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Brain atrophy in Multiple Sclerosis

Received: 25 February 2015     Accepted: 9 March 2015     Published: 31 March 2015
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Abstract

Multiple sclerosis (MS) has traditionally been considered to be primarily an inflammatory demyelinating disorder affecting the white matter. Nowadays it is recognized as both an inflammatory and a neurodegenerative condition involving the white and grey matter. Grey matter atrophy occurs in the earliest stages of MS, progresses faster than in healthy individuals, and shows significant correlations with cognitive function and physical disability; indeed, brain atrophy is the best predictor of subsequent disability and can be measured using magnetic resonance imaging (MRI). There are a number of MRI methods for measuring global or regional brain volume, including cross-sectional and longitudinal techniques. Preventing brain volume loss may therefore have important clinical implications affecting treatment decisions, with several clinical trials now demonstrating an effect of disease-modifying treatments (DMTs) on reducing brain volume loss. In clinical practice, it may therefore be important to consider the potential impact of a therapy on reducing the rate of brain volume loss. This article summarizes the knowledge on brain volume in MS.

Published in American Journal of Psychiatry and Neuroscience (Volume 3, Issue 3)
DOI 10.11648/j.ajpn.20150303.11
Page(s) 40-49
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Multiple Sclerosis, Brain Atrophy, Brain Volume Loss

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Cite This Article
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    Rugilo Carlos, Seifer Gustavo, Kuperman Gaston, Villa Andrés María. (2015). Brain atrophy in Multiple Sclerosis. American Journal of Psychiatry and Neuroscience, 3(3), 40-49. https://doi.org/10.11648/j.ajpn.20150303.11

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    ACS Style

    Rugilo Carlos; Seifer Gustavo; Kuperman Gaston; Villa Andrés María. Brain atrophy in Multiple Sclerosis. Am. J. Psychiatry Neurosci. 2015, 3(3), 40-49. doi: 10.11648/j.ajpn.20150303.11

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    AMA Style

    Rugilo Carlos, Seifer Gustavo, Kuperman Gaston, Villa Andrés María. Brain atrophy in Multiple Sclerosis. Am J Psychiatry Neurosci. 2015;3(3):40-49. doi: 10.11648/j.ajpn.20150303.11

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  • @article{10.11648/j.ajpn.20150303.11,
      author = {Rugilo Carlos and Seifer Gustavo and Kuperman Gaston and Villa Andrés María},
      title = {Brain atrophy in Multiple Sclerosis},
      journal = {American Journal of Psychiatry and Neuroscience},
      volume = {3},
      number = {3},
      pages = {40-49},
      doi = {10.11648/j.ajpn.20150303.11},
      url = {https://doi.org/10.11648/j.ajpn.20150303.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20150303.11},
      abstract = {Multiple sclerosis (MS) has traditionally been considered to be primarily an inflammatory demyelinating disorder affecting the white matter. Nowadays it is recognized as both an inflammatory and a neurodegenerative condition involving the white and grey matter. Grey matter atrophy occurs in the earliest stages of MS, progresses faster than in healthy individuals, and shows significant correlations with cognitive function and physical disability; indeed, brain atrophy is the best predictor of subsequent disability and can be measured using magnetic resonance imaging (MRI). There are a number of MRI methods for measuring global or regional brain volume, including cross-sectional and longitudinal techniques. Preventing brain volume loss may therefore have important clinical implications affecting treatment decisions, with several clinical trials now demonstrating an effect of disease-modifying treatments (DMTs) on reducing brain volume loss. In clinical practice, it may therefore be important to consider the potential impact of a therapy on reducing the rate of brain volume loss. This article summarizes the knowledge on brain volume in MS.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Brain atrophy in Multiple Sclerosis
    AU  - Rugilo Carlos
    AU  - Seifer Gustavo
    AU  - Kuperman Gaston
    AU  - Villa Andrés María
    Y1  - 2015/03/31
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajpn.20150303.11
    DO  - 10.11648/j.ajpn.20150303.11
    T2  - American Journal of Psychiatry and Neuroscience
    JF  - American Journal of Psychiatry and Neuroscience
    JO  - American Journal of Psychiatry and Neuroscience
    SP  - 40
    EP  - 49
    PB  - Science Publishing Group
    SN  - 2330-426X
    UR  - https://doi.org/10.11648/j.ajpn.20150303.11
    AB  - Multiple sclerosis (MS) has traditionally been considered to be primarily an inflammatory demyelinating disorder affecting the white matter. Nowadays it is recognized as both an inflammatory and a neurodegenerative condition involving the white and grey matter. Grey matter atrophy occurs in the earliest stages of MS, progresses faster than in healthy individuals, and shows significant correlations with cognitive function and physical disability; indeed, brain atrophy is the best predictor of subsequent disability and can be measured using magnetic resonance imaging (MRI). There are a number of MRI methods for measuring global or regional brain volume, including cross-sectional and longitudinal techniques. Preventing brain volume loss may therefore have important clinical implications affecting treatment decisions, with several clinical trials now demonstrating an effect of disease-modifying treatments (DMTs) on reducing brain volume loss. In clinical practice, it may therefore be important to consider the potential impact of a therapy on reducing the rate of brain volume loss. This article summarizes the knowledge on brain volume in MS.
    VL  - 3
    IS  - 3
    ER  - 

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Author Information
  • Department of Neurology, British Hospital, Buenos Aires, Argentina

  • Department of Neurology, José María Ramos Mejía Hospital, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina

  • Department of Medicine, Novartis Argentina

  • Department of Neurology, José María Ramos Mejía Hospital, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina

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