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Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Received: 25 April 2021     Accepted: 18 May 2021     Published: 7 June 2021
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Abstract

Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.

Published in American Journal of Internal Medicine (Volume 9, Issue 3)
DOI 10.11648/j.ajim.20210903.17
Page(s) 148-152
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Asthma, Chronic Obstructive Pulmonary Disease, Differential Diagnosis, Immune Inflammation, Cytotoxic Lymphocytes, CD Antibodies

References
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Cite This Article
  • APA Style

    Natalya Avtandilovna Raspopina, Shuganov Evgeny Grigoryevich, Salmasi Jean Mustafaevich, Shuganov Altxander Evgenyevich, Popova Elena Nikolaevna, et al. (2021). Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. American Journal of Internal Medicine, 9(3), 148-152. https://doi.org/10.11648/j.ajim.20210903.17

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    ACS Style

    Natalya Avtandilovna Raspopina; Shuganov Evgeny Grigoryevich; Salmasi Jean Mustafaevich; Shuganov Altxander Evgenyevich; Popova Elena Nikolaevna, et al. Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. Am. J. Intern. Med. 2021, 9(3), 148-152. doi: 10.11648/j.ajim.20210903.17

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    AMA Style

    Natalya Avtandilovna Raspopina, Shuganov Evgeny Grigoryevich, Salmasi Jean Mustafaevich, Shuganov Altxander Evgenyevich, Popova Elena Nikolaevna, et al. Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. Am J Intern Med. 2021;9(3):148-152. doi: 10.11648/j.ajim.20210903.17

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  • @article{10.11648/j.ajim.20210903.17,
      author = {Natalya Avtandilovna Raspopina and Shuganov Evgeny Grigoryevich and Salmasi Jean Mustafaevich and Shuganov Altxander Evgenyevich and Popova Elena Nikolaevna and Subbotina Tatyana Igorevna and Filippova Tamara Vladimirovna},
      title = {Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features},
      journal = {American Journal of Internal Medicine},
      volume = {9},
      number = {3},
      pages = {148-152},
      doi = {10.11648/j.ajim.20210903.17},
      url = {https://doi.org/10.11648/j.ajim.20210903.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210903.17},
      abstract = {Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features
    AU  - Natalya Avtandilovna Raspopina
    AU  - Shuganov Evgeny Grigoryevich
    AU  - Salmasi Jean Mustafaevich
    AU  - Shuganov Altxander Evgenyevich
    AU  - Popova Elena Nikolaevna
    AU  - Subbotina Tatyana Igorevna
    AU  - Filippova Tamara Vladimirovna
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    N1  - https://doi.org/10.11648/j.ajim.20210903.17
    DO  - 10.11648/j.ajim.20210903.17
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
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    EP  - 152
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20210903.17
    AB  - Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.
    VL  - 9
    IS  - 3
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Author Information
  • Institute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia

  • Department of Therapy, State Budgetary Institution Moscow Regional Research and Clinical Institute n. a. M. F. Vladimirsky. Moscow, Russia

  • Pirogov Russian National Research Medical University (RNRMU) of Ministry of Health of Russia, Moscow, Russia

  • Department of Therapy, State Budgetary Institution Moscow Regional Research and Clinical Institute n. a. M. F. Vladimirsky. Moscow, Russia

  • Institute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia

  • nstitute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia

  • nstitute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia

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