This report describes a case which successfully treated with rituximab against autoimmune hemolytic anemia caused by both warm autoantibodies and cold agglutinin (mixed AIHA). A 52-year-old man with malaise was referred to our hospital in December 2002. A diagnosis of mixed AIHA was made. His clinical course showed that the hemolysis was mainly caused by cold agglutinin, with a possible contribution from the warm autoantibody. He was treated with prednisolone (PSL), Cyclosporine (CyA), and cyclophosphamide (CPA). The treatment with PSL, CyA, and CPA failed to stabilize the hemolysis caused by cold exposure in the winter season. In November 2013 (winter season), rituximab therapy (375 mg/m2 weekly for four weeks) was started, and the hemolysis improved. The present case suggests that rituximab is useful against mixed AIHA. Further studies are warranted to establish the effectiveness of rituximab against mixed AIHA.
| Published in | American Journal of Internal Medicine (Volume 3, Issue 4) |
| DOI | 10.11648/j.ajim.20150304.12 |
| Page(s) | 156-159 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Autoimmune Hemolytic Anemia, Rituximab, Mixed Autoimmune Hemolytic Anemia
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APA Style
Motoharu Shibusawa, Yoshirou Murai, Hisashi Tsutsumi. (2015). Successful Rituximab Treatment of Autoimmune Hemolytic Anemia Caused by Both Warm Autoantibodies and Cold Agglutinin: A Case Report. American Journal of Internal Medicine, 3(4), 156-159. https://doi.org/10.11648/j.ajim.20150304.12
ACS Style
Motoharu Shibusawa; Yoshirou Murai; Hisashi Tsutsumi. Successful Rituximab Treatment of Autoimmune Hemolytic Anemia Caused by Both Warm Autoantibodies and Cold Agglutinin: A Case Report. Am. J. Intern. Med. 2015, 3(4), 156-159. doi: 10.11648/j.ajim.20150304.12
AMA Style
Motoharu Shibusawa, Yoshirou Murai, Hisashi Tsutsumi. Successful Rituximab Treatment of Autoimmune Hemolytic Anemia Caused by Both Warm Autoantibodies and Cold Agglutinin: A Case Report. Am J Intern Med. 2015;3(4):156-159. doi: 10.11648/j.ajim.20150304.12
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Download@article{10.11648/j.ajim.20150304.12,
author = {Motoharu Shibusawa and Yoshirou Murai and Hisashi Tsutsumi},
title = {Successful Rituximab Treatment of Autoimmune Hemolytic Anemia Caused by Both Warm Autoantibodies and Cold Agglutinin: A Case Report},
journal = {American Journal of Internal Medicine},
volume = {3},
number = {4},
pages = {156-159},
doi = {10.11648/j.ajim.20150304.12},
url = {https://doi.org/10.11648/j.ajim.20150304.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150304.12},
abstract = {This report describes a case which successfully treated with rituximab against autoimmune hemolytic anemia caused by both warm autoantibodies and cold agglutinin (mixed AIHA). A 52-year-old man with malaise was referred to our hospital in December 2002. A diagnosis of mixed AIHA was made. His clinical course showed that the hemolysis was mainly caused by cold agglutinin, with a possible contribution from the warm autoantibody. He was treated with prednisolone (PSL), Cyclosporine (CyA), and cyclophosphamide (CPA). The treatment with PSL, CyA, and CPA failed to stabilize the hemolysis caused by cold exposure in the winter season. In November 2013 (winter season), rituximab therapy (375 mg/m2 weekly for four weeks) was started, and the hemolysis improved. The present case suggests that rituximab is useful against mixed AIHA. Further studies are warranted to establish the effectiveness of rituximab against mixed AIHA.},
year = {2015}
}
TY - JOUR T1 - Successful Rituximab Treatment of Autoimmune Hemolytic Anemia Caused by Both Warm Autoantibodies and Cold Agglutinin: A Case Report AU - Motoharu Shibusawa AU - Yoshirou Murai AU - Hisashi Tsutsumi Y1 - 2015/06/23 PY - 2015 N1 - https://doi.org/10.11648/j.ajim.20150304.12 DO - 10.11648/j.ajim.20150304.12 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 156 EP - 159 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20150304.12 AB - This report describes a case which successfully treated with rituximab against autoimmune hemolytic anemia caused by both warm autoantibodies and cold agglutinin (mixed AIHA). A 52-year-old man with malaise was referred to our hospital in December 2002. A diagnosis of mixed AIHA was made. His clinical course showed that the hemolysis was mainly caused by cold agglutinin, with a possible contribution from the warm autoantibody. He was treated with prednisolone (PSL), Cyclosporine (CyA), and cyclophosphamide (CPA). The treatment with PSL, CyA, and CPA failed to stabilize the hemolysis caused by cold exposure in the winter season. In November 2013 (winter season), rituximab therapy (375 mg/m2 weekly for four weeks) was started, and the hemolysis improved. The present case suggests that rituximab is useful against mixed AIHA. Further studies are warranted to establish the effectiveness of rituximab against mixed AIHA. VL - 3 IS - 4 ER -
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