; David Sabaté; Laura Ferrer-Soler, et al. A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs. Anim. Vet. Sci. 2019, 6(6), 95-101. doi: 10.11648/j.avs.20180606.11

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AMA Style

Eva Perozo, Joaquim Mallorquí, Ainhoa Puig, David Sabaté, Laura Ferrer-Soler, et al. A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs. Anim Vet Sci. 2019;6(6):95-101. doi: 10.11648/j.avs.20180606.11

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@article{10.11648/j.avs.20180606.11,
  author = {Eva Perozo and Joaquim Mallorquí and Ainhoa Puig and David Sabaté and Laura Ferrer-Soler and Ricard March},
  title = {A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs},
  journal = {Animal and Veterinary Sciences},
  volume = {6},
  number = {6},
  pages = {95-101},
  doi = {10.11648/j.avs.20180606.11},
  url = {https://doi.org/10.11648/j.avs.20180606.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20180606.11},
  abstract = {The aim of this study was to evaluate under field conditions the efficacy and safety of Vepured, a new recombinant vaccine against Edema Disease in pigs. The study was conducted on five commercial farrow-to-finish pig farms, which had historical records of clinical signs and presented F18-positive E.coli producing VT2e. The study was designed as a multicenter, randomized, placebo-controlled, blinded field trial comparing Vepured vaccine to a placebo (phosphate-buffered saline). Animals, at the age of 2-3 days, were administered intramuscularly with 1mL of Vepured (n=945) or with 1mL of phosphate-buffered saline (n=824). After product administration, animals were followed-up until slaughter. During this period, several efficacy and safety parameters were evaluated. On each farm, animals from both groups were held in the same unit and subjected to the same husbandry practices throughout the study. Clinical outbreaks of edema disease were only reported on four farms. On these farms, vaccination with Vepured resulted in a statistically significant reduction in both the mortality rate and the occurrence of clinical signs related to the disease. A statistically significantly higher mean growth performance was also reported in the vaccinated group compared to the placebo group. In the farm without clinical outbreak of edema disease differences were also observed in growth performance in favor of the vaccinated group. No systemic reactions were observed during or immediately after vaccination with Vepured. Only mild transient local reactions, and slight clinically non-relevant temperature increases were reported in some animals. The results obtained in this study demonstrate that vaccination with Vepured is safe and efficacious against naturally occurring edema disease infection.},
 year = {2019}
}

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TY - JOUR
T1 - A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs
AU - Eva Perozo
AU - Joaquim Mallorquí
AU - Ainhoa Puig
AU - David Sabaté
AU - Laura Ferrer-Soler
AU - Ricard March
Y1 - 2019/01/31
PY - 2019
N1 - https://doi.org/10.11648/j.avs.20180606.11
DO - 10.11648/j.avs.20180606.11
T2 - Animal and Veterinary Sciences
JF - Animal and Veterinary Sciences
JO - Animal and Veterinary Sciences
SP - 95
EP - 101
PB - Science Publishing Group
SN - 2328-5850
UR - https://doi.org/10.11648/j.avs.20180606.11
AB - The aim of this study was to evaluate under field conditions the efficacy and safety of Vepured, a new recombinant vaccine against Edema Disease in pigs. The study was conducted on five commercial farrow-to-finish pig farms, which had historical records of clinical signs and presented F18-positive E.coli producing VT2e. The study was designed as a multicenter, randomized, placebo-controlled, blinded field trial comparing Vepured vaccine to a placebo (phosphate-buffered saline). Animals, at the age of 2-3 days, were administered intramuscularly with 1mL of Vepured (n=945) or with 1mL of phosphate-buffered saline (n=824). After product administration, animals were followed-up until slaughter. During this period, several efficacy and safety parameters were evaluated. On each farm, animals from both groups were held in the same unit and subjected to the same husbandry practices throughout the study. Clinical outbreaks of edema disease were only reported on four farms. On these farms, vaccination with Vepured resulted in a statistically significant reduction in both the mortality rate and the occurrence of clinical signs related to the disease. A statistically significantly higher mean growth performance was also reported in the vaccinated group compared to the placebo group. In the farm without clinical outbreak of edema disease differences were also observed in growth performance in favor of the vaccinated group. No systemic reactions were observed during or immediately after vaccination with Vepured. Only mild transient local reactions, and slight clinically non-relevant temperature increases were reported in some animals. The results obtained in this study demonstrate that vaccination with Vepured is safe and efficacious against naturally occurring edema disease infection.
VL - 6
IS - 6
ER -

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Author Information

Eva Perozo

Research and Development Department, HIPRA, Amer, Spain
Joaquim Mallorquí

Research and Development Department, HIPRA, Amer, Spain
Ainhoa Puig

Research and Development Department, HIPRA, Amer, Spain
David Sabaté

Research and Development Department, HIPRA, Amer, Spain
Laura Ferrer-Soler

Research and Development Department, HIPRA, Amer, Spain
Ricard March

Research and Development Department, HIPRA, Amer, Spain

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Eva Perozo, Joaquim Mallorquí, Ainhoa Puig, David Sabaté, Laura Ferrer-Soler, et al. (2019). A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs. Animal and Veterinary Sciences, 6(6), 95-101. https://doi.org/10.11648/j.avs.20180606.11

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ACS Style

Eva Perozo; Joaquim Mallorquí; Ainhoa Puig; David Sabaté; Laura Ferrer-Soler, et al. A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs. Anim. Vet. Sci. 2019, 6(6), 95-101. doi: 10.11648/j.avs.20180606.11

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AMA Style

Eva Perozo, Joaquim Mallorquí, Ainhoa Puig, David Sabaté, Laura Ferrer-Soler, et al. A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs. Anim Vet Sci. 2019;6(6):95-101. doi: 10.11648/j.avs.20180606.11

Copy | Download

@article{10.11648/j.avs.20180606.11,
  author = {Eva Perozo and Joaquim Mallorquí and Ainhoa Puig and David Sabaté and Laura Ferrer-Soler and Ricard March},
  title = {A Multicenter, Randomized Field Trial on the Efficacy and Safety of VEPURED®, A New Vaccine Against Edema Disease in Pigs},
  journal = {Animal and Veterinary Sciences},
  volume = {6},
  number = {6},
  pages = {95-101},
  doi = {10.11648/j.avs.20180606.11},
  url = {https://doi.org/10.11648/j.avs.20180606.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20180606.11},
  abstract = {The aim of this study was to evaluate under field conditions the efficacy and safety of Vepured, a new recombinant vaccine against Edema Disease in pigs. The study was conducted on five commercial farrow-to-finish pig farms, which had historical records of clinical signs and presented F18-positive E.coli producing VT2e. The study was designed as a multicenter, randomized, placebo-controlled, blinded field trial comparing Vepured vaccine to a placebo (phosphate-buffered saline). Animals, at the age of 2-3 days, were administered intramuscularly with 1mL of Vepured (n=945) or with 1mL of phosphate-buffered saline (n=824). After product administration, animals were followed-up until slaughter. During this period, several efficacy and safety parameters were evaluated. On each farm, animals from both groups were held in the same unit and subjected to the same husbandry practices throughout the study. Clinical outbreaks of edema disease were only reported on four farms. On these farms, vaccination with Vepured resulted in a statistically significant reduction in both the mortality rate and the occurrence of clinical signs related to the disease. A statistically significantly higher mean growth performance was also reported in the vaccinated group compared to the placebo group. In the farm without clinical outbreak of edema disease differences were also observed in growth performance in favor of the vaccinated group. No systemic reactions were observed during or immediately after vaccination with Vepured. Only mild transient local reactions, and slight clinically non-relevant temperature increases were reported in some animals. The results obtained in this study demonstrate that vaccination with Vepured is safe and efficacious against naturally occurring edema disease infection.},
 year = {2019}
}

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