Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy

Agbecha Ayu; Anwana Ubong Isaac

doi:doi:10.11648/j.ajlm.20190401.14

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Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy

Agbecha Ayu, Anwana Ubong Isaac

Published in American Journal of Laboratory Medicine (Volume 4, Issue 1)

Received: 3 February 2019 Accepted: 7 March 2019 Published: 18 April 2019

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Abstract

There are existing reports of an association of uric acid with glucose metabolism and their impact on adverse pregnancy outcomes. Hyperuricemia is linked to glucose homeostasis and basically to all components of the metabolic syndrome in the general population. Based on this premise, our study aimed at determining the level of serum uric acid and plasma glucose in second and third-trimester normal pregnancies with a view of establishing cut off values in Makurdi, Nigeria. The hospital-based case-control study involved a total of 103 participants aged 18-35 years attending the antenatal and the general health check up clinics. The participants comprised of 81 normal pregnant females in their second and third trimesters compared with 22 non pregnant controls. Their fasting plasma glucose and serum uric acid levels were compared among age-matched non-pregnant women (n=22), second (n=38), and third (n=43) trimester pregnancies. Serum uric acid level in second (5.89±0.85mg/dl) and third (6.23±1.30mg/dl) trimester pregnancies were significantly (p=0.000) higher than the non-pregnant controls (3.80±1.11mg/dl). A significant (p<0.01) increase in plasma glucose was observed in third-trimester pregnancies (5.19±0.64mmol/l) compared to second-trimester pregnancies (4.87±0.79mmol/l) and controls (4.65±0.51mmol/l). The study provided cut-off values for uric acid, glucose, and further points the need for prenatal care in terms of screening and diagnosis of pregnancy complications in all pregnant women including those considered at low risk.

Published in	American Journal of Laboratory Medicine (Volume 4, Issue 1)
DOI	10.11648/j.ajlm.20190401.14
Page(s)	24-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Pregnancy, Serum Uric Acid, Plasma Glucose, Second Trimester, Third Trimester

References

[1]	Maruhashi, T., Hisatome, I., Kihara, Y., & Higashi, Y. (2018). Hyperuricemia and endothelial function: From molecular background to clinical perspectives. Atherosclerosis, 278:226–231.
[2]	Sautin, Y. Y., & Johnson, R. J. (2008). Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids, 27:608–619.
[3]	Maiuolo J., Oppedisano F., Gratteri S., Muscoli, C., & Mollace., V. (2016). Regulation of uric acid metabolism and excretion. International Journal of Cardiology 213:8–14.
[4]	Johnson, R. J., Merriman, T., &Lanaspa, M. A. (2015). Causal or noncausal relationship of uric acid with diabetes. Diabetes, 64 (8): 2720–2.
[5]	Lv, Q., Meng, X. F, He, F. F., Chen, S., Su, H., Xiong, J., ... Zhang, C. (2013). High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PLoS One, 8(2): e56864.
[6]	Lind, T., Godfrey, K. A., Otun, H, & Philips, P. R. (1984). Changes in serum uric acid concentration during normal pregnancy. British Journal of Obstetrics and Gynaecology, 91:128-132.
[7]	Abbassi-Ghanavati, M., Greer, L. G., & Cunningham, F. G. (2009). Pregnancy and laboratory studies: a reference table for clinicians. Obstetrics and Gynecology, 114(6):1326-31.
[8]	International Association of Diabetes and Pregnancy Study Groups Consensus Panel- IADPSG. (2010). Diabetes Care, 33(3):676-82.
[9]	Bainbridge, S. A., & Roberts, J. M. (2012). Uric Acid as a Pathogenic Factor in Preeclampsia. Placenta, 29(Suppl A): S67–S72.
[10]	Akahori, Y., Masuyama, H., &Hiramatsu, Y. (2012). The correlation of maternal uric acid concentration with small-for-gestational-age fetuses in normotensive pregnant women. Gynecologic & Obstetric Investigation, 73:162–167.
[11]	Matias, M. L., Romão, M., Weel, I. C., Ribeiro, V. R., Nunes, P. R., Borges, V. T.,… Peraçoli, M. T. (2015). Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia. PloS one, 10(6), e0129095. doi:10.1371/journal.pone.0129095.
[12]	Amini, E., Sheikh, M., Hantoushzadeh, S., Shariat, M., Abdollahi, A., &Kashanian, M (2014). Maternal hyperuricemia in normotensive singleton pregnancy, a prenatal finding with continuous perinatal and postnatal effects, a prospective cohort study. BMC Pregnancy & Childbirth, 14:104. http://www.biomedcentral.com/1471-2393/14/104.
[13]	Sonagra, A. D., Biradar, S. M., Dattatreya K., & Murthy, D. S. (2014). Normal pregnancy- a state of insulin resistance. Journal of Clinical & Diagnostic Research, 8(11), CC01-3.
[14]	Metzger, B. E., Lowe, L. P., Dyer, A. R., Trimble, E. R., Chaovarindr, U., Coustan, D. R., … Sacks, D. A. (2008). HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. New England Journal of Medicine, 1991-2002; 8(19):358.
[15]	Mclaughlin, G. B., Cheng, Y. W., &Caughey, A. B. (2006). Women with one elevated 3-hour glucose tolerance test value: are they at risk for adverse perinatal outcomes? American Journal of Obstetrics & Gynecology, 194(5):16–9.
[16]	Basu, P., Som, S., Choudhuri, N., & Das, H (2009). Contribution of the blood glucose level in perinatal asphyxia. European Journal of Pediatrics, 168:833–838.
[17]	Yoo TW, Sung KC, Shin HS, Kim BJ, Kim BS, Kang JH.,… Keum, D. G. (2005). Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circulation Journal, 69:928-33. https://doi.org/10.1253/circj.69.928 PMid:16041161.
[18]	Sui, X., Church, T. S., Meriwether, R. A., Lobelo, F., & Blair, S. N. (2008). Uric acid and the development of metabolic syndrome in women and men. Metabolism, 57:845–852.
[19]	Laughon, S. K., Catov, J., Provins, T., Roberts, J. M, &Gandley, R. E. (2009). Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes. American Journal of Obstetrics & Gynecology, 201(4):402.e1-5. doi: 10.1016/j.ajog.2009.06.065.
[20]	Wolak, T., Sergienko, R., Wiznitzer, A., Paran, E., &Sheiner, E (2012). High uric acid level during the first 20 weeks of pregnancy is associated with higher risk for gestational diabetes mellitus and mild preeclampsia. Hypertension in Pregnancy, 31:307-15.
[21]	Lenfant, C., Chobanian, A. V., Jones, D. W., &Roccella, E. J (2003). For the joint national committee on the prevention, detection, evaluation, and treatment of high blood pressure: Seventh report of the joint national committee on the prevention. Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7): Resetting the hypertension sails. Hypertension, 41(6):1178–1179. DOI: 10.1161/01.HYP.0000075790.33892.
[22]	Ahaneku, J. E., Adinma, J. I., Ahaneku, G. I., Nwosu, B. O., Nwofor, P. C., &Okoli, C. C. (2009). Serum urea and uric acid concentration in pregnant women in sub-urban commercial community in Africa. Nigerian Journal of Clinical Practice, 12(2):216-218.
[23]	Nduka, N., &Ekeke, G. I (1986). Serum creatinine and uric levels in pregnant urban African and Caucasian women. Tropical and Geographical Medicine, 38: 386-390.
[24]	Okonkwo, O. P., Bello, A. C., and Ogbe, J. R (2013). Evaluation of changes in renal functions of pregnant women attending antenatal clinic in Vom Plateau State, North-Central Nigeria. Archives of Applied Science Research 5 (4):111-116.
[25]	Omotayo, O. L., Nura, A., Olajide, O. A., Funsho, A. I., Adekunlae, D. K., &Abayomi, B. S. (2015). Study on comparison of serum levels of calcium, magnesium, and uric acid in mild preeclamptics, severe preeclamptics, and normal pregnant women in Ilorin, Nigeria. Nigerian Journal of Experimental & Clinical Biosciences, 3:71-7.
[26]	Diwan, J., Shah, C., Dixit, R., &Anand, A. K. (2011). A Comparative Study of Serum Uric Acid Level in Normal Pregnancy, and Pregnancy Induced Hypertension International Journal of Medicine & Public Health, 1(1):39-41. www.ijmedph.org.
[27]	Bawah, A. T., Kuffour, F. A., Boateng, M. A., Seini M. M., Amoah, P., Ussher, F. A., &Alidu, H. (2018). Effect of Pregnancy on the Metabolism of Creatinine, Urea and Uric Acid among Pregnant Women at the Volta Regional Hospital. International Journal of Medical and Health Sciences, 7(4):166-171. https://www.ijmhs.net/journals-aid-444.html.
[28]	Ekun, O. A., Olawumi, O. M., Makwe, C. C., &Ogidi, N. O. (2018). Biochemical Assessment of Renal and Liver Function among Preeclamptics in Lagos Metropolis. International Journal of Reproductive Medicine, 2018, 1594182. doi:10.1155/2018/1594182
[29]	Pramanik, T., Khatiwada, B., &Pradhan, P. (2014). Serum uric acid level in normal pregnant and preeclamptic ladies: a comparative study. Nepal Medical College Journal, 16(1): 30-32.
[30]	Deshpande, H. G., Madkar, C. S., Shinde, M., & Kothari, V. S. (2018). Assessment of the level of serum uric acid in patients of pre-eclampsia and their comparison with levels in normotensive pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 7:4900-4905.
[31]	Kasraeian, M., Asadi, N., Vafaei, H., Zamanpour, T., Shahraki, H. R., &Bazrafshan, K. (2018). Evaluation of serum biomarkers for detection of preeclampsia severity in pregnant women. Pakistan Journal of Medical Sciences, 34(4):869-873.
[32]	Wolak, T., Shoham-Vardi, I., Sergienko, R., &Sheiner, E. (2015). High Uric Acid Levels During Pregnancy Linked to Increased Risk for Future Atherosclerotic-Related Hospitalization. The Journal of Clinical Hypertension (Greenwich), 17:481–485. DOI: 10.1111/jch.12535.
[33]	Feig, D. I., Nakagawa, T., Karumanchi, S. A., Oliver, W. J., Kang, D. H., Finch, J., & Johnson, R. J. (2004). Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney International, 66:281–287.
[34]	Ekhator, C. N., & Ebomoyi, M. I. (2012). Blood glucose and serum lipid profiles during pregnancy. African Journal of Diabetes Medicine, 20(1): 16-19.
[35]	Gaya, B. I., Imam, I. A., Abdulaziz, H., Rukayya, A. A., &Hauwa, M. N. (2014). Random Blood Glucose Levels Among Pregnant Women Attending Ante-Natal Clinic in Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), 13(1) Ver. II: 59-63.e ISSN: 2279-0853, p-ISSN: 2279-0861.
[36]	Church, D., Halsall, D., Meek, C., Parker, R. A., Murphy, H. R., & Simmons, D. (2011). Random blood glucose measurement at antenatal booking to screen for overt diabetes in pregnancy: a retrospective study. Diabetes Care, 34(10), 2217-9.
[37]	Zannat, M. R., Nessa, A., Hossain, M. M., Das, R. K., Asrin, M., Sufrin, S.,… Nasreen N. (2016). Serum Glucose Level in First and Third Trimester of Pregnancy. Mymensingh Medical Journal, 25(2):211-214.
[38]	Sufrin, S., Nessa, A., & Islam, T. (2015). Serum Glucose Level and Hemoglobin Concentration in Third Trimester of Pregnancy. J Bangladesh Soc Physiol., 10(2): 67-70. http://www.banglajol.info/index.php/JBSP.
[39]	Afolabi, B. B., Abudu, O. O., &Oyeyinka, O. (2003). Fasting plasma glucose levels in normal pregnant Nigerians, Journal of Obstetrics and Gynaecology, 23:6,640-642, DOI: 10.1080/01443610310001604420.
[40]	Metzger, B. E., Gabbe, S. G., Persson, B., Buchanan, T. A., Catalano, P. A., Damm, P., … Schmidt, M. I. (2010). International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care, 33(3), 676-82.
[41]	Seabra, G., Saunders, C., de CarvalhoPadilha, P., Zajdenverg, L., da Silva, L. B., & de Souza Santos, M. M. Association between maternal glucose levels during pregnancy and gestational diabetes mellitus: an analytical cross-sectional study. Diabetology& Metabolic Syndrome (2015) 7:17. DOI 10.1186/s13098-015-0013-8.
[42]	Landon, M. B., Spong, C. Y., Thom, E., Carpenter, M. W., Ramin, S. M., Casey, B., …Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (2009). A multicenter, randomized trial of treatment for mild gestational diabetes. The New England journal of medicine, 361(14):1339-48.
[43]	Khosla, U. M., Zharikov, S., Finch, J. L., Nakagawa, T., Roncal, C., Mu, W., …Johnson, R. J. (2005). Hyperuricaemia induces endothelial dysfunction. Kidney International, 67(5):1739-42.
[44]	Kang, D. H., Park, S. K., Lee, I. K., & Johnson, R. J. (2005). Uric acid induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. Journal of the American Society of Nephrology, 16(12):3553-62. Epub 2005 Oct 26
[45]	Sembulingam, K., &Sembulingam, P. (2012). Essentials of medical physiology. Jaypee Brothers Medical Publishers (P) Ltd. 6th edition: Pregnancy and Parturition, Chapter 84, pp 501. (ISBN 978-93-5025-936-8.

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Agbecha Ayu, Anwana Ubong Isaac. (2019). Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy. American Journal of Laboratory Medicine, 4(1), 24-30. https://doi.org/10.11648/j.ajlm.20190401.14

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Agbecha Ayu; Anwana Ubong Isaac. Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy. Am. J. Lab. Med. 2019, 4(1), 24-30. doi: 10.11648/j.ajlm.20190401.14

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Agbecha Ayu, Anwana Ubong Isaac. Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy. Am J Lab Med. 2019;4(1):24-30. doi: 10.11648/j.ajlm.20190401.14

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@article{10.11648/j.ajlm.20190401.14,
  author = {Agbecha Ayu and Anwana Ubong Isaac},
  title = {Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {1},
  pages = {24-30},
  doi = {10.11648/j.ajlm.20190401.14},
  url = {https://doi.org/10.11648/j.ajlm.20190401.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190401.14},
  abstract = {There are existing reports of an association of uric acid with glucose metabolism and their impact on adverse pregnancy outcomes. Hyperuricemia is linked to glucose homeostasis and basically to all components of the metabolic syndrome in the general population. Based on this premise, our study aimed at determining the level of serum uric acid and plasma glucose in second and third-trimester normal pregnancies with a view of establishing cut off values in Makurdi, Nigeria. The hospital-based case-control study involved a total of 103 participants aged 18-35 years attending the antenatal and the general health check up clinics. The participants comprised of 81 normal pregnant females in their second and third trimesters compared with 22 non pregnant controls. Their fasting plasma glucose and serum uric acid levels were compared among age-matched non-pregnant women (n=22), second (n=38), and third (n=43) trimester pregnancies. Serum uric acid level in second (5.89±0.85mg/dl) and third (6.23±1.30mg/dl) trimester pregnancies were significantly (p=0.000) higher than the non-pregnant controls (3.80±1.11mg/dl). A significant (p<0.01) increase in plasma glucose was observed in third-trimester pregnancies (5.19±0.64mmol/l) compared to second-trimester pregnancies (4.87±0.79mmol/l) and controls (4.65±0.51mmol/l). The study provided cut-off values for uric acid, glucose, and further points the need for prenatal care in terms of screening and diagnosis of pregnancy complications in all pregnant women including those considered at low risk.},
 year = {2019}
}

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TY  - JOUR
T1  - Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy
AU  - Agbecha Ayu
AU  - Anwana Ubong Isaac
Y1  - 2019/04/18
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190401.14
DO  - 10.11648/j.ajlm.20190401.14
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 24
EP  - 30
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190401.14
AB  - There are existing reports of an association of uric acid with glucose metabolism and their impact on adverse pregnancy outcomes. Hyperuricemia is linked to glucose homeostasis and basically to all components of the metabolic syndrome in the general population. Based on this premise, our study aimed at determining the level of serum uric acid and plasma glucose in second and third-trimester normal pregnancies with a view of establishing cut off values in Makurdi, Nigeria. The hospital-based case-control study involved a total of 103 participants aged 18-35 years attending the antenatal and the general health check up clinics. The participants comprised of 81 normal pregnant females in their second and third trimesters compared with 22 non pregnant controls. Their fasting plasma glucose and serum uric acid levels were compared among age-matched non-pregnant women (n=22), second (n=38), and third (n=43) trimester pregnancies. Serum uric acid level in second (5.89±0.85mg/dl) and third (6.23±1.30mg/dl) trimester pregnancies were significantly (p=0.000) higher than the non-pregnant controls (3.80±1.11mg/dl). A significant (p<0.01) increase in plasma glucose was observed in third-trimester pregnancies (5.19±0.64mmol/l) compared to second-trimester pregnancies (4.87±0.79mmol/l) and controls (4.65±0.51mmol/l). The study provided cut-off values for uric acid, glucose, and further points the need for prenatal care in terms of screening and diagnosis of pregnancy complications in all pregnant women including those considered at low risk.
VL  - 4
IS  - 1
ER  -

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Author Information

Agbecha Ayu

Department of Chemical Pathology, Federal Medical Center, Makurdi, Nigeria
Anwana Ubong Isaac

Department of Biochemistry, University of Uyo, Uyo, Nigeria

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Agbecha Ayu, Anwana Ubong Isaac. (2019). Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy. American Journal of Laboratory Medicine, 4(1), 24-30. https://doi.org/10.11648/j.ajlm.20190401.14

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ACS Style

Agbecha Ayu; Anwana Ubong Isaac. Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy. Am. J. Lab. Med. 2019, 4(1), 24-30. doi: 10.11648/j.ajlm.20190401.14

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AMA Style

Agbecha Ayu, Anwana Ubong Isaac. Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy. Am J Lab Med. 2019;4(1):24-30. doi: 10.11648/j.ajlm.20190401.14

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@article{10.11648/j.ajlm.20190401.14,
  author = {Agbecha Ayu and Anwana Ubong Isaac},
  title = {Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {1},
  pages = {24-30},
  doi = {10.11648/j.ajlm.20190401.14},
  url = {https://doi.org/10.11648/j.ajlm.20190401.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190401.14},
  abstract = {There are existing reports of an association of uric acid with glucose metabolism and their impact on adverse pregnancy outcomes. Hyperuricemia is linked to glucose homeostasis and basically to all components of the metabolic syndrome in the general population. Based on this premise, our study aimed at determining the level of serum uric acid and plasma glucose in second and third-trimester normal pregnancies with a view of establishing cut off values in Makurdi, Nigeria. The hospital-based case-control study involved a total of 103 participants aged 18-35 years attending the antenatal and the general health check up clinics. The participants comprised of 81 normal pregnant females in their second and third trimesters compared with 22 non pregnant controls. Their fasting plasma glucose and serum uric acid levels were compared among age-matched non-pregnant women (n=22), second (n=38), and third (n=43) trimester pregnancies. Serum uric acid level in second (5.89±0.85mg/dl) and third (6.23±1.30mg/dl) trimester pregnancies were significantly (p=0.000) higher than the non-pregnant controls (3.80±1.11mg/dl). A significant (p<0.01) increase in plasma glucose was observed in third-trimester pregnancies (5.19±0.64mmol/l) compared to second-trimester pregnancies (4.87±0.79mmol/l) and controls (4.65±0.51mmol/l). The study provided cut-off values for uric acid, glucose, and further points the need for prenatal care in terms of screening and diagnosis of pregnancy complications in all pregnant women including those considered at low risk.},
 year = {2019}
}

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TY  - JOUR
T1  - Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy
AU  - Agbecha Ayu
AU  - Anwana Ubong Isaac
Y1  - 2019/04/18
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190401.14
DO  - 10.11648/j.ajlm.20190401.14
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 24
EP  - 30
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190401.14
AB  - There are existing reports of an association of uric acid with glucose metabolism and their impact on adverse pregnancy outcomes. Hyperuricemia is linked to glucose homeostasis and basically to all components of the metabolic syndrome in the general population. Based on this premise, our study aimed at determining the level of serum uric acid and plasma glucose in second and third-trimester normal pregnancies with a view of establishing cut off values in Makurdi, Nigeria. The hospital-based case-control study involved a total of 103 participants aged 18-35 years attending the antenatal and the general health check up clinics. The participants comprised of 81 normal pregnant females in their second and third trimesters compared with 22 non pregnant controls. Their fasting plasma glucose and serum uric acid levels were compared among age-matched non-pregnant women (n=22), second (n=38), and third (n=43) trimester pregnancies. Serum uric acid level in second (5.89±0.85mg/dl) and third (6.23±1.30mg/dl) trimester pregnancies were significantly (p=0.000) higher than the non-pregnant controls (3.80±1.11mg/dl). A significant (p<0.01) increase in plasma glucose was observed in third-trimester pregnancies (5.19±0.64mmol/l) compared to second-trimester pregnancies (4.87±0.79mmol/l) and controls (4.65±0.51mmol/l). The study provided cut-off values for uric acid, glucose, and further points the need for prenatal care in terms of screening and diagnosis of pregnancy complications in all pregnant women including those considered at low risk.
VL  - 4
IS  - 1
ER  -

Copy | Download