L-carnitine is essential for energy production and fatty acid metabolism. This study was designed to evaluate effects of L-carnitine on liver enzymes in rats fed cholesterol rich diet. Thirty two healthy male Wistar Albino rats were divided to four groups as Control (K), Cholesterol (C), L-carnitine (L) and L-carnitine+cholesterol (LC). All rats were kept in individual cages during the experiment for 40 days. K group was fed standard rat pellets ad libitum, C group was fed standard rat pellets containing 7.5 % cholesterol powder, L group was fed standard rat pellets and water containing 75 mg/l L-carnitine and LC group was fed standard rat pellets containing 7.5% cholesterol and water containing 75 mg/l L-carnitine. At the end of the study, blood samples were taken from all animals in order to determine aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT)levels. AST, ALT, ALP, and GGT levels significantly increased in C group compared to K group (p<0.05). In LC group, AST, ALT, ALP levels significantly decreased compared with the C group (p<0.05). Although GGT level in LC group was decreased, the change was not different from C group. These results indicate that L-carnitine may prevent liver damage caused by high cholesterol diet in rats.
| Published in | Animal and Veterinary Sciences (Volume 3, Issue 4) |
| DOI | 10.11648/j.avs.20150304.14 |
| Page(s) | 117-119 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
L-carnitine, Cholesterol, Liver Enzymes, Rat
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APA Style
Ercan Keskin, Deniz Uluisik, Mehmet Altin. (2015). Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet. Animal and Veterinary Sciences, 3(4), 117-119. https://doi.org/10.11648/j.avs.20150304.14
ACS Style
Ercan Keskin; Deniz Uluisik; Mehmet Altin. Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet. Anim. Vet. Sci. 2015, 3(4), 117-119. doi: 10.11648/j.avs.20150304.14
AMA Style
Ercan Keskin, Deniz Uluisik, Mehmet Altin. Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet. Anim Vet Sci. 2015;3(4):117-119. doi: 10.11648/j.avs.20150304.14
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Download@article{10.11648/j.avs.20150304.14,
author = {Ercan Keskin and Deniz Uluisik and Mehmet Altin},
title = {Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet},
journal = {Animal and Veterinary Sciences},
volume = {3},
number = {4},
pages = {117-119},
doi = {10.11648/j.avs.20150304.14},
url = {https://doi.org/10.11648/j.avs.20150304.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20150304.14},
abstract = {L-carnitine is essential for energy production and fatty acid metabolism. This study was designed to evaluate effects of L-carnitine on liver enzymes in rats fed cholesterol rich diet. Thirty two healthy male Wistar Albino rats were divided to four groups as Control (K), Cholesterol (C), L-carnitine (L) and L-carnitine+cholesterol (LC). All rats were kept in individual cages during the experiment for 40 days. K group was fed standard rat pellets ad libitum, C group was fed standard rat pellets containing 7.5 % cholesterol powder, L group was fed standard rat pellets and water containing 75 mg/l L-carnitine and LC group was fed standard rat pellets containing 7.5% cholesterol and water containing 75 mg/l L-carnitine. At the end of the study, blood samples were taken from all animals in order to determine aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT)levels. AST, ALT, ALP, and GGT levels significantly increased in C group compared to K group (p<0.05). In LC group, AST, ALT, ALP levels significantly decreased compared with the C group (p<0.05). Although GGT level in LC group was decreased, the change was not different from C group. These results indicate that L-carnitine may prevent liver damage caused by high cholesterol diet in rats.},
year = {2015}
}
TY - JOUR T1 - Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet AU - Ercan Keskin AU - Deniz Uluisik AU - Mehmet Altin Y1 - 2015/07/08 PY - 2015 N1 - https://doi.org/10.11648/j.avs.20150304.14 DO - 10.11648/j.avs.20150304.14 T2 - Animal and Veterinary Sciences JF - Animal and Veterinary Sciences JO - Animal and Veterinary Sciences SP - 117 EP - 119 PB - Science Publishing Group SN - 2328-5850 UR - https://doi.org/10.11648/j.avs.20150304.14 AB - L-carnitine is essential for energy production and fatty acid metabolism. This study was designed to evaluate effects of L-carnitine on liver enzymes in rats fed cholesterol rich diet. Thirty two healthy male Wistar Albino rats were divided to four groups as Control (K), Cholesterol (C), L-carnitine (L) and L-carnitine+cholesterol (LC). All rats were kept in individual cages during the experiment for 40 days. K group was fed standard rat pellets ad libitum, C group was fed standard rat pellets containing 7.5 % cholesterol powder, L group was fed standard rat pellets and water containing 75 mg/l L-carnitine and LC group was fed standard rat pellets containing 7.5% cholesterol and water containing 75 mg/l L-carnitine. At the end of the study, blood samples were taken from all animals in order to determine aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT)levels. AST, ALT, ALP, and GGT levels significantly increased in C group compared to K group (p<0.05). In LC group, AST, ALT, ALP levels significantly decreased compared with the C group (p<0.05). Although GGT level in LC group was decreased, the change was not different from C group. These results indicate that L-carnitine may prevent liver damage caused by high cholesterol diet in rats. VL - 3 IS - 4 ER -
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