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Radiocontrast-Induced Acute Kidney Injury Following Coronary Angiography and Percutaneous Coronary Intervention: A Retrospective Cohort Study

Received: 22 August 2018     Accepted: 10 September 2018     Published: 10 October 2018
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Abstract

Despite the remarkable technological advances in coronary angiography (CA)/percutaneous coronary intervention (PCI) for diagnosis and treatment of coronary artery disease, the contrast-induced acute kidney injury (CI-AKI) is always an important cause of hospital-acquired AKI. Most local CI-AKI studies in Vietnam had small sample sizes and short-term follow-up of only 24-48 hours following CA or PCI intervention, resulting in controversial conclusions. We conducted a study of the incidence of CI-AKI during a longer follow-up time period and associated risk factors among adult patients undergoing CA/ PCI at Nguyen Tri Phuong University Public Hospital and Tam Duc Private Cardiology Center in Ho Chi Minh City, Vietnam between January 2014 and March 2015. All 320 patients with CA/PCI at the two hospitals were enrolled in a retrospective cohort study. Information on demographic data, treatment, and laboratory test results was collected from the patients’ records. The total cumulative incidence of CI-AKI at 24, 48, 72 and ≥72 hours following CA/PCI was 6.7%, 12%, 14% and 16.9% respectively. Prognostic factors for CI-AKI included an increase by 1 ml/min/1,73m² in clearance creatinine before the intervention (P = 0.006, Hazard Ratio (HR) = 0.970, 95%CI 0.949 – 0.991) and an increase by 1% in ejection fraction (P = 0.023, HR = 0.984, 95%CI 0.970 – 0.998). Delayed CI-AKI was not rare after CA/PCI intervention. Therefore, it is pivotal to monitor serum creatinine in a longer time after the intervention to timely detect CI-AKI. Also, information on risk factors such as emergency interventions, chronic kidney disease, and ejection fraction < 45% could assist in predicting CI-AKI development.

Published in American Journal of Internal Medicine (Volume 6, Issue 5)
DOI 10.11648/j.ajim.20180605.18
Page(s) 138-143
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Acute Kidney Injury, Coronary Angiography, Percutaneous Coronary Intervention, Radiocontrast Media

References
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    Van Bui Pham, Quang Dung Nguyen, Nghia Huynh Thi Nguyen, Thanh Phuong Pham Nguyen, Thanh Liem Vo, et al. (2018). Radiocontrast-Induced Acute Kidney Injury Following Coronary Angiography and Percutaneous Coronary Intervention: A Retrospective Cohort Study. American Journal of Internal Medicine, 6(5), 138-143. https://doi.org/10.11648/j.ajim.20180605.18

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    Van Bui Pham; Quang Dung Nguyen; Nghia Huynh Thi Nguyen; Thanh Phuong Pham Nguyen; Thanh Liem Vo, et al. Radiocontrast-Induced Acute Kidney Injury Following Coronary Angiography and Percutaneous Coronary Intervention: A Retrospective Cohort Study. Am. J. Intern. Med. 2018, 6(5), 138-143. doi: 10.11648/j.ajim.20180605.18

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    AMA Style

    Van Bui Pham, Quang Dung Nguyen, Nghia Huynh Thi Nguyen, Thanh Phuong Pham Nguyen, Thanh Liem Vo, et al. Radiocontrast-Induced Acute Kidney Injury Following Coronary Angiography and Percutaneous Coronary Intervention: A Retrospective Cohort Study. Am J Intern Med. 2018;6(5):138-143. doi: 10.11648/j.ajim.20180605.18

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  • @article{10.11648/j.ajim.20180605.18,
      author = {Van Bui Pham and Quang Dung Nguyen and Nghia Huynh Thi Nguyen and Thanh Phuong Pham Nguyen and Thanh Liem Vo and Minh Cuong Duong},
      title = {Radiocontrast-Induced Acute Kidney Injury Following Coronary Angiography and Percutaneous Coronary Intervention: A Retrospective Cohort Study},
      journal = {American Journal of Internal Medicine},
      volume = {6},
      number = {5},
      pages = {138-143},
      doi = {10.11648/j.ajim.20180605.18},
      url = {https://doi.org/10.11648/j.ajim.20180605.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20180605.18},
      abstract = {Despite the remarkable technological advances in coronary angiography (CA)/percutaneous coronary intervention (PCI) for diagnosis and treatment of coronary artery disease, the contrast-induced acute kidney injury (CI-AKI) is always an important cause of hospital-acquired AKI. Most local CI-AKI studies in Vietnam had small sample sizes and short-term follow-up of only 24-48 hours following CA or PCI intervention, resulting in controversial conclusions. We conducted a study of the incidence of CI-AKI during a longer follow-up time period and associated risk factors among adult patients undergoing CA/ PCI at Nguyen Tri Phuong University Public Hospital and Tam Duc Private Cardiology Center in Ho Chi Minh City, Vietnam between January 2014 and March 2015. All 320 patients with CA/PCI at the two hospitals were enrolled in a retrospective cohort study. Information on demographic data, treatment, and laboratory test results was collected from the patients’ records. The total cumulative incidence of CI-AKI at 24, 48, 72 and ≥72 hours following CA/PCI was 6.7%, 12%, 14% and 16.9% respectively. Prognostic factors for CI-AKI included an increase by 1 ml/min/1,73m² in clearance creatinine before the intervention (P = 0.006, Hazard Ratio (HR) = 0.970, 95%CI 0.949 – 0.991) and an increase by 1% in ejection fraction (P = 0.023, HR = 0.984, 95%CI 0.970 – 0.998). Delayed CI-AKI was not rare after CA/PCI intervention. Therefore, it is pivotal to monitor serum creatinine in a longer time after the intervention to timely detect CI-AKI. Also, information on risk factors such as emergency interventions, chronic kidney disease, and ejection fraction < 45% could assist in predicting CI-AKI development.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Radiocontrast-Induced Acute Kidney Injury Following Coronary Angiography and Percutaneous Coronary Intervention: A Retrospective Cohort Study
    AU  - Van Bui Pham
    AU  - Quang Dung Nguyen
    AU  - Nghia Huynh Thi Nguyen
    AU  - Thanh Phuong Pham Nguyen
    AU  - Thanh Liem Vo
    AU  - Minh Cuong Duong
    Y1  - 2018/10/10
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ajim.20180605.18
    DO  - 10.11648/j.ajim.20180605.18
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 138
    EP  - 143
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20180605.18
    AB  - Despite the remarkable technological advances in coronary angiography (CA)/percutaneous coronary intervention (PCI) for diagnosis and treatment of coronary artery disease, the contrast-induced acute kidney injury (CI-AKI) is always an important cause of hospital-acquired AKI. Most local CI-AKI studies in Vietnam had small sample sizes and short-term follow-up of only 24-48 hours following CA or PCI intervention, resulting in controversial conclusions. We conducted a study of the incidence of CI-AKI during a longer follow-up time period and associated risk factors among adult patients undergoing CA/ PCI at Nguyen Tri Phuong University Public Hospital and Tam Duc Private Cardiology Center in Ho Chi Minh City, Vietnam between January 2014 and March 2015. All 320 patients with CA/PCI at the two hospitals were enrolled in a retrospective cohort study. Information on demographic data, treatment, and laboratory test results was collected from the patients’ records. The total cumulative incidence of CI-AKI at 24, 48, 72 and ≥72 hours following CA/PCI was 6.7%, 12%, 14% and 16.9% respectively. Prognostic factors for CI-AKI included an increase by 1 ml/min/1,73m² in clearance creatinine before the intervention (P = 0.006, Hazard Ratio (HR) = 0.970, 95%CI 0.949 – 0.991) and an increase by 1% in ejection fraction (P = 0.023, HR = 0.984, 95%CI 0.970 – 0.998). Delayed CI-AKI was not rare after CA/PCI intervention. Therefore, it is pivotal to monitor serum creatinine in a longer time after the intervention to timely detect CI-AKI. Also, information on risk factors such as emergency interventions, chronic kidney disease, and ejection fraction < 45% could assist in predicting CI-AKI development.
    VL  - 6
    IS  - 5
    ER  - 

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Author Information
  • Department of Nephrology-Urology-Transplantation, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam

  • Department of Cardiology and Cardiovascular Intervention, Nguyen Tri Phuong Hospital, Ho Chi Minh City, Vietnam

  • Department of Internal Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam

  • Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

  • Department of Family Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam

  • School of Public Health and Community Medicine, University of New South Wales, Kensington, Australia

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