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Relationship Between Neutrophil-Lymphocyte Ratio and Microvascular Complications in Egyptian Patients with Type 2 Diabetes

Received: 29 October 2015     Accepted: 18 November 2015     Published: 22 December 2015
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Abstract

Several epidemiological studies have shown that chronic inflammation plays a central role in the pathogenesis of diabetes and its various complications. Neutrophil-lymphocyte ratio (NLR) is a novel potential marker in determining inflammation. The aim of this study was to evaluate the relationship between diabetic microvascular complications, namely diabetic retinopathy, nephropathy, neuropathy, and neutrophil-lymphocyte ratio in type 2 diabetic patients. The study took place in the Unit of Diabetes & Metabolism at the Faculty of Medicine, Alexandria University, Alexandria, Egypt, and included a total of 280 subjects, 200 male patients with type 2 diabetes, 108 of them having one or more microvascular complication, and a control group including 80 healthy age and sex-matched subjects. Results of our study showed that neutrophil-lymphocyte ratio (NLR) values were significantly higher in diabetic patients with retinopathy (p<0.001), neuropathy (p=0.025) and nephropathy (p<0.001) than those of diabetic patients without any microvascular complications and healthy control subjects. NLR levels correlated positively with body mass index (BMI) (r=0.436, p<0.001), glycosylated hemoglobin (HbA1c) (r=0.526, p=0.001) and erythrocyte sedimentation rate (ESR) (r=0.396, p=0.017). Based on the results of this study, we can conclude that neutrophil-lymphocyte ratio (NLR), which is an efficient, simple and stable marker of inflammation, can serve as an important predictor for the presence of microvascular complications in Egyptian patients with type 2 diabetes.

Published in American Journal of Internal Medicine (Volume 3, Issue 6)
DOI 10.11648/j.ajim.20150306.16
Page(s) 250-255
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Neutrophil-Lymphocyte Ratio (NLR), Type 2 Diabetes, Microvascular Complications, Diabetic Retinopathy, Diabetic Nephropathy, Diabetic Neuropathy, Egypt

References
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Cite This Article
  • APA Style

    Eman Youssef Moursy, Magdy Helmy Megallaa, Reham Fadl Mouftah, Soha Magdy Ahmed. (2015). Relationship Between Neutrophil-Lymphocyte Ratio and Microvascular Complications in Egyptian Patients with Type 2 Diabetes. American Journal of Internal Medicine, 3(6), 250-255. https://doi.org/10.11648/j.ajim.20150306.16

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    ACS Style

    Eman Youssef Moursy; Magdy Helmy Megallaa; Reham Fadl Mouftah; Soha Magdy Ahmed. Relationship Between Neutrophil-Lymphocyte Ratio and Microvascular Complications in Egyptian Patients with Type 2 Diabetes. Am. J. Intern. Med. 2015, 3(6), 250-255. doi: 10.11648/j.ajim.20150306.16

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    AMA Style

    Eman Youssef Moursy, Magdy Helmy Megallaa, Reham Fadl Mouftah, Soha Magdy Ahmed. Relationship Between Neutrophil-Lymphocyte Ratio and Microvascular Complications in Egyptian Patients with Type 2 Diabetes. Am J Intern Med. 2015;3(6):250-255. doi: 10.11648/j.ajim.20150306.16

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  • @article{10.11648/j.ajim.20150306.16,
      author = {Eman Youssef Moursy and Magdy Helmy Megallaa and Reham Fadl Mouftah and Soha Magdy Ahmed},
      title = {Relationship Between Neutrophil-Lymphocyte Ratio and Microvascular Complications in Egyptian Patients with Type 2 Diabetes},
      journal = {American Journal of Internal Medicine},
      volume = {3},
      number = {6},
      pages = {250-255},
      doi = {10.11648/j.ajim.20150306.16},
      url = {https://doi.org/10.11648/j.ajim.20150306.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150306.16},
      abstract = {Several epidemiological studies have shown that chronic inflammation plays a central role in the pathogenesis of diabetes and its various complications. Neutrophil-lymphocyte ratio (NLR) is a novel potential marker in determining inflammation. The aim of this study was to evaluate the relationship between diabetic microvascular complications, namely diabetic retinopathy, nephropathy, neuropathy, and neutrophil-lymphocyte ratio in type 2 diabetic patients. The study took place in the Unit of Diabetes & Metabolism at the Faculty of Medicine, Alexandria University, Alexandria, Egypt, and included a total of 280 subjects, 200 male patients with type 2 diabetes, 108 of them having one or more microvascular complication, and a control group including 80 healthy age and sex-matched subjects. Results of our study showed that neutrophil-lymphocyte ratio (NLR) values were significantly higher in diabetic patients with retinopathy (p<0.001), neuropathy (p=0.025) and nephropathy (p<0.001) than those of diabetic patients without any microvascular complications and healthy control subjects. NLR levels correlated positively with body mass index (BMI) (r=0.436, p<0.001), glycosylated hemoglobin (HbA1c) (r=0.526, p=0.001) and erythrocyte sedimentation rate (ESR) (r=0.396, p=0.017). Based on the results of this study, we can conclude that neutrophil-lymphocyte ratio (NLR), which is an efficient, simple and stable marker of inflammation, can serve as an important predictor for the presence of microvascular complications in Egyptian patients with type 2 diabetes.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Relationship Between Neutrophil-Lymphocyte Ratio and Microvascular Complications in Egyptian Patients with Type 2 Diabetes
    AU  - Eman Youssef Moursy
    AU  - Magdy Helmy Megallaa
    AU  - Reham Fadl Mouftah
    AU  - Soha Magdy Ahmed
    Y1  - 2015/12/22
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajim.20150306.16
    DO  - 10.11648/j.ajim.20150306.16
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 250
    EP  - 255
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20150306.16
    AB  - Several epidemiological studies have shown that chronic inflammation plays a central role in the pathogenesis of diabetes and its various complications. Neutrophil-lymphocyte ratio (NLR) is a novel potential marker in determining inflammation. The aim of this study was to evaluate the relationship between diabetic microvascular complications, namely diabetic retinopathy, nephropathy, neuropathy, and neutrophil-lymphocyte ratio in type 2 diabetic patients. The study took place in the Unit of Diabetes & Metabolism at the Faculty of Medicine, Alexandria University, Alexandria, Egypt, and included a total of 280 subjects, 200 male patients with type 2 diabetes, 108 of them having one or more microvascular complication, and a control group including 80 healthy age and sex-matched subjects. Results of our study showed that neutrophil-lymphocyte ratio (NLR) values were significantly higher in diabetic patients with retinopathy (p<0.001), neuropathy (p=0.025) and nephropathy (p<0.001) than those of diabetic patients without any microvascular complications and healthy control subjects. NLR levels correlated positively with body mass index (BMI) (r=0.436, p<0.001), glycosylated hemoglobin (HbA1c) (r=0.526, p=0.001) and erythrocyte sedimentation rate (ESR) (r=0.396, p=0.017). Based on the results of this study, we can conclude that neutrophil-lymphocyte ratio (NLR), which is an efficient, simple and stable marker of inflammation, can serve as an important predictor for the presence of microvascular complications in Egyptian patients with type 2 diabetes.
    VL  - 3
    IS  - 6
    ER  - 

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Author Information
  • Unit of Diabetes & Metabolism, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt

  • Unit of Diabetes & Metabolism, Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt

  • Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

  • Alexandria Students Hospital, Ministry of Health, Alexandria, Egypt

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