Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are neurological diseases that affect a considerable population around the world. In this research two articles that implement trials on mice regarding these diseases were analyzed and compared to determine which advancement is most significant to human process. The articles were: Boosting a gut bacterium helps mice fight an ALS-like disease, and a protein helps disease-causing immune cells invade patients’ brains. Gene expression in healthy mice and human brains can provide data to explore the capability of modeling neurological diseases in these rodents. Therefore, if different neurological pathologies found in mice can be modeled into the human brain, both research papers equally contribute to the scientific knowledge. The approach used was a direct compare and contrast method of both papers. In addition, a meta-analysis implementing different criteria to identify trends in different data. After the investigation was carried, it was found that 31% of genes were similar between human and mice brains. This provides a pronounced framework for human diseases to be modeled onto mice; this could open the possibility to discover new treatments and further understand the diseases’ etiologies. Although there is still margin for error. Considering there is a lot still unknown about ALS when compared to MS, it was concluded that both research papers contribute to the scientific community, but not equally. The ALS article provides a new framework for finally understanding and treating this disease. Some factors that influenced the findings were the difficult access to information and the timeframe implemented.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 10, Issue 6) |
| DOI | 10.11648/j.ajcem.20221006.12 |
| Page(s) | 129-132 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Disease Modeling, Clinical Trials, Mice, Neurodegenerative Diseases, ALS, Immune Disease, MS
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APA Style
Emilio Guzmán Rojas. (2023). Different Neurological Pathologies Found in Humans Can Be Modelled into Mice Brains. American Journal of Clinical and Experimental Medicine, 10(6), 129-132. https://doi.org/10.11648/j.ajcem.20221006.12
ACS Style
Emilio Guzmán Rojas. Different Neurological Pathologies Found in Humans Can Be Modelled into Mice Brains. Am. J. Clin. Exp. Med. 2023, 10(6), 129-132. doi: 10.11648/j.ajcem.20221006.12
AMA Style
Emilio Guzmán Rojas. Different Neurological Pathologies Found in Humans Can Be Modelled into Mice Brains. Am J Clin Exp Med. 2023;10(6):129-132. doi: 10.11648/j.ajcem.20221006.12
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Download@article{10.11648/j.ajcem.20221006.12,
author = {Emilio Guzmán Rojas},
title = {Different Neurological Pathologies Found in Humans Can Be Modelled into Mice Brains},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {10},
number = {6},
pages = {129-132},
doi = {10.11648/j.ajcem.20221006.12},
url = {https://doi.org/10.11648/j.ajcem.20221006.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221006.12},
abstract = {Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are neurological diseases that affect a considerable population around the world. In this research two articles that implement trials on mice regarding these diseases were analyzed and compared to determine which advancement is most significant to human process. The articles were: Boosting a gut bacterium helps mice fight an ALS-like disease, and a protein helps disease-causing immune cells invade patients’ brains. Gene expression in healthy mice and human brains can provide data to explore the capability of modeling neurological diseases in these rodents. Therefore, if different neurological pathologies found in mice can be modeled into the human brain, both research papers equally contribute to the scientific knowledge. The approach used was a direct compare and contrast method of both papers. In addition, a meta-analysis implementing different criteria to identify trends in different data. After the investigation was carried, it was found that 31% of genes were similar between human and mice brains. This provides a pronounced framework for human diseases to be modeled onto mice; this could open the possibility to discover new treatments and further understand the diseases’ etiologies. Although there is still margin for error. Considering there is a lot still unknown about ALS when compared to MS, it was concluded that both research papers contribute to the scientific community, but not equally. The ALS article provides a new framework for finally understanding and treating this disease. Some factors that influenced the findings were the difficult access to information and the timeframe implemented.},
year = {2023}
}
TY - JOUR T1 - Different Neurological Pathologies Found in Humans Can Be Modelled into Mice Brains AU - Emilio Guzmán Rojas Y1 - 2023/01/09 PY - 2023 N1 - https://doi.org/10.11648/j.ajcem.20221006.12 DO - 10.11648/j.ajcem.20221006.12 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 129 EP - 132 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20221006.12 AB - Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are neurological diseases that affect a considerable population around the world. In this research two articles that implement trials on mice regarding these diseases were analyzed and compared to determine which advancement is most significant to human process. The articles were: Boosting a gut bacterium helps mice fight an ALS-like disease, and a protein helps disease-causing immune cells invade patients’ brains. Gene expression in healthy mice and human brains can provide data to explore the capability of modeling neurological diseases in these rodents. Therefore, if different neurological pathologies found in mice can be modeled into the human brain, both research papers equally contribute to the scientific knowledge. The approach used was a direct compare and contrast method of both papers. In addition, a meta-analysis implementing different criteria to identify trends in different data. After the investigation was carried, it was found that 31% of genes were similar between human and mice brains. This provides a pronounced framework for human diseases to be modeled onto mice; this could open the possibility to discover new treatments and further understand the diseases’ etiologies. Although there is still margin for error. Considering there is a lot still unknown about ALS when compared to MS, it was concluded that both research papers contribute to the scientific community, but not equally. The ALS article provides a new framework for finally understanding and treating this disease. Some factors that influenced the findings were the difficult access to information and the timeframe implemented. VL - 10 IS - 6 ER -
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