2. Factors Influencing on Global Public Attitude and Acceptance Towards Modern Biotechnology
Public opinion on a specific technology can be evaluated through six main categories (agreement, knowledge, technical, economic, social, and political), with the effectiveness of each category in advancing the overall solution regularly evaluated. However, only four of these categories—agreement, knowledge, technology, and social—closely aligned with attitude factors, while economic and political considerations had minimal impact on the acceptance of modern biotechnology
[27] | Amin OM, Heckmann RA, Dallarés S, Constenla M, Ha NV. Morphological and molecular description of Rhadinorhynchus laterospinosus Amin, Heckmann & Ha, 2011 (Acanthocephala, Rhadinorhynchidae) from marine fish off the Pacific coast of Vietnam. Parasite. 2019; 26: 14. https://doi.org/10.1051/parasite/2019015 Epub 2019 Mar 6. PMID: 30838975; PMCID: PMC6402367. |
[27]
. During the initial commercial rollout of genetically modified (GM) foods, only a small fraction of farmers in the United States of America (USA) were willing to gamble on the commercial viability of GM crops. However, over time, US farmers have increasingly recognized the potential benefits of GM crops in the global agricultural market. This understanding has led to a significant growth in commercial large-scale plantings of GM crops, with annual increases exceeding 10%, expanding from 1.7 hectares to 58.7 million hectares
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
Asians exhibit less worry about genetically engineered therapeutic items compared to genetically modified food. Conversely, in Europe, public awareness of GM technology and its current implementation level is lacking. Concerns persist regarding the long-term effects of genetically modified food on the environment and human health, and skepticism surrounds its potential benefits for farmers and consumers
[27] | Amin OM, Heckmann RA, Dallarés S, Constenla M, Ha NV. Morphological and molecular description of Rhadinorhynchus laterospinosus Amin, Heckmann & Ha, 2011 (Acanthocephala, Rhadinorhynchidae) from marine fish off the Pacific coast of Vietnam. Parasite. 2019; 26: 14. https://doi.org/10.1051/parasite/2019015 Epub 2019 Mar 6. PMID: 30838975; PMCID: PMC6402367. |
[27]
. Acceptance of modern biotechnology in Ghana is mediocre to low, evident in the public's understanding and the necessity of creating new genetically modified crop varieties to address food insecurity, poverty, and malnutrition, crucial for Africa's burgeoning modern biotechnology sector
[16] | McCullum, C., Benbrook, C., Knowles, L., Roberts, S., & Schryver, T. (2003). Application of modern biotechnology to food and agriculture: food systems perspective. Journal of Nutrition Education and Behavior, 35(6), 319-332. |
[16]
. Concerned Ghanaians fear that GM products primarily favor large multinational corporations, amplifying their distrust in the government
[27] | Amin OM, Heckmann RA, Dallarés S, Constenla M, Ha NV. Morphological and molecular description of Rhadinorhynchus laterospinosus Amin, Heckmann & Ha, 2011 (Acanthocephala, Rhadinorhynchidae) from marine fish off the Pacific coast of Vietnam. Parasite. 2019; 26: 14. https://doi.org/10.1051/parasite/2019015 Epub 2019 Mar 6. PMID: 30838975; PMCID: PMC6402367. |
[27]
.
2.1. Globally Genetic Engineering Crops and Their Role in Building Global Food Security
Meeting the needs of the planet's expanding population requires a 25 to 70 percent increase in global food production. While expanding farmable land seems a solution, the majority is already utilized for various agricultural purposes. Approximately 36% of the world's total land area, around 4.7 billion hectares, is classified as agricultural, with 10.8% deemed arable. Genetic engineering's role in food security prompts public debate
[28] | N. Muzhinji and V. Ntuli, “Genetically modified organisms and food security in Southern Africa: conundrum and discourse,” GM Crops & Food, vol. 12, no. 1, pp. 25–35, 2021. |
[28]
.
The advancement of genetically modified crops can boost food production, availability, and nutritional quality. Additional benefits encompass decreased pesticide exposure, reduced cancer incidences, fewer farmer suicides, and improved mental well-being among farmers
[22] | Zaidi, S. S. E. A., Vanderschuren, H., Qaim, M., Mahfouz, M. M., Kohli, A., Mansoor, S., & Tester, M. (2019). New plant breeding technologies for food security. Science, 363(6434), 1390-1391. |
[22]
. Genetic engineering and GM in agriculture aim to create crops with enhanced nutritional content, resilience against emerging diseases and environmental stresses, and the capacity to minimize pesticide usage. As per the International Service for the Assessment of Agri-biotech applications, regulatory approval has been granted in 44 countries for 436 GM events, comprising 33 plant species and 44 commercial traits utilized in food, feed, and cultivation
[33] | KNBS and ICF, Kenya Demographic and Health Survey 2022, Kenya National Bureau of Statistics, Nairobi, Kenya, and Rockville, Maryland, USA, 2022. |
[33]
. The most commonly targeted features are herbicide tolerance and insect resistance, followed by improved product quality, a pollination control system, disease resistance, abiotic stress tolerance, and changed growth and yield
[35] | K. Ala-Kokko, Economic and ecosystem impacts of GM maize in South Africa, Graduate thesis and dissertations, University of Arkansas, Fayetteville, 2021. |
[35]
.
The most widely modified plants (by events) are maize (
Zea mays) - 152, cotton (
Gossypium hirstum L.), potato (
Solanum tuberosum L.), soybean (
Glycine max L.), and Argentine canola (
Brassicanapus). The top countries that have grown GM plants are being produced in 47 African countries, with South Africa leading the continent in production
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
2.1.1. Latin America
Latin American nations cultivate 44% of the world's GM crop area, with Brazil and Argentina among the top five GM farming countries. Furthermore, eight Latin American countries, including Brazil, Chile, Colombia, Ecuador, Guatemala, Honduras, Paraguay, and Argentina, have implemented regulatory frameworks for NBTs and are actively engaged in research to develop their own genetically engineered foods and crops
[28] | N. Muzhinji and V. Ntuli, “Genetically modified organisms and food security in Southern Africa: conundrum and discourse,” GM Crops & Food, vol. 12, no. 1, pp. 25–35, 2021. |
[28]
. In Brazil, a tomato rich in antioxidants and high lycopene content was developed. Researchers at the University of Costa Rica are employing gene editing in rice, specifically targeting drought tolerance. Similarly, studies in Argentina utilized genetic engineering methods to produce potatoes that resist browning
[13] | Haile, G., Adamu, M., & Tekle, T. (2020). The effects of genetically modified organisms (GMO) on environment and molecular techniques to minimize its risk. American Journal of Polymer Science and Technology, 6(4), 32-39. |
[13]
. Ecuador, Venezuela, and Peru prohibit the commercial cultivation of genetically modified crops. While Ecuador permits imports of GM foods if labeled, Announcement 752 in Ecuador established a regulatory framework for "genetically improved organisms" exempting products without foreign genes from risk assessment. Mexico's President banned GMO corn imports and licenses, despite being a major importer of GMO corn and soybeans
[17] | Moualhi, I., Galhena, H., Maredia, K., & Weebadde, C. (2014). Perceptions of non-Europeans on biotechnology in Europe: Bridging the knowledge gap. Asian Biotechnology and Development Review, 16(2), 43-52. |
[17]
.
2.1.2. Europe
In 2020, Europe cultivated only one biotech crop, GM maize, limited to Spain and Portugal. Renewed authorization was granted for two maize varieties and one oilseed rape for food and animal feed use, along with approval for importing seven GM crops. Although GM cultivation remains illegal in most EU countries, 109 GM events have been approved for import, primarily benefiting from soybean, canola, maize, and cotton imports
[32] | WHO (World Health Organization), “Responding to community spread of COVID-19,” Reference WHO/COVID-19/ Community Transmission/2020.1, Accessed on 15th August2023, 2020. |
[32]
. New legislation was introduced in the UK to enable researchers to conduct field trials on specific GE plants. Despite this, field studies still require registration via a notification process. The next step involves assessing regulatory definitions of GMOs to exclude species developed through GE or other genetic methods if conventional breeding could have achieved the same for commercial release and cultivation
[8] | Ashebir Seyoum Feyisa (2022). Potential Impact of using Genetically Modified Crops in Ethiopia: A Review. Agricultural Reviews, 43(4), 419-427. |
[8]
.
2.1.3. Africa
Africa holds the highest potential for GM crop adoption. South Africa planted maize, soybean, and cotton on 2.7 million hectares, while Sudan, Malawi, Nigeria, Eswatini, and Ethiopia grew cotton on a combined 2.9 million hectares. Nigeria particularly stands out as a leader in GM crop adoption
[34] | C. N. Kunyanga, F. B. Morten, K. Hyams, S. Mburu, G. Werikhe, and C. M. Onyango, “Perceptions of the governance of the technological risks of food innovations for addressing food security,” Sustainability, vol. 15, no. 15, Article ID 11503, 2023. |
[34]
. The government has allowed the cultivation of Bt-cowpea in 2019 and has now approved the release of drought tolerant and insect resistant maize (TELA)
[33] | KNBS and ICF, Kenya Demographic and Health Survey 2022, Kenya National Bureau of Statistics, Nairobi, Kenya, and Rockville, Maryland, USA, 2022. |
[33]
. Africa exhibits the greatest potential for adopting GM crops. In South Africa, maize, soybean, and cotton were cultivated across 2.7 million hectares. Additionally, cotton was grown in Sudan, Malawi, Nigeria, Eswatini, and Ethiopia, totaling 2.9 million hectares. Nigeria notably leads in the adoption of GM crops, highlighting the continent's growing embrace of this technology
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
2.1.4. North America
The United States has a rich history of developing, commercializing, and using GM plants and, more recently, animals. The Fla-vrSavr tomato, introduced in 1996, marked the first commercially available GM plant in the US. It was among the first countries to establish clear regulatory decisions on unique plant breeding advancements, followed by Canada. With 71.5 million hectares, the US leads in biotech crop cultivation, with over 90% of corn, cotton, and soybeans being genetically engineered. Its robust regulatory framework has significantly contributed to the progress and public acceptance of genetically altered plants
[30] | FAO, World Food and Agriculture—Statistical Yearbook 2022, Food and Agriculture Organization of the United Nations, Rome, 2022. |
[30]
. In 2017, GM non-browning apples were offered in US supermarkets. The first TALEN-based Genetic Engineering crop, a soybean with a changed oil content, was harvested on a modest scale in the fall of 2018
[34] | C. N. Kunyanga, F. B. Morten, K. Hyams, S. Mburu, G. Werikhe, and C. M. Onyango, “Perceptions of the governance of the technological risks of food innovations for addressing food security,” Sustainability, vol. 15, no. 15, Article ID 11503, 2023. |
[34]
. Health Canada has assessed GM foods for over two decades. Golden rice, a GM rice variant, gained commercial approval in Canada in March 2018, while non-browning potatoes were approved in 2016. A list of approved GM events in Canada is available in the ISAAA database. As of 2019, Canada permits the sale of around 140 genetically modified foods
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
2.1.5. Asia
In 1992, Asia saw its first commercialized GM crop with a virus-resistant tobacco. India, China, and Pakistan were the leading contributors to GM crop development in 2019. Japan and Australia have recently refined their regulatory frameworks and made initial determinations on several objects. In September 2021, Japan approved Madai, a CRISPR-edited red sea bream with 20% more flesh
[31] | Kunyanga Nkirote Catherine, B. Roy Mugiira, and N. Josephat Muchiri, “Public Perception of Genetically Modified Organisms and the Implementation of Biosafety Measures in Kenya”, Advances in Agriculture Volume 2024, Article ID 5544617, 15 pages https://doi.org/10.1155/2024/5544617 |
[31]
. The University of Tokyo's researchers developed high-yield canola and rice strains using a technique known as "mito-TALENs." In July 2021, the Philippines allowed the production of Bt eggplant for direct consumption, feed, or processing
[16] | McCullum, C., Benbrook, C., Knowles, L., Roberts, S., & Schryver, T. (2003). Application of modern biotechnology to food and agriculture: food systems perspective. Journal of Nutrition Education and Behavior, 35(6), 319-332. |
[16]
. Bt-eggplant, a genetically modified variety resistant to the eggplant fruit and shoot borer, promises significant benefits. Recent research indicates a projected 192% increase in marketable yield and a 48% reduction in insecticide usage per hectare upon its commercialization. Bangladesh is undergoing the final regulatory assessment of golden rice, with political leaders like Prime Minister Sheikh Hasina and Agricultural Minister Begum Matia Chowdhury advocating for GM food crop adoption to enhance economic and food security
[9] | Gastrow, M., Roberts, B., Reddy, V., & Ismail, S. (2018). Public perceptions of biotechnology in South Africa. South African Journal of Science, 114(1-2), 1-9. |
[9]
.
2.1.6. Australia and New Zealand
Australia has approved 142 GM crop events, with cultivation of GM cotton, canola, and safflower covering 0.6 million hectares. Products lacking foreign DNA are exempt from GMO regulation. Only one GE crop, developed with SDN-1 genome-editing, has been deregulated as a conventional variety. Researchers at Murdoch University used CRISPR to create a low-gluten potato. New Zealand regulates all GE crop varieties under GMO regulations
[34] | C. N. Kunyanga, F. B. Morten, K. Hyams, S. Mburu, G. Werikhe, and C. M. Onyango, “Perceptions of the governance of the technological risks of food innovations for addressing food security,” Sustainability, vol. 15, no. 15, Article ID 11503, 2023. |
[34]
. As of October 2021, no organization in New Zealand has applied for conditional or full-scale release of a GE plant. Nonetheless, the country allows the import of GE food products approved by Food Standards Australia New Zealand (FSANZ). These products, approved for direct human consumption or animal feed, are based on sanctioned GE events
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
2.2. Status of GMO Production in Ethiopia
As long as agricultural biotechnology is embraced by farmers all over the world, it will have a significant impact on agricultural production, as evidenced by the on-going expansion in the production of biotech crops
[13] | Haile, G., Adamu, M., & Tekle, T. (2020). The effects of genetically modified organisms (GMO) on environment and molecular techniques to minimize its risk. American Journal of Polymer Science and Technology, 6(4), 32-39. |
[13]
. African nations like Malawi, Kenya, and Nigeria are progressing from field trial experiments towards granting environmental release approvals for GM crops. Burkina Faso, Ghana, Ethiopia, Nigeria, Uganda, and Eswatini are making significant strides towards multi-location field trials for commercial approval. Tanzania has also expressed interest in GM crops. South Africa and Sudan lead GM crop production in Africa, with Egypt joining them in producing GM crops
[31] | Kunyanga Nkirote Catherine, B. Roy Mugiira, and N. Josephat Muchiri, “Public Perception of Genetically Modified Organisms and the Implementation of Biosafety Measures in Kenya”, Advances in Agriculture Volume 2024, Article ID 5544617, 15 pages https://doi.org/10.1155/2024/5544617 |
[31]
. At the request of the Ministry of Agriculture, the Ministry of Environment, Forest, and Climate (MEFC) in Ethiopia sanctioned the importation of Bt cotton seeds for field trials and research. Consequently, field trials for Bt cotton are ongoing at various locations within Ethiopia's cotton-producing regions
[13] | Haile, G., Adamu, M., & Tekle, T. (2020). The effects of genetically modified organisms (GMO) on environment and molecular techniques to minimize its risk. American Journal of Polymer Science and Technology, 6(4), 32-39. |
[13]
. The Bt Cotton crop is on the concluding stage, which will permit the commercialization of the crop
[12] | Godheja, J. (2013). Impact of GMO ‘S on environment and human health. Recent Research in Science and Technology, 5(5). |
[12]
. The Ethiopian Agricultural Research Institute's agricultural biotechnology sector is likely to introduce biotech Bt cotton seed varieties to farmers within the next one to two years. The outcome of this trial will significantly influence the development of other transgenic crops in the country
[10] | Gebretsadik, K., & Kiflu, A. (2018). Challenges and opportunities of genetically modified crops production; future perspectives in ethiopia, review. The Open Agriculture Journal, 12(1). |
[10]
.
Ethiopia has permitted the commercial cultivation of genetically modified (GM) cotton and field research on GM maize to boost agricultural productivity and security. After two years of controlled field trials conducted by the Ethiopian Institute of Agricultural Research (EIAR), the Ministry of Environment, Forest, and Climate (MEFC) approved the environmental release of Bt cotton. The two cotton hybrids slated for commercial cultivation underwent rigorous testing to ensure compatibility with Ethiopia's growing conditions.
[19] | Terefe, M. (2018). Biosafety issues of genetically modified crops: Addressing the potential risks and the status of GMO crops in Ethiopia. Clon Transgen, 7(2), 164. |
[19]
. Ethiopia must thus evaluate the benefits that may arise from the use of biotechnology and the potential difficulties that may be met by the cultivation of GM crops if it is to feed its alarmingly expanding population
[14] | Hanumanthaiah, P., & Alemu, A. C. (2021). Plant Biotechnology in Ethiopia: Current Status, Opportunities and Challenges. Plant Cell Biotechnology and Molecular Biology, 22(13&14), 136-156. |
[14]
.
2.3. Challenges and Opportunities of Genetically Modified Crops
Biotechnology is revolutionizing science, offering hope for addressing hunger, malnutrition, and reducing reliance on animal and plant-based industrial resources. Despite its promise, concerns persist about biosafety, particularly regarding the potential unforeseen and harmful impacts of GM crops on human health, the environment, and both target and non-target organisms
[22] | Zaidi, S. S. E. A., Vanderschuren, H., Qaim, M., Mahfouz, M. M., Kohli, A., Mansoor, S., & Tester, M. (2019). New plant breeding technologies for food security. Science, 363(6434), 1390-1391. |
[22]
. Many countries are adopting international and national biosafety regulations to address potential issues. America, Brazil, Belgium, China, and India are prominent users of GM crops globally, while Egypt, Sudan, South Africa, and Burkina Faso lead GM crop production in Africa. Ethiopia has established its own policy and biosafety regulations for biotechnology products, recognizing the importance of GM crops in enhancing agricultural quality and output
[33] | KNBS and ICF, Kenya Demographic and Health Survey 2022, Kenya National Bureau of Statistics, Nairobi, Kenya, and Rockville, Maryland, USA, 2022. |
[33]
. Bt cotton, which contains a toxic protein from
Bacillus thuringiensis, was recently introduced to Ethiopia and is expected to fundamentally alter how fibers are produced for the textile industry
[13] | Haile, G., Adamu, M., & Tekle, T. (2020). The effects of genetically modified organisms (GMO) on environment and molecular techniques to minimize its risk. American Journal of Polymer Science and Technology, 6(4), 32-39. |
[13]
. It will also have a significant impact on how modern biotechnological science will be used in the country in the coming years. The introduction of Bt cotton is a typical example worth mentioning here which shows a relative flexibility of the current Ethiopian biosafety regulation
[6] | Einsiedel, E. (2012). The landscape of public participation on biotechnology. In M. Weitz, M. Puhler, W. M. Heckle, B. Muller-Rober, and O. Renn (Eds.), Biotechnologie-Kommunikation: Kontroversen, Analysen, Aktivitäten (pp. 379–412). Springer., Chapter Google Scholar. |
[6]
.
2.4. Bio Policy for Biotechnology Products, Regulatory Frameworks of Governments
Regulatory frameworks play a crucial role in overseeing the development and sale of biotechnology products. They typically involve a comprehensive evaluation to determine effectiveness, safety, and potential risks. This assessment includes details on intended use, manufacturing, composition, and environmental impact. Pre-market evaluations, possible clinical trials, and post-market surveillance are common components of this process
[22] | Zaidi, S. S. E. A., Vanderschuren, H., Qaim, M., Mahfouz, M. M., Kohli, A., Mansoor, S., & Tester, M. (2019). New plant breeding technologies for food security. Science, 363(6434), 1390-1391. |
[22]
.
2.4.1. Risk Assessment and Management on Genetically Modified Crops
Bio policy underscores the necessity of conducting thorough risk assessments for biotechnology products. It involves evaluating potential risks to the environment, animal welfare, and public health, followed by implementing risk management strategies to mitigate or eliminate identified hazards. These strategies may include labeling regulations, adverse event monitoring systems, containment protocols during research, and procedures for addressing unintentional releases or contamination
[21] | Wesseler, J., & Kalaitzandonakes, N. (2019). Present and future EU GMO policy. EU Bio economy Economics and Policies: Volume II, 245-256. |
[21]
.
2.4.2. Ethical Considerations
Bio policies address moral dilemmas arising from biotechnology use, including informed consent in human subject research, genetic privacy, equal access to medical technology, and cultural and biodiversity preservation. Ethical standards guide the development and implementation of biotechnological advancements, ensuring they align with human rights, social equity, and environmental conservation
[12] | Godheja, J. (2013). Impact of GMO ‘S on environment and human health. Recent Research in Science and Technology, 5(5). |
[12]
.
2.4.3. Intellectual Property Rights
Bio policy often addresses intellectual property rights (IPR) concerning biotechnology products. These rights grant the assignee or inventor full control over the invention's development, production, and marketing. While IPR protection promotes investment and research in biotechnology, it also raises concerns about equitable access to essential technologies, healthcare product costs, and benefit distribution
[10] | Gebretsadik, K., & Kiflu, A. (2018). Challenges and opportunities of genetically modified crops production; future perspectives in ethiopia, review. The Open Agriculture Journal, 12(1). |
[10]
.
2.4.4. International Cooperation and Harmonization
International cooperation and policy alignment are vital in the global landscape of biotechnology. Nations collaborate through entities like the WHO, FAO, and WTO to create unified standards, regulations, and guidelines. Harmonization initiatives aim to streamline trade, ensure uniform safety protocols, and overcome regulatory barriers that could impede the advancement and acceptance of biotechnology products
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
2.4.5. Public Engagement and Communication
Bio policies acknowledge the significance of public engagement and communication in shaping the development and acceptance of biotechnology products. Governments and regulatory bodies aim to engage stakeholders, including scientists, industry representatives, consumer groups, environmental organizations, and the public, in decision-making processes. Transparent communication about risks, benefits, and regulatory decisions builds trust, addresses concerns, and encourages informed public debate
[17] | Moualhi, I., Galhena, H., Maredia, K., & Weebadde, C. (2014). Perceptions of non-Europeans on biotechnology in Europe: Bridging the knowledge gap. Asian Biotechnology and Development Review, 16(2), 43-52. |
[17]
.
2.5. Intellectual Property Rights
Protecting the inventions and investments made by businesses and individuals in the field of biotechnology is essential for modern biotechnology goods
[18] | Oberthür, S., Pozarowska, J., Rabitz, F., Gerstetter, C., Christine Lucha, K. M., & Tedsen, E. (2011). Intellectual Property Rights on Genetic Resources and the Fight against Poverty. |
[18]
. As biotechnology continues to advance rapidly, intellectual property rights become increasingly important to incentivize innovation, ensure fair competition, and enable the commercialization of biotech products. These rights provide exclusive control over the use and exploitation of the protected creations, allowing the creators to benefit from their work and prevent others from using it without permission
[11] | Giugni, D., & Giugni, V. (2010). Intellectual property: a powerful tool to develop biotech research. Microbial biotechnology, 3(5), 493-506. |
[11]
. In the context of modern biotechnology products, there are several types of intellectual property rights that can be utilized:
2.5.1. Patents
Patents are a widely employed method of safeguarding intellectual property in biotechnology. They afford the owner exclusive rights to an invention for typically 20 years. Various biotech products, like novel genes, GMOs, and diagnostic methods, are eligible for patents. Through patents, innovators can prohibit unauthorized creation, use, sale, or importation of their innovation. An invention must meet criteria of novelty, inventive step, and industrial applicability to qualify for patent protection
[11] | Giugni, D., & Giugni, V. (2010). Intellectual property: a powerful tool to develop biotech research. Microbial biotechnology, 3(5), 493-506. |
[11]
.
2.5.2. Copyright
Copyright protection extends beyond traditional creative works to include software utilized in genetic analysis and bioinformatics within the biotechnology domain. This protection grants authors exclusive rights over their work for a specified duration, allowing them sole authority to reproduce, distribute, display, perform, and modify it
[13] | Haile, G., Adamu, M., & Tekle, T. (2020). The effects of genetically modified organisms (GMO) on environment and molecular techniques to minimize its risk. American Journal of Polymer Science and Technology, 6(4), 32-39. |
[13]
.
2.5.3. Trade Secrets
Trade secrets are confidential information that offer a competitive edge to businesses, especially in biotechnology. These secrets encompass proprietary formulas, manufacturing methods, research findings, customer lists, etc. Unlike patents or copyrights, trade secrets don't need registration or disclosure for protection. Instead, safeguarding secrecy and implementing reasonable measures to prevent unauthorized access or disclosure are essential
[18] | Oberthür, S., Pozarowska, J., Rabitz, F., Gerstetter, C., Christine Lucha, K. M., & Tedsen, E. (2011). Intellectual Property Rights on Genetic Resources and the Fight against Poverty. |
[18]
.
2.5.4. Plant Variety Protection (PVP)
Plant Variety Protection (PVP) is a specialized form of intellectual property protection used to safeguard new, uniform, and stable plant species. It provides plant breeders with exclusive rights to develop, market, and distribute the protected plant variety for a specified duration. PVP is vital in modern biotechnology as it enables the protection of crops or plants that have undergone enhanced breeding techniques
[20] | Van Eenennaam, A. L., & Young, A. E. (2018). Public perception of animal biotechnology. Animal Biotechnology 2: Emerging Breeding Technologies, 275-303. |
[20]
.
2.5.5. Trademarks
Despite not being explicitly related to biotechnology products themselves, trademarks are crucial for branding and differentiating items in the market. Trademarks can be used to protect the names, logos, phrases, and other distinctive signs associated with biotech products. They help consumers distinguish between diverse brands and provide legal protection against unauthorized usage or intellectual property violation
[14] | Hanumanthaiah, P., & Alemu, A. C. (2021). Plant Biotechnology in Ethiopia: Current Status, Opportunities and Challenges. Plant Cell Biotechnology and Molecular Biology, 22(13&14), 136-156. |
[14]
.
2.6. Intellectual Property Rights and Patents
Biotechnology intellectual property laws address various issues, including patentability of genes, gene sequences, and derived parts from humans, animals, plants, and microorganisms. The main types of intellectual property rights (IPRs) in agricultural biotechnology are patents, material transfer agreements, and plant breeder's rights. Patents offer robust protection for genetically modified plants and associated processes. Material transfer agreements govern the exchange of biological materials for research purposes
[12] | Godheja, J. (2013). Impact of GMO ‘S on environment and human health. Recent Research in Science and Technology, 5(5). |
[12]
.
2.7. Agreement on Trade-Related Intellectual Property Rights (TRIPS Agreement)
The TRIPS Agreement sets the minimal requirements for intellectual property protection at the global level. According to the TRIPS Agreement, which specifies the circumstances under which patents must be awarded; nations are required to do so for all technological sectors, including biotechnology
[14] | Hanumanthaiah, P., & Alemu, A. C. (2021). Plant Biotechnology in Ethiopia: Current Status, Opportunities and Challenges. Plant Cell Biotechnology and Molecular Biology, 22(13&14), 136-156. |
[14]
. The TRIPs agreement was a significant step towards making international intellectual property systems legally binding
[32] | WHO (World Health Organization), “Responding to community spread of COVID-19,” Reference WHO/COVID-19/ Community Transmission/2020.1, Accessed on 15th August2023, 2020. |
[32]
. The TRIPS Agreement acknowledges seven types of intellectual property rights (IPRs), encompassing copyright, trademarks, geographical indications, industrial designs, patents (including plant varieties and layout-designs), and protection of confidential information. It suggests the potential for a sui generis regime to safeguard indigenous knowledge databases, thereby protecting traditional knowledge
[24] | S. A. O. Adeyeye and F. Idowu-Adebayo, “Genetically modified and biofortified crops and food security in developing countries: a review,” Nutrition & Food Sc ence, vol. 49, no. 5, pp. 978–986, 2019. |
[24]
.
The issue of intellectual property protection on a worldwide scale has caused conflict between wealthy and developing countries. The protection of IPRs in agricultural biotechnology is the most recent example of the confrontation between industrialized and developing countries accusing one another of bio-piracy
[18] | Oberthür, S., Pozarowska, J., Rabitz, F., Gerstetter, C., Christine Lucha, K. M., & Tedsen, E. (2011). Intellectual Property Rights on Genetic Resources and the Fight against Poverty. |
[18]
. During the WTO's Uruguay Round negotiations, poor countries reluctantly backed the TRIPS Agreement. The global significance of intellectual property rights (IPRs) in agriculture emerged through the establishment of international structures like the CBD and WTO, and the signing of ITPGRFA. TRIPS includes clauses on competition law, allowing members to limit licensing practices that may abuse IPR and harm competition, while requiring new product creation for partial patent utilization
[23] | Pandey, P., & Sharma, A. (2020). Swinging between responsibility and rationality—Science policy and technology visions in India. In L. Nierling, H. Torgerson (Eds.), Die neutrale Normativität der Technikfolgenabschätzung (pp. 155–174). Nomos. Google Scholar. |
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GMO Production across Different Regions in the World
Since GMOs entered the market, global studies on public perception of genetic engineering have increased. Scientific advancements in genetic engineering have reignited public interest in biotechnology. About 69% of respondents worldwide support biotech use in crops, with 58% of Americans favoring it in food. However, 33% in the US oppose its application
[29] | International Service for the Acquisition of Agri-biotech Applications (ISAAA), “Global status of commercialized biotech/GM crops in 2019,” (accessed on 4 February 2023), (ISAAA Brief 55), 2020. |
[29]
.
Research in Latin America indicates varying levels of acceptance based on context. For instance, in Brazil, genetic modification for drug and vaccine production is more widely accepted (87%) than for crops (81%) or food (66%). Similarly, in Jamaica, 58% of respondents support using genetic engineering to enhance crop plants
[8] | Ashebir Seyoum Feyisa (2022). Potential Impact of using Genetically Modified Crops in Ethiopia: A Review. Agricultural Reviews, 43(4), 419-427. |
[8]
. Costa Ricans generally perceive little to no harm from consuming genetically engineered food. However, 21% express concern about potential health and environmental risks. In Mexico, over 60% view GM food as a solution to world hunger, while 39% fear risks to future generations' safety, 35% see potential harm, and 46% worry about disrupting the natural order
[22] | Zaidi, S. S. E. A., Vanderschuren, H., Qaim, M., Mahfouz, M. M., Kohli, A., Mansoor, S., & Tester, M. (2019). New plant breeding technologies for food security. Science, 363(6434), 1390-1391. |
[22]
. While European society acknowledges the benefits of biotechnology in medicine, acceptance of GM products, particularly GM plants, remains lower. Resistance to consuming GM food in Europe declined from 86% in 1999 to 60% in 2019. In Norway, attitudes toward genetic engineering prioritize reducing pesticide use (68%), climate adaptation of crops (65%), and enhancing animal and fish health (58-60%)
[22] | Zaidi, S. S. E. A., Vanderschuren, H., Qaim, M., Mahfouz, M. M., Kohli, A., Mansoor, S., & Tester, M. (2019). New plant breeding technologies for food security. Science, 363(6434), 1390-1391. |
[22]
. In Sweden, 69% of men and 54% of women hold favorable or neutral attitudes toward genetically modified organisms (GMOs). In the UK, 45% believe genetic engineering offers new solutions to global issues. However, 46% disagree, expressing concerns about the risks associated with genetic engineering
[31] | Kunyanga Nkirote Catherine, B. Roy Mugiira, and N. Josephat Muchiri, “Public Perception of Genetically Modified Organisms and the Implementation of Biosafety Measures in Kenya”, Advances in Agriculture Volume 2024, Article ID 5544617, 15 pages https://doi.org/10.1155/2024/5544617 |
[31]
. In Italy, a 2019 study found that 54% of the general public and 81% of scientists believed GM foods were safe to consume. No perception studies on Genetic Engineering have been done in African nations, but several papers on GMO perception focus solely on GM food and crops. In South Africa, 41% felt that consuming GM food contradicted their religious beliefs, while 30% disagreed
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
In Uganda, 86% of farmers said they would plant GM maize that was resistant to insects, drought, or both because they saw it as a way to reduce crop loss. 75% of respondents in a 2016 survey in South Africa agreed with the assertion that GM food products should be marked
[15] | Hossain, F., Onyango, B. M., Schilling, B. J., & Hallman, W. K. (2012). Public perceptions of biotechnology and acceptance of genetically modified food. Journal of Food Distribution Research, 34(3), 36-50. |
[15]
. Asian countries, which comprise 59.76% of the global population, vary in their acceptance and views on plant genetic technologies. In China and South Korea, individuals with higher education levels tend to use more deliberate reasoning and are less receptive to GM foods. In Japan, molecular biology experts hold the most favorable views on benefits and the least concern regarding risks compared to non-experts
[30] | FAO, World Food and Agriculture—Statistical Yearbook 2022, Food and Agriculture Organization of the United Nations, Rome, 2022. |
[30]
. In China, about 40% perceived GM foods as safe, 26% perceived them as unsafe, and 35% did not know whether GM foods are safe
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
. Approximately 73% of consumers believe they've consumed GM foods unknowingly. Both GMO and non-GMO labels are deemed important by consumers, with 89% and 83% respectively considering them significant. In South Korea, 36% expressed willingness to buy biotech-produced fresh fruit, the highest among surveyed nations. In Turkey, 80% expressed a strong desire for GMO labeling, with 65% finding the information on food packaging unconvincing
[4] | De Witt, A., Osseweijer, P., & Pierce, R. (2017). Understanding public perceptions of biotechnology through the ―Integrative Worldview Framework‖. Public Understanding of Science, 26(1), 70-88. |
[4]
. In Singapore and India, public backing for novel food labeling was linked to concerns about food safety and awareness of novel food-related news. In Malaysia, where 54% of Muslim respondents participated, there was little belief that contemporary biotechnology posed a substantial threat to the natural order. However, 75% agreed that modern biotechnology could bring significant societal benefits
[7] | Ewa, W. G., Agata, T., Milica, P., Anna, B., Dennis, E., Nick, V.,... & Tomasz, T. (2022). Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food, 13(1), 218-241. |
[7]
.
Public support for labelling was strongly associated only with public support for outlawing novel foods in Singapore and India, where attention to food safety and news about novel foods was also connected with public support for labelling. Modern biotechnology was not seen as posing a significant threat to the natural order of things, according to studies done in Malaysia (N = 434), where the majority of participants were Muslims (54%)
[35] | K. Ala-Kokko, Economic and ecosystem impacts of GM maize in South Africa, Graduate thesis and dissertations, University of Arkansas, Fayetteville, 2021. |
[35]
. According to a poll (N = 210) conducted in Iran, religiosity and moral and ethical convictions were the best predictors of social risk perception. In the Australian surveys, a greater awareness of hazards than advantages were frequently linked to a more negative attitude towards GMOs. Recent surveys on GM rice found that 69% of respondents were willing to eat the grain if it was insect-resistant, compared to about 60% for herbicide-resistant rice
[2] | G. Brookes, “Genetically modified (GM) crop use 1996–2020: environmental impacts associated with pesticide use change,” GM Crops & Food, vol. 13, no. 1, pp. 262–289, 2022View at: Publisher Site | Google Scholar. |
[2]
.
2.8. The Outcome of Public Perception of Biotechnology and Related Biopolies
The results of the investigation also suggest that public attitudes on food biotechnology are heavily influenced by people's confidence in and trust in the government, the scientific community, and the public image of biotechnology corporations. The public's acceptance of biotechnology in food production is influenced positively by their trust in scientists and the government, and negatively by their distrust of biotechnology corporations and lack of faith in the government's ability to effectively control genetically modified (GM) products
[17] | Moualhi, I., Galhena, H., Maredia, K., & Weebadde, C. (2014). Perceptions of non-Europeans on biotechnology in Europe: Bridging the knowledge gap. Asian Biotechnology and Development Review, 16(2), 43-52. |
[17]
. Similar findings were reported in terms of popular acceptance of genetically modified organisms. Recent study has demonstrated popular skepticism of the biotechnology sector, as well as a lack of trust in the authorities as a defender of the common good. Based to a recent Eurobarometer survey, only 30% of Europeans believe that "the industry developing new products through the use of biotechnology does a good work for society." According to the findings of De Witt et al.
[4] | De Witt, A., Osseweijer, P., & Pierce, R. (2017). Understanding public perceptions of biotechnology through the ―Integrative Worldview Framework‖. Public Understanding of Science, 26(1), 70-88. |
[4]
, a lack of trust in private and public organizations associated with biotechnology can have major negative consequences for public acceptability of food biotechnology
[2] | G. Brookes, “Genetically modified (GM) crop use 1996–2020: environmental impacts associated with pesticide use change,” GM Crops & Food, vol. 13, no. 1, pp. 262–289, 2022View at: Publisher Site | Google Scholar. |
[2]
.
Important moral, theological, and ethical questions have been raised in the public debate over biotechnology. Some biotechnology skeptics argue that modern genetic research has pushed humanity into territory that only God should regulate. Many people regard genetic alterations, particularly gene transfer across species, as violating Natural Law. Gastrow
et al.
[9] | Gastrow, M., Roberts, B., Reddy, V., & Ismail, S. (2018). Public perceptions of biotechnology in South Africa. South African Journal of Science, 114(1-2), 1-9. |
[9]
found that those who are less religious are more optimistic about biotechnology and its application to plants than those who attend church on a regular basis. Unlike those who are more dedicated, they no longer approve of its use in animals. Social liberals appear to be less enthusiastic about biotechnology and its applications, including in plants. Furthermore, our findings show that attitudes towards the use of genetic technologies in food production vary significantly by gender and race. On the other hand, this study finds no regional difference in the acceptance of biotechnology. Additionally, factors like income, family size, occupation, and marital status don't seem to have a big impact on whether people accept food biotechnology
[4] | De Witt, A., Osseweijer, P., & Pierce, R. (2017). Understanding public perceptions of biotechnology through the ―Integrative Worldview Framework‖. Public Understanding of Science, 26(1), 70-88. |
[4]
.