Background: Endometrial cancer is the second most common gynecological cancer and a leading cause of gynecologic cancer-related deaths worldwide. The aberration in the expression of programmed cell death 1 (PD-1) and its gene polymorphisms have been indicated in several human cancers. In the current study, we aimed to investigate the association between rs11568821 polymorphism in PD-1 and the risk of endometrial cancer. Methods: This experiment was a hospital based, case-control study. We enrolled 91 patients with endometrial cancer and 50 healthy individuals as the control in this study. The mean age of patients in the case and control groups were 57.4 ± 9.7 and 55.1 ± 14 years, respectively. Peripheral blood was taken from these individuals, and DNA extraction was carried out. Polymerase chain reaction (PCR) amplified the region containing rs11568821, followed by restriction fragment length polymorphism (RFLP). Results: Comparison of disease incidence across rs11568821 genotypes showed significant association in recessive model GG vs. AG+AA (P = 0.028) with GG genotype increasing the risk of endometrial cancer. Conclusion: Our results indicated that rs11568821 polymorphism in PD-1 is associated with endometrial cancer. However, further studies in larger cohorts are needed to unravel the exact distribution of the genotypes and alleles of this polymorphism in women with endometrial cancer.
| Published in | Advances in Surgical Sciences (Volume 10, Issue 2) |
| DOI | 10.11648/j.ass.20221002.11 |
| Page(s) | 13-17 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Endometrial Cancer, PD-1, rs11568821, PCR-RFLP
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APA Style
Soheila Aminimoghaddam, Roghayeh Amiri, Forough Taheri, Zeynab Nickhah Klashami, Shahla Noori Ardebili, et al. (2022). The Association Between rs11568821 Polymorphism in Programmed Cell Death 1 (PD-1) and the Risk of Endometrial Cancer. Advances in Surgical Sciences, 10(2), 13-17. https://doi.org/10.11648/j.ass.20221002.11
ACS Style
Soheila Aminimoghaddam; Roghayeh Amiri; Forough Taheri; Zeynab Nickhah Klashami; Shahla Noori Ardebili, et al. The Association Between rs11568821 Polymorphism in Programmed Cell Death 1 (PD-1) and the Risk of Endometrial Cancer. Adv. Surg. Sci. 2022, 10(2), 13-17. doi: 10.11648/j.ass.20221002.11
AMA Style
Soheila Aminimoghaddam, Roghayeh Amiri, Forough Taheri, Zeynab Nickhah Klashami, Shahla Noori Ardebili, et al. The Association Between rs11568821 Polymorphism in Programmed Cell Death 1 (PD-1) and the Risk of Endometrial Cancer. Adv Surg Sci. 2022;10(2):13-17. doi: 10.11648/j.ass.20221002.11
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Download@article{10.11648/j.ass.20221002.11,
author = {Soheila Aminimoghaddam and Roghayeh Amiri and Forough Taheri and Zeynab Nickhah Klashami and Shahla Noori Ardebili and Nafise Noroozi and Mahsa M. Amoli},
title = {The Association Between rs11568821 Polymorphism in Programmed Cell Death 1 (PD-1) and the Risk of Endometrial Cancer},
journal = {Advances in Surgical Sciences},
volume = {10},
number = {2},
pages = {13-17},
doi = {10.11648/j.ass.20221002.11},
url = {https://doi.org/10.11648/j.ass.20221002.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20221002.11},
abstract = {Background: Endometrial cancer is the second most common gynecological cancer and a leading cause of gynecologic cancer-related deaths worldwide. The aberration in the expression of programmed cell death 1 (PD-1) and its gene polymorphisms have been indicated in several human cancers. In the current study, we aimed to investigate the association between rs11568821 polymorphism in PD-1 and the risk of endometrial cancer. Methods: This experiment was a hospital based, case-control study. We enrolled 91 patients with endometrial cancer and 50 healthy individuals as the control in this study. The mean age of patients in the case and control groups were 57.4 ± 9.7 and 55.1 ± 14 years, respectively. Peripheral blood was taken from these individuals, and DNA extraction was carried out. Polymerase chain reaction (PCR) amplified the region containing rs11568821, followed by restriction fragment length polymorphism (RFLP). Results: Comparison of disease incidence across rs11568821 genotypes showed significant association in recessive model GG vs. AG+AA (P = 0.028) with GG genotype increasing the risk of endometrial cancer. Conclusion: Our results indicated that rs11568821 polymorphism in PD-1 is associated with endometrial cancer. However, further studies in larger cohorts are needed to unravel the exact distribution of the genotypes and alleles of this polymorphism in women with endometrial cancer.},
year = {2022}
}
TY - JOUR T1 - The Association Between rs11568821 Polymorphism in Programmed Cell Death 1 (PD-1) and the Risk of Endometrial Cancer AU - Soheila Aminimoghaddam AU - Roghayeh Amiri AU - Forough Taheri AU - Zeynab Nickhah Klashami AU - Shahla Noori Ardebili AU - Nafise Noroozi AU - Mahsa M. Amoli Y1 - 2022/08/04 PY - 2022 N1 - https://doi.org/10.11648/j.ass.20221002.11 DO - 10.11648/j.ass.20221002.11 T2 - Advances in Surgical Sciences JF - Advances in Surgical Sciences JO - Advances in Surgical Sciences SP - 13 EP - 17 PB - Science Publishing Group SN - 2376-6182 UR - https://doi.org/10.11648/j.ass.20221002.11 AB - Background: Endometrial cancer is the second most common gynecological cancer and a leading cause of gynecologic cancer-related deaths worldwide. The aberration in the expression of programmed cell death 1 (PD-1) and its gene polymorphisms have been indicated in several human cancers. In the current study, we aimed to investigate the association between rs11568821 polymorphism in PD-1 and the risk of endometrial cancer. Methods: This experiment was a hospital based, case-control study. We enrolled 91 patients with endometrial cancer and 50 healthy individuals as the control in this study. The mean age of patients in the case and control groups were 57.4 ± 9.7 and 55.1 ± 14 years, respectively. Peripheral blood was taken from these individuals, and DNA extraction was carried out. Polymerase chain reaction (PCR) amplified the region containing rs11568821, followed by restriction fragment length polymorphism (RFLP). Results: Comparison of disease incidence across rs11568821 genotypes showed significant association in recessive model GG vs. AG+AA (P = 0.028) with GG genotype increasing the risk of endometrial cancer. Conclusion: Our results indicated that rs11568821 polymorphism in PD-1 is associated with endometrial cancer. However, further studies in larger cohorts are needed to unravel the exact distribution of the genotypes and alleles of this polymorphism in women with endometrial cancer. VL - 10 IS - 2 ER -
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