Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (P<0.05). Secondly, contents of malondialdehyde (MDA) in blood serum degraded remarkably (P<0.05). Thirdly, activity of superoxide dismutases (SOD) and glutathione. Peroxidase (GSH-Px) in blood serum stepped up strikingly (P<0.05). Fourthly, vis vitalis of nitric oxide synthase (NOS) and contents of nitrogen monoxidum (NO) in blood serum stepped down surprisingly (P<0.05). Conclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6) |
| DOI | 10.11648/j.ajcem.20210906.14 |
| Page(s) | 209-214 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Astragalus Mongholicus and Its Fermentation Objects, Hypothyroidism Rats, Anti-oxidation Capability
| [1] | Castellana M, Castellana C, Giovanella L, et al. Prevalence of gastrointestinal disorders having an impact on tablet levothyroxine absorption: should this formulation still be considered as the first-line therapy? [J]. Endocrine, 2020, 67 (2): 281-290. |
| [2] | Zhoujing, Jiang Sunfang. Think highly of subclinical hypothyroidism [J]. China General Practitioner Journal, 2021, 20 (9): 1024-1026. |
| [3] | Wangshu. Hypothyroidism of Aged People [J]. Geriatric Medicine and Health Care, 2021, 27 (4): 690-692. |
| [4] | Luoqi, Fang Chaohui. Clinical research advancement of therapy for hypothyroidism through Traditional Chinese Medicine [J]. Traditional Chinese Medicine Clinic Journal, 2019, 31 (11): 2181-2183. |
| [5] | Lai Yiwen, Gao Tianshu. Brief state of therapy for hypothyroidism through Traditional Chinese Medicine [J]. Practical Traditional Chinese Medicine Medical Department Journal, 2015, 29 (9): 183-185. |
| [6] | Lijian, Hanlin, Ma Yufang, et al. Depressant effects of the three ingredients of Astragalus mongholicus on oxidative stress of Chang Liver cells [J]. China Traditional Chinese Medicine Journal, 2015, 40 (2): 318-323. |
| [7] | Limin, Yanshuai, Xue Huiqing, et al. Determination of antioxidative peculiarity of proteinum constituents of Astragalus mongholicus [J]. World Combination of Traditional Chinese Medicine with Western Medicine Journal, 2015, 10 (5): 642-644. |
| [8] | Xu Rongfang, Xue Huiqing, Yan Runhong, et al. Advancement of research on fermentation of medical materials of Astragalus mongholicus [J]. Journal of Shanxi Traditional Chinese Medicine College, 2012, 13 (3): 136-138. |
| [9] | Yan Jinjin, Yang Xinzheng, Yaomiao, et al. Research of influence of general extract of Astragalus mongholicus on model of subacute insenecenceof rats caused by D-galactose [J]. Technology Creation and Application, 2018, 18 (28): 5-8. |
| [10] | Liuchao, Chen Junrong, Yu Chuntao. Optimizing fermentation technology of Astragalus mongholicus by response surface method [J]. Food Research and Development, 2019, 40 (7): 184-188. |
| [11] | Pantos C, Malliopoulou V, Mourouzis I, et al. Propylthiouracil - induced hypothyroidism is associated with increased tolerance of the isolated rat heart to ischaemia -reperfusion [J]. J Endocrinol, 2003, 178 (3): 427-435. |
| [12] | Gu Dongmei, Liang Yuhan, Liu Chaoqi, et al. Research of influence on function of thyroid gland of rats by incomplete sleep deprivation [J]. Environment and Health Journal, 2016, 33 (12): 1047-1050. |
| [13] | Heping, Mao Huijuan. Research advancement of correlation of function of thyroid gland and cardiovascular diseases in chronicity renal disease patients [J]. Clinic Renal Disease Journal, 2015, 15 (7): 443-446. |
| [14] | Yang Lina, Zhang Cuilan, Dingmeng, et al. Therapeutic effects analysis of treating autoimmune thyroiditis by Bailing gelatin capsule together with Levothyroxine Sodium Tablets [J]. Southwest National Defense Medicine, 2018, 28 (6): 503-506. |
| [15] | Wei Junping, Zheng Huijuan, Wang Qiuhong, et al. Program discussion of combination of Traditional Chinese Medicine with Western medicine to diagnose and treat subclinical hypothyroidism [J]. World Combination of Traditional Chinese Medicine with Western Medicine Journal, 2018, 13 (10): 1451-1455. |
| [16] | Mancini A, Di Segni C, Raimondo S, et al. Thyroid hormones, oxidative stress, and inflammation [J]. Mediators Inflamm, 2016, 2016: 6757154. |
| [17] | Buyukokuroglu ME, Taysi S, Koc M, Bakan N. Dantrolene protects erythrocytes against oxidative stress during whole-body irradiation in rats [J]. Cell Biochem Funct, 2003, 21: 127-131. |
| [18] | Toler SM. Oxidative stress plays an important role in the pathogenesis of drug-induced retinopathy [J]. Exp Biol Med (Maywood), 2004, V229N7: 607-615. |
| [19] | Tongjing, Zhuqing, Guoyao, et al. Influence on heart function of chronicity congestive heart failure induced by Adriamycin [J]. Journal of Nanjing University of Chinese Medicine, 2019, 35 (2): 166-170. |
| [20] | Bhalla AK, Yehya N, Mack WJ, et al. The association between inhaled nitric oxide treatment and ICU mortality and 28-day ventilator-free days in pediatric acute respiratory distress syndrome [J]. Crit Care Med, 2018, 46 (11): 1803-1810. |
| [21] | Fanyun. Clinical experience of treating thyroid gland’s post-surgical hypothyroidism with self-made Traditional Chinese Medicine prescription [J]. Inner Mongolia Chinese Medicine, 2019, 34 (9): 15. |
| [22] | Li Yanxun, Li Zhangpeng, Yan Shili, et al. Study on chemical composition of Astragalus membranaceus [J]. Chinese Herbal Medicine, 2017, 48 (13): 2601-2607. |
| [23] | Jianghui, Gu Shenglong, Zhang Yuting, et al. Research advancement of chemical composition and pharmacologic action of Astragalus mongholicus [J]. Journal of Anhui University of Chinese Medicine, 2020, 39 (5): 93-96. |
| [24] | Li Y, Ye Y, Chen H. Astragaloside IV inhibits cell migration and viability of hepatocellular carcinoma cells via suppressing long noncoding RNA ATB [J]. Biomed Pharmacother, 2018, 99: 134-141. |
| [25] | Xu N, Kan P, Yao X, et al. Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice [J]. J Microbiol, 2018, 56 (11): 838-846. |
APA Style
Yang Xiaohui, Li Chao, Zhang Jingjing, Yu Yongjun, Li Rongyao, et al. (2021). Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. American Journal of Clinical and Experimental Medicine, 9(6), 209-214. https://doi.org/10.11648/j.ajcem.20210906.14
ACS Style
Yang Xiaohui; Li Chao; Zhang Jingjing; Yu Yongjun; Li Rongyao, et al. Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. Am. J. Clin. Exp. Med. 2021, 9(6), 209-214. doi: 10.11648/j.ajcem.20210906.14
AMA Style
Yang Xiaohui, Li Chao, Zhang Jingjing, Yu Yongjun, Li Rongyao, et al. Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. Am J Clin Exp Med. 2021;9(6):209-214. doi: 10.11648/j.ajcem.20210906.14
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajcem.20210906.14,
author = {Yang Xiaohui and Li Chao and Zhang Jingjing and Yu Yongjun and Li Rongyao and Liu Chao and Hou Zhenjiang},
title = {Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {9},
number = {6},
pages = {209-214},
doi = {10.11648/j.ajcem.20210906.14},
url = {https://doi.org/10.11648/j.ajcem.20210906.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.14},
abstract = {Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (PConclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats.},
year = {2021}
}
TY - JOUR T1 - Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats AU - Yang Xiaohui AU - Li Chao AU - Zhang Jingjing AU - Yu Yongjun AU - Li Rongyao AU - Liu Chao AU - Hou Zhenjiang Y1 - 2021/12/07 PY - 2021 N1 - https://doi.org/10.11648/j.ajcem.20210906.14 DO - 10.11648/j.ajcem.20210906.14 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 209 EP - 214 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20210906.14 AB - Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (PConclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats. VL - 9 IS - 6 ER -
Information
Email: