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Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome

Received: 17 August 2022     Accepted: 2 September 2022     Published: 16 September 2022
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Abstract

Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.

Published in American Journal of Psychiatry and Neuroscience (Volume 10, Issue 3)
DOI 10.11648/j.ajpn.20221003.18
Page(s) 145-153
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Post-Traumatic Neuropathies and Plexopathies, Chronic Neuropathic Pain Syndrome, Anxiety, Depression, Lymphocytotoxicity, Nerve Growth Factor

References
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    Olena Borodai, Tetyana Litovchenko. (2022). Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. American Journal of Psychiatry and Neuroscience, 10(3), 145-153. https://doi.org/10.11648/j.ajpn.20221003.18

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    ACS Style

    Olena Borodai; Tetyana Litovchenko. Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. Am. J. Psychiatry Neurosci. 2022, 10(3), 145-153. doi: 10.11648/j.ajpn.20221003.18

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    AMA Style

    Olena Borodai, Tetyana Litovchenko. Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. Am J Psychiatry Neurosci. 2022;10(3):145-153. doi: 10.11648/j.ajpn.20221003.18

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  • @article{10.11648/j.ajpn.20221003.18,
      author = {Olena Borodai and Tetyana Litovchenko},
      title = {Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome},
      journal = {American Journal of Psychiatry and Neuroscience},
      volume = {10},
      number = {3},
      pages = {145-153},
      doi = {10.11648/j.ajpn.20221003.18},
      url = {https://doi.org/10.11648/j.ajpn.20221003.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221003.18},
      abstract = {Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.},
     year = {2022}
    }
    

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    T1  - Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome
    AU  - Olena Borodai
    AU  - Tetyana Litovchenko
    Y1  - 2022/09/16
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    DO  - 10.11648/j.ajpn.20221003.18
    T2  - American Journal of Psychiatry and Neuroscience
    JF  - American Journal of Psychiatry and Neuroscience
    JO  - American Journal of Psychiatry and Neuroscience
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    EP  - 153
    PB  - Science Publishing Group
    SN  - 2330-426X
    UR  - https://doi.org/10.11648/j.ajpn.20221003.18
    AB  - Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.
    VL  - 10
    IS  - 3
    ER  - 

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Author Information
  • Department of Neurology and Child Neurology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

  • Department of Neurology and Child Neurology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

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