Background: Spatial memory is a cognitive process that allows us to locate ourselves in space based on visual references. Vestibular signals reaching the hippocampus from the vestibular nuclei have an important role in building this process. Vestibular conditions could affect this cognitive process. Meniere's disease is a chronic internal ear disease that causes impairment of hearing and vestibular function Objective: To determine the relationship between Meniere's disease and spatial memory in patients who attend the Anglo American clinic between 2016 and 2018. Specific objectives are: 1) identify patients with Meniere's disease and 2) assess spatial memory in these patients. Design: It is a cross-sectional correlated analytical study, where two groups were evaluated: a) with Meniere's disease and b) without Meniere's disease, comparable in age and sex. As a student T test statistic for mean difference in independent samples, considering equal variances. Methodology: Hearing and vestibular functions were evaluated, and Morris' virtual test was used to measure spatial memory. Four indicators were measured in the latter: time, percentage, distance and angle. Results: Group with Meniere's disease: N = 76, 38 males and 38 females, average age of 44.21-10 years; Meniere's disease-free group: N = 76, 38 males and 38 females, average age of 43.85-10. Comparing spatial memory between the two groups found a statistically significant difference (p < 0.000) in favor of Meniere's disease-free group in the four indicators. Within the group with Meniere's disease, spatial memory was evaluated according to the stage, without any significant difference between the different stages for the time indicators (p = 0.334), percentage (p = 0.659), distance (p = 0.955) and angle (p = 0.916). As for vestibular function, in which there was unilateral vestibular deficit, when compared to the Meniere's disease-free group, there was significant difference (p < 0.000) in the four indicators. The worst results were in those who had bilateral vestibular deficits. Conclusions: The group with Meniere's disease had poor spatial memory when compared to Meniere's disease-free group. The greatest commitment to space memory was in subjects with bilateral vestibular deficits.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 10, Issue 3) |
| DOI | 10.11648/j.ajpn.20221003.13 |
| Page(s) | 95-101 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Meniere's Disease, Spatial Memory, Spatial Orientation, Hippocampus, Allocentric Memory
| [1] | Kotimäki J (2003). Meniere’s disease in Finland. An epidemiological and clinical study on occurrence, clinical picture and policy. Academic Dissertation presented with the assent of the Faculty of Medicine, University of Oulu. October 17th. |
| [2] | Tassinari MT, Mandrioli D, Gaglioli N, Di Sarsina PR (2015). Meniere’s disease treatment; A patient-centered systematic review. Audiol Neurotol; 20: 153-165. |
| [3] | Neuhauser HK, Lempert T (2009). Vertigo: epidemiologic aspects. Seminars in Neurology. 29 (5): 473-481. |
| [4] | Tolman EC. Cognitive maps in rats and men (1948). Phychological Review. 55: 189-208. |
| [5] | O’Keefe J, Dostrovsky J [1971). The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Research. 34: 171-175. |
| [6] | Poucet B, Lenck-Santini PP, Hok V, Lave E, Banquet JP, Gaussier P, Muller RU (2004). Spatial navigation and hippocampal place cell firing: The problem of goal encoding. Reviews in The Neuroscience. 15: 89-107. |
| [7] | Good M (2002). Spatial memory and hippocampal function: where are we now? Psicologica. 23: 109-138. |
| [8] | Allen GL (2004) Human spatial memory. Remembering where (XIII-XVIII). London: Lawrence Erlbaum Associates, Publishers. 368. |
| [9] | Stackman RW, Clark As, Taube JS (2002). Hippocampal spatial representations require vestibular input. Hippocampus. 12: 291-303. |
| [10] | Medendorp WP, Selen LJP (2017): Vestibular contribution to high-level sensorimotor functions. Neuropsychologia. 105: 144-152. |
| [11] | Brandt T, Zwergal A and Glasauer S (2017): 3-D spatial memory and navigation: functions and disorders. Curr Opin Neurol. 30: 000-000. DOI: 10.1097/WCO.0000000000000415. |
| [12] | Russell NA, Horii A, Smith PF, Darlington CL, Bilkey DK (2003). Long-term effects of permanent vestibular lesions on hippocampal spatial firing. Journal of Neuroscience. 23 (16): 6490-6498. |
| [13] | Cuthbert PC, Gilchrist DP, Hicks SL, Mac Dougall HG, Curthoys IS (2000). Electrophysiological evidence for vestibular activation of the guinea pig hippocampus. NeuroReport. 11: 1443-1447. |
| [14] | Hanes DA, McCollum G (2006). Cognitive-vestibular interactions: A review of patient’s difficulties and possible mechanisms. Journal of Vestibular Research. 16: 75-91. |
| [15] | Dobbels B, Mertens G, Gilles A, Claes A, Moyaert J, Raymond Van den Berg et al (2019). Cognitive Function in Acquired Bilateral Vestibulopathy: A Cross-sectional Study on Cognition, Hearing, And Vestibular Loss. Front Neurosci. 13: 340. DOI: 10.3389/fnins.2019.00340. |
| [16] | Lopez-Escamez JA, Carey J, Chung WH Goebel JA, Magnusson M, Mandalá M et al (2015). Classification comittee of the Barany Society; Japan Society for Equilibrium Research: European Academy of Otology and Neurotology (EAONO); Equilibrium Committe of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); Korean Balance Society Diagnostic criterio for Meniere’s disease. J Vestib Res. 25 (1): 1-7. DOI: 10.3233/VES-150549. PMID: 25882471. |
| [17] | Van Esch BF, Abolhosseini K, Masius-Olthof S, Van Der Zaag-Loonen HJ, Van Benthem PPG, Bruintjes TJD (2019). Video-Head Impulse Test Results in Patients with Meniere’s Disease Related to Duration and Stage of Disease. Journal of Vestibular Disease Research. DOI: 10.3233/VES.190654. |
| [18] | Fukushima M, Oya R, Nozaki K, Eguchi H, Akahani S, Inohara H et al (2019). Vertical Head Impulse and Caloric Are Complementary but React Opposite to Meniere’s Disease Hydrops. Laryngoscope 00: 1-7. DOI: 10.1002/lary.27580. |
| [19] | Blodow A, Heinze M, Bloching MB, Von Brevern M, Radtke A, Lempert T (2014). Caloric Stimulation and Video. Head Impulse Testing in Meniere’s Disease and Vestibular Migraine. Acta Oto-Laryngologica. 134: 1239-1244. |
| [20] | Limviriyakul S, Luangsawang Ch, Suvansit K, Prakairugthong, Thongyai K, Atipas S (2019). Video head impulse test and caloric test in definite Meniere’s disease. European Archives of Oto-Rhino-Laryngology. DOI: 10.1007/s00405-019-05735-8. |
| [21] | Mc Mullen KP, Lin Ch, Harris MS, Adunka OF (2017). Correlation Of Objetive Audiometric and Caloric Function in Meniere’s Disease. Otolaryngology-Head and Neck Surgery. DOI: 10.1177/0194599817690103. |
| [22] | Cordero-Yanza JA, Arrieta Vásquez EV, Hernaiz Leonardo JC, Mancera Sánchez J, Hernández Palestina MS, Pérez-Fernández N (2017). Comparative Study Between the Caloric Vestibular and The Video- Head Impulse Tests in Unilateral Meniere’s Disease. Acta Oto-Laryngologica. DOI: 10.1080/00016489.2017.1354395. |
| [23] | Schautzer F, Hamilton D, Kalla R, Strupp M, Brandt T (2003). Spatial memory deficits in patients with chronic bilateral vestibular failure. Ann. N. Y. Acad. Sci. 1004: 316-324. |
| [24] | Brandt T, Schautzer F, Hamilton DA, Brüning R, Markowitsch HJ, Kalla R et al (2005). Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain. 128: 2732-2741. |
| [25] | Kremmyda O, Hüfner K, Flanagin VL, Hamilton DA, Linn J, Strupp M et al (2016). Beyond Dizzines: Virtual Navigation, Spatial Anxiety and Hippocampal Volume in Bilateral Vestibulopath. Front Hum Neurosci. 10: 139. DOI: 10.3389/fnhum.2016.00139. |
| [26] | Göttlich M, Jandl NM, Sprenger A, Wojak JF, Münte TF, Krämer UM et al (2016). Hippocampal Gray Matter Volume in Bilateral Vestibular Failure. Hum Brain Mapp. 37: 1998-2006. |
| [27] | Liu L, Xuan Ch, Shen P, He T, Chang Y, Shi L et al (2018). Hippocampal mechanisms underlying impairment in spatial learning long after establishment of noise-induced hearing loss in CBA mice. Front Syst Neurosci 12: 35. DOI: 10.3389/fnsys.2018.00035. |
| [28] | Allum JHJ, Scheltinga A, Honegger F (2017). The effect of peripheral vestibular recovery on improvements in vestibulo-ocular reflexes and balance control after acute unilateral peripheral vestibular loss. Otol Neurotol. 38: e531-e538. |
| [29] | Guidetti G, Guidetti R, Manfredi M (2019). Vestibular Pathology and Spatial Working Memory. Acta Otorhinolaryngol Ital. Jul 31. DOI: 10.14639/0392-100X-2189. |
| [30] | Babichev A, Morozov D, Dabaghian Y (2018). Robust spatial memory maps encoded by networks with transient connections. PLoS Comput Biol. 14 (9): e1006433. DOI: 10.1371/journal.pcbi.1006433. |
| [31] | Seo YJ, Kim J, Kim SH (2016). The Change of Hypocampal Volume and its Relevance with inner ear Function in Meniere’s Disease Patients. Auris Nasus Larynx. DOI: 10.1016/j.anl.2016.01.006. |
APA Style
Manuel Arturo Gallardo-Flores. (2022). Spatial Memory Deficits in Patients with Meniere’s Disease. American Journal of Psychiatry and Neuroscience, 10(3), 95-101. https://doi.org/10.11648/j.ajpn.20221003.13
ACS Style
Manuel Arturo Gallardo-Flores. Spatial Memory Deficits in Patients with Meniere’s Disease. Am. J. Psychiatry Neurosci. 2022, 10(3), 95-101. doi: 10.11648/j.ajpn.20221003.13
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajpn.20221003.13,
author = {Manuel Arturo Gallardo-Flores},
title = {Spatial Memory Deficits in Patients with Meniere’s Disease},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {10},
number = {3},
pages = {95-101},
doi = {10.11648/j.ajpn.20221003.13},
url = {https://doi.org/10.11648/j.ajpn.20221003.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221003.13},
abstract = {Background: Spatial memory is a cognitive process that allows us to locate ourselves in space based on visual references. Vestibular signals reaching the hippocampus from the vestibular nuclei have an important role in building this process. Vestibular conditions could affect this cognitive process. Meniere's disease is a chronic internal ear disease that causes impairment of hearing and vestibular function Objective: To determine the relationship between Meniere's disease and spatial memory in patients who attend the Anglo American clinic between 2016 and 2018. Specific objectives are: 1) identify patients with Meniere's disease and 2) assess spatial memory in these patients. Design: It is a cross-sectional correlated analytical study, where two groups were evaluated: a) with Meniere's disease and b) without Meniere's disease, comparable in age and sex. As a student T test statistic for mean difference in independent samples, considering equal variances. Methodology: Hearing and vestibular functions were evaluated, and Morris' virtual test was used to measure spatial memory. Four indicators were measured in the latter: time, percentage, distance and angle. Results: Group with Meniere's disease: N = 76, 38 males and 38 females, average age of 44.21-10 years; Meniere's disease-free group: N = 76, 38 males and 38 females, average age of 43.85-10. Comparing spatial memory between the two groups found a statistically significant difference (p Conclusions: The group with Meniere's disease had poor spatial memory when compared to Meniere's disease-free group. The greatest commitment to space memory was in subjects with bilateral vestibular deficits.},
year = {2022}
}
TY - JOUR T1 - Spatial Memory Deficits in Patients with Meniere’s Disease AU - Manuel Arturo Gallardo-Flores Y1 - 2022/08/04 PY - 2022 N1 - https://doi.org/10.11648/j.ajpn.20221003.13 DO - 10.11648/j.ajpn.20221003.13 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 95 EP - 101 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.20221003.13 AB - Background: Spatial memory is a cognitive process that allows us to locate ourselves in space based on visual references. Vestibular signals reaching the hippocampus from the vestibular nuclei have an important role in building this process. Vestibular conditions could affect this cognitive process. Meniere's disease is a chronic internal ear disease that causes impairment of hearing and vestibular function Objective: To determine the relationship between Meniere's disease and spatial memory in patients who attend the Anglo American clinic between 2016 and 2018. Specific objectives are: 1) identify patients with Meniere's disease and 2) assess spatial memory in these patients. Design: It is a cross-sectional correlated analytical study, where two groups were evaluated: a) with Meniere's disease and b) without Meniere's disease, comparable in age and sex. As a student T test statistic for mean difference in independent samples, considering equal variances. Methodology: Hearing and vestibular functions were evaluated, and Morris' virtual test was used to measure spatial memory. Four indicators were measured in the latter: time, percentage, distance and angle. Results: Group with Meniere's disease: N = 76, 38 males and 38 females, average age of 44.21-10 years; Meniere's disease-free group: N = 76, 38 males and 38 females, average age of 43.85-10. Comparing spatial memory between the two groups found a statistically significant difference (p Conclusions: The group with Meniere's disease had poor spatial memory when compared to Meniere's disease-free group. The greatest commitment to space memory was in subjects with bilateral vestibular deficits. VL - 10 IS - 3 ER -
Information
Email: