Guillain Barre Syndrome (GBS), Miller Fisher Syndrome (MFS) and Bickerstaff Brainstem Encephalitis (BBE) form part of the same disease spectrum, sharing some clinical signs and auto-immune based mechanisms with antiganglioside antibodies. GBS, the most common cause of subacute flaccid paralysis, is a well-known and extensively described syndrome. MFS is characterized by subacute ophthalmoplegia, ataxia and areflexia. In 1957, Bickerstaff described some patients who, in addition to ataxia and ophthalmoplegia, had abnormal mental status, corresponding to brainstem involvment. Neurological manifestations associated with anti-GQ1b antibodies can occur in isolation or in association. We report the case of a woman with an unusual psychiatric presentation (peduncular hallucinosis) of anti-GQ1b antibody syndrome, with features of these three diseases, and a dramatic improvement with immunoglobulin therapy. Peduncular hallucinosis are a rare form of visual hallucination. They are often described as colourful visions of people and animals, and are usually associated with vascular lesions in the midbrain and thalamus. This provides further evidence of the broad spectrum of neurological diseases associated with antiganglioside antibodies. To the best of our knowledge this is the first description of PH complicating BBE. Clinicians should be aware of the existence of overlapping syndrome with combined central and peripherical neurological system involvement.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 7, Issue 1) |
| DOI | 10.11648/j.ajpn.20190701.12 |
| Page(s) | 8-11 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Antiganglioside Antibodies Overlapping Syndromes, Guillain Barre, Miller Fisher, Bickerstaff's Brainstem Encephalitis, Peduncular Hallucinosis
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APA Style
Alexis Demas, Guillaume Costentin, Vincent Langlois, Yvan Vaschalde, Jean Philippe Cochin. (2019). Peduncular Hallucinosis and Overlapping Antiganglioside Antibody Syndrome. American Journal of Psychiatry and Neuroscience, 7(1), 8-11. https://doi.org/10.11648/j.ajpn.20190701.12
ACS Style
Alexis Demas; Guillaume Costentin; Vincent Langlois; Yvan Vaschalde; Jean Philippe Cochin. Peduncular Hallucinosis and Overlapping Antiganglioside Antibody Syndrome. Am. J. Psychiatry Neurosci. 2019, 7(1), 8-11. doi: 10.11648/j.ajpn.20190701.12
AMA Style
Alexis Demas, Guillaume Costentin, Vincent Langlois, Yvan Vaschalde, Jean Philippe Cochin. Peduncular Hallucinosis and Overlapping Antiganglioside Antibody Syndrome. Am J Psychiatry Neurosci. 2019;7(1):8-11. doi: 10.11648/j.ajpn.20190701.12
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Download@article{10.11648/j.ajpn.20190701.12,
author = {Alexis Demas and Guillaume Costentin and Vincent Langlois and Yvan Vaschalde and Jean Philippe Cochin},
title = {Peduncular Hallucinosis and Overlapping Antiganglioside Antibody Syndrome},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {7},
number = {1},
pages = {8-11},
doi = {10.11648/j.ajpn.20190701.12},
url = {https://doi.org/10.11648/j.ajpn.20190701.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20190701.12},
abstract = {Guillain Barre Syndrome (GBS), Miller Fisher Syndrome (MFS) and Bickerstaff Brainstem Encephalitis (BBE) form part of the same disease spectrum, sharing some clinical signs and auto-immune based mechanisms with antiganglioside antibodies. GBS, the most common cause of subacute flaccid paralysis, is a well-known and extensively described syndrome. MFS is characterized by subacute ophthalmoplegia, ataxia and areflexia. In 1957, Bickerstaff described some patients who, in addition to ataxia and ophthalmoplegia, had abnormal mental status, corresponding to brainstem involvment. Neurological manifestations associated with anti-GQ1b antibodies can occur in isolation or in association. We report the case of a woman with an unusual psychiatric presentation (peduncular hallucinosis) of anti-GQ1b antibody syndrome, with features of these three diseases, and a dramatic improvement with immunoglobulin therapy. Peduncular hallucinosis are a rare form of visual hallucination. They are often described as colourful visions of people and animals, and are usually associated with vascular lesions in the midbrain and thalamus. This provides further evidence of the broad spectrum of neurological diseases associated with antiganglioside antibodies. To the best of our knowledge this is the first description of PH complicating BBE. Clinicians should be aware of the existence of overlapping syndrome with combined central and peripherical neurological system involvement.},
year = {2019}
}
TY - JOUR T1 - Peduncular Hallucinosis and Overlapping Antiganglioside Antibody Syndrome AU - Alexis Demas AU - Guillaume Costentin AU - Vincent Langlois AU - Yvan Vaschalde AU - Jean Philippe Cochin Y1 - 2019/05/27 PY - 2019 N1 - https://doi.org/10.11648/j.ajpn.20190701.12 DO - 10.11648/j.ajpn.20190701.12 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 8 EP - 11 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.20190701.12 AB - Guillain Barre Syndrome (GBS), Miller Fisher Syndrome (MFS) and Bickerstaff Brainstem Encephalitis (BBE) form part of the same disease spectrum, sharing some clinical signs and auto-immune based mechanisms with antiganglioside antibodies. GBS, the most common cause of subacute flaccid paralysis, is a well-known and extensively described syndrome. MFS is characterized by subacute ophthalmoplegia, ataxia and areflexia. In 1957, Bickerstaff described some patients who, in addition to ataxia and ophthalmoplegia, had abnormal mental status, corresponding to brainstem involvment. Neurological manifestations associated with anti-GQ1b antibodies can occur in isolation or in association. We report the case of a woman with an unusual psychiatric presentation (peduncular hallucinosis) of anti-GQ1b antibody syndrome, with features of these three diseases, and a dramatic improvement with immunoglobulin therapy. Peduncular hallucinosis are a rare form of visual hallucination. They are often described as colourful visions of people and animals, and are usually associated with vascular lesions in the midbrain and thalamus. This provides further evidence of the broad spectrum of neurological diseases associated with antiganglioside antibodies. To the best of our knowledge this is the first description of PH complicating BBE. Clinicians should be aware of the existence of overlapping syndrome with combined central and peripherical neurological system involvement. VL - 7 IS - 1 ER -
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