Comparison of Radiology and Histopathology in Thymic Epithelial Tumours

Blane Gordon McMillan; Sanjeet Avtaar Singh; Sudeep Das De; Alan Kirk

doi:doi:10.11648/j.ass.20170501.12

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Comparison of Radiology and Histopathology in Thymic Epithelial Tumours

Blane Gordon McMillan, Sanjeet Avtaar Singh, Sudeep Das De, Alan Kirk

Published in Advances in Surgical Sciences (Volume 5, Issue 1)

Received: 24 February 2017 Accepted: 28 March 2017 Published: 17 April 2017

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Abstract

Tumours of the thymus gland have a limited evidence base due to their low incidence rate. The Masaoka-Koga staging system has been known as the strongest prognostic indicator for both survival and recurrence of thymic tumours but there is no standardised way to assess clinical staging in pre-operative images. As appropriate staging can influence patients’ need for adjuvant therapy, it is important to evaluate if current imaging can accurately predict post-operative staging. This was a retrospective study comparing the pre-operative radiological staging and post-operative pathological staging of 34 patients. This was conducted at the Golden Jubilee National Hospital between March 2013 and October 2016. A Kappa statistic was used to evaluate agreement between the assessments. 61.8% (21 out of 34) of the CT stages agreed with the pathology stages: 78.6% (11 out of 14) in stage I; 41.7% (5 out of 12) in stage II; 40% (2 out of 5) in stage III; and 100% (3 out of 3) in stage IV. There was moderate agreement between the preoperative CT assessment and the post-operative pathological staging (kappa coefficient = 0.42, p value < 0.01). With further analysis of a larger sample size it could be concluded that radiological staging of thymic tumours before surgery is quite accurate but requires standardisation and utilisation of other imaging techniques to ensure appropriate levels of care.

Published in	Advances in Surgical Sciences (Volume 5, Issue 1)
DOI	10.11648/j.ass.20170501.12
Page(s)	7-14
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Thymoma, Masaoka-Koga Staging, Histopathology

References

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[11]	DETTERBECK, F. C., NICHOLSON, A. G., KONDO, K., VAN SCHIL, P. & MORAN, C. 2011. The Masaoka-Koga stage classification for thymic malignancies: clarification and definition of terms. J Thorac Oncol, 6, S1710-6.
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APA Style

Blane Gordon McMillan, Sanjeet Avtaar Singh, Sudeep Das De, Alan Kirk. (2017). Comparison of Radiology and Histopathology in Thymic Epithelial Tumours. Advances in Surgical Sciences, 5(1), 7-14. https://doi.org/10.11648/j.ass.20170501.12

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ACS Style

Blane Gordon McMillan; Sanjeet Avtaar Singh; Sudeep Das De; Alan Kirk. Comparison of Radiology and Histopathology in Thymic Epithelial Tumours. Adv. Surg. Sci. 2017, 5(1), 7-14. doi: 10.11648/j.ass.20170501.12

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AMA Style

Blane Gordon McMillan, Sanjeet Avtaar Singh, Sudeep Das De, Alan Kirk. Comparison of Radiology and Histopathology in Thymic Epithelial Tumours. Adv Surg Sci. 2017;5(1):7-14. doi: 10.11648/j.ass.20170501.12

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@article{10.11648/j.ass.20170501.12,
  author = {Blane Gordon McMillan and Sanjeet Avtaar Singh and Sudeep Das De and Alan Kirk},
  title = {Comparison of Radiology and Histopathology in Thymic Epithelial Tumours},
  journal = {Advances in Surgical Sciences},
  volume = {5},
  number = {1},
  pages = {7-14},
  doi = {10.11648/j.ass.20170501.12},
  url = {https://doi.org/10.11648/j.ass.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20170501.12},
  abstract = {Tumours of the thymus gland have a limited evidence base due to their low incidence rate. The Masaoka-Koga staging system has been known as the strongest prognostic indicator for both survival and recurrence of thymic tumours but there is no standardised way to assess clinical staging in pre-operative images. As appropriate staging can influence patients’ need for adjuvant therapy, it is important to evaluate if current imaging can accurately predict post-operative staging. This was a retrospective study comparing the pre-operative radiological staging and post-operative pathological staging of 34 patients. This was conducted at the Golden Jubilee National Hospital between March 2013 and October 2016. A Kappa statistic was used to evaluate agreement between the assessments. 61.8% (21 out of 34) of the CT stages agreed with the pathology stages: 78.6% (11 out of 14) in stage I; 41.7% (5 out of 12) in stage II; 40% (2 out of 5) in stage III; and 100% (3 out of 3) in stage IV. There was moderate agreement between the preoperative CT assessment and the post-operative pathological staging (kappa coefficient = 0.42, p value < 0.01). With further analysis of a larger sample size it could be concluded that radiological staging of thymic tumours before surgery is quite accurate but requires standardisation and utilisation of other imaging techniques to ensure appropriate levels of care.},
 year = {2017}
}

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TY  - JOUR
T1  - Comparison of Radiology and Histopathology in Thymic Epithelial Tumours
AU  - Blane Gordon McMillan
AU  - Sanjeet Avtaar Singh
AU  - Sudeep Das De
AU  - Alan Kirk
Y1  - 2017/04/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ass.20170501.12
DO  - 10.11648/j.ass.20170501.12
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
SP  - 7
EP  - 14
PB  - Science Publishing Group
SN  - 2376-6182
UR  - https://doi.org/10.11648/j.ass.20170501.12
AB  - Tumours of the thymus gland have a limited evidence base due to their low incidence rate. The Masaoka-Koga staging system has been known as the strongest prognostic indicator for both survival and recurrence of thymic tumours but there is no standardised way to assess clinical staging in pre-operative images. As appropriate staging can influence patients’ need for adjuvant therapy, it is important to evaluate if current imaging can accurately predict post-operative staging. This was a retrospective study comparing the pre-operative radiological staging and post-operative pathological staging of 34 patients. This was conducted at the Golden Jubilee National Hospital between March 2013 and October 2016. A Kappa statistic was used to evaluate agreement between the assessments. 61.8% (21 out of 34) of the CT stages agreed with the pathology stages: 78.6% (11 out of 14) in stage I; 41.7% (5 out of 12) in stage II; 40% (2 out of 5) in stage III; and 100% (3 out of 3) in stage IV. There was moderate agreement between the preoperative CT assessment and the post-operative pathological staging (kappa coefficient = 0.42, p value < 0.01). With further analysis of a larger sample size it could be concluded that radiological staging of thymic tumours before surgery is quite accurate but requires standardisation and utilisation of other imaging techniques to ensure appropriate levels of care.
VL  - 5
IS  - 1
ER  -

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Author Information

Blane Gordon McMillan

College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland
Sanjeet Avtaar Singh

Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow, Scotland
Sudeep Das De

Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow, Scotland
Alan Kirk

Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow, Scotland

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Plain Text BibTeX RIS

APA Style

Blane Gordon McMillan, Sanjeet Avtaar Singh, Sudeep Das De, Alan Kirk. (2017). Comparison of Radiology and Histopathology in Thymic Epithelial Tumours. Advances in Surgical Sciences, 5(1), 7-14. https://doi.org/10.11648/j.ass.20170501.12

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ACS Style

Blane Gordon McMillan; Sanjeet Avtaar Singh; Sudeep Das De; Alan Kirk. Comparison of Radiology and Histopathology in Thymic Epithelial Tumours. Adv. Surg. Sci. 2017, 5(1), 7-14. doi: 10.11648/j.ass.20170501.12

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AMA Style

Blane Gordon McMillan, Sanjeet Avtaar Singh, Sudeep Das De, Alan Kirk. Comparison of Radiology and Histopathology in Thymic Epithelial Tumours. Adv Surg Sci. 2017;5(1):7-14. doi: 10.11648/j.ass.20170501.12

Copy | Download

@article{10.11648/j.ass.20170501.12,
  author = {Blane Gordon McMillan and Sanjeet Avtaar Singh and Sudeep Das De and Alan Kirk},
  title = {Comparison of Radiology and Histopathology in Thymic Epithelial Tumours},
  journal = {Advances in Surgical Sciences},
  volume = {5},
  number = {1},
  pages = {7-14},
  doi = {10.11648/j.ass.20170501.12},
  url = {https://doi.org/10.11648/j.ass.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20170501.12},
  abstract = {Tumours of the thymus gland have a limited evidence base due to their low incidence rate. The Masaoka-Koga staging system has been known as the strongest prognostic indicator for both survival and recurrence of thymic tumours but there is no standardised way to assess clinical staging in pre-operative images. As appropriate staging can influence patients’ need for adjuvant therapy, it is important to evaluate if current imaging can accurately predict post-operative staging. This was a retrospective study comparing the pre-operative radiological staging and post-operative pathological staging of 34 patients. This was conducted at the Golden Jubilee National Hospital between March 2013 and October 2016. A Kappa statistic was used to evaluate agreement between the assessments. 61.8% (21 out of 34) of the CT stages agreed with the pathology stages: 78.6% (11 out of 14) in stage I; 41.7% (5 out of 12) in stage II; 40% (2 out of 5) in stage III; and 100% (3 out of 3) in stage IV. There was moderate agreement between the preoperative CT assessment and the post-operative pathological staging (kappa coefficient = 0.42, p value < 0.01). With further analysis of a larger sample size it could be concluded that radiological staging of thymic tumours before surgery is quite accurate but requires standardisation and utilisation of other imaging techniques to ensure appropriate levels of care.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Comparison of Radiology and Histopathology in Thymic Epithelial Tumours
AU  - Blane Gordon McMillan
AU  - Sanjeet Avtaar Singh
AU  - Sudeep Das De
AU  - Alan Kirk
Y1  - 2017/04/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ass.20170501.12
DO  - 10.11648/j.ass.20170501.12
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
SP  - 7
EP  - 14
PB  - Science Publishing Group
SN  - 2376-6182
UR  - https://doi.org/10.11648/j.ass.20170501.12
AB  - Tumours of the thymus gland have a limited evidence base due to their low incidence rate. The Masaoka-Koga staging system has been known as the strongest prognostic indicator for both survival and recurrence of thymic tumours but there is no standardised way to assess clinical staging in pre-operative images. As appropriate staging can influence patients’ need for adjuvant therapy, it is important to evaluate if current imaging can accurately predict post-operative staging. This was a retrospective study comparing the pre-operative radiological staging and post-operative pathological staging of 34 patients. This was conducted at the Golden Jubilee National Hospital between March 2013 and October 2016. A Kappa statistic was used to evaluate agreement between the assessments. 61.8% (21 out of 34) of the CT stages agreed with the pathology stages: 78.6% (11 out of 14) in stage I; 41.7% (5 out of 12) in stage II; 40% (2 out of 5) in stage III; and 100% (3 out of 3) in stage IV. There was moderate agreement between the preoperative CT assessment and the post-operative pathological staging (kappa coefficient = 0.42, p value < 0.01). With further analysis of a larger sample size it could be concluded that radiological staging of thymic tumours before surgery is quite accurate but requires standardisation and utilisation of other imaging techniques to ensure appropriate levels of care.
VL  - 5
IS  - 1
ER  -

Copy | Download