Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis

Ying Li; Tingting Cao; Chao Shen; Rongqin Dai; Yi Su; Yanxia Li; Cuicui Wang; Guiran Yang; Zhenjiang Hou

doi:doi:10.11648/j.ajcem.20210906.18

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Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis

Ying Li, Tingting Cao, Chao Shen, Rongqin Dai, Yi Su, Yanxia Li, Cuicui Wang, Guiran Yang, Zhenjiang Hou

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)

Received: 7 January 2022 Published: 8 January 2022

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Abstract

Object: To investigate the levels of serum interleukin-10 (IL-10) and IL-17 in papillary thyroid carcinoma (PTC) and their relationship with prognosis. Method: 120 PTC patients who underwent radical mastectomy in the Department of Thyroid and Mammary Surgery of Cangzhou Central Hospital from January 2018 to April 2019 were randomly selected as the experimental group, and 120 healthy people who matched 1:1 with the hospital physical examination center in the same period were selected as the control group according to the sex, age and body mass index of the experimental group. Compare the levels of serum IL-10 and IL-17 between the two groups, analyze the relationship between the levels and the pathological features of PTC patients, draw the characteristic curve of subjects' working characteristics, and calculate the area under the curve (AUC) to evaluate the diagnostic value of serum IL-10 and IL-17 for PTC. All patients were followed up for 12 months after operation. Imaging and pathological examination results were used as prognostic indicators. Kaplan-Meier survival analysis was used to analyze the relationship between serum IL-10 and IL-17 levels and the prognosis of PTC patients. COX regression analysis was used to analyze the prognostic factors of PTC patients. Result: The levels of serum IL-10 and IL-17 in experimental group were significantly higher than those in control group (P<0.05). Comparison of serum IL-10 levels in PTC patients with different tumor diameters and lymphatic metastasis showed statistically significant difference (P<0.05). The level of IL-17 in serum of PTC patients with different TNM stages, differentiation degree and lymphatic metastasis was statistically significant (P<0.05). The diagnostic value of serum IL-10 combined with IL-17 in PTC is significantly higher than that of single detection (P<0.05). According to the median serum IL-10 and IL-17 for PTC diagnosis, the postoperative recurrence rate of IL-10 high expression group was significantly higher than that of IL-10 low expression group, and the postoperative recurrence rate of IL-17 high expression group was significantly higher than that of IL-17 low expression group (P<0.05). TNM stage, IL-10 level and IL-17 level are independent risk factors for postoperative recurrence of PTC patients (P<0.05). Conclusion: The elevated levels of serum IL-10 and IL-17 in PTC patients are related to TNM stage, degree of differentiation, maximum tumor diameter and lymphatic metastasis, and are independent risk factors for postoperative recurrence of PTC patients, which may be a reference index for disease diagnosis and prognosis evaluation.

Published in	American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)
DOI	10.11648/j.ajcem.20210906.18
Page(s)	238-245
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Papillary Thyroid Carcinoma, Interleukin 10, Interleukin 17, Diagnosis, Prognosis

References

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APA Style

Ying Li, Tingting Cao, Chao Shen, Rongqin Dai, Yi Su, et al. (2022). Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis. American Journal of Clinical and Experimental Medicine, 9(6), 238-245. https://doi.org/10.11648/j.ajcem.20210906.18

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ACS Style

Ying Li; Tingting Cao; Chao Shen; Rongqin Dai; Yi Su, et al. Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis. Am. J. Clin. Exp. Med. 2022, 9(6), 238-245. doi: 10.11648/j.ajcem.20210906.18

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AMA Style

Ying Li, Tingting Cao, Chao Shen, Rongqin Dai, Yi Su, et al. Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis. Am J Clin Exp Med. 2022;9(6):238-245. doi: 10.11648/j.ajcem.20210906.18

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@article{10.11648/j.ajcem.20210906.18,
  author = {Ying Li and Tingting Cao and Chao Shen and Rongqin Dai and Yi Su and Yanxia Li and Cuicui Wang and Guiran Yang and Zhenjiang Hou},
  title = {Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {6},
  pages = {238-245},
  doi = {10.11648/j.ajcem.20210906.18},
  url = {https://doi.org/10.11648/j.ajcem.20210906.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.18},
  abstract = {Object: To investigate the levels of serum interleukin-10 (IL-10) and IL-17 in papillary thyroid carcinoma (PTC) and their relationship with prognosis. Method: 120 PTC patients who underwent radical mastectomy in the Department of Thyroid and Mammary Surgery of Cangzhou Central Hospital from January 2018 to April 2019 were randomly selected as the experimental group, and 120 healthy people who matched 1:1 with the hospital physical examination center in the same period were selected as the control group according to the sex, age and body mass index of the experimental group. Compare the levels of serum IL-10 and IL-17 between the two groups, analyze the relationship between the levels and the pathological features of PTC patients, draw the characteristic curve of subjects' working characteristics, and calculate the area under the curve (AUC) to evaluate the diagnostic value of serum IL-10 and IL-17 for PTC. All patients were followed up for 12 months after operation. Imaging and pathological examination results were used as prognostic indicators. Kaplan-Meier survival analysis was used to analyze the relationship between serum IL-10 and IL-17 levels and the prognosis of PTC patients. COX regression analysis was used to analyze the prognostic factors of PTC patients. Result: The levels of serum IL-10 and IL-17 in experimental group were significantly higher than those in control group (P<0.05). Comparison of serum IL-10 levels in PTC patients with different tumor diameters and lymphatic metastasis showed statistically significant difference (P<0.05). The level of IL-17 in serum of PTC patients with different TNM stages, differentiation degree and lymphatic metastasis was statistically significant (P<0.05). The diagnostic value of serum IL-10 combined with IL-17 in PTC is significantly higher than that of single detection (P<0.05). According to the median serum IL-10 and IL-17 for PTC diagnosis, the postoperative recurrence rate of IL-10 high expression group was significantly higher than that of IL-10 low expression group, and the postoperative recurrence rate of IL-17 high expression group was significantly higher than that of IL-17 low expression group (P<0.05). TNM stage, IL-10 level and IL-17 level are independent risk factors for postoperative recurrence of PTC patients (P<0.05). Conclusion: The elevated levels of serum IL-10 and IL-17 in PTC patients are related to TNM stage, degree of differentiation, maximum tumor diameter and lymphatic metastasis, and are independent risk factors for postoperative recurrence of PTC patients, which may be a reference index for disease diagnosis and prognosis evaluation.},
 year = {2022}
}

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TY  - JOUR
T1  - Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis
AU  - Ying Li
AU  - Tingting Cao
AU  - Chao Shen
AU  - Rongqin Dai
AU  - Yi Su
AU  - Yanxia Li
AU  - Cuicui Wang
AU  - Guiran Yang
AU  - Zhenjiang Hou
Y1  - 2022/01/08
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20210906.18
DO  - 10.11648/j.ajcem.20210906.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 238
EP  - 245
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210906.18
AB  - Object: To investigate the levels of serum interleukin-10 (IL-10) and IL-17 in papillary thyroid carcinoma (PTC) and their relationship with prognosis. Method: 120 PTC patients who underwent radical mastectomy in the Department of Thyroid and Mammary Surgery of Cangzhou Central Hospital from January 2018 to April 2019 were randomly selected as the experimental group, and 120 healthy people who matched 1:1 with the hospital physical examination center in the same period were selected as the control group according to the sex, age and body mass index of the experimental group. Compare the levels of serum IL-10 and IL-17 between the two groups, analyze the relationship between the levels and the pathological features of PTC patients, draw the characteristic curve of subjects' working characteristics, and calculate the area under the curve (AUC) to evaluate the diagnostic value of serum IL-10 and IL-17 for PTC. All patients were followed up for 12 months after operation. Imaging and pathological examination results were used as prognostic indicators. Kaplan-Meier survival analysis was used to analyze the relationship between serum IL-10 and IL-17 levels and the prognosis of PTC patients. COX regression analysis was used to analyze the prognostic factors of PTC patients. Result: The levels of serum IL-10 and IL-17 in experimental group were significantly higher than those in control group (P<0.05). Comparison of serum IL-10 levels in PTC patients with different tumor diameters and lymphatic metastasis showed statistically significant difference (P<0.05). The level of IL-17 in serum of PTC patients with different TNM stages, differentiation degree and lymphatic metastasis was statistically significant (P<0.05). The diagnostic value of serum IL-10 combined with IL-17 in PTC is significantly higher than that of single detection (P<0.05). According to the median serum IL-10 and IL-17 for PTC diagnosis, the postoperative recurrence rate of IL-10 high expression group was significantly higher than that of IL-10 low expression group, and the postoperative recurrence rate of IL-17 high expression group was significantly higher than that of IL-17 low expression group (P<0.05). TNM stage, IL-10 level and IL-17 level are independent risk factors for postoperative recurrence of PTC patients (P<0.05). Conclusion: The elevated levels of serum IL-10 and IL-17 in PTC patients are related to TNM stage, degree of differentiation, maximum tumor diameter and lymphatic metastasis, and are independent risk factors for postoperative recurrence of PTC patients, which may be a reference index for disease diagnosis and prognosis evaluation.
VL  - 9
IS  - 6
ER  -

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Author Information

Ying Li

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Tingting Cao

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Chao Shen

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Rongqin Dai

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Yi Su

Thyroid and Breast Surgical Department, People's Hospital of Nanpi County, Cangzhou, China
Yanxia Li

Department of Rheumatology and Immunology, Cangzhou Central Hospital, Cangzhou, China
Cuicui Wang

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Guiran Yang

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Zhenjiang Hou

Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

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APA Style

Ying Li, Tingting Cao, Chao Shen, Rongqin Dai, Yi Su, et al. (2022). Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis. American Journal of Clinical and Experimental Medicine, 9(6), 238-245. https://doi.org/10.11648/j.ajcem.20210906.18

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ACS Style

Ying Li; Tingting Cao; Chao Shen; Rongqin Dai; Yi Su, et al. Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis. Am. J. Clin. Exp. Med. 2022, 9(6), 238-245. doi: 10.11648/j.ajcem.20210906.18

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AMA Style

Ying Li, Tingting Cao, Chao Shen, Rongqin Dai, Yi Su, et al. Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis. Am J Clin Exp Med. 2022;9(6):238-245. doi: 10.11648/j.ajcem.20210906.18

Copy | Download

@article{10.11648/j.ajcem.20210906.18,
  author = {Ying Li and Tingting Cao and Chao Shen and Rongqin Dai and Yi Su and Yanxia Li and Cuicui Wang and Guiran Yang and Zhenjiang Hou},
  title = {Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {6},
  pages = {238-245},
  doi = {10.11648/j.ajcem.20210906.18},
  url = {https://doi.org/10.11648/j.ajcem.20210906.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.18},
  abstract = {Object: To investigate the levels of serum interleukin-10 (IL-10) and IL-17 in papillary thyroid carcinoma (PTC) and their relationship with prognosis. Method: 120 PTC patients who underwent radical mastectomy in the Department of Thyroid and Mammary Surgery of Cangzhou Central Hospital from January 2018 to April 2019 were randomly selected as the experimental group, and 120 healthy people who matched 1:1 with the hospital physical examination center in the same period were selected as the control group according to the sex, age and body mass index of the experimental group. Compare the levels of serum IL-10 and IL-17 between the two groups, analyze the relationship between the levels and the pathological features of PTC patients, draw the characteristic curve of subjects' working characteristics, and calculate the area under the curve (AUC) to evaluate the diagnostic value of serum IL-10 and IL-17 for PTC. All patients were followed up for 12 months after operation. Imaging and pathological examination results were used as prognostic indicators. Kaplan-Meier survival analysis was used to analyze the relationship between serum IL-10 and IL-17 levels and the prognosis of PTC patients. COX regression analysis was used to analyze the prognostic factors of PTC patients. Result: The levels of serum IL-10 and IL-17 in experimental group were significantly higher than those in control group (P<0.05). Comparison of serum IL-10 levels in PTC patients with different tumor diameters and lymphatic metastasis showed statistically significant difference (P<0.05). The level of IL-17 in serum of PTC patients with different TNM stages, differentiation degree and lymphatic metastasis was statistically significant (P<0.05). The diagnostic value of serum IL-10 combined with IL-17 in PTC is significantly higher than that of single detection (P<0.05). According to the median serum IL-10 and IL-17 for PTC diagnosis, the postoperative recurrence rate of IL-10 high expression group was significantly higher than that of IL-10 low expression group, and the postoperative recurrence rate of IL-17 high expression group was significantly higher than that of IL-17 low expression group (P<0.05). TNM stage, IL-10 level and IL-17 level are independent risk factors for postoperative recurrence of PTC patients (P<0.05). Conclusion: The elevated levels of serum IL-10 and IL-17 in PTC patients are related to TNM stage, degree of differentiation, maximum tumor diameter and lymphatic metastasis, and are independent risk factors for postoperative recurrence of PTC patients, which may be a reference index for disease diagnosis and prognosis evaluation.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis
AU  - Ying Li
AU  - Tingting Cao
AU  - Chao Shen
AU  - Rongqin Dai
AU  - Yi Su
AU  - Yanxia Li
AU  - Cuicui Wang
AU  - Guiran Yang
AU  - Zhenjiang Hou
Y1  - 2022/01/08
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20210906.18
DO  - 10.11648/j.ajcem.20210906.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 238
EP  - 245
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210906.18
AB  - Object: To investigate the levels of serum interleukin-10 (IL-10) and IL-17 in papillary thyroid carcinoma (PTC) and their relationship with prognosis. Method: 120 PTC patients who underwent radical mastectomy in the Department of Thyroid and Mammary Surgery of Cangzhou Central Hospital from January 2018 to April 2019 were randomly selected as the experimental group, and 120 healthy people who matched 1:1 with the hospital physical examination center in the same period were selected as the control group according to the sex, age and body mass index of the experimental group. Compare the levels of serum IL-10 and IL-17 between the two groups, analyze the relationship between the levels and the pathological features of PTC patients, draw the characteristic curve of subjects' working characteristics, and calculate the area under the curve (AUC) to evaluate the diagnostic value of serum IL-10 and IL-17 for PTC. All patients were followed up for 12 months after operation. Imaging and pathological examination results were used as prognostic indicators. Kaplan-Meier survival analysis was used to analyze the relationship between serum IL-10 and IL-17 levels and the prognosis of PTC patients. COX regression analysis was used to analyze the prognostic factors of PTC patients. Result: The levels of serum IL-10 and IL-17 in experimental group were significantly higher than those in control group (P<0.05). Comparison of serum IL-10 levels in PTC patients with different tumor diameters and lymphatic metastasis showed statistically significant difference (P<0.05). The level of IL-17 in serum of PTC patients with different TNM stages, differentiation degree and lymphatic metastasis was statistically significant (P<0.05). The diagnostic value of serum IL-10 combined with IL-17 in PTC is significantly higher than that of single detection (P<0.05). According to the median serum IL-10 and IL-17 for PTC diagnosis, the postoperative recurrence rate of IL-10 high expression group was significantly higher than that of IL-10 low expression group, and the postoperative recurrence rate of IL-17 high expression group was significantly higher than that of IL-17 low expression group (P<0.05). TNM stage, IL-10 level and IL-17 level are independent risk factors for postoperative recurrence of PTC patients (P<0.05). Conclusion: The elevated levels of serum IL-10 and IL-17 in PTC patients are related to TNM stage, degree of differentiation, maximum tumor diameter and lymphatic metastasis, and are independent risk factors for postoperative recurrence of PTC patients, which may be a reference index for disease diagnosis and prognosis evaluation.
VL  - 9
IS  - 6
ER  -

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