Suphodoxine-Pyrimethamine (SP) acts by inhibiting P. falciparum replication, therefore, long term use of SP in malarial endemic sittings as intermittent preventive treatment (IPT) during pregnancy might lead to increased risk of submicroscopic parasitaemia. The present study aimed to determine the prevalence of submicroscopic P. falciparum infection in women at delivery from southern Brazzaville, where IPT-SP has been implemented since 2004, and investigate the relationship between the submicroscopic parasitaemia and pregnancy outcomes. This descriptive cross-sectional study was carried out from March 2014 to April 2015 with 281 women randomly recruited at delivery at a Health Centre in southern Brazzaville, Republic of Congo. Matched peripheral, placental, and cord blood collected from each women with malaria negative thick smears, were used for the diagnostic of P.falciparum submicroscopic infection by nested-polymerase chain reaction (nPCR) targeting the multi-copy 18 S ribosomal ARN gene. The prevalence of P.falciparum submicroscopic infection was 31.7%, 36.37%, and 12.9%, when using the peripheral, placental, and cord blood respectively. The submicroscopic P. falciparum was slightly associated with increased risk of maternal anaemia (adjusted odds ratio [OR] 1.33, 95% CI 0.82-2.17). No significant association was found between the submicroscopic parasitaemia and low birth weight, or preterm delivery. The data suggest that the prevalence of submicroscopic P. falciparum infection is high in women at delivery in Brazzaville; and might increase the risk for maternal anaemia. The infection had no impact on the prevalence of low birth weight and preterm delivery in this study sitting.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 10, Issue 1) |
| DOI | 10.11648/j.ajcem.20221001.13 |
| Page(s) | 15-22 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Plasmodium falciparum, Submicroscopic Infection, Pregnant Women, Republic of Congo
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APA Style
Jean Erick Massamba, Jean Claude Djontu, Christevy Jeannhey Vouvoungui, Nerly Chirere Gampio Gueye, Charles Kobawila, et al. (2022). Prevalence of Plasmodium falciparum Submicroscopic Infection and Pregnancy Outcomes in Congolese Women at Delivery. American Journal of Clinical and Experimental Medicine, 10(1), 15-22. https://doi.org/10.11648/j.ajcem.20221001.13
ACS Style
Jean Erick Massamba; Jean Claude Djontu; Christevy Jeannhey Vouvoungui; Nerly Chirere Gampio Gueye; Charles Kobawila, et al. Prevalence of Plasmodium falciparum Submicroscopic Infection and Pregnancy Outcomes in Congolese Women at Delivery. Am. J. Clin. Exp. Med. 2022, 10(1), 15-22. doi: 10.11648/j.ajcem.20221001.13
AMA Style
Jean Erick Massamba, Jean Claude Djontu, Christevy Jeannhey Vouvoungui, Nerly Chirere Gampio Gueye, Charles Kobawila, et al. Prevalence of Plasmodium falciparum Submicroscopic Infection and Pregnancy Outcomes in Congolese Women at Delivery. Am J Clin Exp Med. 2022;10(1):15-22. doi: 10.11648/j.ajcem.20221001.13
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Download@article{10.11648/j.ajcem.20221001.13,
author = {Jean Erick Massamba and Jean Claude Djontu and Christevy Jeannhey Vouvoungui and Nerly Chirere Gampio Gueye and Charles Kobawila and Francine Ntoumi},
title = {Prevalence of Plasmodium falciparum Submicroscopic Infection and Pregnancy Outcomes in Congolese Women at Delivery},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {10},
number = {1},
pages = {15-22},
doi = {10.11648/j.ajcem.20221001.13},
url = {https://doi.org/10.11648/j.ajcem.20221001.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221001.13},
abstract = {Suphodoxine-Pyrimethamine (SP) acts by inhibiting P. falciparum replication, therefore, long term use of SP in malarial endemic sittings as intermittent preventive treatment (IPT) during pregnancy might lead to increased risk of submicroscopic parasitaemia. The present study aimed to determine the prevalence of submicroscopic P. falciparum infection in women at delivery from southern Brazzaville, where IPT-SP has been implemented since 2004, and investigate the relationship between the submicroscopic parasitaemia and pregnancy outcomes. This descriptive cross-sectional study was carried out from March 2014 to April 2015 with 281 women randomly recruited at delivery at a Health Centre in southern Brazzaville, Republic of Congo. Matched peripheral, placental, and cord blood collected from each women with malaria negative thick smears, were used for the diagnostic of P.falciparum submicroscopic infection by nested-polymerase chain reaction (nPCR) targeting the multi-copy 18 S ribosomal ARN gene. The prevalence of P.falciparum submicroscopic infection was 31.7%, 36.37%, and 12.9%, when using the peripheral, placental, and cord blood respectively. The submicroscopic P. falciparum was slightly associated with increased risk of maternal anaemia (adjusted odds ratio [OR] 1.33, 95% CI 0.82-2.17). No significant association was found between the submicroscopic parasitaemia and low birth weight, or preterm delivery. The data suggest that the prevalence of submicroscopic P. falciparum infection is high in women at delivery in Brazzaville; and might increase the risk for maternal anaemia. The infection had no impact on the prevalence of low birth weight and preterm delivery in this study sitting.},
year = {2022}
}
TY - JOUR T1 - Prevalence of Plasmodium falciparum Submicroscopic Infection and Pregnancy Outcomes in Congolese Women at Delivery AU - Jean Erick Massamba AU - Jean Claude Djontu AU - Christevy Jeannhey Vouvoungui AU - Nerly Chirere Gampio Gueye AU - Charles Kobawila AU - Francine Ntoumi Y1 - 2022/01/28 PY - 2022 N1 - https://doi.org/10.11648/j.ajcem.20221001.13 DO - 10.11648/j.ajcem.20221001.13 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 15 EP - 22 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20221001.13 AB - Suphodoxine-Pyrimethamine (SP) acts by inhibiting P. falciparum replication, therefore, long term use of SP in malarial endemic sittings as intermittent preventive treatment (IPT) during pregnancy might lead to increased risk of submicroscopic parasitaemia. The present study aimed to determine the prevalence of submicroscopic P. falciparum infection in women at delivery from southern Brazzaville, where IPT-SP has been implemented since 2004, and investigate the relationship between the submicroscopic parasitaemia and pregnancy outcomes. This descriptive cross-sectional study was carried out from March 2014 to April 2015 with 281 women randomly recruited at delivery at a Health Centre in southern Brazzaville, Republic of Congo. Matched peripheral, placental, and cord blood collected from each women with malaria negative thick smears, were used for the diagnostic of P.falciparum submicroscopic infection by nested-polymerase chain reaction (nPCR) targeting the multi-copy 18 S ribosomal ARN gene. The prevalence of P.falciparum submicroscopic infection was 31.7%, 36.37%, and 12.9%, when using the peripheral, placental, and cord blood respectively. The submicroscopic P. falciparum was slightly associated with increased risk of maternal anaemia (adjusted odds ratio [OR] 1.33, 95% CI 0.82-2.17). No significant association was found between the submicroscopic parasitaemia and low birth weight, or preterm delivery. The data suggest that the prevalence of submicroscopic P. falciparum infection is high in women at delivery in Brazzaville; and might increase the risk for maternal anaemia. The infection had no impact on the prevalence of low birth weight and preterm delivery in this study sitting. VL - 10 IS - 1 ER -
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