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Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy

Received: 22 March 2020     Accepted: 6 May 2020     Published: 19 May 2020
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Abstract

Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.

Published in American Journal of Internal Medicine (Volume 8, Issue 3)
DOI 10.11648/j.ajim.20200803.15
Page(s) 121-124
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Lymphoblastic Lymphoma, Acute Lymphoblastic Leukemia B, t (9.22), Hyperdiploidy, Child

References
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[3] J. Bruneaua, D. Canionia, and T. Jo Molinaa, ‘‘Révision 2016/2017 de la classification OMS des hémopathies lymphoïdes matures: ce qui va changer dans la pratique quotidienne’’, Revue Francophone Des Laboratoires, vol. 488, pp. 39-48, Janvier 2017.
[4] S. De Botton, P. Fenaux, and B. Quesnel, ‘‘Facteurs pronostiques des leucémies aiguës et des lymphomes’’, Réanimation, vol. 11, pp. 306-16, 2002.
[5] Laboratoire d’hématologie cellulaire du CHU d’Angers, ‘‘Leucémies Aiguës Lymphoblastiques’’, www.hematocell.fr, Juin 2016.
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[7] A. Vogetseder, C. Gengler, T. Reineke, and M. Tinguely, ‘‘Diagnostic du lymphome en pédiatrie Actualité du point de vue des pathologistes’’, Forum Med Suisse, vol. 11 (5), pp. 73–78, 2011.
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[14] S. Garciaz, D. Coso, P. Brice, and R. Bouabdallah, ‘‘Lymphomes hodgkiniens et non hodgkiniens des adolescents et des jeunes adultes’’, Bulletin du Cancer, Vol. 103, pp. 1035-1049, December 2016.
[15] M. Lafage-Pochitaloff, and C. Charrin, ‘‘Anomalies cytogénétiques dans les leucémies aiguës lymphoblastiques’’, Pathologie Biologie, vol. 51, pp. 329–336, 2003.
[16] C. Bastard, E. Callet Bauchu, A. Daudignon, D. Leroux, H. Poirel, and P. Talmant, ‘‘Recommandations pour la prise en charge cytogénétique des lymphomes malins non hodgkiniens de l’adulte établies par le Groupe Français de Cytogénétique Hématologique (GFCH)’’, Pathologie Biologie, vol. 52, pp. 260–262. 2004.
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Cite This Article
  • APA Style

    Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi. (2020). Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. American Journal of Internal Medicine, 8(3), 121-124. https://doi.org/10.11648/j.ajim.20200803.15

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    ACS Style

    Sophia Kahouli; Hafid Zahid; Saâd El kabbaj; Majid Benkirane; Nezha Messaoudi. Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. Am. J. Intern. Med. 2020, 8(3), 121-124. doi: 10.11648/j.ajim.20200803.15

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    AMA Style

    Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi. Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. Am J Intern Med. 2020;8(3):121-124. doi: 10.11648/j.ajim.20200803.15

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  • @article{10.11648/j.ajim.20200803.15,
      author = {Sophia Kahouli and Hafid Zahid and Saâd El kabbaj and Majid Benkirane and Nezha Messaoudi},
      title = {Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy},
      journal = {American Journal of Internal Medicine},
      volume = {8},
      number = {3},
      pages = {121-124},
      doi = {10.11648/j.ajim.20200803.15},
      url = {https://doi.org/10.11648/j.ajim.20200803.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200803.15},
      abstract = {Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy
    AU  - Sophia Kahouli
    AU  - Hafid Zahid
    AU  - Saâd El kabbaj
    AU  - Majid Benkirane
    AU  - Nezha Messaoudi
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    DO  - 10.11648/j.ajim.20200803.15
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 121
    EP  - 124
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20200803.15
    AB  - Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.
    VL  - 8
    IS  - 3
    ER  - 

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Author Information
  • Laboratory of Research and Medical Analysis of the Fraternal of the Royal Gendarmerie, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

  • Hematology-Immunohematology Service of the Military Instruction Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

  • Laboratory Center of the Military Instructional Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

  • Hematology-Immunohematology Service of the Military Instruction Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

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