Background: Tiger nut tuberis very common and abundant in Nigeria. Aluminium chloride is the third must abundant metal present naturally on earth crust. Objective: The objective of thestudy was to assess the increase in rate of aluminium chloride exposure and toxicity on the pancreas of adult wistar rats. Aim: To evaluate the protective effect of ethanolic extract of tigernut on pancreas of adult wistar rats. Methods: In this study twenty five adult rats were used. The animals were grouped into a control group A and treatment groups B, C, D and E. Group A served as control and was administered orally with normal saline, group B wasadministered orally with 500 mg/kg of aluminum chloride, group C, D and E were administered with 1250 mg/kg of the ethanolic extract of Cyperus esculentus only, 500 mg/kg of aluminum chloride followed by 2500 mg/kg of the ethanolic extract of Cyperus esculentus and 500 mg/kg of aluminum chloride followed by 3750 mg/kg of the ethanolic extract of Cyperus esculentus respectively. The treatment was for six weeks, weights of the rats were recorded weekly. Result: The histo-morphology of the pancreas revealed that group A showed the normal pancreatic histo-architecture, group B showed sign of inflammation and paucity of islet cells. Groups C, D and E showed normal pancreatic histomorphology. Conclusion: Tissue exposed to aluminum chloride showed fibrosis and inflammation due to toxicity while those exposed to tiger nut therapy showed recovery and regeneration of damaged cells thus indicating ameliorative role of tigernut seed.
| Published in | Advances in Surgical Sciences (Volume 11, Issue 1) |
| DOI | 10.11648/j.ass.20231101.14 |
| Page(s) | 17-21 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Ameliorative, Tigernut, Ethanolic Extract, Pancreas, Wistar Rats
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APA Style
Gudaji Abdullahi, Umar Zailani. (2023). Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats. Advances in Surgical Sciences, 11(1), 17-21. https://doi.org/10.11648/j.ass.20231101.14
ACS Style
Gudaji Abdullahi; Umar Zailani. Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats. Adv. Surg. Sci. 2023, 11(1), 17-21. doi: 10.11648/j.ass.20231101.14
AMA Style
Gudaji Abdullahi, Umar Zailani. Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats. Adv Surg Sci. 2023;11(1):17-21. doi: 10.11648/j.ass.20231101.14
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Download@article{10.11648/j.ass.20231101.14,
author = {Gudaji Abdullahi and Umar Zailani},
title = {Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats},
journal = {Advances in Surgical Sciences},
volume = {11},
number = {1},
pages = {17-21},
doi = {10.11648/j.ass.20231101.14},
url = {https://doi.org/10.11648/j.ass.20231101.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20231101.14},
abstract = {Background: Tiger nut tuberis very common and abundant in Nigeria. Aluminium chloride is the third must abundant metal present naturally on earth crust. Objective: The objective of thestudy was to assess the increase in rate of aluminium chloride exposure and toxicity on the pancreas of adult wistar rats. Aim: To evaluate the protective effect of ethanolic extract of tigernut on pancreas of adult wistar rats. Methods: In this study twenty five adult rats were used. The animals were grouped into a control group A and treatment groups B, C, D and E. Group A served as control and was administered orally with normal saline, group B wasadministered orally with 500 mg/kg of aluminum chloride, group C, D and E were administered with 1250 mg/kg of the ethanolic extract of Cyperus esculentus only, 500 mg/kg of aluminum chloride followed by 2500 mg/kg of the ethanolic extract of Cyperus esculentus and 500 mg/kg of aluminum chloride followed by 3750 mg/kg of the ethanolic extract of Cyperus esculentus respectively. The treatment was for six weeks, weights of the rats were recorded weekly. Result: The histo-morphology of the pancreas revealed that group A showed the normal pancreatic histo-architecture, group B showed sign of inflammation and paucity of islet cells. Groups C, D and E showed normal pancreatic histomorphology. Conclusion: Tissue exposed to aluminum chloride showed fibrosis and inflammation due to toxicity while those exposed to tiger nut therapy showed recovery and regeneration of damaged cells thus indicating ameliorative role of tigernut seed.},
year = {2023}
}
TY - JOUR T1 - Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats AU - Gudaji Abdullahi AU - Umar Zailani Y1 - 2023/06/27 PY - 2023 N1 - https://doi.org/10.11648/j.ass.20231101.14 DO - 10.11648/j.ass.20231101.14 T2 - Advances in Surgical Sciences JF - Advances in Surgical Sciences JO - Advances in Surgical Sciences SP - 17 EP - 21 PB - Science Publishing Group SN - 2376-6182 UR - https://doi.org/10.11648/j.ass.20231101.14 AB - Background: Tiger nut tuberis very common and abundant in Nigeria. Aluminium chloride is the third must abundant metal present naturally on earth crust. Objective: The objective of thestudy was to assess the increase in rate of aluminium chloride exposure and toxicity on the pancreas of adult wistar rats. Aim: To evaluate the protective effect of ethanolic extract of tigernut on pancreas of adult wistar rats. Methods: In this study twenty five adult rats were used. The animals were grouped into a control group A and treatment groups B, C, D and E. Group A served as control and was administered orally with normal saline, group B wasadministered orally with 500 mg/kg of aluminum chloride, group C, D and E were administered with 1250 mg/kg of the ethanolic extract of Cyperus esculentus only, 500 mg/kg of aluminum chloride followed by 2500 mg/kg of the ethanolic extract of Cyperus esculentus and 500 mg/kg of aluminum chloride followed by 3750 mg/kg of the ethanolic extract of Cyperus esculentus respectively. The treatment was for six weeks, weights of the rats were recorded weekly. Result: The histo-morphology of the pancreas revealed that group A showed the normal pancreatic histo-architecture, group B showed sign of inflammation and paucity of islet cells. Groups C, D and E showed normal pancreatic histomorphology. Conclusion: Tissue exposed to aluminum chloride showed fibrosis and inflammation due to toxicity while those exposed to tiger nut therapy showed recovery and regeneration of damaged cells thus indicating ameliorative role of tigernut seed. VL - 11 IS - 1 ER -
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