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An Ephemeral Review on Pulmonary Arterial Hypertension

Received: 23 May 2019     Accepted: 25 June 2019     Published: 9 July 2019
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Abstract

Pulmonary arterial hypertension [PAH] is a rare and potentially fatal disease whose management is usually restricted to a few specialized centers. The crucial vascular modifications in pulmonary arterial hypertension are endothelial-cell proliferation, vasoconstriction, thrombosis and smooth-muscle cell. As patients don’t essentially board in the neighborhood to those centers, daily care and emergencies ought to be delegated to the primary and second lines. Reduced contractility of mycardium, decreased venous return and abnormal rate of exchange of gases leads to deprivation of oxygen to cell and death. Diagnosing and management of pulmonary arterial hypertension is critical. There is no cure for PAH. Modern developments regarding cell biology, molecular genetics and of idiopathic pulmonary arterial hypertension create new insights and therapeutic targets in the management. However, there are several treatment options that aim to reduce symptoms, improve the quality of life, and slow disease progression. This short review provides an outline of our therapeutic protocols supported out there information. Based on the analysis of the reasons for death in the PAH population, a review of the main emergencies is provided. Drugs include vasodilators, anticoagulants, antiplatelet agents, antiinflammatory therapies, and vascular-remodeling therapies. Most of the drugs have pleiotropic effects.

Published in American Journal of Internal Medicine (Volume 7, Issue 4)
DOI 10.11648/j.ajim.20190704.11
Page(s) 81-85
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Pulmonary Arterial Hypertension, Nitric Oxide, Hypoxemia, Thromboembolism, Vasopressors

References
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  • APA Style

    Akshima Gupta, Kanaparthi Sushrutha, Nikhil Kumar Vanjari. (2019). An Ephemeral Review on Pulmonary Arterial Hypertension. American Journal of Internal Medicine, 7(4), 81-85. https://doi.org/10.11648/j.ajim.20190704.11

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    ACS Style

    Akshima Gupta; Kanaparthi Sushrutha; Nikhil Kumar Vanjari. An Ephemeral Review on Pulmonary Arterial Hypertension. Am. J. Intern. Med. 2019, 7(4), 81-85. doi: 10.11648/j.ajim.20190704.11

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    AMA Style

    Akshima Gupta, Kanaparthi Sushrutha, Nikhil Kumar Vanjari. An Ephemeral Review on Pulmonary Arterial Hypertension. Am J Intern Med. 2019;7(4):81-85. doi: 10.11648/j.ajim.20190704.11

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  • @article{10.11648/j.ajim.20190704.11,
      author = {Akshima Gupta and Kanaparthi Sushrutha and Nikhil Kumar Vanjari},
      title = {An Ephemeral Review on Pulmonary Arterial Hypertension},
      journal = {American Journal of Internal Medicine},
      volume = {7},
      number = {4},
      pages = {81-85},
      doi = {10.11648/j.ajim.20190704.11},
      url = {https://doi.org/10.11648/j.ajim.20190704.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20190704.11},
      abstract = {Pulmonary arterial hypertension [PAH] is a rare and potentially fatal disease whose management is usually restricted to a few specialized centers. The crucial vascular modifications in pulmonary arterial hypertension are endothelial-cell proliferation, vasoconstriction, thrombosis and smooth-muscle cell. As patients don’t essentially board in the neighborhood to those centers, daily care and emergencies ought to be delegated to the primary and second lines. Reduced contractility of mycardium, decreased venous return and abnormal rate of exchange of gases leads to deprivation of oxygen to cell and death. Diagnosing and management of pulmonary arterial hypertension is critical. There is no cure for PAH. Modern developments regarding cell biology, molecular genetics and of idiopathic pulmonary arterial hypertension create new insights and therapeutic targets in the management. However, there are several treatment options that aim to reduce symptoms, improve the quality of life, and slow disease progression. This short review provides an outline of our therapeutic protocols supported out there information. Based on the analysis of the reasons for death in the PAH population, a review of the main emergencies is provided. Drugs include vasodilators, anticoagulants, antiplatelet agents, antiinflammatory therapies, and vascular-remodeling therapies. Most of the drugs have pleiotropic effects.},
     year = {2019}
    }
    

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    AU  - Akshima Gupta
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    AU  - Nikhil Kumar Vanjari
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    N1  - https://doi.org/10.11648/j.ajim.20190704.11
    DO  - 10.11648/j.ajim.20190704.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
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    UR  - https://doi.org/10.11648/j.ajim.20190704.11
    AB  - Pulmonary arterial hypertension [PAH] is a rare and potentially fatal disease whose management is usually restricted to a few specialized centers. The crucial vascular modifications in pulmonary arterial hypertension are endothelial-cell proliferation, vasoconstriction, thrombosis and smooth-muscle cell. As patients don’t essentially board in the neighborhood to those centers, daily care and emergencies ought to be delegated to the primary and second lines. Reduced contractility of mycardium, decreased venous return and abnormal rate of exchange of gases leads to deprivation of oxygen to cell and death. Diagnosing and management of pulmonary arterial hypertension is critical. There is no cure for PAH. Modern developments regarding cell biology, molecular genetics and of idiopathic pulmonary arterial hypertension create new insights and therapeutic targets in the management. However, there are several treatment options that aim to reduce symptoms, improve the quality of life, and slow disease progression. This short review provides an outline of our therapeutic protocols supported out there information. Based on the analysis of the reasons for death in the PAH population, a review of the main emergencies is provided. Drugs include vasodilators, anticoagulants, antiplatelet agents, antiinflammatory therapies, and vascular-remodeling therapies. Most of the drugs have pleiotropic effects.
    VL  - 7
    IS  - 4
    ER  - 

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Author Information
  • Department of Clinical Pharmacy, Vaageswari College of Pharmacy, Karimnagar, Telangana, India

  • Department of Clinical Pharmacy, Vaageswari College of Pharmacy, Karimnagar, Telangana, India

  • Department of Clinical Pharmacy, Vaageswari College of Pharmacy, Karimnagar, Telangana, India

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