Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma

Lali Bugadze; Nino Manjavidze; Lia Jor Joliani

doi:doi:10.11648/j.ass.20210902.12

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Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani

Published in Advances in Surgical Sciences (Volume 9, Issue 2)

Received: 27 May 2021 Accepted: 30 July 2021 Published: 12 October 2021

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Abstract

Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.

Published in	Advances in Surgical Sciences (Volume 9, Issue 2)
DOI	10.11648/j.ass.20210902.12
Page(s)	20-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Vitamin D, Children, Uncontrolled Asthma, Prick-test, Spirometry, IgE

References

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[3]	Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma: A case-control study. Bai YJ, Dai RJ. Medicine (Baltimore). 2018 Feb; 97 (7): e9830. doi: 10.1097/MD.0000000000009830.PMID: 29443744 (Free PMC Article).
[4]	Association between the oxidative status, Vitamin D levels and respiratory function in asthmatic children. Igde M, Baran P, Oksuz BG, Topcuoglu S, Karatekin G. Niger J Clin Pract. 2018 Jan; 21 (1): 63-68. doi: 10.4103/njcp.njcp_373_16.PMID: 29411726.
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[6]	Vitamin D Status, Lung Function and Atopy in Children with Asthma. Ozdogan S, Sari G, Aktan IH, Aydin B, Irmak C, Cavdar S. J Coll Physicians Surg Pak. 2017 May; 27 (5): 292-295. PMID: 28599691.
[7]	Association between vitamin D status and asthma control: A meta-analysis of randomized trials. Wang M, Liu M, Wang C, Xiao Y, An T, Zou M, Cheng G. Respir Med. 2019 Apr; 150: 85-94. doi: 10.1016/j.rmed.2019.02.016. Epub 2019 Feb 21. PMID: 30961957.
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[9]	Vitamin D for secondary prevention of acute wheeze attacks in preschool and school-age children. Stefanidis C, Martineau AR, Nwokoro C, Griffiths CJ, Bush A. Thorax. 2019 Oct; 74 (10): 977-985. doi: 10.1136/thoraxjnl-2019-213278. Epub 2019 Jul 5. PMID: 31278171.
[10]	Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait. AbdelKader AM, Nassar MF. East Mediterr Health J. 2019 Apr 25; 25 (3): 197-204. doi: 10.26719/emhj.18.031. PMID: 31054230.
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APA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. (2021). Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Advances in Surgical Sciences, 9(2), 20-24. https://doi.org/10.11648/j.ass.20210902.12

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ACS Style

Lali Bugadze; Nino Manjavidze; Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv. Surg. Sci. 2021, 9(2), 20-24. doi: 10.11648/j.ass.20210902.12

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AMA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv Surg Sci. 2021;9(2):20-24. doi: 10.11648/j.ass.20210902.12

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@article{10.11648/j.ass.20210902.12,
  author = {Lali Bugadze and Nino Manjavidze and Lia Jor Joliani},
  title = {Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma},
  journal = {Advances in Surgical Sciences},
  volume = {9},
  number = {2},
  pages = {20-24},
  doi = {10.11648/j.ass.20210902.12},
  url = {https://doi.org/10.11648/j.ass.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20210902.12},
  abstract = {Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.},
 year = {2021}
}

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TY  - JOUR
T1  - Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma
AU  - Lali Bugadze
AU  - Nino Manjavidze
AU  - Lia Jor Joliani
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ass.20210902.12
DO  - 10.11648/j.ass.20210902.12
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
SP  - 20
EP  - 24
PB  - Science Publishing Group
SN  - 2376-6182
UR  - https://doi.org/10.11648/j.ass.20210902.12
AB  - Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.
VL  - 9
IS  - 2
ER  -

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Author Information

Lali Bugadze

School of Medicine and Stomatology, David Aghmashenebeli University of Georgia, Tbilisi, Georgia
Nino Manjavidze

School of Medicine and Stomatology, David Aghmashenebeli University of Georgia, Tbilisi, Georgia
Lia Jor Joliani

School of Medicine and Stomatology, David Aghmashenebeli University of Georgia, Tbilisi, Georgia

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Plain Text BibTeX RIS

APA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. (2021). Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Advances in Surgical Sciences, 9(2), 20-24. https://doi.org/10.11648/j.ass.20210902.12

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ACS Style

Lali Bugadze; Nino Manjavidze; Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv. Surg. Sci. 2021, 9(2), 20-24. doi: 10.11648/j.ass.20210902.12

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AMA Style

Lali Bugadze, Nino Manjavidze, Lia Jor Joliani. Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma. Adv Surg Sci. 2021;9(2):20-24. doi: 10.11648/j.ass.20210902.12

Copy | Download

@article{10.11648/j.ass.20210902.12,
  author = {Lali Bugadze and Nino Manjavidze and Lia Jor Joliani},
  title = {Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma},
  journal = {Advances in Surgical Sciences},
  volume = {9},
  number = {2},
  pages = {20-24},
  doi = {10.11648/j.ass.20210902.12},
  url = {https://doi.org/10.11648/j.ass.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20210902.12},
  abstract = {Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma
AU  - Lali Bugadze
AU  - Nino Manjavidze
AU  - Lia Jor Joliani
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ass.20210902.12
DO  - 10.11648/j.ass.20210902.12
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
SP  - 20
EP  - 24
PB  - Science Publishing Group
SN  - 2376-6182
UR  - https://doi.org/10.11648/j.ass.20210902.12
AB  - Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.
VL  - 9
IS  - 2
ER  -

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