| Peer-Reviewed

Development and Research of Polyurethane Foam Composite Materials with Albucid

Received: 12 July 2021     Accepted: 23 July 2021     Published: 4 August 2021
Views:       Downloads:
Abstract

In modern surgery there is a need for restorative and reconstructive operations in the orbit and periorbital area as a result of eye injuries. This study is aimed at the development and research of the structure and properties of polyurethane foam (PUF) composite materials filled by antimicrobial drug substance albucid as implants for ophthalmic surgery. PUF composite materials with albucid (in the amount of 5 wt.%) based on diisocyanate prepolymer (synthesized from polyoxypropylene glycol and 2.4-; 2.6-toluylene diisocyanate) were obtained. The structure, adhesive, thermophysical and thermogravimetric properties, morphology of composite materials have been characterized using Fourier transform infrared (FTIR), mechanical tests, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and transmission optical microscopy (TOM). It is established that the immobilization of albucid occurs due to intermolecular hydrogen bonds by the method of IR spectroscopy. According to the results of physical-mechanical tests the presence of albucid in the composition of polyurethane foams does not affect the value of the adhesive strength of composite materials. According to DSC the investigated systems are single-phase with a glass transition temperature from minus 48.40 to minus 48.64°C. The introduction of albucid into the PUF causes a decrease of the specific heat capacity at the glass-transition temperature and does not affect on the Tg of composite materials. According to the results of analysis of TOM photomicrograph, it was found that the presence of albucid in the composite materials leads to a decrease in the porosity percentage, an increase in the quantity of pores with a diameter less than 300 μm, which is 82% (while for PUF it is 69.5%) and the absence of pores with a diameter more than 954 μm. Thermogravimetric characteristics indicate the heat resistance of the synthesized PUF to a temperature of 162.84°C, which makes it possible to carry out dry sterilization of samples without changing their characteristics. Therefore, the obtained PUF composite materials with albucid exhibit adhesion, heat resistance and have a microporous structure. It allows us to conclude that they are promising materials that can be used in medical practice, in particular in ophthalmic surgery as implants with antimicrobial action.

Published in American Journal of Polymer Science and Technology (Volume 7, Issue 3)
DOI 10.11648/j.ajpst.20210703.11
Page(s) 38-43
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Polyurethane Foam, Composite Material, Albucid, Porosity

References
[1] Smirnov, S. V. Shakhlamov M. V., Litinsky M. A., Yanshin D. V., Sachkov A. V., Obolensky V. N. Polyurethane foam covering for wounds, burns and ulcers. Wound Medicine, 2013, № 2-3, 6-8. https://doi.org/10.1016/j.wndm.2013.10.001.
[2] Namviriyachote N., Lipipun V., Akkhawattanangkul Y., Charoonrut P., Ritthidej G. C. Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound. Asian Journal of Pharmaceutical Sciences, 2019, 14 (1): 63-77. https://doi.org/10.1016/j.ajps.2018.09.001.
[3] Lee S. M., Park I. K., Kim Y. S., Kim H. J., Moon H., Mueller S., Jeong Y.-I. Physical, morphological, and wound healing properties of a polyurethane foam-film dressing. Biomaterials Research, 2016, 20, 15. https://doi.org/10.1186/s40824-016-0063-5.
[4] Karpenko O. S., Galatenko N. A., Kiseleva T. A., Narozhayko L. F. Synthesis of new polyurethane foams for medical use. Polymer journal, 2018, 40 (1): 51-57.
[5] Galatenko N., Rozhnova R. Biologically active polymer materials for medicine. Kyiv: Naukova dumka, 2013. 210 p.
[6] Buckley M. J., Beckman E. J. Adhesive Use in Oral and Maxillofacial Surgery. Oral and maxillofacial surgery clinics of North America, 2010, 22 (1): 195-199. https://doi.org/10.1016/j.coms.2009.10.008.
[7] Bufius N., Galatenko N. Patent US 5474779A, Compositions for aiding in the regeneration of tissue with a prolonged immunomodulating effect. publ. 12.12.1995.
[8] K. Lei, Q. Zhu, X. Wang, H Xiao, Z. Zheng. In Vitro and in Vivo Characterization of a Foam-Like Polyurethane Bone Adhesive for Promoting Bone Tissue Growth. ACS Biomaterials Science & Engineering, 2019, 5 (10): 5489-5497. http://dx.doi.org/10.1021/acsbiomaterials.9b00918.
[9] Lebedev Ye. V., Galatenko N. A., Rozhnova R. A., Kulesh D. V. Serial Production of Domestic Biologically Active Glue for Medical Purposes. Science and innovation, 2016, 12 (1): 61-65. http://dx.doi.org/10.15407/scine12.01.054.
[10] Sivak W. N., Pollack I. F., Petoud S., Zamboni W. C., Zhang J., Beckman E. J. Catalyst-dependent drug loading of LDI–glycerol polyurethane foams leads to differing controlled release profiles. Acta Biomaterialia, 2008, 4, 1263-1274. https://doi.org/10.1016/j.actbio.2008.01.008.
[11] Gerges I., Tamplenizza M., Lopa S., Recordati C., Martello F., Tocchio A., Ricotti L., Arrigoni C., Milani P., Moretti M., Lenardi C. Creep-Resistant Dextran-Based Polyurethane Foam as a Candidate Scaffold for Bone Tissue Engineering: Synthesis, Chemico-Physical Characterization, In vitro and In vivo Biocompatibility. International Journal of Polymeric Materials and Polymeric Biomaterials, 2016, 65 (14): 729-740. https://doi.org/10.1080/00914037.2016.1163565.
[12] Galatenko N. A., Kulyesh D. V., Maletskyi A. P., Karpenko O. S. Soft-tissue response to synthetic polymer implants made of cross-linked polyurethane and containing a biologically active substance, albucid or dacarbazine, in animals. Journal of Ophthalmology, 2018, № 6, 52-58. http://doi.org/10.31288/oftalmolzh201865258.
[13] Abdullah N., Karamat F., Qamar S., Abbas M., Khan A. M., Ullah N. Development and validation of RP-HPLC method for simultaneous quantification of sulfacetamide sodium and prednisolone sodium phosphate. Acta Poloniae Pharmaceutica n Drug Research, 2019, 76 (1): 37-47. http://doi.org/10.32383/appdr/93843.
[14] Sheshala R., Ming N. J., Kok Y. Y., Raj Singh T. R., Dua K. Formulation and Characterization of pH Induced in situ Gels Containing Sulfacetamide Sodium for Ocular Drug Delivery: A Combination of Carbopol®/ HPMC Polymer. Indian Journal of Pharmaceutical Education and Research, 2019, 53 (4): 654-662. http://doi.org/10.5530/ijper.53.4.127.
[15] Guliy O. I., Bunin V. D., Balko A. B., Volkov A. A., Staroverov S. A., Karavaeva O. A., Ignatov O. V. Effect of Sulfonamides on the Electrophysical Properties of Bacterial Cells. Anti-Infective Agents, 2014, 12 (2): 191-197. http://doi.org/10.2174/2211352512666140630171501.
[16] Pretsch E., Bёllmann P., Affolter C. Structure determination of organic compounds. Tables of Spectral Data. Springer-Verlag Berlin Heidelberg, 2009. 433 p.
[17] Vislohuzova T. V., Rozhnova R. A., Galatenko N. A. Development and research of polyurethane foam composite materials with lysozyme. Polymer journal, 2021, 43 (3).
Cite This Article
  • APA Style

    Tetiana Vislohuzova, Rita Rozhnova, Nataliia Galatenko. (2021). Development and Research of Polyurethane Foam Composite Materials with Albucid. American Journal of Polymer Science and Technology, 7(3), 38-43. https://doi.org/10.11648/j.ajpst.20210703.11

    Copy | Download

    ACS Style

    Tetiana Vislohuzova; Rita Rozhnova; Nataliia Galatenko. Development and Research of Polyurethane Foam Composite Materials with Albucid. Am. J. Polym. Sci. Technol. 2021, 7(3), 38-43. doi: 10.11648/j.ajpst.20210703.11

    Copy | Download

    AMA Style

    Tetiana Vislohuzova, Rita Rozhnova, Nataliia Galatenko. Development and Research of Polyurethane Foam Composite Materials with Albucid. Am J Polym Sci Technol. 2021;7(3):38-43. doi: 10.11648/j.ajpst.20210703.11

    Copy | Download

  • @article{10.11648/j.ajpst.20210703.11,
      author = {Tetiana Vislohuzova and Rita Rozhnova and Nataliia Galatenko},
      title = {Development and Research of Polyurethane Foam Composite Materials with Albucid},
      journal = {American Journal of Polymer Science and Technology},
      volume = {7},
      number = {3},
      pages = {38-43},
      doi = {10.11648/j.ajpst.20210703.11},
      url = {https://doi.org/10.11648/j.ajpst.20210703.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20210703.11},
      abstract = {In modern surgery there is a need for restorative and reconstructive operations in the orbit and periorbital area as a result of eye injuries. This study is aimed at the development and research of the structure and properties of polyurethane foam (PUF) composite materials filled by antimicrobial drug substance albucid as implants for ophthalmic surgery. PUF composite materials with albucid (in the amount of 5 wt.%) based on diisocyanate prepolymer (synthesized from polyoxypropylene glycol and 2.4-; 2.6-toluylene diisocyanate) were obtained. The structure, adhesive, thermophysical and thermogravimetric properties, morphology of composite materials have been characterized using Fourier transform infrared (FTIR), mechanical tests, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and transmission optical microscopy (TOM). It is established that the immobilization of albucid occurs due to intermolecular hydrogen bonds by the method of IR spectroscopy. According to the results of physical-mechanical tests the presence of albucid in the composition of polyurethane foams does not affect the value of the adhesive strength of composite materials. According to DSC the investigated systems are single-phase with a glass transition temperature from minus 48.40 to minus 48.64°C. The introduction of albucid into the PUF causes a decrease of the specific heat capacity at the glass-transition temperature and does not affect on the Tg of composite materials. According to the results of analysis of TOM photomicrograph, it was found that the presence of albucid in the composite materials leads to a decrease in the porosity percentage, an increase in the quantity of pores with a diameter less than 300 μm, which is 82% (while for PUF it is 69.5%) and the absence of pores with a diameter more than 954 μm. Thermogravimetric characteristics indicate the heat resistance of the synthesized PUF to a temperature of 162.84°C, which makes it possible to carry out dry sterilization of samples without changing their characteristics. Therefore, the obtained PUF composite materials with albucid exhibit adhesion, heat resistance and have a microporous structure. It allows us to conclude that they are promising materials that can be used in medical practice, in particular in ophthalmic surgery as implants with antimicrobial action.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Development and Research of Polyurethane Foam Composite Materials with Albucid
    AU  - Tetiana Vislohuzova
    AU  - Rita Rozhnova
    AU  - Nataliia Galatenko
    Y1  - 2021/08/04
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajpst.20210703.11
    DO  - 10.11648/j.ajpst.20210703.11
    T2  - American Journal of Polymer Science and Technology
    JF  - American Journal of Polymer Science and Technology
    JO  - American Journal of Polymer Science and Technology
    SP  - 38
    EP  - 43
    PB  - Science Publishing Group
    SN  - 2575-5986
    UR  - https://doi.org/10.11648/j.ajpst.20210703.11
    AB  - In modern surgery there is a need for restorative and reconstructive operations in the orbit and periorbital area as a result of eye injuries. This study is aimed at the development and research of the structure and properties of polyurethane foam (PUF) composite materials filled by antimicrobial drug substance albucid as implants for ophthalmic surgery. PUF composite materials with albucid (in the amount of 5 wt.%) based on diisocyanate prepolymer (synthesized from polyoxypropylene glycol and 2.4-; 2.6-toluylene diisocyanate) were obtained. The structure, adhesive, thermophysical and thermogravimetric properties, morphology of composite materials have been characterized using Fourier transform infrared (FTIR), mechanical tests, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and transmission optical microscopy (TOM). It is established that the immobilization of albucid occurs due to intermolecular hydrogen bonds by the method of IR spectroscopy. According to the results of physical-mechanical tests the presence of albucid in the composition of polyurethane foams does not affect the value of the adhesive strength of composite materials. According to DSC the investigated systems are single-phase with a glass transition temperature from minus 48.40 to minus 48.64°C. The introduction of albucid into the PUF causes a decrease of the specific heat capacity at the glass-transition temperature and does not affect on the Tg of composite materials. According to the results of analysis of TOM photomicrograph, it was found that the presence of albucid in the composite materials leads to a decrease in the porosity percentage, an increase in the quantity of pores with a diameter less than 300 μm, which is 82% (while for PUF it is 69.5%) and the absence of pores with a diameter more than 954 μm. Thermogravimetric characteristics indicate the heat resistance of the synthesized PUF to a temperature of 162.84°C, which makes it possible to carry out dry sterilization of samples without changing their characteristics. Therefore, the obtained PUF composite materials with albucid exhibit adhesion, heat resistance and have a microporous structure. It allows us to conclude that they are promising materials that can be used in medical practice, in particular in ophthalmic surgery as implants with antimicrobial action.
    VL  - 7
    IS  - 3
    ER  - 

    Copy | Download

Author Information
  • Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine

  • Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine

  • Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine

  • Sections