Coumarins are the most important oxygenated heterocyclic of natural compounds. They are widely used as raw materials in many areas such as agrochemical, perfume, pharmaceutical industries. They therefore have several physical, chemical and biological properties. In order to enlarge this family of compounds and elucidate almost all of its properties, researchers have developed various synthetic methods that are not very complex and less expensive. Thus, from 4-hydroxycoumarin we have synthesized a series of 3-acyl-4-hydroxycoumarins by C-acylation. This study is therefore dedicated to the reactivity of 3-acyl-4-hydroxycoumarins. The synthesized coumarins showed a high reaction potential based on the chemical functions present in their structures. To enhance them later, we can try to graft other functions which can be the subject of several transformations such as: condensation, functionalization, cyclization, acylation. So to access more interesting new poly-functionalized compounds both at the reactivity and biological level. These molecules (3-acyl-4-hydroxycoumarins) being new, very little information is known on their physicochemical behavior in writings. On the other hand, the reactivity of molecules with similar structures to those of acyl-hydroxycoumarins such as 4-acylisochroman-1,3-diones and 3-acetyl-4-hydroxycoumarin have been the subject of scientists’ work. It emerges from this study that 3-acyl-4-hydroxycoumarins shows strong chemical reactivity which can be used biologically.
| Published in | American Journal of Heterocyclic Chemistry (Volume 7, Issue 2) |
| DOI | 10.11648/j.ajhc.20210702.13 |
| Page(s) | 33-38 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
4-hydroxycoumarins, C-acylation, Acyl-hydroxycoumarins, Heterocyclic Compound
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APA Style
Youssoufou Bakouan, Bintou Sessouma, Têeda Hamidou Ganamé, Lassané Tarpaga, Jules Yoda, et al. (2021). Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins. American Journal of Heterocyclic Chemistry, 7(2), 33-38. https://doi.org/10.11648/j.ajhc.20210702.13
ACS Style
Youssoufou Bakouan; Bintou Sessouma; Têeda Hamidou Ganamé; Lassané Tarpaga; Jules Yoda, et al. Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins. Am. J. Heterocycl. Chem. 2021, 7(2), 33-38. doi: 10.11648/j.ajhc.20210702.13
AMA Style
Youssoufou Bakouan, Bintou Sessouma, Têeda Hamidou Ganamé, Lassané Tarpaga, Jules Yoda, et al. Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins. Am J Heterocycl Chem. 2021;7(2):33-38. doi: 10.11648/j.ajhc.20210702.13
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Download@article{10.11648/j.ajhc.20210702.13,
author = {Youssoufou Bakouan and Bintou Sessouma and Têeda Hamidou Ganamé and Lassané Tarpaga and Jules Yoda and Karifa Bayo},
title = {Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins},
journal = {American Journal of Heterocyclic Chemistry},
volume = {7},
number = {2},
pages = {33-38},
doi = {10.11648/j.ajhc.20210702.13},
url = {https://doi.org/10.11648/j.ajhc.20210702.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20210702.13},
abstract = {Coumarins are the most important oxygenated heterocyclic of natural compounds. They are widely used as raw materials in many areas such as agrochemical, perfume, pharmaceutical industries. They therefore have several physical, chemical and biological properties. In order to enlarge this family of compounds and elucidate almost all of its properties, researchers have developed various synthetic methods that are not very complex and less expensive. Thus, from 4-hydroxycoumarin we have synthesized a series of 3-acyl-4-hydroxycoumarins by C-acylation. This study is therefore dedicated to the reactivity of 3-acyl-4-hydroxycoumarins. The synthesized coumarins showed a high reaction potential based on the chemical functions present in their structures. To enhance them later, we can try to graft other functions which can be the subject of several transformations such as: condensation, functionalization, cyclization, acylation. So to access more interesting new poly-functionalized compounds both at the reactivity and biological level. These molecules (3-acyl-4-hydroxycoumarins) being new, very little information is known on their physicochemical behavior in writings. On the other hand, the reactivity of molecules with similar structures to those of acyl-hydroxycoumarins such as 4-acylisochroman-1,3-diones and 3-acetyl-4-hydroxycoumarin have been the subject of scientists’ work. It emerges from this study that 3-acyl-4-hydroxycoumarins shows strong chemical reactivity which can be used biologically.},
year = {2021}
}
TY - JOUR T1 - Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins AU - Youssoufou Bakouan AU - Bintou Sessouma AU - Têeda Hamidou Ganamé AU - Lassané Tarpaga AU - Jules Yoda AU - Karifa Bayo Y1 - 2021/12/07 PY - 2021 N1 - https://doi.org/10.11648/j.ajhc.20210702.13 DO - 10.11648/j.ajhc.20210702.13 T2 - American Journal of Heterocyclic Chemistry JF - American Journal of Heterocyclic Chemistry JO - American Journal of Heterocyclic Chemistry SP - 33 EP - 38 PB - Science Publishing Group SN - 2575-5722 UR - https://doi.org/10.11648/j.ajhc.20210702.13 AB - Coumarins are the most important oxygenated heterocyclic of natural compounds. They are widely used as raw materials in many areas such as agrochemical, perfume, pharmaceutical industries. They therefore have several physical, chemical and biological properties. In order to enlarge this family of compounds and elucidate almost all of its properties, researchers have developed various synthetic methods that are not very complex and less expensive. Thus, from 4-hydroxycoumarin we have synthesized a series of 3-acyl-4-hydroxycoumarins by C-acylation. This study is therefore dedicated to the reactivity of 3-acyl-4-hydroxycoumarins. The synthesized coumarins showed a high reaction potential based on the chemical functions present in their structures. To enhance them later, we can try to graft other functions which can be the subject of several transformations such as: condensation, functionalization, cyclization, acylation. So to access more interesting new poly-functionalized compounds both at the reactivity and biological level. These molecules (3-acyl-4-hydroxycoumarins) being new, very little information is known on their physicochemical behavior in writings. On the other hand, the reactivity of molecules with similar structures to those of acyl-hydroxycoumarins such as 4-acylisochroman-1,3-diones and 3-acetyl-4-hydroxycoumarin have been the subject of scientists’ work. It emerges from this study that 3-acyl-4-hydroxycoumarins shows strong chemical reactivity which can be used biologically. VL - 7 IS - 2 ER -
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