Securidaca longepedunculata is a plant which various parts are widely used in traditional medicine. Its roots are used to treat snakebite. Beyond its efficacy for snakebite treatment, S. longepedunculata is used for the treatment of other diseases including dysentery, stomach ache and mental disorders. The interest of the present study was to investigate the anxiolytic properties of S. longepedunculata roots decoction. The plant material of our study consisted of S. longepedunculata roots. The animal material consisted of male and female Mus musculus Swiss mice of 18 g and above, approximately 9 weeks old and not previously tested. They were used for the acute toxicity assessment following OECD 425 protocols. Then the evaluation of the anxiolytic activity of the decoction on acute and chronic anxiety was done using the following paradigms: Elevated Plus Maze (EPM), Open Field (OF), Hole Board (HB) and the Restrictor. Finally, some oxidative stress parameters such as catalase, sulfoxide dismutase, reduced glutathione and malondialdehyde were measured. The plant screening revealed the presence of phenolic compounds like flavonoids, saponosides and triterpenes. There were no signs of toxicity at the dose of 5000 mg/kg fourteen (14) days after treatment. The evaluation of the anxiolytic activity of this decoction on acute and chronic anxiety through the different tests showed that, the most effective dose of S. longepedunculata decoction was 213 mg/kg. In the EPM test, there was a significant (p<0.001) increase of the number of entries into the open arms entries from 7±1.30 in the negative control mice to 36 ±3.16 in the (Sl 213 mg/kg) group. The Diazepam also induced a significant (p<0.001) increase of this number. The time spent in the open arms and their respective percentages were equally increased. However, there was also a significant (p<0.001) decrease of the number of entries and the time spent in the closed arms and their percentages indicating a decrease of the level of anxiety in these mice. The OF and HB tests also showed that, the S. longepedunculata decoction would possess anxiolytic properties. This could be justified by the presence of secondary metabolites such as saponins and flavonoids. These results justify the use of S. longepedunculata roots in the traditional medicine for the treatment of mental disorders. It would be beneficial to suggest them to local populations against these pathologies.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 11, Issue 1) |
| DOI | 10.11648/j.ajpn.202311014.11 |
| Page(s) | 1-12 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Securidaca longepedunculata, Decoction, Anxiolytics, Antioxidant
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APA Style
Jean Pierre Omam Omam, Samuel Mbouh, Antoine Kavaye Kandeda, Juliette Koube, Djibrilla Mana Moussa, et al. (2023). Anxiety Curing Evaluation with the Aqueous Extract of Securidaca longepedunculata (Polygalaceae) Decoction in Mice on the Stress Paradigm Tests. American Journal of Psychiatry and Neuroscience, 11(1), 1-12. https://doi.org/10.11648/j.ajpn.202311014.11
ACS Style
Jean Pierre Omam Omam; Samuel Mbouh; Antoine Kavaye Kandeda; Juliette Koube; Djibrilla Mana Moussa, et al. Anxiety Curing Evaluation with the Aqueous Extract of Securidaca longepedunculata (Polygalaceae) Decoction in Mice on the Stress Paradigm Tests. Am. J. Psychiatry Neurosci. 2023, 11(1), 1-12. doi: 10.11648/j.ajpn.202311014.11
AMA Style
Jean Pierre Omam Omam, Samuel Mbouh, Antoine Kavaye Kandeda, Juliette Koube, Djibrilla Mana Moussa, et al. Anxiety Curing Evaluation with the Aqueous Extract of Securidaca longepedunculata (Polygalaceae) Decoction in Mice on the Stress Paradigm Tests. Am J Psychiatry Neurosci. 2023;11(1):1-12. doi: 10.11648/j.ajpn.202311014.11
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Download@article{10.11648/j.ajpn.202311014.11,
author = {Jean Pierre Omam Omam and Samuel Mbouh and Antoine Kavaye Kandeda and Juliette Koube and Djibrilla Mana Moussa and Mireille Delphine Minkoulou Ze and Ronald Bidingha à Goufani and Alain Mbom and Fleur Clarisse Okomolo Moto and Elisabeth Ngo Bum},
title = {Anxiety Curing Evaluation with the Aqueous Extract of Securidaca longepedunculata (Polygalaceae) Decoction in Mice on the Stress Paradigm Tests},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {11},
number = {1},
pages = {1-12},
doi = {10.11648/j.ajpn.202311014.11},
url = {https://doi.org/10.11648/j.ajpn.202311014.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.202311014.11},
abstract = {Securidaca longepedunculata is a plant which various parts are widely used in traditional medicine. Its roots are used to treat snakebite. Beyond its efficacy for snakebite treatment, S. longepedunculata is used for the treatment of other diseases including dysentery, stomach ache and mental disorders. The interest of the present study was to investigate the anxiolytic properties of S. longepedunculata roots decoction. The plant material of our study consisted of S. longepedunculata roots. The animal material consisted of male and female Mus musculus Swiss mice of 18 g and above, approximately 9 weeks old and not previously tested. They were used for the acute toxicity assessment following OECD 425 protocols. Then the evaluation of the anxiolytic activity of the decoction on acute and chronic anxiety was done using the following paradigms: Elevated Plus Maze (EPM), Open Field (OF), Hole Board (HB) and the Restrictor. Finally, some oxidative stress parameters such as catalase, sulfoxide dismutase, reduced glutathione and malondialdehyde were measured. The plant screening revealed the presence of phenolic compounds like flavonoids, saponosides and triterpenes. There were no signs of toxicity at the dose of 5000 mg/kg fourteen (14) days after treatment. The evaluation of the anxiolytic activity of this decoction on acute and chronic anxiety through the different tests showed that, the most effective dose of S. longepedunculata decoction was 213 mg/kg. In the EPM test, there was a significant (pS. longepedunculata decoction would possess anxiolytic properties. This could be justified by the presence of secondary metabolites such as saponins and flavonoids. These results justify the use of S. longepedunculata roots in the traditional medicine for the treatment of mental disorders. It would be beneficial to suggest them to local populations against these pathologies.},
year = {2023}
}
TY - JOUR T1 - Anxiety Curing Evaluation with the Aqueous Extract of Securidaca longepedunculata (Polygalaceae) Decoction in Mice on the Stress Paradigm Tests AU - Jean Pierre Omam Omam AU - Samuel Mbouh AU - Antoine Kavaye Kandeda AU - Juliette Koube AU - Djibrilla Mana Moussa AU - Mireille Delphine Minkoulou Ze AU - Ronald Bidingha à Goufani AU - Alain Mbom AU - Fleur Clarisse Okomolo Moto AU - Elisabeth Ngo Bum Y1 - 2023/02/04 PY - 2023 N1 - https://doi.org/10.11648/j.ajpn.202311014.11 DO - 10.11648/j.ajpn.202311014.11 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 1 EP - 12 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.202311014.11 AB - Securidaca longepedunculata is a plant which various parts are widely used in traditional medicine. Its roots are used to treat snakebite. Beyond its efficacy for snakebite treatment, S. longepedunculata is used for the treatment of other diseases including dysentery, stomach ache and mental disorders. The interest of the present study was to investigate the anxiolytic properties of S. longepedunculata roots decoction. The plant material of our study consisted of S. longepedunculata roots. The animal material consisted of male and female Mus musculus Swiss mice of 18 g and above, approximately 9 weeks old and not previously tested. They were used for the acute toxicity assessment following OECD 425 protocols. Then the evaluation of the anxiolytic activity of the decoction on acute and chronic anxiety was done using the following paradigms: Elevated Plus Maze (EPM), Open Field (OF), Hole Board (HB) and the Restrictor. Finally, some oxidative stress parameters such as catalase, sulfoxide dismutase, reduced glutathione and malondialdehyde were measured. The plant screening revealed the presence of phenolic compounds like flavonoids, saponosides and triterpenes. There were no signs of toxicity at the dose of 5000 mg/kg fourteen (14) days after treatment. The evaluation of the anxiolytic activity of this decoction on acute and chronic anxiety through the different tests showed that, the most effective dose of S. longepedunculata decoction was 213 mg/kg. In the EPM test, there was a significant (pS. longepedunculata decoction would possess anxiolytic properties. This could be justified by the presence of secondary metabolites such as saponins and flavonoids. These results justify the use of S. longepedunculata roots in the traditional medicine for the treatment of mental disorders. It would be beneficial to suggest them to local populations against these pathologies. VL - 11 IS - 1 ER -
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