Background and Aim: Eosinophilic esophagitis is an inflammatory disorder of the esophagus that is being increasingly diagnosed in the adult population. The present study aimed to determine the prevalence of eosinophilic esophagitis among Egyptian patients presenting with refractory GERD symptoms. Methods: 40 consecutive adult Egyptian patients with refractory GERD symptoms were enrolled in the study. Upper GIT endoscopy was done for all participants with at least 3 biopsies taken from 2 different sites in the esophagus including the distal and either mid or proximal esophagus even if the esophagus appeared endoscopically normal. Gastric and duodenal biopsies were also taken along with esophageal biopsies. All biopsies were examined histopathologically by blinded gastrointestinal pathologists. An esophageal eosinophilic count > 15/HPF, along with normal gastric and duodenal biopsies, substantiated the diagnosis of eosinophilic esophagitis. Results: The prevalence of eosinophilic esophagitis in this cohort was 2.5% (1/40). The affected participant was a 27 year old female patient who had a history of bronchial asthma (type 1 hypersensitivity reaction) for which she was treated with ,on demand, inhaled bronchodilators (short acting β agonist). The endoscopic examination of the affected participant showed furrows and plaques which are strongly suggestive of eosinophilic esophagitis. Conclusion: the low prevalence rate of eosinophilic esophagitis among the current small cohort of Egyptian patients with refractory GERD symptoms strongly mandates the search for additional data concerning the indications for esophageal biopsy in this subset of patients. History of atopy may warrant suspicion of eosinophilic esophagitis in this subset of patients.
| Published in | American Journal of Internal Medicine (Volume 2, Issue 2) |
| DOI | 10.11648/j.ajim.20140202.12 |
| Page(s) | 15-19 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Eosinophilic, Esophagitis, Refractory, GERD
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APA Style
Mohamed El malatawy, Hanan Badawy, Nanees Adel, Behnam Tahmasebpour, Reham Al Swaff. (2014). Prevalence of Eosinophilic Esophagitis in Patients with Refractory Gastro-esophageal Reflux Disease Symptoms. American Journal of Internal Medicine, 2(2), 15-19. https://doi.org/10.11648/j.ajim.20140202.12
ACS Style
Mohamed El malatawy; Hanan Badawy; Nanees Adel; Behnam Tahmasebpour; Reham Al Swaff. Prevalence of Eosinophilic Esophagitis in Patients with Refractory Gastro-esophageal Reflux Disease Symptoms. Am. J. Intern. Med. 2014, 2(2), 15-19. doi: 10.11648/j.ajim.20140202.12
AMA Style
Mohamed El malatawy, Hanan Badawy, Nanees Adel, Behnam Tahmasebpour, Reham Al Swaff. Prevalence of Eosinophilic Esophagitis in Patients with Refractory Gastro-esophageal Reflux Disease Symptoms. Am J Intern Med. 2014;2(2):15-19. doi: 10.11648/j.ajim.20140202.12
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Download@article{10.11648/j.ajim.20140202.12,
author = {Mohamed El malatawy and Hanan Badawy and Nanees Adel and Behnam Tahmasebpour and Reham Al Swaff},
title = {Prevalence of Eosinophilic Esophagitis in Patients with Refractory Gastro-esophageal Reflux Disease Symptoms},
journal = {American Journal of Internal Medicine},
volume = {2},
number = {2},
pages = {15-19},
doi = {10.11648/j.ajim.20140202.12},
url = {https://doi.org/10.11648/j.ajim.20140202.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20140202.12},
abstract = {Background and Aim: Eosinophilic esophagitis is an inflammatory disorder of the esophagus that is being increasingly diagnosed in the adult population. The present study aimed to determine the prevalence of eosinophilic esophagitis among Egyptian patients presenting with refractory GERD symptoms. Methods: 40 consecutive adult Egyptian patients with refractory GERD symptoms were enrolled in the study. Upper GIT endoscopy was done for all participants with at least 3 biopsies taken from 2 different sites in the esophagus including the distal and either mid or proximal esophagus even if the esophagus appeared endoscopically normal. Gastric and duodenal biopsies were also taken along with esophageal biopsies. All biopsies were examined histopathologically by blinded gastrointestinal pathologists. An esophageal eosinophilic count > 15/HPF, along with normal gastric and duodenal biopsies, substantiated the diagnosis of eosinophilic esophagitis. Results: The prevalence of eosinophilic esophagitis in this cohort was 2.5% (1/40). The affected participant was a 27 year old female patient who had a history of bronchial asthma (type 1 hypersensitivity reaction) for which she was treated with ,on demand, inhaled bronchodilators (short acting β agonist). The endoscopic examination of the affected participant showed furrows and plaques which are strongly suggestive of eosinophilic esophagitis. Conclusion: the low prevalence rate of eosinophilic esophagitis among the current small cohort of Egyptian patients with refractory GERD symptoms strongly mandates the search for additional data concerning the indications for esophageal biopsy in this subset of patients. History of atopy may warrant suspicion of eosinophilic esophagitis in this subset of patients.},
year = {2014}
}
TY - JOUR T1 - Prevalence of Eosinophilic Esophagitis in Patients with Refractory Gastro-esophageal Reflux Disease Symptoms AU - Mohamed El malatawy AU - Hanan Badawy AU - Nanees Adel AU - Behnam Tahmasebpour AU - Reham Al Swaff Y1 - 2014/03/10 PY - 2014 N1 - https://doi.org/10.11648/j.ajim.20140202.12 DO - 10.11648/j.ajim.20140202.12 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 15 EP - 19 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20140202.12 AB - Background and Aim: Eosinophilic esophagitis is an inflammatory disorder of the esophagus that is being increasingly diagnosed in the adult population. The present study aimed to determine the prevalence of eosinophilic esophagitis among Egyptian patients presenting with refractory GERD symptoms. Methods: 40 consecutive adult Egyptian patients with refractory GERD symptoms were enrolled in the study. Upper GIT endoscopy was done for all participants with at least 3 biopsies taken from 2 different sites in the esophagus including the distal and either mid or proximal esophagus even if the esophagus appeared endoscopically normal. Gastric and duodenal biopsies were also taken along with esophageal biopsies. All biopsies were examined histopathologically by blinded gastrointestinal pathologists. An esophageal eosinophilic count > 15/HPF, along with normal gastric and duodenal biopsies, substantiated the diagnosis of eosinophilic esophagitis. Results: The prevalence of eosinophilic esophagitis in this cohort was 2.5% (1/40). The affected participant was a 27 year old female patient who had a history of bronchial asthma (type 1 hypersensitivity reaction) for which she was treated with ,on demand, inhaled bronchodilators (short acting β agonist). The endoscopic examination of the affected participant showed furrows and plaques which are strongly suggestive of eosinophilic esophagitis. Conclusion: the low prevalence rate of eosinophilic esophagitis among the current small cohort of Egyptian patients with refractory GERD symptoms strongly mandates the search for additional data concerning the indications for esophageal biopsy in this subset of patients. History of atopy may warrant suspicion of eosinophilic esophagitis in this subset of patients. VL - 2 IS - 2 ER -
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