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Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population

Received: 8 September 2014     Accepted: 25 September 2014     Published: 30 October 2014
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Abstract

Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.

Published in American Journal of Internal Medicine (Volume 2, Issue 6)
DOI 10.11648/j.ajim.20140206.11
Page(s) 95-101
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Chronic Kidney Disease, Essential Hypertension, Hypertensive Nephrosclerosis, MYH9 Polymorphisms

References
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[8] Freedman BI, Hicks PJ, Bostrom MA, et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int 2009;75:736-45.
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    Diez-Ojea Beatriz, Marin Rafael, Coto Eliecer, Tavira Beatriz, Fernandez-Vega Francisco, et al. (2014). Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. American Journal of Internal Medicine, 2(6), 95-101. https://doi.org/10.11648/j.ajim.20140206.11

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    ACS Style

    Diez-Ojea Beatriz; Marin Rafael; Coto Eliecer; Tavira Beatriz; Fernandez-Vega Francisco, et al. Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. Am. J. Intern. Med. 2014, 2(6), 95-101. doi: 10.11648/j.ajim.20140206.11

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    AMA Style

    Diez-Ojea Beatriz, Marin Rafael, Coto Eliecer, Tavira Beatriz, Fernandez-Vega Francisco, et al. Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. Am J Intern Med. 2014;2(6):95-101. doi: 10.11648/j.ajim.20140206.11

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  • @article{10.11648/j.ajim.20140206.11,
      author = {Diez-Ojea Beatriz and Marin Rafael and Coto Eliecer and Tavira Beatriz and Fernandez-Vega Francisco and Alvarez Rafael and Fernandez-Fresnedo Gema and Pobes Alfonso and Suarez-Laures Ana and Garcia-Monteavaro Camino and Gorostidi Manuel and Sanchez Emilio and Arias Manuel and Ortega Francisco},
      title = {Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population},
      journal = {American Journal of Internal Medicine},
      volume = {2},
      number = {6},
      pages = {95-101},
      doi = {10.11648/j.ajim.20140206.11},
      url = {https://doi.org/10.11648/j.ajim.20140206.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20140206.11},
      abstract = {Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population
    AU  - Diez-Ojea Beatriz
    AU  - Marin Rafael
    AU  - Coto Eliecer
    AU  - Tavira Beatriz
    AU  - Fernandez-Vega Francisco
    AU  - Alvarez Rafael
    AU  - Fernandez-Fresnedo Gema
    AU  - Pobes Alfonso
    AU  - Suarez-Laures Ana
    AU  - Garcia-Monteavaro Camino
    AU  - Gorostidi Manuel
    AU  - Sanchez Emilio
    AU  - Arias Manuel
    AU  - Ortega Francisco
    Y1  - 2014/10/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajim.20140206.11
    DO  - 10.11648/j.ajim.20140206.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 95
    EP  - 101
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20140206.11
    AB  - Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Nephrology Service, Hospital Universitario De Torrevieja-Vinalopo, Alicante, Spain

  • Nephrology Service, Centro Médico De Asturias, Oviedo (Asturias), Spain

  • Laboratory of Molecular Genetics, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

  • Laboratory of Molecular Genetics, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

  • Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

  • Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

  • Nephrology Service, Hospital Universitario Marqués De Valdecilla, Santander (Cantabria), Spain

  • Nephrology Service, Hospital Valle Del Nalón, Langreo (Asturias), Spain

  • Nephrology Service, Hospital De Cabue?es, Gijón (Asturias), Spain

  • Nephrology Service, Hospital San Agustín, Avilés (Asturias), Spain

  • Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

  • Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

  • Nephrology Service, Hospital Universitario Marqués De Valdecilla, Santander (Cantabria), Spain

  • Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

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