Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation

Mei-Min Shiu; Bo-Yu Huang; Chien-Chi Liu; Chin-Sheng Liao; Ming-Cheng Lin

doi:doi:10.11648/j.ajlm.20180301.12

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Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation

Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin

Published in American Journal of Laboratory Medicine (Volume 3, Issue 1)

Received: 23 September 2017 Accepted: 16 October 2017 Published: 14 December 2017

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Abstract

Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.

Published in	American Journal of Laboratory Medicine (Volume 3, Issue 1)
DOI	10.11648/j.ajlm.20180301.12
Page(s)	6-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Antrodia Camphorata, Lipid Peroxidation, Antioxidative Effect, Malondialdehyde

References

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APA Style

Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin. (2017). Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. American Journal of Laboratory Medicine, 3(1), 6-10. https://doi.org/10.11648/j.ajlm.20180301.12

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ACS Style

Mei-Min Shiu; Bo-Yu Huang; Chien-Chi Liu; Chin-Sheng Liao; Ming-Cheng Lin. Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. Am. J. Lab. Med. 2017, 3(1), 6-10. doi: 10.11648/j.ajlm.20180301.12

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AMA Style

Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin. Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. Am J Lab Med. 2017;3(1):6-10. doi: 10.11648/j.ajlm.20180301.12

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@article{10.11648/j.ajlm.20180301.12,
  author = {Mei-Min Shiu and Bo-Yu Huang and Chien-Chi Liu and Chin-Sheng Liao and Ming-Cheng Lin},
  title = {Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation},
  journal = {American Journal of Laboratory Medicine},
  volume = {3},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.ajlm.20180301.12},
  url = {https://doi.org/10.11648/j.ajlm.20180301.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20180301.12},
  abstract = {Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.},
 year = {2017}
}

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TY  - JOUR
T1  - Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation
AU  - Mei-Min Shiu
AU  - Bo-Yu Huang
AU  - Chien-Chi Liu
AU  - Chin-Sheng Liao
AU  - Ming-Cheng Lin
Y1  - 2017/12/14
PY  - 2017
N1  - https://doi.org/10.11648/j.ajlm.20180301.12
DO  - 10.11648/j.ajlm.20180301.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20180301.12
AB  - Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.
VL  - 3
IS  - 1
ER  -

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Author Information

Mei-Min Shiu

Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Bo-Yu Huang

Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Chien-Chi Liu

Department of Nursing, Hung Kuang University, Taichung, Taiwan
Chin-Sheng Liao

Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Ming-Cheng Lin

Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan

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APA Style

Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin. (2017). Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. American Journal of Laboratory Medicine, 3(1), 6-10. https://doi.org/10.11648/j.ajlm.20180301.12

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ACS Style

Mei-Min Shiu; Bo-Yu Huang; Chien-Chi Liu; Chin-Sheng Liao; Ming-Cheng Lin. Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. Am. J. Lab. Med. 2017, 3(1), 6-10. doi: 10.11648/j.ajlm.20180301.12

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AMA Style

Mei-Min Shiu, Bo-Yu Huang, Chien-Chi Liu, Chin-Sheng Liao, Ming-Cheng Lin. Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation. Am J Lab Med. 2017;3(1):6-10. doi: 10.11648/j.ajlm.20180301.12

Copy | Download

@article{10.11648/j.ajlm.20180301.12,
  author = {Mei-Min Shiu and Bo-Yu Huang and Chien-Chi Liu and Chin-Sheng Liao and Ming-Cheng Lin},
  title = {Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation},
  journal = {American Journal of Laboratory Medicine},
  volume = {3},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.ajlm.20180301.12},
  url = {https://doi.org/10.11648/j.ajlm.20180301.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20180301.12},
  abstract = {Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.},
 year = {2017}
}

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TY  - JOUR
T1  - Protective Effect of Antrodia Camphorate on the Tissues of Brain, Kidney, Lung, and Liver Is Correlated with Declining Lipid Peroxidation
AU  - Mei-Min Shiu
AU  - Bo-Yu Huang
AU  - Chien-Chi Liu
AU  - Chin-Sheng Liao
AU  - Ming-Cheng Lin
Y1  - 2017/12/14
PY  - 2017
N1  - https://doi.org/10.11648/j.ajlm.20180301.12
DO  - 10.11648/j.ajlm.20180301.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20180301.12
AB  - Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.
VL  - 3
IS  - 1
ER  -

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