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Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh

Received: 18 December 2020     Accepted: 30 December 2020     Published: 15 January 2021
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Abstract

Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.

Published in American Journal of Internal Medicine (Volume 9, Issue 1)
DOI 10.11648/j.ajim.20210901.12
Page(s) 11-16
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

SARS-CoV-2, COVID-19, Pregnancy, Outcome

References
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[3] Cascella M, Rajnik M, Cuomo A, et al. Features, Evaluation and Treatment Corona virus (COVID-19) [Updated 2020 Jul 4]. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554776.
[4] Zhu J, Ji P, Pang J, et al. Clinical characteristics of 3062 COVID-19 patients: A meta analysis. J Med Virol. 2020.92: 1902-1914. 10.1002/jmv.25884.
[5] Wang D, Li FR, Wang J, et al. Association between severity of COVID-19 and clinical and biochemical characteristics: a cross-sectional Study, Research square: infectious disease [preprint]. 10.21203/rs.3.rs-18482/v1.
[6] Contreras G, Gutiérrez M, Beroíza T, et al. Ventilatory drive and respiratory muscle function in pregnancy. Am Rev Respir Dis. 1991; 144: 837–41. https://doi.org/10.1164/ajrccm/144.4.
[7] Lederman MM. Cell-mediated immunity and pregnancy [J]. Chest. 1984; 86: 6S-9S.https://doi.org/10.1186/s12884-020-03026-3.
[8] WHO guidance on management of severe acute respiratory infection (SARI) when COVID19 is suspected; https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected.
[9] National Guidelines on Clinical Management of Coronavirus Disease 2019 (Covid-19), 27 May, 2020 https://dghs.gov.bd/images/docs/Guideline/COVID_Guideline.pdf.
[10] Zhang, L., Dong, L., Ming, L. et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during late pregnancy: a report of 18 patients from Wuhan, China. BMC Pregnancy Childbirth 20, 394 (2020). https://doi.org/10.1186/s12884-020-03026-3.
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[12] Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99 (7): 823-829. 10.1111/aogs.13867.
[13] San-Juana R, Barberob P, Fernandez-Ruiz M, et al. Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain. Eclinical medicine. 2020; 23: 100407. https://doi.org/10.1016/j.eclinm.2020.100407.
[14] Martínez-Perez O, Vouga M, Cruz Melguizo S, et al. Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain [published online ahead of print, 2020 Jun 8] [published correction appears in JAMA. 2020 21; 324 (3): 305]. JAMA. 2020; e2010125. 10.1001/jama.2020.10125.
[15] Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost. 2020; 18: 1648-1652.10.1111/jth.14856.
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Cite This Article
  • APA Style

    S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, et al. (2021). Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. American Journal of Internal Medicine, 9(1), 11-16. https://doi.org/10.11648/j.ajim.20210901.12

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    ACS Style

    S. K. Jakaria Been Sayeed; Md. Mujibur Rahman; A. K. M. Humayon Kabir; Md. Moniruzzaman; Reaz Mahmud, et al. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. Am. J. Intern. Med. 2021, 9(1), 11-16. doi: 10.11648/j.ajim.20210901.12

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    AMA Style

    S. K. Jakaria Been Sayeed, Md. Mujibur Rahman, A. K. M. Humayon Kabir, Md. Moniruzzaman, Reaz Mahmud, et al. Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh. Am J Intern Med. 2021;9(1):11-16. doi: 10.11648/j.ajim.20210901.12

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  • @article{10.11648/j.ajim.20210901.12,
      author = {S. K. Jakaria Been Sayeed and Md. Mujibur Rahman and A. K. M. Humayon Kabir and Md. Moniruzzaman and Reaz Mahmud and Mohammad Abdullah Yusuf and Sabrina Rahman},
      title = {Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh},
      journal = {American Journal of Internal Medicine},
      volume = {9},
      number = {1},
      pages = {11-16},
      doi = {10.11648/j.ajim.20210901.12},
      url = {https://doi.org/10.11648/j.ajim.20210901.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210901.12},
      abstract = {Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Clinical, Laboratory Characteristics and Pregnancy Outcome of COVID-19 Patients Admitted in the Largest COVID Dedicated Hospital of Bangladesh
    AU  - S. K. Jakaria Been Sayeed
    AU  - Md. Mujibur Rahman
    AU  - A. K. M. Humayon Kabir
    AU  - Md. Moniruzzaman
    AU  - Reaz Mahmud
    AU  - Mohammad Abdullah Yusuf
    AU  - Sabrina Rahman
    Y1  - 2021/01/15
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajim.20210901.12
    DO  - 10.11648/j.ajim.20210901.12
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 11
    EP  - 16
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20210901.12
    AB  - Background: The 2019 novel corona virus (SARS-CoV-2) has become pandemic, it is of paramount importance to conduct near-real-time surveillance of women who are hospitalized and test positive for COVID-19 during pregnancy. Objective: The purpose of the present study was to evaluate clinical and laboratory characteristics and pregnancy outcome among COVID-19 patients. Methodology: This was a prospective longitudinal study done in COVID dedicated unit of Dhaka Medical College Hospital. All pregnant women admitted with confirmed COVID-19 were included. Result: Among 68 pregnant COVID patients mean (SD) age was 26.58 (4.30) years where gestational age was 25.90 (5.34) weeks. Most common symptoms were fever (94%), cough (79%), sore throat (59%), shortness of breath (44), myalgia (34%). According to severity assessment, 51 (75%) was found to be mild, moderate 9 (13%) and severe 8 (12%) respectively. Regarding overall maternal outcome among 68 patients 64 (94%) recovered and discharged, 2 (3%) of them recovered but abortion occurred and 2 (3%) died. Mean (SD) gestational age during delivery was 37.8 (1.2) weeks. Vaginal delivery was done in 18 (35%), cesarean section in 33 (65%) and 13 (19%) continuing pregnancy. Among fifty one neonate, only 41 (80%) completed RT-PCR test and found negative. Regarding neonatal outcome, 48 (94.2%) term baby, 3 (5.8%) preterm, neonatal pneumonia 1 (1%), neonatal hyperbilirubinemia 3 (6%) were observed. Conclusion: The SARS-CoV-2 infection during pregnancy might not associate with adverse obstetrical and neonatal outcomes. It appears to be unlikely of perinatal transmission of SARS-CoV-2.
    VL  - 9
    IS  - 1
    ER  - 

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Author Information
  • Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh

  • Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh

  • Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh

  • Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh

  • Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh

  • Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh

  • Medicine Department, Dhaka Medical College Hospital, Dhaka, Bangladesh

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